Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions

Genetics

Volumn 159, Issue 4, 2001, Pages 1501-1509

  Klein, Hannah L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ANEUPLOIDY; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CHROMOSOME DUPLICATION; CHROMOSOME LOSS; CHROMOSOME NUMBER; CHROMOSOME REARRANGEMENT; CHROMOSOME STRUCTURE; DNA DAMAGE; DNA REPLICATION; GENE MUTATION; GENETIC RECOMBINATION; GENETIC STABILITY; HETEROZYGOSITY LOSS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CHROMOSOME DELETION; DIPLOIDY; DNA DAMAGE; DNA REPAIR; G2 PHASE; HETEROZYGOTE; LOSS OF HETEROZYGOSITY; MITOSIS; MODELS, GENETIC; MUTATION; RECOMBINATION, GENETIC; S PHASE; SACCHAROMYCES CEREVISIAE; SUPPRESSION, GENETIC;

PROKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035697323     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints
2. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
3. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
4. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
5. The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast
6. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
7. Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
8. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
9. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
10. The Saccharomyces cerevisiae RAD9 checkpoint reduces the DNA damage-associated stimulation of directed translocations
11. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
12. S-phase DNA damage checkpoint in budding yeast
13. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
14. The effect of the mating-type alleles on intragenic recombination in yeast
15. Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast
16. Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice
17. Recombination: A frank view of exchanges and vice versa
18. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
19. Cell cycle control and cancer
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22. Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells
23. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
24. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
25. DNA double strand break repair in mammalian cells
26. An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
27. Landscaping the cancer terrain
28. The distribution of the numbers of mutants in bacterial populations
29. Genetic instabilities in human cancers
30. Double-strand break repair in the absence of RAD51 in yeast: A possible role for break-induced DNA replication
31. The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast
32. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
33. Multiple heterologies increase mitotic double-strand break-induced allelic gene conversion tract lengths in yeast
34. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
35. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage
36. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins
37. Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation
38. Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombination
39. Multiple pathways for homologous recombination in Saccharomyces cerevisiae
40. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
41. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
42. Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break
43. Genetic control of recombination partner preference in yeast meiosis: Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination
44. Yeast checkpoint controls and relevance to cancer
45. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage
46. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
47. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools