Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

Nature Biotechnology

Volumn 29, Issue 6, 2011, Pages 505-511

  Magtanong, Leslie ^a,d   Ho, Cheuk Hei ^a   Barker, Sarah L ^a   Jiao, Wei ^a   Baryshnikova, Anastasia ^a   Bahr, Sondra ^a   Smith, Andrew M ^a   Heisler, Lawrence E ^a   Choy, John S ^b   Kuzmin, Elena ^a   Andrusiak, Kerry ^a   Kobylianski, Anna ^a   Li, Zhijian ^a   Costanzo, Michael ^a   Basrai, Munira A ^b   Giaever, Guri ^a,c   Nislow, Corey ^a   Andrews, Brenda ^a   Boone, Charles ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR FUNCTION; ESSENTIAL GENE; FUNCTIONAL CONNECTION; GENETIC INTERACTION; INTERACTION NETWORKS; MUTANT CELLS; MUTANT PHENOTYPE; NETWORK PROPERTIES; OPEN READING FRAME; PHYSICAL INTERACTIONS; RELATIVE FREQUENCIES; SUPPRESSION MECHANISM; TEMPERATURE-SENSITIVE; WIRING DIAGRAM;

ACTIVE NETWORKS;

GENES;

ARTICLE; CELL CYCLE PROGRESSION; CHROMOSOME LOSS; DNA BARCODING; FUNGAL CELL; GENE DOSAGE; GENE INTERACTION; GENE REPRESSION; GLYCOSYLATION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA PROCESSING; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVE MUTANT;

CYCLIC AMP-DEPENDENT PROTEIN KINASES; DECISION TREES; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENE LIBRARY; GENE REGULATORY NETWORKS; GENES, ESSENTIAL; GENES, FUNGAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; KINETOCHORES; MUTATION; OPEN READING FRAMES; PHENOTYPE; PROTEIN INTERACTION MAPPING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; TRANSCRIPTION, GENETIC;

EID: 79958081747     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1855     Document Type: Article

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