Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles

Protein Science

Volumn 13, Issue 1, 2004, Pages 166-176

  Baerga Ortiz, Abel ^a   Bergqvist, Simon ^b   Mandell, Jeffrey G ^c   Komives, Elizabeth A ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Amide H 2H exchange; Calorimetry; Enthalpy; Entropy; Hydration; MALDI TOF mass spectrometry; Surface plasmon resonance

Indexed keywords

ANION; MONOCLONAL ANTIBODY; THROMBIN; THROMBOMODULIN;

ARTICLE; BINDING KINETICS; BINDING SITE; CALORIMETRY; ENTHALPY; ENTROPY; IONIC STRENGTH; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; BIOREACTORS; CALORIMETRY; ELECTROSTATICS; ENTROPY; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; OSMOLAR CONCENTRATION; PEPTIDE FRAGMENTS; PICHIA; PROTEIN BINDING; SOLVENTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PLASMON RESONANCE; TEMPERATURE; THERMODYNAMICS; THROMBIN; THROMBOMODULIN; WATER;

EID: 0347994109     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03120604     Document Type: Article

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