Aging, Body Fat, and Carbohydrate Metabolism

Handbook of the Biology of Aging

Volumn , Issue , 2005, Pages 498-511

  Rincon, Marielisa ^a   Muzumdar, Radhika ^b   Barzilai, Nir ^a  

^a Institute for Aging Research   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79958062786     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088387-5/50021-2     Document Type: Chapter

References (123)

1. Adelman R.C. Secretion of insulin during aging. Journal of the American Geriatric Society 1989, 37:983-990.
2. Allison D.B., Fontaine K.R., Manson J.E., Stevens J., VanItallie T.B. Annual deaths attributable to obesity in the United States. Journal of the American Medical Association 1999, 282:1530-1538.
3. Anantharaju A., Feller A., Chedid A. Aging liver. Gerontology 2002, 48:343-353.
4. Anderson L.A., McTernan P.G., Barnett A.H., Kumar S. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site. Journal of Clinical Endocrinology and Metabolism 2001, 86(10):5045-5051.
5. Andres R., Bierman E.L., Hazzard W.R. Principles of geriatric medicine 1985, McGraw-Hill, New York.
6. Atzmon G., Yang X.M., Muzumdar R., Ma X.H., Gabriely I., Barzilai N. Differential gene expression between visceral and subcutaneous fat depot. Hormone and Metabolic Research 2002, 34:622-628.
7. Barnett J.B., Woods M.N., Rosner B., McCormack C., Longcope C., Houser R.F., Gorbach S.L. Sex hormone levels in premenopausal African-American women with upper and lower body fat phenotypes. Nutrition and Cancer 2001, 41(1-2):47-56.
8. Barzilai N., Gabriely I. The role of fat depletion in the biological benefits of caloric restriction. Journal of Nutrition 2001, 131:903S-906S.
9. Barzilai N., Gabriely I. Effect of age on the emergence of insulin resistance. Insulin resistance and insulin resistance syndrome 2002, 337-348. Taylor & Francis, New York. 1st ed. B. Hansen, E. Shafrir (Eds.).
10. Barzilai N., Gupta G. Revisiting the role of fat mass in the life extension induced by caloric restriction. Journal of Gerontology Series A Biological Sciences and Medical Sciences 1999, 54(3):B89-B96.
11. Barzilai N., Banerjee S., Hawkins M., Chen W., Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. Journal of Clinical Investigation 1998, 101:1353-1361.
12. Barzilai N., She L., Liu L., Wang J., Hu M., Vuguin P., Rossetti L. Decreased visceral adiposity account for leptin effect on hepatic but not peripheral insulin action. American Journal of Physiology 1999, 277:E291-E298.
13. Barzilai N., Wang J., Massilon D., Vuguin P., Hawkins M., Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. Journal of Clinical Investigation 1997, 100:3105-3110.
14. Basu R., Breda E., Oberg A.L., Powell C.C., Dalla Man C., Basu A., Vittone J.L., Klee G.G., Arora P., Jensen M.D., Toffolo G., Cobelli C., Rizza A. Mechanisms of age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes 2003, 52:1738-1748.
15. Beysen C., Karpe F., Fielding B.A., Clark A., Levy C., Frayn K.N. Interaction between specific fatty acids, GLP-1 and insulin secretion in humans. Diabetologia 2002, 45:1533-1541.
16. Bjorbaek C., Kahn B.B. Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research 2004, 59:305-331.
17. Bjorntrop P. Portal adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990, 10:493-496.
18. Bjorntrop P. Metabolic implications of body fat distribution. Diabetes Care 1991, 14:1132-1143.
19. Blüher M., Kahn B., Kahn R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003, 299:572-574.
20. Blüher M., Michael M.D., Peroni O.D., Ueki K., Carter N., Kahn B., Kahn R. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Developmental Cell 2002, 3:25-38.
21. Bourey R.E., Kohrt W.M., Kirwan J.P., Staten M.A., King D.S., Holloszy J.O. Relationship between glucose tolerance and glucose-stimulated insulin response in 65-year olds. Journal of Gerontology 1993, 48:M122-M127.
22. Boyko E.J., Fujimoto W.Y., Leonetti D.L., Newell-Morris L. Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care 2000, 23:465-471.
23. Brochu M., Tchernof A., Turner A.N., Ades P.A., Poehlman E.T. Is there a threshold of visceral fat loss that improves the metabolic profile in obese postmenopausal women?. Metabolism 2003, 52:599-604.
24. Brüning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., Klein R., Krone W., Muller-Wieland D., Kahn C.R. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
25. Brüning J.C., Michael M.D., Winnay J.N., Hayashi T., Hörsch D., Accili D., Goodyear L.J., Kahn R. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Molecular Cell 1998, 3:559-569.
26. Calle E.E., Thun M.J., Petrelli J.M., Rodriguez C., Health C.W. Body-mass index and mortality in a prospective cohort of US adults. New England Journal of Medicine 1991, 341:1097-1105.
27. Carr D.B., Utzschneider K.M., Hull R.L., Kodama K., Retzlaff B.M., Brunzell J.D., Shofer J.B., Fish B.E., Knopp R.H., Kahn S.E. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 2004, 53:2087-2094.
28. Cases J.A., Gabriely I., Ma X.H., Yang X.M., Michaeli T., Fleischer N., Rossetti L., Barzilai N. Physiologic increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 2001, 50:348-352.
29. Caterson I.D., Gill T.P. Obesity: epidemiology and possible prevention. Best Practice & Research Clinical Endocrinology & Metabolism 2002, 16(4):595-610.
30. Chalkley S.M., Kraegen E.W., Furler S.M., Campbell L.V., Chisholm D.J. NEFA elevation during a hyperglycemic clamp enhances insulin secretion. Diabetic Medicine 1998, 15:327-333.
31. Chang A.M., Halter J.B. Aging and insulin secretion. American Journal of Physiology-Endocrinology and Metabolism 2003, 284:E7-E12.
32. Chen M., Bergman R.N., Pacini G., Porte D. Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased beta cell function. Journal of Clinical Endocrinology and Metabolism 1985, 60:13-20.
33. Chua S.C., Chung W.K., Wu-Peng X.S., Zhang Y., Liu S.M., Tartaglia L., Leibel R.L. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (lep tin) receptor. Science 1996, 271:994-996.
34. Chumlea W.C., Rhyne R.L., Garry P.G., Hunt W.C. Changes in anthropometric indices of body composition with age in a healthy elederly population. American Journal of Human Biology 1989, 1:457-462.
35. Coleman D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978, 14:141-148.
36. Combs T.P., Berg A.H., Obici S., Scherer P.E., Rossetti L. Endogenous glucose roduction is inhibited by the adipose-derived protein Acrp30. Journal of Clinical Investigation 2001, 108:1875-1881.
37. Considine R.V., Sinha M.K., Heiman A., Kriauciunas T.W., Stephens M.R., Nyce J.P., Ohannesian C.C., Marco L.J., McKee T., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 1996, 334:292-295.
38. Corpas E., Harman S.M., Blackman M.R. Human growth hormone and human aging. Endocrine Reviews 1993, 14:20-39.
39. Das M., Gabriely I., Barzilai N. Caloric restriction, body fat and aging in experimental models. Obesity Reviews 2004, 5(1):13-19.
40. de Boer H., Block G.J., Voerman B., Derriks P., van der Veen E. Changes in subcutaneous and visceral, fat mass during growth hormone replacement therapy in adult men. International Journal of Obesity Related Metabolic Disorders 1996, 20(6):580-587.
41. Deeney J.T., Gromada J., Hoy M., Olsen H.L., Rhodes C.J., Prentki M., Bergren P.O., Corkey B.E. Acute stimulation with long chain acyl-coA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells. Journal of Biological Chemistry 2000, 275:9363-9368.
42. DeFronzo R.A. Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 1979, 28:1095-1101.
43. Elahi D., Muller D.C., McAloon-Dyke M., Tobin J.D., Andres R. The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus. Experimental Gerontology 1993, 28:393-409.
44. Elia M. Obesity in the elderly. Obesity Research 2001, 9(Suppl. 4):244S-248S.
45. Enzi G., Gasparo M., Binodetti P.R., Fiore D., Semisa M., Zurlo F. Subcutaneous and visceral fat distribution according to sex, age and overweight evaluated by computed tomography. American Journal of Clinical Nutrition 1986, 44:739-746.
46. Ferrannini E., Vichi S., Beck-Nielsen H., Laakso M., Paolisso G., Smith U. Insulin action and age. Diabetes 1996, 45:947-953.
47. Fink R.I., Revers R.R., Kolterman O.G., Olefsky J.M. The metabolic clearance of insulin and the feedback inhibition of insulin secreation are altered with aging. Diabetes 1985, 34:275-280.
48. Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. Prevalence and trends in obesity among US adults, 1999-2000. Journal of the American Medical Association 2002, 288:1723-1727.
49. Folsom A.R., Kushi L.H., Anderson K.E., Mink P.J., Olson J.E., Hong C.P., Sellers T.A., Lazovich D., Prineas R.J. Association of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Archives of Internal Medicine 2000, 160:2117-2128.
50. Folsom A.R., Sellers T.A., Hong C.P., Cerhan J.R., Potter J.D. Body fat distribution and 5-year risk of death in older women. Journal of the American Medical Association o 1993, 269:483-487.
51. Fraze E., Chlou M., Chen Y., Reaven G.M. Age related changes in postprandial plasma glucose, insulin, and FFA concentrations in non-diabetic individuals. Journal of the American Geriatric Society 1987, 35:212-218.
52. Friedman J.M., Hallaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
53. Fritsche A., Madaus A., Stefan N., Tschritter O., Maerker E., Teigeler A., Haring H., Stumvol M. Relationships among age, proinsulin conversion, and ß-cell function in nondiabetic human. Diabetes 2002, 51(Suppl 1):S234-S239.
54. Fujimoto W.Y., Bergstrom R.W., Boyko E.J., Chen K.W., Leonetti D.L., Newell-Morris L., Shofer J.B., Wahl P.W. Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. Diabetes Care 1999, 22:1808-1812.
55. Gabriely I., Barzilai N. The role of fat cell derived peptides in age-related metabolic alterations. Mechanisms of Ageing and Development 2001, 122:1565-1576.
56. Gabriely I., Ma X.H., Yang X.M., Atzmon G., Rajala M.W., Berg A.H., Scherer P., Rossetti L., Barzilai N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokinemediated process. Diabetes 2002, 51:2951-2958.
57. Gabriely I., Ma X.H., Yang X.M., Rossetti L., Barzilai N. Leptin resistance during aging is independent of fat mass. Diabetes 2002, 51(4):1016-1021.
58. Gumbiner B., Polonsky K.S., Beltz W.F., Wallave P., Bretchel G., Fink R.I. Effects of aging on insulin secretion. Diabetes 1989, 38:1549-1556.
59. Gupta G., Cases J.A., She L., Ma X.H., Yang X.M., Hu M., Wu J., Rossetti L., Barzilai N. Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. American Journal of Physiology-Endocrinology and Metabolism 2000, 278:E985-E991.
60. Gupta G., She L., Ma X.H., Yang X.M., Hu M., Cases J.A., Vuguin P., Rossetti L., Barzilai N. Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats. American Journal of Physiology Regulatory Integrative Comparative, Physiology 2000, 278:R111-R117.
61. Halter J.B. Carbohydrate metabolism. Handbook of physiology: aging 1995, 119-145. American Physiology Society, Bethesda, MD. J. Masoro (Ed.).
62. Hansen T.B., Vahl N., Jorgensen J.O., Christiansen J.S., Hagen C. Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind randomized, placebo-controlled study. Clinical Endocrinology (Oxf) 1995, 43(6):689-696.
63. Harris M.I., Flegal K.M., Cowie C.C., Eberhardt M.S., Goldstein D.E., Little R.R., Weidmeyer H.M., Byrd-Holt D.D. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 1998, 21(4):475-476.
64. Harrison D.E., Archer J.R., Astle C.M. Effects of food restriction, on aging: separation of food intake and adiposity. Procedings of the National Academy of Sciences of the USA 1984, 81(6):1835-1838.
65. Hayashi T., Boyko E.J., Leonetti D.L., McNeely M.J., Newell-Morris L., Kahn S.E., Fujimoto W.Y. Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans. Diabetes Care 2003, 26:650-655.
66. Henry C.J. Mechanisms of changes in basal metabolism during ageing. European Journal of Clinical Nutrition 2000, 54(Suppl. 3):S77-S91.
67. Hofmann C., Lorenz K., Braithwaite S.S., Colca J.R., Palazuk B.J., Hotamisliqil G.S. Altered gene expression for tumor, necrosis, factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994, 134:264-270.
68. Holloszy J.O. Exercise and food restriction in rats. Journal of Nutrition 1992, 122:774-777.
69. Holloszy J.O. Exercise increases average longevity of female rats despite increased food intake and no growth retardation. Journal of Gerontology 1993, 48:B97-B100.
70. Inoue K., Norgren S., Luthman H., Moller C., Grill V. B cells of aging rats: impaired stimulus-secretion coupling but normal susceptibility to adverse effects of a diabetic state. Metabolism 1997, 46:242-246.
71. Kahn S.E., Larson V.J., Beard J.C., Cain K.C., Abrass I.B. Effect of exercise on insulin action, glucose tolerance and insulin secretion in aging. American Journal of Physiology 1990, 258:E937-E943.
72. Kahn S.E., Prigeo R.L., McCulloch D.K., Boyko E.J., Bergman R.N., Schwartz M.W., Neifing J.L., Ward W.K., Beard J.C., Palmer J.P., Porte D. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993, 42:1663-1672.
73. Kanai H., Tokunaga K., Fujioka S., Yamashita S., Kameda-Takemura K.K., Matsuzawa Y. Decrease in intrabodominal visceral fat may reduce blood pressure in obese hypertensive women. Hypertension 1996, 27:125-129.
74. Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology & Metabolism 2004, 89(6):2548-2556.
75. Kissebah A.H. Insulin resistance in visceral obesity. International Journal of Obesity 1991, 15:109-115.
76. Kissebah A.H. Intra-abdominal fat: it is a major factor in developing diabetes and coronary artery disease. Diabetes Research and Clinical Practice 1996, 25-30(Suppl.).
77. Lamarche B., Lemieux S., Dagenais G.R., Despres J.P. Visceral obesity and the risk of ischaemic heart disease: insights from the Quebec Cardiovascular Study. Growth Hormone & IGF Research 1998, 8(Suppl. B):1-8.
78. Larson B. Regional obesity as a health hazard in men-prospective studies. Acta Medica 1992, 723:45-51.
79. Lawrence J.C., Colvin J., Cartee G.D., Holloszy J.O. Effects of aging and exercise on insulin action in rat adipocytes are correlated with changes in fat cell volume. Journal of Gerontology 1989, 44(4):B88-B92.
80. Lee I.M., Paffenbarger R.S., Hennekens C.H. Physical activity, physical fitness and longevity. Aging (Milano) 1997, 9(1-2):2-11.
81. Loland N.W. Exercise; health, and aging. Journal of Aging and Physical Activity 2004, 12(2):170-184.
82. Ma X.H., Muzumdar R., Yang X.M., Gabriely I., Berger R., Barzilai N. Aging is associated with resistance to effects of Leptin on fat distribution and insulin action. Journal of Gerontology: Biological Science 2002, 57:B225-B231.
83. Masoro E.J. Possible mechanisms underlying the antiaging actions of caloric restriction. Toxicologic Pathology 1996, 24:738-741.
84. Masoro E.J. Caloric restriction and aging: an update. Experimental Gerontology 2000, 35(3):299-305.
85. Masoro E.J. A forum for commentaries on recent publications. FIRKO mouse report: important new model but questionable interpretation. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2003, 58:B871-B872.
86. Masoro E.J., Austad S.N. The evolution of the antiaging action of dietary restriction: a hypothesis. Journals of Gerontology: Series A Biological Science and Medical Sciences 1996, 51A:B387-B391.
87. Mattison J.A., Lane M.A., Roth G.S., Ingram D.K. Calorie restriction in rhesus monkeys. Experimental Gerontology 2003, 38(1-2):35-46.
88. McCay C., Crowell M., Maynard L. The effect of retarded growth upon the length of life and upon ultimate size. Journal of Nutrition 1935, 10:63-79.
89. Michael M.D., Kulkarni R.N., Postic C., Previs S.F., Shulman G.I., Magnuson M.A., Kahn C.R. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular Cell 2000, 6(1):87-97.
90. Minaker K.J., Rowe J.W., Tonino R., Plotta J.A. Influence of age on clearance of insulin in man. Diabetes 1982, 31:851-855.
91. Mitchell D., Haan M.N., Steinberg F.M., Visser M. Body composition in the elderly: the influence of nutritional factors and physical activity. Journal of Nutrition, Health and Aging 2003, 7(3):130-139.
92. Miyazaki Y., Mahankali A., Matsuda M., Mahankali S., Hardies J., Cusi K., Mandarino L.J., DeFronzo R.A. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. Journal of Clinical Endocrinology and Metabolism 2002, 87(6):2784-2791.
93. Munzer T., Harman S.M., Hees P., Shapiro E., Christmas C., Bellantoni M.F., Stevens T.E., O'Connor K.G., Pabst K.M., St Clair C., Sorkin J.D., Blackman M.R. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. Journal of Clinical Endocrinology and Metabolism 2001, 86(8):3604-3610.
94. Muzumdar R., Ma X., Atzmon G., Vuguin P., Yang X., Barzilai N. Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes 2004, 53(2):441-446.
95. Muzumdar R., Ma X., Yang X., Atzmon G., Bernstein J., Karkanias G., Barzilai N. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB Journal 2003, J17:1130-1132.
96. Nass R., Thorner M.O. Impact of the GH-cortisol ratio on the age-dependent changes in body composition. Growth Hormone & IGF Research 2002, 12:147-161.
97. National Task Force on the Prevention and Treatment of Obesity Overweight, obesity, and health risk. Archives of Internal Medicine 2000, 160:898-904.
98. Novelli M., Pocai A., Skalicky M., Viidik A., Bergamini E., Masiello P. Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats. Experimental Gerontology 2004, 39:1333-1340.
99. O'Rahilly S., Yeo G.S., Farooqi I.S. Melanocortin receptors weigh in. Nature Medicine 2004, 10:351-352.
100. Peiris A.N., Struve M.F., Mueller R.A., Lee M.B., Kissebah A.H. Glucose metabolism in obesity: influence of body fat distribution. Journal of Clinical Endocrinology and Metabolism 1988, 67:760-767.
101. Poehlman E.T., Turturro A., Bodkin N., Cefalu W., Heymsfield S., Holloszy J., Kemnitz J. Caloric restriction mimetics: physical activity and body composition changes. Journals of Gerontology: Series A 2001, 56A:45-54.
102. Prentki M., Tornheim K., Corkey B. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia 1997, 40:S32-S41.
103. Prineas R.J., Folsom A.R., Kaye S.A. Central adiposity and increased risk of coronary artery disease mortality in older women. Annals of Epidemiology 1993, 3:35-41.
104. Rasmussen M.H., Frystyk J., Andersen T., Breum L., Christiansen J.S., Hilsted J. The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone. Metabolism 1994, 43(3):315-319.
105. Reaven C., Curry D., Moore J., Reaven G. Effects of age and environment factors on insulin release from perifused pancreas of the rats. Journal of Clinical Investigation 1983, 71:345-350.
106. Reaven E., Wright D., Solomon R., Ho H., Reaven G.M. Effect of age and diet on insulin secretion and insulin action in the rat. Diabetes 1983, 32:175-180.
107. Reaven E.P., Reaven G.M. Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restriction. Journal of Clinical Investigation 1981, 68:75-84.
108. Reaven E.P., Curry D.L., Reaven G.M. Effect of age and sex on rat endocrine pancreas. Diabetes 1987, 36:1397-1400.
109. Reaven E.P., Gold G., Reaven G.M. Effect of age on glucose stimulated insulin release by the beta cell of the rat. Journal of Clinical Investigation 1979, 64:591-599.
110. Reaven G.M. Role of insulin resistance in human disease (Banting lecture). Diabetes 1988, 37:1595-1607.
111. Ross M., Bras G. Food preference and length of life. Science 1975, 190:165-167.
112. Rowe J.W., Minaker K.L., Plotta J.A., Flier J.S. Characterization of the insulin resistance in aging. Journal of Clinical Investigation 1993, 71:1523-1535.
113. Russell J.C., Epling W.F., Pierce D., Amy R.M., Boer D.P. Induction of voluntary prolonged running by rats. Journal of Applied Physiology 1987, 63:2549-2553.
114. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
115. Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., Lazar M.A. The hormone resistin links obesity to diabetes. Nature 2001, 409:307-312.
116. St-Pierre J., Lemieux I., Vohl M.C., Perron P., Tremblay G., Despres J.P., Gaudet D. Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. American Journal of Cardiology 2002, 90:15-18.
117. Stumvoll M., Tataranni P.A., Stefan N., Vozarova B., Bogardus C. Glucose allostasis. Diabetes 2003, 52:903-909.
118. Tschöp M., Heiman M.L. Rodent obesity models: an overview. Experimental and Clinical Endocrinology and Diabetes 2001, 109:307-319.
119. Wang J., Liu R., Liu L., Chowdhury R., Barzilai N., Tan J., Rossetti L. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nature Medicine 1999, 5:895-899.
120. Weyer C., Bogardus C., Mott D.M., Pratey R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Journal of Clinical Investigation 1999, 104:787-794.
121. Williamson D.F., Thompson J.T., Thun M., Flanders D., Pamuk E., Byers E. Intentional weight loss and mortality among overweight individuals with diabetes. Diabetes Care 2000, 23:1499-1504.
122. Yamashita T., Murakami T., Iida M., Kuwajima M., Shima K. Leptin receptor of Zucker fatty rat performs reduced signal transduction. Diabetes 1997, 46:1077-1080.
123. Zawich W.S., Zawich K.C., Shulman G.I., Rossetti L. Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perfused rat islets. Endocrinology 1990, 126:253-260.