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Volumn 12, Issue 3, 2002, Pages 147-161

Impact of the GH-cortisol ratio on the age-dependent changes in body composition

Author keywords

Aging; Body composition; Growth hormone; Hypercortisolism

Indexed keywords

GHRELIN; GLUCOCORTICOID; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HYDROCORTISONE; SOMATOMEDIN C;

EID: 0036592189     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-6374(02)00022-9     Document Type: Review
Times cited : (50)

References (251)
  • 1
    • 0015412912 scopus 로고
    • Aging, total body potassium, fat-free mass, and cell mass in males and females between ages 18 and 85 years
    • Novack L. Aging, total body potassium, fat-free mass, and cell mass in males and females between ages 18 and 85 years. J Gerontol 1972; 27: 443-483.
    • (1972) J. Gerontol , vol.27 , pp. 443-483
    • Novack, L.1
  • 2
    • 0029064540 scopus 로고
    • The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women
    • Thompson JL, Butterfield GE, Marcus R, et al. The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 1995; 80: 1845-1852.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 1845-1852
    • Thompson, J.L.1    Butterfield, G.E.2    Marcus, R.3
  • 3
    • 0034887335 scopus 로고    scopus 로고
    • Abdominal visceral fat and fasting insulin are important predictors of 24-hour GH release independent of age, gender, and other physiological factors
    • Clasey JL, Weltman A, Patrie J, et al. Abdominal visceral fat and fasting insulin are important predictors of 24-hour GH release independent of age, gender, and other physiological factors. J Clin Endocrinol Metab 2001; 86: 3845-3852.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3845-3852
    • Clasey, J.L.1    Weltman, A.2    Patrie, J.3
  • 4
    • 0039228752 scopus 로고
    • Studies in the distribution of body fat. I. Effects of age, sex, and obesity
    • Shimokata H, Tobin J, Muller D, Elahi D, Coon P, Andres R. Studies in the distribution of body fat. I. Effects of age, sex, and obesity. J Gerontol 1989; 44: 67-73.
    • (1989) J. Gerontol , vol.44 , pp. 67-73
    • Shimokata, H.1    Tobin, J.2    Muller, D.3    Elahi, D.4    Coon, P.5    Andres, R.6
  • 5
    • 0023035033 scopus 로고
    • Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography
    • Enzi G, Gasparo M, Biondetti P, Fiore D, Semissa M, Zurlo F. Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. Am J Clin Nutr 1986; 44: 739-746.
    • (1986) Am. J. Clin. Nutr , vol.44 , pp. 739-746
    • Enzi, G.1    Gasparo, M.2    Biondetti, P.3    Fiore, D.4    Semissa, M.5    Zurlo, F.6
  • 6
    • 17944362705 scopus 로고    scopus 로고
    • Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men
    • Muenzer T, Harman S, Hees P, et al. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. J Clin Endocrinol Metab 2001; 86: 3604-610.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3604-3610
    • Muenzer, T.1    Harman, S.2    Hees, P.3
  • 7
    • 0014851083 scopus 로고
    • Adult lean body mass declines with age: Some longitudinal observations
    • Forbes G, Reina J. Adult lean body mass declines with age: some longitudinal observations. Metabolism 1970; 19: 653-663.
    • (1970) Metabolism , vol.19 , pp. 653-663
    • Forbes, G.1    Reina, J.2
  • 8
    • 0022370713 scopus 로고
    • Growth hormone, body composition, and aging
    • Rudman D. Growth hormone, body composition, and aging. J Am Geriatr Soc 1985; 33: 800-807.
    • (1985) J. Am. Geriatr. Soc , vol.33 , pp. 800-807
    • Rudman, D.1
  • 9
    • 0025905013 scopus 로고
    • Skeletal Aging-Understanding the functional and structural basis of osteoporosis
    • Marcus R. Skeletal Aging-Understanding the functional and structural basis of osteoporosis. Trends Endocrinol Metab 1991; 2: 53-58.
    • (1991) Trends Endocrinol. Metab , vol.2 , pp. 53-58
    • Marcus, R.1
  • 10
    • 0026720354 scopus 로고
    • Bone mineral density in elderly men and women: Results from the Framingham Osteoporosis Study
    • Hannan M, Felson D, Anderson J. Bone mineral density in elderly men and women: results from the Framingham Osteoporosis Study. J Bone Miner Res 1992; 7: 547-553.
    • (1992) J. Bone Miner. Res , vol.7 , pp. 547-553
    • Hannan, M.1    Felson, D.2    Anderson, J.3
  • 13
    • 0025368959 scopus 로고
    • Effects of human growth hormone in men over 60 years old
    • Rudman D, Feller A, Nagraj H, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323: 1-6.
    • (1990) N. Engl. J. Med , vol.323 , pp. 1-6
    • Rudman, D.1    Feller, A.2    Nagraj, H.3
  • 14
    • 0024854194 scopus 로고
    • The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
    • Salomon F, Cuneo R, Hesp R, Sonksen P. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989; 321: 1797-1803.
    • (1989) N. Engl. J. Med , vol.321 , pp. 1797-1803
    • Salomon, F.1    Cuneo, R.2    Hesp, R.3    Sonksen, P.4
  • 17
    • 0026427453 scopus 로고
    • Erhohte Praevalenz von Osteoporose und Arteriosklerose bei konventionell substituierter Hypophysenvorderlappeninsuffizienz: Bedarf einer zusatzlichen Wachstumshormonsubstitution?
    • Wuester C, Slenczka E, Ziegler R. Erhohte Praevalenz von Osteoporose und Arteriosklerose bei konventionell substituierter Hypophysenvorderlappeninsuffizienz: Bedarf einer zusatzlichen Wachstumshormonsubstitution?. Klin Wochenschr 1991; 69: 769-773.
    • (1991) Klin Wochenschr , vol.69 , pp. 769-773
    • Wuester, C.1    Slenczka, E.2    Ziegler, R.3
  • 18
    • 0027398458 scopus 로고
    • Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency
    • Rosen T, Bosaeus I, Tolli J, Lindstedt G, Bengtsson B. Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol (Oxford) 1993; 38: 63-71.
    • (1993) Clin. Endocrinol. (Oxford) , vol.38 , pp. 63-71
    • Rosen, T.1    Bosaeus, I.2    Tolli, J.3    Lindstedt, G.4    Bengtsson, B.5
  • 19
    • 0027514167 scopus 로고
    • Treatment of adults with growth hormone (GH) deficiency with recombinant human GH
    • Bengtsson BA, Eden S, Lonn L, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993; 76: 309-317.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 309-317
    • Bengtsson, B.A.1    Eden, S.2    Lonn, L.3
  • 20
    • 0029052046 scopus 로고
    • Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: The effect of growth hormone replacement and a comparison with control subjects
    • Snel YE, Brummer RJ, Doerga ME, et al. Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects. Am J Clin Nutr 1995; 61: 1290-1294.
    • (1995) Am. J. Clin. Nutr , vol.61 , pp. 1290-1294
    • Snel, Y.E.1    Brummer, R.J.2    Doerga, M.E.3
  • 21
    • 0029096944 scopus 로고
    • Magnetic resonance imaging-assessed adipose tissue and serum lipid and insulin concentrations in growth hormone-deficient adults. Effect of growth hormone replacement
    • Snel YE, Doerga ME, Brummer RM, Zelissen PM, Koppeschaar HP. Magnetic resonance imaging-assessed adipose tissue and serum lipid and insulin concentrations in growth hormone-deficient adults. Effect of growth hormone replacement. Arterioscler Thromb Vasc Biol 1995; 15: 1543-1548.
    • (1995) Arterioscler. Thromb Vasc. Biol , vol.15 , pp. 1543-1548
    • Snel, Y.E.1    Doerga, M.E.2    Brummer, R.M.3    Zelissen, P.M.4    Koppeschaar, H.P.5
  • 22
    • 0028956202 scopus 로고
    • Obesity, fat patterning and cardiovascular risk
    • Stevens J. Obesity, fat patterning and cardiovascular risk. Adv Exp Med Biol 1995; 369: 21-27.
    • (1995) Adv. Exp. Med. Biol , vol.369 , pp. 21-27
    • Stevens, J.1
  • 23
    • 0035464053 scopus 로고    scopus 로고
    • Ultrasonography for the evaluation of visceral fat and cardiovascular risk
    • Ribeiro-Filho FF, Faria AN, Kohlmann O Jr., et al. Ultrasonography for the evaluation of visceral fat and cardiovascular risk. Hypertension 2001; 38: 713-717.
    • (2001) Hypertension , vol.38 , pp. 713-717
    • Ribeiro-Filho, F.F.1    Faria, A.N.2    Kohlmann O., Jr.3
  • 24
    • 0035100259 scopus 로고    scopus 로고
    • Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men
    • Kobayashi H, Nakamura T, Miyaoka K, et al. Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men. Jpn Circulation J 2001; 65: 193-199.
    • (2001) Jpn. Circulation J , vol.65 , pp. 193-199
    • Kobayashi, H.1    Nakamura, T.2    Miyaoka, K.3
  • 25
    • 0035717514 scopus 로고    scopus 로고
    • Elevated C-reactive protein: Another component of the atherothrombotic profile of abdominal obesity
    • Lemieux I, Pascot A, Prud'homme D, et al. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 2001; 21: 961-967.
    • (2001) Arterioscler. Thromb Vasc. Biol , vol.21 , pp. 961-967
    • Lemieux, I.1    Pascot, A.2    Prud'homme, D.3
  • 26
    • 0033816516 scopus 로고    scopus 로고
    • Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with impaired glucose tolerance
    • Pascot A, Despres JP, Lemieux I, et al. Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with impaired glucose tolerance. Diabetologia 2000; 43: 1126-1135.
    • (2000) Diabetologia , vol.43 , pp. 1126-1135
    • Pascot, A.1    Despres, J.P.2    Lemieux, I.3
  • 27
    • 0343526435 scopus 로고    scopus 로고
    • Fat and protein redistribution with aging: Metabolic considerations
    • Beaufrere B, Morio B. Fat and protein redistribution with aging: metabolic considerations. Eur J Clin Nutr 2000; 54(Suppl 3): S48-53.
    • (2000) Eur. J. Clin. Nutr , vol.54 , Issue.SUPPL. 3
    • Beaufrere, B.1    Morio, B.2
  • 28
    • 0028866912 scopus 로고
    • Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women
    • Ghiron LJ, Thompson JL, Holloway L, et al. Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women. J Bone Miner Res 1995; 10: 1844-1852.
    • (1995) J. Bone Miner. Res , vol.10 , pp. 1844-1852
    • Ghiron, L.J.1    Thompson, J.L.2    Holloway, L.3
  • 29
    • 0029993686 scopus 로고    scopus 로고
    • Growth hormone replacement in healthy older men improves body composition but not functional ability
    • Papadakis MA, Grady D, Black D, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996; 124: 708-716.
    • (1996) Ann. Intern. Med , vol.124 , pp. 708-716
    • Papadakis, M.A.1    Grady, D.2    Black, D.3
  • 30
    • 0028116813 scopus 로고
    • Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men
    • Taaffe DR, Pruitt L, Reim J, et al. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 1994; 79: 1361-1366.
    • (1994) J. Clin. Endocrinol. Metab , vol.79 , pp. 1361-1366
    • Taaffe, D.R.1    Pruitt, L.2    Reim, J.3
  • 31
    • 0008077420 scopus 로고    scopus 로고
    • Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men
    • Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism 1997; 46: 89-96.
    • (1997) Metabolism , vol.46 , pp. 89-96
    • Vittone, J.1    Blackman, M.R.2    Busby-Whitehead, J.3
  • 32
    • 85031370715 scopus 로고    scopus 로고
    • Three months of recombinant human GHRH-1,44-amide administration in the older male enhances body composition and functional performance
    • Endocrine Society Meeting, Denver, (Abstract P2-286)
    • Frick K, Weltman JY, Wideman L, et al. Three months of recombinant human GHRH-1,44-amide administration in the older male enhances body composition and functional performance. In: Endocrine Society Meeting, Denver, 2001 (Abstract P2-286).
    • (2001)
    • Frick, K.1    Weltman, J.Y.2    Wideman, L.3
  • 33
    • 0035044615 scopus 로고    scopus 로고
    • Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women
    • Murphy MG, Weiss S, McClung M, et al. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2001; 86: 1116-1125.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 1116-1125
    • Murphy, M.G.1    Weiss, S.2    McClung, M.3
  • 34
    • 0030685741 scopus 로고    scopus 로고
    • With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens
    • Deuschle M, Gotthardt U, Schweiger U, et al. With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sci 1997; 61: 2239-2246.
    • (1997) Life Sci , vol.61 , pp. 2239-2246
    • Deuschle, M.1    Gotthardt, U.2    Schweiger, U.3
  • 35
    • 0034675049 scopus 로고    scopus 로고
    • Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men
    • Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 2000; 284: 861-868.
    • (2000) JAMA , vol.284 , pp. 861-868
    • Van Cauter, E.1    Leproult, R.2    Plat, L.3
  • 36
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect Cushing's disease of the omentum?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect Cushing's disease of the omentum?. Lancet 1997; 349: 1210-1213.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 37
    • 0031792510 scopus 로고    scopus 로고
    • Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the growth hormone research society workshop on adult growth hormone deficiency
    • Growth Hormone Research Society
    • Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the growth hormone research society workshop on adult growth hormone deficiency, J. Clin. Endocrinol. Metab. 1998; 83: 379-381.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 379-381
  • 38
    • 0026573037 scopus 로고
    • Growth hormone treatment of adults with growth hormone deficiency: Results of a 13-month placebo controlled cross-over study
    • Whitehead HM, Boreham C, McIlrath EM, et al. Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin Endocrinol (Oxford) 1992; 36: 45-52.
    • (1992) Clin. Endocrinol. (Oxford) , vol.36 , pp. 45-52
    • Whitehead, H.M.1    Boreham, C.2    McIlrath, E.M.3
  • 39
    • 0026767143 scopus 로고
    • The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition
    • Binnerts A, Swart GR, Wilson JH, et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body com~osition. Clin Endocrinol (Oxford) 1992; 37: 79-87.
    • (1992) Clin. Endocrinol. (Oxford) , vol.37 , pp. 79-87
    • Binnerts, A.1    Swart, G.R.2    Wilson, J.H.3
  • 40
    • 8044255242 scopus 로고    scopus 로고
    • Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment
    • Adult Growth Hormone Deficiency Study Group
    • Attanasio AF, Lamberts SW, Matranga AM, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab 1997; 82: 82-88.
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 82-88
    • Attanasio, A.F.1    Lamberts, S.W.2    Matranga, A.M.3
  • 41
    • 0025143155 scopus 로고
    • Skeletal muscle performance in adults with growth hormone deficiency
    • Cuneo RC, Salomon F, Wiles CM, Sonksen PH. Skeletal muscle performance in adults with growth hormone deficiency. Horm Res 1990; 33(Suppl 4): 55-60.
    • (1990) Horm. Res , vol.33 , Issue.SUPPL. 4 , pp. 55-60
    • Cuneo, R.C.1    Salomon, F.2    Wiles, C.M.3    Sonksen, P.H.4
  • 42
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-288.
    • (1990) Lancet , vol.336 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.A.2
  • 43
    • 0027480283 scopus 로고
    • Low bone mineral density in adultswith previous hypothalamic-pituitary tumors: Correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3
    • Bing-You RG, Denis MC, Rosen CJ. Low bone mineral density in adultswith previous hypothalamic-pituitary tumors: correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3. Calcif Tissue Int 1993; 52: 183-187.
    • (1993) Calcif. Tissue Int , vol.52 , pp. 183-187
    • Bing-You, R.G.1    Denis, M.C.2    Rosen, C.J.3
  • 44
    • 0015364542 scopus 로고
    • Skin collagen and thickness in acromegaly and hypopituitarism
    • Black MM, Shuster S, Bottoms E. Skin collagen and thickness in acromegaly and hypopituitarism. Clin Endocrinol (Oxford) 1972; 1: 259-263.
    • (1972) Clin. Endocrinol. (Oxford) , vol.1 , pp. 259-263
    • Black, M.M.1    Shuster, S.2    Bottoms, E.3
  • 45
    • 0024390712 scopus 로고
    • Beneficial effects of growth hormone treatment in GH-deficient adults
    • Jorgensen JO, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989; 1: 1221-1225.
    • (1989) Lancet , vol.1 , pp. 1221-1225
    • Jorgensen, J.O.1    Pedersen, S.A.2    Thuesen, L.3
  • 46
    • 0028868301 scopus 로고
    • Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood
    • Nass R, Huber RM, Klauss V, Muller OA, Schopohl J, Strasburger CJ. Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. J Clin Endocrinol Metab 1995; 80: 552-557.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 552-557
    • Nass, R.1    Huber, R.M.2    Klauss, V.3    Muller, O.A.4    Schopohl, J.5    Strasburger, C.J.6
  • 47
    • 0025974623 scopus 로고
    • Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance
    • Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH. Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol 1991; 70: 695-700.
    • (1991) J. Appl. Physiol , vol.70 , pp. 695-700
    • Cuneo, R.C.1    Salomon, F.2    Wiles, C.M.3    Hesp, R.4    Sonksen, P.H.5
  • 48
    • 0001769251 scopus 로고
    • Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults
    • Rosen T, Johannson G, Hallgren P, Caidahl K, Bosaeus I, Bengtsson BA. Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults. Endocrinol Metab 1994; 1: 55-66.
    • (1994) Endocrinol. Metab , vol.1 , pp. 55-66
    • Rosen, T.1    Johannson, G.2    Hallgren, P.3    Caidahl, K.4    Bosaeus, I.5    Bengtsson, B.A.6
  • 49
    • 0027519485 scopus 로고
    • Short and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males
    • Vandeweghe M, Taelman P, Kaufman JM. Short and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males. Clin Endocrinol (Oxford) 1993; 39: 409-415.
    • (1993) Clin. Endocrinol. (Oxford) , vol.39 , pp. 409-415
    • Vandeweghe, M.1    Taelman, P.2    Kaufman, J.M.3
  • 50
    • 0030319373 scopus 로고    scopus 로고
    • Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial
    • Baum HB, Biller BM, Finkelstein JS, et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med 1996; 125: 883-890.
    • (1996) Ann. Intern. Med , vol.125 , pp. 883-890
    • Baum, H.B.1    Biller, B.M.2    Finkelstein, J.S.3
  • 51
    • 0029812889 scopus 로고    scopus 로고
    • Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency
    • Johannsson G, Rosen T, Bosaeus I, Sjostrom L, Bengtsson BA. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J Clin Endocrinol Metab 1996; 81: 2865-2873.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , pp. 2865-2873
    • Johannsson, G.1    Rosen, T.2    Bosaeus, I.3    Sjostrom, L.4    Bengtsson, B.A.5
  • 52
    • 0035723728 scopus 로고    scopus 로고
    • The effect of long term GH replacement on bone mineral density and metabolism in hypopituitary adults
    • Drake WM, Rodriguez-Arnao J, Weaver JU, et al. The effect of long term GH replacement on bone mineral density and metabolism in hypopituitary adults. Clin Endocrinol (Oxford) 2001; 54: 525-532.
    • (2001) Clin. Endocrinol. (Oxford) , vol.54 , pp. 525-532
    • Drake, W.M.1    Rodriguez-Arnao, J.2    Weaver, J.U.3
  • 53
    • 0027286153 scopus 로고
    • Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency
    • O'Halloran D, Tsatsoulis A, Whitehouse R, Holmes S, Adams J, Shalet S. Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab 1993; 76: 1344-1348.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 1344-1348
    • O'Halloran, D.1    Tsatsoulis, A.2    Whitehouse, R.3    Holmes, S.4    Adams, J.5    Shalet, S.6
  • 54
    • 0034913839 scopus 로고    scopus 로고
    • Additional beneficial effects of alendronate in growth hormone (GH)-deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy: A randomized controlled trial
    • Biermasz NR, Hamdy NA, Janssen YJ, Roelfsema F. Additional beneficial effects of alendronate in growth hormone (GH)-deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy: a randomized controlled trial. J Clin Endocrinol Metab 2001; 86: 3079-3085.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3079-3085
    • Biermasz, N.R.1    Hamdy, N.A.2    Janssen, Y.J.3    Roelfsema, F.4
  • 55
    • 84961045907 scopus 로고
    • Effect of growth hormone on plasma fatty acids
    • Raben MS, Hollenberg H. Effect of growth hormone on plasma fatty acids. J Clin Invest 1959; 38: 484-488.
    • (1959) J. Clin. Invest , vol.38 , pp. 484-488
    • Raben, M.S.1    Hollenberg, H.2
  • 56
    • 0034524398 scopus 로고    scopus 로고
    • Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats
    • Ng FM, Jiang WJ, Gianello R, Pitt S, Roupas P. Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats. J Mol Endocrinol 2000; 25: 287-298.
    • (2000) J. Mol. Endocrinol , vol.25 , pp. 287-298
    • Ng, F.M.1    Jiang, W.J.2    Gianello, R.3    Pitt, S.4    Roupas, P.5
  • 57
    • 0031432684 scopus 로고    scopus 로고
    • Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: Generation of an obese phenotype
    • Oberbauer AM, Stem JS, Johnson PR, et al. Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype. Growth Dev Aging 1997; 61: 169-179.
    • (1997) Growth Dev. Aging , vol.61 , pp. 169-179
    • Oberbauer, A.M.1    Stem, J.S.2    Johnson, P.R.3
  • 58
    • 0027455584 scopus 로고
    • Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protem-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
    • Donahue LR, Beamer WG. Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protem-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol 1993; 136: 91-104.
    • (1993) J. Endocrinol , vol.136 , pp. 91-104
    • Donahue, L.R.1    Beamer, W.G.2
  • 59
    • 0033780069 scopus 로고    scopus 로고
    • Development of obesity in transgenic rats with low circulating growth hormone levels: Involvement of leptin resistance
    • Furuhata Y, Kagaya R, Hirabayashi K, et al. Development of obesity in transgenic rats with low circulating growth hormone levels: involvement of leptin resistance. Eur J Endocrinol 2000; 143: 535-541.
    • (2000) Eur. J. Endocrinol , vol.143 , pp. 535-541
    • Furuhata, Y.1    Kagaya, R.2    Hirabayashi, K.3
  • 60
    • 0028537612 scopus 로고
    • Growth patterns and body composition of transgenic mice expressing mutated bovine somatotropin genes
    • Knapp JR, Chen WY, Turner ND, Byers FM, Kopchick JJ. Growth patterns and body composition of transgenic mice expressing mutated bovine somatotropin genes. J Anim Sci 1994; 72: 2812-2819.
    • (1994) J. Anim. Sci , vol.72 , pp. 2812-2819
    • Knapp, J.R.1    Chen, W.Y.2    Turner, N.D.3    Byers, F.M.4    Kopchick, J.J.5
  • 62
    • 0014881901 scopus 로고
    • Pituitary response to insulin-induced hypoglycemia in obese subjects before and after fasting
    • Bell JP, Donald RA, Espiner EA. Pituitary response to insulin-induced hypoglycemia in obese subjects before and after fasting. J Clin Endocrinol Metab 1970; 31: 546-551.
    • (1970) J. Clin. Endocrinol. Metab , vol.31 , pp. 546-551
    • Bell, J.P.1    Donald, R.A.2    Espiner, E.A.3
  • 63
    • 0021746013 scopus 로고
    • Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction
    • Williams T, Berelowitz M, Joffe SN, et al. Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. N Engl J Med 1984; 311: 1403-1407.
    • (1984) N. Engl. J. Med , vol.311 , pp. 1403-1407
    • Williams, T.1    Berelowitz, M.2    Joffe, S.N.3
  • 64
    • 0021855117 scopus 로고
    • Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity
    • Kopelman PG, Noonan K, Goulton R, Forrest AJ. Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity. Clin Endocrinol (Oxford) 1985; 23: 87-94.
    • (1985) Clin. Endocrinol. (Oxford) , vol.23 , pp. 87-94
    • Kopelman, P.G.1    Noonan, K.2    Goulton, R.3    Forrest, A.J.4
  • 65
    • 0025274391 scopus 로고
    • Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects
    • Cordido F, Dieguez C, Casanueva FF. Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. J Clin Endocrinol Metab 1990; 70: 1361-1370.
    • (1990) J. Clin. Endocrinol. Metab , vol.70 , pp. 1361-1370
    • Cordido, F.1    Dieguez, C.2    Casanueva, F.F.3
  • 66
    • 0023850369 scopus 로고
    • Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects
    • Kelijman M, Frohmnan LA. Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects. J Clin Endocrinol Metab 1988; 66: 489-494.
    • (1988) J. Clin. Endocrinol. Metab , vol.66 , pp. 489-494
    • Kelijman, M.1    Frohmnan, L.A.2
  • 67
    • 0014620518 scopus 로고
    • Effect of weight reduction, triiodothyronine, and diethylstilbestrol on growth hormone in obesity
    • Londono HJ, Gallagher TF, Bray GA. Effect of weight reduction, triiodothyronine, and diethylstilbestrol on growth hormone in obesity. Metabolism 1969; 18: 986-992.
    • (1969) Metabolism , vol.18 , pp. 986-992
    • Londono, H.J.1    Gallagher, T.F.2    Bray, G.A.3
  • 68
    • 0028349307 scopus 로고
    • Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: Effects of gender
    • Weltman A, Weltman JY, Hartman ML, et al. Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab 1994; 78: 543-548.
    • (1994) J. Clin. Endocrinol. Metab , vol.78 , pp. 543-548
    • Weltman, A.1    Weltman, J.Y.2    Hartman, M.L.3
  • 69
    • 0028088251 scopus 로고
    • The effect of hypocaloric diet with and without D-fenfluramine treatment on growth hormone release after growth hormone-releasing factor stimulation in patients with android obesity
    • Medeiros-Neto G, Lima N, Perozim L, Pedrinola F, Wajchenberg BL. The effect of hypocaloric diet with and without D-fenfluramine treatment on growth hormone release after growth hormone-releasing factor stimulation in patients with android obesity. Metabolism 1994; 43: 969-973.
    • (1994) Metabolism , vol.43 , pp. 969-973
    • Medeiros-Neto, G.1    Lima, N.2    Perozim, L.3    Pedrinola, F.4    Wajchenberg, B.L.5
  • 70
    • 0027419864 scopus 로고
    • Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: Evidence for a marked somatotroph secretory capability in obesity
    • [see comments]
    • Cordido F, Penalva A, Dieguez C, Casanueva FF. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity [see comments] J Clin Endocrinol Metab 1993; 76: 819-823.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 819-823
    • Cordido, F.1    Penalva, A.2    Dieguez, C.3    Casanueva, F.F.4
  • 71
    • 0027968860 scopus 로고
    • Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects
    • Andreotti AC, Lanzi R, Manzoni MF, Caumo A, Moreschi A, Pontiroli AE. Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects. Metabolism 1994; 43: 1207-1213.
    • (1994) Metabolism , vol.43 , pp. 1207-1213
    • Andreotti, A.C.1    Lanzi, R.2    Manzoni, M.F.3    Caumo, A.4    Moreschi, A.5    Pontiroli, A.E.6
  • 72
    • 0023616485 scopus 로고
    • Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary
    • Casanueva FF, Villanueva L, Dieguez C, et al. Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. J Clin Endocrinol Metab 1987; 65: 634-642.
    • (1987) J. Clin. Endocrinol. Metab , vol.65 , pp. 634-642
    • Casanueva, F.F.1    Villanueva, L.2    Dieguez, C.3
  • 73
    • 0029118436 scopus 로고
    • Acipimox potentiates growth hormone (GH) response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty acid in normal and obese subjects
    • Lee EJ, Nam SY, Kim KR, et al. Acipimox potentiates growth hormone (GH) response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty acid in normal and obese subjects. J Clin Endocrinol Metab 1995; 80: 2495-2498.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 2495-2498
    • Lee, E.J.1    Nam, S.Y.2    Kim, K.R.3
  • 74
    • 0029550385 scopus 로고
    • Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidism
    • Lee EJ, Kim KR, Lee HC, et al. Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidism. Metabolism 1995; 44: 1509-1512.
    • (1995) Metabolism , vol.44 , pp. 1509-1512
    • Lee, E.J.1    Kim, K.R.2    Lee, H.C.3
  • 75
    • 15844380039 scopus 로고    scopus 로고
    • Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesity
    • Nam SY, Lee, Kim KR, et al. Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesity. Metabolism 1996; 45: 594-597.
    • (1996) Metabolism , vol.45 , pp. 594-597
    • Nam, S.Y.1    Lee Kim, K.R.2
  • 76
    • 0028348734 scopus 로고
    • The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone
    • Rasmussen MH, Frystyk J, Andersen T, Breum L, Christiansen JS, Hilsted J. The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone. Metabolism 1994; 43: 315-319.
    • (1994) Metabolism , vol.43 , pp. 315-319
    • Rasmussen, M.H.1    Frystyk, J.2    Andersen, T.3    Breum, L.4    Christiansen, J.S.5    Hilsted, J.6
  • 79
    • 0026347185 scopus 로고
    • Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
    • Haarbo J, Marslew U, Gotfredsen A, Christiansen C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 1991; 40: 1323-1326.
    • (1991) Metabolism , vol.40 , pp. 1323-1326
    • Haarbo, J.1    Marslew, U.2    Gotfredsen, A.3    Christiansen, C.4
  • 80
    • 0021813687 scopus 로고
    • Obesity: New insight into the anthropometric classification of fat distribution shown by computed tomography
    • Ashwell M, Cole TJ, Dixon AK. Obesity: new insight into the anthropometric classification of fat distribution shown by computed tomography. British Medical Journal Clinical Research Ed 1985; 290: 1692-1694.
    • (1985) British Medical Journal Clinical Research Ed , vol.290 , pp. 1692-1694
    • Ashwell, M.1    Cole, T.J.2    Dixon, A.K.3
  • 81
    • 0035347211 scopus 로고    scopus 로고
    • Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women
    • DeNino WF, Tchernof A, Dionne IJ, et al. Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women. Diabetes Care 2001; 24: 925-932.
    • (2001) Diabetes Care , vol.24 , pp. 925-932
    • DeNino, W.F.1    Tchernof, A.2    Dionne, I.J.3
  • 84
    • 38149147594 scopus 로고
    • One year of replacement therapy in adults with growth hormone deficiency
    • Stiegler C, Leb G. One year of replacement therapy in adults with growth hormone deficiency. Endocrinol Metab 1994; 1: 37-42.
    • (1994) Endocrinol. Metab , vol.1 , pp. 37-42
    • Stiegler, C.1    Leb, G.2
  • 86
    • 0034635778 scopus 로고    scopus 로고
    • Low serum IGF-I and occurrence of osteoporotic fractures in postmenopausal women
    • Gamero P, Sornay-Rendu E, Delmas PD. Low serum IGF-I and occurrence of osteoporotic fractures in postmenopausal women. Lancet 2000; 355: 898-899.
    • (2000) Lancet , vol.355 , pp. 898-899
    • Gamero, P.1    Sornay-Rendu, E.2    Delmas, P.D.3
  • 87
    • 0025159241 scopus 로고
    • Effects of short term administration of recombinant human growth hormone to elderly people
    • Marcus R, Butterfield G, Holloway L, et al. Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metabol 1990; 70: 519-527.
    • (1990) J. Clin. Endocrinol. Metabol , vol.70 , pp. 519-527
    • Marcus, R.1    Butterfield, G.2    Holloway, L.3
  • 88
    • 0035021519 scopus 로고    scopus 로고
    • Recombinant human growth hormone, but not insulin-like growth factor-I, enhances central fat loss in postmenopausal women undergoing a diet and exercise program
    • Taaffe DR, Thompson JL, Butterfield GE, Hoffman AR, Marcus R. Recombinant human growth hormone, but not insulin-like growth factor-I, enhances central fat loss in postmenopausal women undergoing a diet and exercise program. Horm Metab Res 2001; 33: 156-162.
    • (2001) Horm. Metab. Res , vol.33 , pp. 156-162
    • Taaffe, D.R.1    Thompson, J.L.2    Butterfield, G.E.3    Hoffman, A.R.4    Marcus, R.5
  • 90
    • 0023098492 scopus 로고
    • Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations
    • Ho KY, Evans WS, Blizzard RM, et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987; 64: 51-58.
    • (1987) J. Clin. Endocrinol. Metab , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 91
    • 0025787687 scopus 로고
    • Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
    • Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991; 7: 1081-1088.
    • (1991) J. Clin. Endocrinol. Metab , vol.7 , pp. 1081-1088
    • Iranmanesh, A.1    Lizarralde, G.2    Veldhuis, J.D.3
  • 92
    • 0023181868 scopus 로고
    • Nyctohemoral growth hormone profiles in young and aged men: Correlations with somatomedin-C levels
    • Vermeulen A. Nyctohemoral growth hormone profiles in young and aged men: correlations with somatomedin-C levels. J Clin Endocrinol Metab 1987; 64: 884-888.
    • (1987) J. Clin. Endocrinol. Metab , vol.64 , pp. 884-888
    • Vermeulen, A.1
  • 93
    • 0015349640 scopus 로고
    • Absence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly
    • Carlson HE, Gillin JC, Gordon P, Snyder F. Absence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly. J Clin Endocrinol Metab 1972; 34: 1102-1105.
    • (1972) J. Clin. Endocrinol. Metab , vol.34 , pp. 1102-1105
    • Carlson, H.E.1    Gillin, J.C.2    Gordon, P.3    Snyder, F.4
  • 94
    • 0020618522 scopus 로고
    • Plasma growth hormone secretion during nocturnal sleep in course of aging
    • Prinz PN, Weitzman ED, Cunningham GR, Karacan I. Plasma growth hormone secretion during nocturnal sleep in course of aging. J Gerontol 1983; 38: 519-524.
    • (1983) J. Gerontol , vol.38 , pp. 519-524
    • Prinz, P.N.1    Weitzman, E.D.2    Cunningham, G.R.3    Karacan, I.4
  • 95
    • 0030039542 scopus 로고    scopus 로고
    • Changes in cortisol and growth hormone secretion during nocturnal sleep in the course of aging
    • Kern W, Dodt C, Born J, Fehm HL. Changes in cortisol and growth hormone secretion during nocturnal sleep in the course of aging. J Gerontol Series A-Biol Sci Med Sci 1996; 51: M3-9.
    • (1996) J. Gerontol. Series A-Biol Sci. Med. Sci , vol.51
    • Kern, W.1    Dodt, C.2    Born, J.3    Fehm, H.L.4
  • 96
    • 0003136486 scopus 로고    scopus 로고
    • The adrenal cortex
    • Wilson JD, Foster DW (eds). 9th ed. Philadelphia: W.B. Saunders
    • Orth D, Kovacs W, DeBold C. The adrenal cortex. In: Wilson JD, Foster DW (eds). Williams Textbook of Endocrinology, 9th ed. Philadelphia: W.B. Saunders; 1998: pp. 517-665.
    • (1998) Williams Textbook of Endocrinology , pp. 517-665
    • Orth, D.1    Kovacs, W.2    DeBold, C.3
  • 97
    • 0027726015 scopus 로고
    • CT-determined body composition changes with recombinant human growth hormone treatment to adults with growth hormone deficiency
    • Lonn L, Kvist H, Grangard U, Bengtsson BA, Sjostrom L. CT-determined body composition changes with recombinant human growth hormone treatment to adults with growth hormone deficiency. Basic Life Sci 1993; 60: 229-231.
    • (1993) Basic Life Sci , vol.60 , pp. 229-231
    • Lonn, L.1    Kvist, H.2    Grangard, U.3    Bengtsson, B.A.4    Sjostrom, L.5
  • 98
    • 0028075339 scopus 로고
    • Glucocorticoid action and the clinical features of Cushing's syndrome
    • Yanovski J, Cutler G. Glucocorticoid action and the clinical features of Cushing's syndrome. Endocrinol Metab Clin North Am 1994; 23: 487-509.
    • (1994) Endocrinol. Metab. Clin. North Am , vol.23 , pp. 487-509
    • Yanovski, J.1    Cutler, G.2
  • 99
    • 0029114151 scopus 로고
    • Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease
    • Wajchenberg BL, Bosco A, Marone MM, et al. Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease. J Clin Endocrinol Metab 1995; 80: 2791-2794.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 2791-2794
    • Wajchenberg, B.L.1    Bosco, A.2    Marone, M.M.3
  • 100
    • 0028801263 scopus 로고
    • Bone mineral density and bone turnover before and after surgical cure of Cushing's syndrome
    • [see comments]
    • Hermus AR, Smals AG, Swinkels LM, et al. Bone mineral density and bone turnover before and after surgical cure of Cushing's syndrome [see comments]. J Clin Endocrinol Metab 1995; 80: 2859-2865.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 2859-2865
    • Hermus, A.R.1    Smals, A.G.2    Swinkels, L.M.3
  • 101
  • 103
    • 0028049663 scopus 로고
    • Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy
    • Magiakou MA, Mastorakos G, Oldfield EH, et al. Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med 1994; 331: 629-636.
    • (1994) N. Engl. J. Med , vol.331 , pp. 629-636
    • Magiakou, M.A.1    Mastorakos, G.2    Oldfield, E.H.3
  • 105
    • 0019997417 scopus 로고
    • Cushing's syndrome - Killing disease: Discriminatory value of signs and symptoms aiding early diagnosis
    • Ross EJ, Linch DC. Cushing's syndrome - killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet 1982; 2: 646-649.
    • (1982) Lancet , vol.2 , pp. 646-649
    • Ross, E.J.1    Linch, D.C.2
  • 107
    • 0024489441 scopus 로고
    • Body fat distribution measured with CT: Correlations in healthy subjects, patients with anorexia nervosa and patients with Cushing's syndrome
    • Mayo-Smith W, Hayes C, Biller B. Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa and patients with Cushing's syndrome. Radiology 1989; 170: 515-518.
    • (1989) Radiology , vol.170 , pp. 515-518
    • Mayo-Smith, W.1    Hayes, C.2    Biller, B.3
  • 108
    • 0028027675 scopus 로고
    • Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome
    • Loenn L, Kvist H, Ernest I, Sjostrom L. Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome. Metabolism 1994; 43: 1517-1522.
    • (1994) Metabolism , vol.43 , pp. 1517-1522
    • Loenn, L.1    Kvist, H.2    Ernest, I.3    Sjostrom, L.4
  • 109
    • 0026685047 scopus 로고
    • Cortisol secretion in relation to body fat distribution in obese premenopausal women
    • Marin P, Darin N, Amemyia T, Andersson B, Jern S, Bjoerntrop P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992; 41: 882-886.
    • (1992) Metabolism , vol.41 , pp. 882-886
    • Marin, P.1    Darin, N.2    Amemyia, T.3    Andersson, B.4    Jern, S.5    Bjoerntrop, P.6
  • 110
    • 0027185253 scopus 로고
    • The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution
    • Pasquali R, Cantobelli S, Casimirri F, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 1993; 77: 341-346.
    • (1993) J. Clin. Endocrinol. Metab , vol.77 , pp. 341-346
    • Pasquali, R.1    Cantobelli, S.2    Casimirri, F.3
  • 112
    • 0027249267 scopus 로고
    • Is hypothalamic-pituitary-adrenal hyperactivity important in the pathogenesis of excessive abdominal fat distribution?
    • [letter; comment]
    • Streeten DH. Is hypothalamic-pituitary-adrenal hyperactivity important in the pathogenesis of excessive abdominal fat distribution? [letter; comment] J Clin Endocrinol Metab 1993; 77:339-340.
    • (1993) J. Clin. Endocrinol. Metab , vol.77 , pp. 339-340
    • Streeten, D.H.1
  • 113
    • 0027531626 scopus 로고
    • Stress update. Adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress
    • Dallman MF. Stress update. Adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress. Trends Endocrinol Metab 1993; 4: 62-69.
    • (1993) Trends Endocrinol. Metab , vol.4 , pp. 62-69
    • Dallman, M.F.1
  • 115
    • 0035019845 scopus 로고    scopus 로고
    • The N363S polymorphism of the glucocorticoid receptor: Potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus
    • Dobson MG, Redfern CP, Unwin N, WeaverJU. The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.J Clin Endocrinol Metab 2001; 86: 2270-2274.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2270-2274
    • Dobson, M.G.1    Redfern, C.P.2    Unwin, N.3    Weaver, J.U.4
  • 116
    • 0034184087 scopus 로고    scopus 로고
    • A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    • Rosmond R, Chagnon YC, Holm G, et al. A glucocorticoid. receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res 2000; 8: 211-218.
    • (2000) Obes. Res , vol.8 , pp. 211-218
    • Rosmond, R.1    Chagnon, Y.C.2    Holm, G.3
  • 117
    • 0031869516 scopus 로고    scopus 로고
    • Sexual dimorphism in 11β-hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects
    • [see comments]
    • Weaver JU, Taylor NF, Monson JP, Wood PJ, Kelly WF. Sexual dimorphism in 11β-hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects [see comments] Clin Endocrinol (Oxford) 1998; 49: 13-20.
    • (1998) Clin. Endocrinol. (Oxford) , vol.49 , pp. 13-20
    • Weaver, J.U.1    Taylor, N.F.2    Monson, J.P.3    Wood, P.J.4    Kelly, W.F.5
  • 118
    • 0031821044 scopus 로고    scopus 로고
    • 'The fat lady sings', but what is she telling us?
    • [letter; comment]
    • Stewart PM. 'The fat lady sings', but what is she telling us? [letter; comment] Clin Endocrinol (Oxford) 1998; 49: 9-10.
    • (1998) Clin. Endocrinol. (Oxford) , vol.49 , pp. 9-10
    • Stewart, P.M.1
  • 119
    • 0031948398 scopus 로고    scopus 로고
    • Cortisol, hypertension and obesity: The role of 11β-hydroxysteroid dehydrogenase
    • Stewart PM. Cortisol, hypertension and obesity: the role of 11β-hydroxysteroid dehydrogenase. J R Coll Physicians Lond 1998; 32: 154-159.
    • (1998) J. R. Coll. Physicians Lond , vol.32 , pp. 154-159
    • Stewart, P.M.1
  • 120
    • 0034463972 scopus 로고    scopus 로고
    • Understanding the role of glucocorticoids in obesity: Tissue-specific alterations of corticosterone metabolism in obese zucker rats
    • Livingstone DEW, Jones GC, Smith K, et al. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese zucker rats. Endocrinology 2000; 141(2): 560-563.
    • (2000) Endocrinology , vol.141 , Issue.2 , pp. 560-563
    • Livingstone, D.E.W.1    Jones, G.C.2    Smith, K.3
  • 121
    • 0003513253 scopus 로고
    • Glucocorticoid receptor expression in patients with Cushing syndrome
    • North American Society for the Study of Obesity, Minneapolis, MI (Abstract)
    • Peeke P, Oldfield E, Alexander H, et al. Glucocorticoid receptor expression in patients with Cushing syndrome. In: North American Society for the Study of Obesity, Minneapolis, MI, 1993 (Abstract).
    • (1993)
    • Peeke, P.1    Oldfield, E.2    Alexander, H.3
  • 122
    • 0025151910 scopus 로고
    • Metabolism of adipose tissue in intraabdominal depots in severly obese men and women
    • Rebuffe-Scrive M, Andersson B, Olbe L, Bjoerntorp P. Metabolism of adipose tissue in intraabdominal depots in severly obese men and women. Metabolism 1990; 39: 1021-1025.
    • (1990) Metabolism , vol.39 , pp. 1021-1025
    • Rebuffe-Scrive, M.1    Andersson, B.2    Olbe, L.3    Bjoerntorp, P.4
  • 123
    • 0029303454 scopus 로고
    • Blockade of the glucocorticoid receptor with RU 486: Effects in vitro and in vivo on human adipose tissue lipoprotein lipase activity
    • Ottosson M, Marin P, Karason K, Elander A, Bjorntorp P. Blockade of the glucocorticoid receptor with RU 486: effects in vitro and in vivo on human adipose tissue lipoprotein lipase activity. Obes Res 1995; 3: 233-240.
    • (1995) Obes. Res , vol.3 , pp. 233-240
    • Ottosson, M.1    Marin, P.2    Karason, K.3    Elander, A.4    Bjorntorp, P.5
  • 126
    • 0022625980 scopus 로고
    • Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men
    • Pavlov EP, Harman SM, Chrousos GP, Loriaux DL, Blackman MR. Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men. J Clin Endocrinol Metab 1986; 62: 767-772.
    • (1986) J. Clin. Endocrinol. Metab , vol.62 , pp. 767-772
    • Pavlov, E.P.1    Harman, S.M.2    Chrousos, G.P.3    Loriaux, D.L.4    Blackman, M.R.5
  • 128
    • 0014542486 scopus 로고
    • Assessment of hypothalamic-pituitary-adrenal function in the geriatric age group
    • Friedman M, Green MF, Sharland DE. Assessment of hypothalamic-pituitary-adrenal function in the geriatric age group. J Gerontol 1969; 24: 292-297.
    • (1969) J. Gerontol , vol.24 , pp. 292-297
    • Friedman, M.1    Green, M.F.2    Sharland, D.E.3
  • 129
    • 0014226290 scopus 로고
    • Hypothalamic-pituitary-adrenal function in the elderly
    • Green MF, Friedman M. Hypothalamic-pituitary-adrenal function in the elderly. Gerontol Clin 1968; 10: 334-339.
    • (1968) Gerontol. Clin , vol.10 , pp. 334-339
    • Green, M.F.1    Friedman, M.2
  • 131
    • 0035836756 scopus 로고    scopus 로고
    • Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
    • Yau JL, Noble J, Kenyon CJ, et al. Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc Nat Acad Sci USA 2001; 98: 4716-4721.
    • (2001) Proc. Nat. Acad. Sci. USA , vol.98 , pp. 4716-4721
    • Yau, J.L.1    Noble, J.2    Kenyon, C.J.3
  • 133
    • 0032057656 scopus 로고    scopus 로고
    • Cortisol levels during human aging predict hippocampal atrophy and memory deficits
    • [see comments]
    • Lupien SJ, de Leon M, de Santi S, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits [see comments]. Nature Neurosci 1998; 1: 69-73.
    • (1998) Nature Neurosci , vol.1 , pp. 69-73
    • Lupien, S.J.1    de Leon, M.2    de Santi, S.3
  • 134
    • 0029060715 scopus 로고
    • Glucocorticoid hypersecretion and the age-impaired hippocampus: Cause or effect?
    • Seckl JR, Olsson T. Glucocorticoid hypersecretion and the age-impaired hippocampus: cause or effect?. J Endocrinol 1995; 145: 201-211.
    • (1995) J. Endocrinol , vol.145 , pp. 201-211
    • Seckl, J.R.1    Olsson, T.2
  • 135
    • 0031308208 scopus 로고    scopus 로고
    • Altered pulsatile and coordinate secretion of pituitary hormones in aging: Evidence of feedback disruption
    • Veldhuis JD. Altered pulsatile and coordinate secretion of pituitary hormones in aging: evidence of feedback disruption. Aging (Milano) 1997; 9: 19-20.
    • (1997) Aging (Milano) , vol.9 , pp. 19-20
    • Veldhuis, J.D.1
  • 136
    • 0023003643 scopus 로고
    • The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition
    • Sapolsky RM, Krey LC, McEwen BS. The adrenocortical axis in the aged rat: impaired sensitivity to both fast and delayed feedback inhibition. Neurobiol Aging 1986; 7: 331-335.
    • (1986) Neurobiol. Aging , vol.7 , pp. 331-335
    • Sapolsky, R.M.1    Krey, L.C.2    McEwen, B.S.3
  • 139
    • 0028793088 scopus 로고
    • Steroids, stability and stress
    • De Kloet E. Steroids, stability and stress. Front Neuroendocrinol 1995; 16: 416-425.
    • (1995) Front Neuroendocrinol , vol.16 , pp. 416-425
    • De Kloet, E.1
  • 140
    • 0024361789 scopus 로고
    • On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation
    • Ratka A, Sutanto W, Bloemers M, de Kloet ER. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology 1989; 50: 117-123.
    • (1989) Neuroendocrinology , vol.50 , pp. 117-123
    • Ratka, A.1    Sutanto, W.2    Bloemers, M.3    de Kloet, E.R.4
  • 141
    • 0023221667 scopus 로고
    • Cloning of human mineralocorticold receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor
    • Arriza JL, Weinberger C, Cerelli G, et al. Cloning of human mineralocorticold receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987; 237: 268-275.
    • (1987) Science , vol.237 , pp. 268-275
    • Arriza, J.L.1    Weinberger, C.2    Cerelli, G.3
  • 142
    • 0016606568 scopus 로고
    • Differences in corticosterone and dexamethasone binding to rat brain and pituitary
    • De Kloet R, Wallach G, McEwen BS. Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 1975; 96: 598-609.
    • (1975) Endocrinology , vol.96 , pp. 598-609
    • De Kloet, R.1    Wallach, G.2    McEwen, B.S.3
  • 143
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 144
    • 0022383620 scopus 로고
    • Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
    • Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985; 117: 2505-2511.
    • (1985) Endocrinology , vol.117 , pp. 2505-2511
    • Reul, J.M.1    de Kloet, E.R.2
  • 145
    • 0025126153 scopus 로고
    • Binding characteristics of mineralocorticoid and glucocorticoid receptors in dog brain and pituitary
    • Reul JM, de Kloet ER, van Sluijs FJ, Rijnberk A, Rothuizen J. Binding characteristics of mineralocorticoid and glucocorticoid receptors in dog brain and pituitary. Endocrinology 1990; 127: 907-915.
    • (1990) Endocrinology , vol.127 , pp. 907-915
    • Reul, J.M.1    de Kloet, E.R.2    van Sluijs, F.J.3    Rijnberk, A.4    Rothuizen, J.5
  • 146
    • 0023633827 scopus 로고
    • Species-specificity of corticosteroid receptors in hamster and rat brains
    • Sutanto W, De Kloet ER. Species-specificity of corticosteroid receptors in hamster and rat brains. Endocrinology 1987; 121: 1405-1411.
    • (1987) Endocrinology , vol.121 , pp. 1405-1411
    • Sutanto, W.1    De Kloet, E.R.2
  • 147
    • 0018263702 scopus 로고
    • Hippocampal aging and adrenocorticoids: Quantitative correlations
    • Landfield PW, Waymire JC, Lynch G. Hippocampal aging and adrenocorticoids: quantitative correlations. Science 1978; 202: 1098-1102.
    • (1978) Science , vol.202 , pp. 1098-1102
    • Landfield, P.W.1    Waymire, J.C.2    Lynch, G.3
  • 148
    • 0025324636 scopus 로고
    • Glucocorticoid endangerment of the hippocampus: Tissue steroid and receptor specificity
    • Packan DR, Sapolsky RM. Glucocorticoid endangerment of the hippocampus: tissue steroid and receptor specificity. Neuroendocrinology 1990; 51: 613-618.
    • (1990) Neuroendocrinology , vol.51 , pp. 613-618
    • Packan, D.R.1    Sapolsky, R.M.2
  • 149
    • 0035109490 scopus 로고    scopus 로고
    • Hypothalamo-pituitary-adrenocortical dysregulation in aging F344/Brown-Norway F1 hybrid rats
    • Herman JP, Larson BR, Speert DB, Seasholtz AF. Hypothalamo-pituitary-adrenocortical dysregulation in aging F344/Brown-Norway F1 hybrid rats. Neurobiol Aging 2001; 22: 323-332.
    • (2001) Neurobiol. Aging , vol.22 , pp. 323-332
    • Herman, J.P.1    Larson, B.R.2    Speert, D.B.3    Seasholtz, A.F.4
  • 150
    • 0025955324 scopus 로고
    • Spontaneous and glucocorticoid-inhibited adrenocorticotropic hormone and cortisol secretion are similar in healthy young and old men
    • Waltman C, Blackman MR, Chrousos GP, Riemann C, Harman SM. Spontaneous and glucocorticoid-inhibited adrenocorticotropic hormone and cortisol secretion are similar in healthy young and old men. J Clin Endocrinol Metab 1991; 73: 495-502.
    • (1991) J. Clin. Endocrinol. Metab , vol.73 , pp. 495-502
    • Waltman, C.1    Blackman, M.R.2    Chrousos, G.P.3    Riemann, C.4    Harman, S.M.5
  • 152
    • 0028297973 scopus 로고
    • Aging and hypothalamic-pituitary-adrenal response to challenge in humans
    • Seeman TE, Robbins RJ. Aging and hypothalamic-pituitary-adrenal response to challenge in humans. Endocr Rev 1994; 15: 233-260.
    • (1994) Endocr. Rev , vol.15 , pp. 233-260
    • Seeman, T.E.1    Robbins, R.J.2
  • 153
    • 0034828594 scopus 로고    scopus 로고
    • Elderly subjects show severe impairment of dehydroepiandrosterone sulphate and reduced sensitivity of cortisol and aldosterone response to the stimulatory effect of ACTH(1-24)
    • Giordano R, Di Vito L, Lanfranco F, et al. Elderly subjects show severe impairment of dehydroepiandrosterone sulphate and reduced sensitivity of cortisol and aldosterone response to the stimulatory effect of ACTH(1-24). Clin Endocrinol (Oxford) 2001; 55: 259-265.
    • (2001) Clin. Endocrinol. (Oxford) , vol.55 , pp. 259-265
    • Giordano, R.1    Di Vito, L.2    Lanfranco, F.3
  • 154
    • 0016416475 scopus 로고
    • Secretion of Corticotrophin and Somatototrophin by the Senescent Aderrohypophysis in man
    • Blichert-Toft M. Secretion of Corticotrophin and Somatototrophin by the Senescent Aderrohypophysis in man. Acta Endocrinol (Copenh) Supplementum 1975; 78: 15-154.
    • (1975) Acta Endocrinol. (Copenh) , vol.78 , Issue.SUPPL. , pp. 15-154
    • Blichert-Toft, M.1
  • 155
    • 0014179379 scopus 로고
    • Adrenal cortical function as reflected by the plasma hydrocortisone and urinary 17-ketogenic steroids in relation to surgery in elderly patients
    • Blichert-Toft M, Hippe E, Kjensen HK. Adrenal cortical function as reflected by the plasma hydrocortisone and urinary 17-ketogenic steroids in relation to surgery in elderly patients. Acta Chir Scand 1967; 133: 591-599.
    • (1967) Acta Chir. Scand , vol.133 , pp. 591-599
    • Blichert-Toft, M.1    Hippe, E.2    Kjensen, H.K.3
  • 156
    • 0021724901 scopus 로고
    • Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
    • Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 1984; 5: 25-44.
    • (1984) Endocr. Rev , vol.5 , pp. 25-44
    • Munck, A.1    Guyre, P.M.2    Holbrook, N.J.3
  • 157
    • 0021741839 scopus 로고
    • The dexamethasone suppression test in normal control subjects: Comparison of two assays and effect of age
    • Rosenbaum AH, Schatzberg AF, MacLaughlin RA, et al. The dexamethasone suppression test in normal control subjects: comparison of two assays and effect of age. Am J Psychiatry 1984; 141: 1550-1555.
    • (1984) Am. J. Psychiatry , vol.141 , pp. 1550-1555
    • Rosenbaum, A.H.1    Schatzberg, A.F.2    MacLaughlin, R.A.3
  • 159
    • 0021186170 scopus 로고
    • Age and the dexamethasone suppression test in depression
    • Davis KL, Davis BM, Mathe AA, et al. Age and the dexamethasone suppression test in depression. Am J Psychiatry 1984; 141: 872-874.
    • (1984) Am. J. Psychiatry , vol.141 , pp. 872-874
    • Davis, K.L.1    Davis, B.M.2    Mathe, A.A.3
  • 160
    • 0021688251 scopus 로고
    • Influence of age on the cortisol response to dexamethasone
    • Lewis DA, Pfohl B, Schlechte J, Coryell W. influence of age on the cortisol response to dexamethasone. Psychiatry Res 1984; 13: 213-220.
    • (1984) Psychiatry Res , vol.13 , pp. 213-220
    • Lewis, D.A.1    Pfohl, B.2    Schlechte, J.3    Coryell, W.4
  • 161
    • 0021837727 scopus 로고
    • Occurrence of high concentrations of postdexamethasone cortisol in elderly psychiatric inpatients
    • Fogel BS, Satel SL, Levy S. Occurrence of high concentrations of postdexamethasone cortisol in elderly psychiatric inpatients. Psychiatry Res 1985; 15: 85-90.
    • (1985) Psychiatry Res , vol.15 , pp. 85-90
    • Fogel, B.S.1    Satel, S.L.2    Levy, S.3
  • 162
    • 0022602079 scopus 로고
    • Cortisol and Alzheimer's disease, II: Dexamethasone suppression, dementia severity, and affective symptoms
    • Greenwald BS, Mathe AA, Mohs RC, Levy MI, Johns CA, Davis KL. Cortisol and Alzheimer's disease, II: dexamethasone suppression, dementia severity, and affective symptoms. Am J Psychiatry 1986; 143: 442-446.
    • (1986) Am. J. Psychiatry , vol.143 , pp. 442-446
    • Greenwald, B.S.1    Mathe, A.A.2    Mohs, R.C.3    Levy, M.I.4    Johns, C.A.5    Davis, K.L.6
  • 163
    • 0023077823 scopus 로고
    • Urinary free cortisol in psychotic depression
    • Anton RF. Urinary free cortisol in psychotic depression. Biol Psychiatry 1987; 22: 24-34.
    • (1987) Biol. Psychiatry , vol.22 , pp. 24-34
    • Anton, R.F.1
  • 164
    • 0019852415 scopus 로고
    • The dexamethasone suppression test in an elderly population
    • Tourigny-Rivard ME, Raskind M, Rivard D. The dexamethasone suppression test in an elderly population. Biol Psychiatry 1981; 16: 1177-1184.
    • (1981) Biol. Psychiatry , vol.16 , pp. 1177-1184
    • Tourigny-Rivard, M.E.1    Raskind, M.2    Rivard, D.3
  • 165
    • 0031737777 scopus 로고    scopus 로고
    • Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals
    • Huizenga NA, Koper JW, de Lange P, et al. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab 1998; 83: 47-54.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 47-54
    • Huizenga, N.A.1    Koper, J.W.2    de Lange, P.3
  • 166
    • 0023026436 scopus 로고
    • Aging is without effect on the pituitary-adrenal axis in men
    • Ohashi M, Fujio N, Kato K, Nawata H, Ibayashi H. Aging is without effect on the pituitary-adrenal axis in men. Gerontology 1986; 32: 335-339.
    • (1986) Gerontology , vol.32 , pp. 335-339
    • Ohashi, M.1    Fujio, N.2    Kato, K.3    Nawata, H.4    Ibayashi, H.5
  • 168
    • 0034793514 scopus 로고    scopus 로고
    • A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction
    • Rosmond R, Chagnon M, Bouchard C, Bjorntorp P. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. Metabolism 2001; 50: 1059-1062.
    • (2001) Metabolism , vol.50 , pp. 1059-1062
    • Rosmond, R.1    Chagnon, M.2    Bouchard, C.3    Bjorntorp, P.4
  • 169
    • 0030036523 scopus 로고    scopus 로고
    • Immunocytochemical and molecular analysis of the effects of
    • Fife SK, Brogan RS, Giustina A, Wehrenberg WB. immunocytochemical and molecular analysis of the effects of glucocorticoid-treatment on the hypothalamic-somatotropic axis in the rat. Neuroendocrinology 1996; 64: 131-138.
    • (1996) Neuroendocrinology , vol.64 , pp. 131-138
    • Fife, S.K.1    Brogan, R.S.2    Giustina, A.3    Wehrenberg, W.B.4
  • 170
    • 0030915729 scopus 로고    scopus 로고
    • Gene expression of hypothalamic somatostatin and growth hormone-releasing hormone in dexamethasone-treated rats
    • Lam KS, Srivastava G. Gene expression of hypothalamic somatostatin and growth hormone-releasing hormone in dexamethasone-treated rats. Neuroendocrinology 1997; 66: 2-8.
    • (1997) Neuroendocrinology , vol.66 , pp. 2-8
    • Lam, K.S.1    Srivastava, G.2
  • 171
    • 0030459397 scopus 로고    scopus 로고
    • Regulation of hypothalamic somatostatin, growth-hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids
    • Senaris RM, Lago F, Coya R, Pineda J, Dieguez C. Regulation of hypothalamic somatostatin, growth-hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids. Endocrinology 1996; 137: 5236-5241.
    • (1996) Endocrinology , vol.137 , pp. 5236-5241
    • Senaris, R.M.1    Lago, F.2    Coya, R.3    Pineda, J.4    Dieguez, C.5
  • 174
    • 0014408093 scopus 로고
    • Cortisol stimulation of growth hormone production by monkey adenohypophysis in tissue culture
    • Kohler PO, Bridson WE, Rayford PL. Cortisol stimulation of growth hormone production by monkey adenohypophysis in tissue culture. Biophys Res Commun 1968; 33: 834-840.
    • (1968) Biophys. Res. Commun , vol.33 , pp. 834-840
    • Kohler, P.O.1    Bridson, W.E.2    Rayford, P.L.3
  • 175
    • 0020741852 scopus 로고
    • Effects of synthetic human pancreatic (tumor) GH releasing factor and somatostatin, triiodothyronine and dexamethasone on GH secretion in vitro
    • Vale W, Vaughan J, Yamamoto G, Spiess J, Rivier J. Effects of synthetic human pancreatic (tumor) GH releasing factor and somatostatin, triiodothyronine and dexamethasone on GH secretion in vitro. Endocrinology 1983; 112: 1553-1555.
    • (1983) Endocrinology , vol.112 , pp. 1553-1555
    • Vale, W.1    Vaughan, J.2    Yamamoto, G.3    Spiess, J.4    Rivier, J.5
  • 176
    • 0014630868 scopus 로고
    • Control of growth hormone production by a clonal strain of rat pituitary cells: Stimulation by hydrocortisone
    • Bancroft FC, Levine L, Tashjian AH. Control of growth hormone production by a clonal strain of rat pituitary cells: stimulation by hydrocortisone. J Cell Biol 1969; 43: 432-441.
    • (1969) J. Cell Biol , vol.43 , pp. 432-441
    • Bancroft, F.C.1    Levine, L.2    Tashjian, A.H.3
  • 177
    • 0023728712 scopus 로고
    • Depending on the time of administration, dexamethasone potentiates or blocks growth honnone-releasing hormone-induced growth hormone release in man
    • Casanueva FF, Burguera B, Tome MA, et al. Depending on the time of administration, dexamethasone potentiates or blocks growth honnone-releasing hormone-induced growth hormone release in man. Neuroendocrinology 1988; 47: 46-49.
    • (1988) Neuroendocrinology , vol.47 , pp. 46-49
    • Casanueva, F.F.1    Burguera, B.2    Tome, M.A.3
  • 178
  • 179
    • 84995856149 scopus 로고
    • Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure
    • Magiakou M, Mastorakos G, Gomez M, Rose S, Chrousos G. Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure. J Clin Endocrinol Metab 1994; 78: 131-137.
    • (1994) J. Clin. Endocrinol. Metab , vol.78 , pp. 131-137
    • Magiakou, M.1    Mastorakos, G.2    Gomez, M.3    Rose, S.4    Chrousos, G.5
  • 180
    • 0031726147 scopus 로고    scopus 로고
    • Treatment of glucocorticoid-induced growth suppression with growth hormone
    • National Cooperative Growth Study
    • Allen D, Julius J, Breen T, Attie K. Treatment of glucocorticoid-induced growth suppression with growth hormone. National Cooperative Growth Study. J Clin Endocrinol Metab 1998; 83: 2824-2829.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 2824-2829
    • Allen, D.1    Julius, J.2    Breen, T.3    Attie, K.4
  • 181
    • 0015335581 scopus 로고
    • Responses of plasma ACTH, GH, LH, and 11-hydroxycorticosteroids to various stimuli in patients with Cushing's syndrome
    • Demura R, Demura H, Nunokawa T, Baba H, Imura K. Responses of plasma ACTH, GH, LH, and 11-hydroxycorticosteroids to various stimuli in patients with Cushing's syndrome. J Clin Endocrinol Metab 1972; 34: 852-859.
    • (1972) J. Clin. Endocrinol. Metab , vol.34 , pp. 852-859
    • Demura, R.1    Demura, H.2    Nunokawa, T.3    Baba, H.4    Imura, K.5
  • 182
    • 0024210155 scopus 로고
    • Inhibition by prednisone of growth hormone (GH) response to GH-releasing hormone in normal men
    • Kaufmann S, Jones KL, Wehrenberg WB, Culler FL. Inhibition by prednisone of growth hormone (GH) response to GH-releasing hormone in normal men. J Clin Endocrinol Metab 1988; 67: 1258-1261.
    • (1988) J. Clin. Endocrinol. Metab , vol.67 , pp. 1258-1261
    • Kaufmann, S.1    Jones, K.L.2    Wehrenberg, W.B.3    Culler, F.L.4
  • 183
    • 0016291731 scopus 로고
    • Sleep EEG stages and plasma growth hormone concentration in states of endogenous hypercortisolemia or ACTH elevation
    • Krieger DT, Glick SM. Sleep EEG stages and plasma growth hormone concentration in states of endogenous hypercortisolemia or ACTH elevation. J Clin Endocrinol Metabol 1974; 39: 986-1000.
    • (1974) J. Clin. Endocrinol. Metabol , vol.39 , pp. 986-1000
    • Krieger, D.T.1    Glick, S.M.2
  • 184
    • 0022599654 scopus 로고
    • Human pancreatic growth hormone releasing hormone fails to stimulate human growth hormone both in Cushing's disease and in Cushing's syndrome due to adrenocortical adenoma
    • Smals AE, Pieters GF, Smals AG, Benraad TJ, Kloppenborg PW. Human pancreatic growth hormone releasing hormone fails to stimulate human growth hormone both in Cushing's disease and in Cushing's syndrome due to adrenocortical adenoma. Clin Endocrinol (Oxford) 1986; 24: 401-407.
    • (1986) Clin. Endocrinol. (Oxford) , vol.24 , pp. 401-407
    • Smals, A.E.1    Pieters, G.F.2    Smals, A.G.3    Benraad, T.J.4    Kloppenborg, P.W.5
  • 185
  • 186
    • 0034927684 scopus 로고    scopus 로고
    • Joint growth hormone and cortisol spontaneous secretion is more asynchronous in older females than in their male counterparts
    • Charmandari E, Pincus SM, Matthews DR, Dennison E, Fall CH, Hindmarsh PC. joint growth hormone and cortisol spontaneous secretion is more asynchronous in older females than in their male counterparts. J Clin Endocrinol Metab 2001; 86:3393-3399.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3393-3399
    • Charmandari, E.1    Pincus, S.M.2    Matthews, D.R.3    Dennison, E.4    Fall, C.H.5    Hindmarsh, P.C.6
  • 187
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998; 19: 717-797.
    • (1998) Endocr. Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 188
    • 0029972402 scopus 로고    scopus 로고
    • The regulation of adipose tissue distribution in humans
    • Bjoerntorp P. The regulation of adipose tissue distribution in humans. Int J Obes 1996; 20: 291-302.
    • (1996) Int. J. Obes , vol.20 , pp. 291-302
    • Bjoerntorp, P.1
  • 189
    • 0032753801 scopus 로고    scopus 로고
    • The molecular mechanism of the stimulation of adipocyte differentiation by a glucocorticoid
    • Wolf G. The molecular mechanism of the stimulation of adipocyte differentiation by a glucocorticoid. Nutr Rev 1999; 57:324-326.
    • (1999) Nutr. Rev , vol.57 , pp. 324-326
    • Wolf, G.1
  • 190
    • 0032230286 scopus 로고    scopus 로고
    • Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation
    • Hansen L, Madsen B, Teisner B, Nielsen J, Billestrup N. Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation. Mol Endocrinol 1998; 12: 1140-1149.
    • (1998) Mol. Endocrinol , vol.12 , pp. 1140-1149
    • Hansen, L.1    Madsen, B.2    Teisner, B.3    Nielsen, J.4    Billestrup, N.5
  • 191
    • 0032924123 scopus 로고    scopus 로고
    • Growth hormone increases cortical and cancellous bone mass in young growing rats with glucocorticoid-induced osteopenia
    • Ortoft G, Andreassen T, Oxlund H. Growth hormone increases cortical and cancellous bone mass in young growing rats with glucocorticoid-induced osteopenia. J Bone Miner Res 1999; 14: 710-721.
    • (1999) J. Bone Miner. Res , vol.14 , pp. 710-721
    • Ortoft, G.1    Andreassen, T.2    Oxlund, H.3
  • 192
    • 0026570919 scopus 로고
    • Growth hormone and lean tissue catabolism during long-term glucocorticoid treatment
    • Bennet WM, Haymond MW. Growth hormone and lean tissue catabolism during long-term glucocorticoid treatment. Clin Endocrinol (Oxford) 1992; 36: 161-164.
    • (1992) Clin. Endocrinol. (Oxford) , vol.36 , pp. 161-164
    • Bennet, W.M.1    Haymond, M.W.2
  • 193
    • 0025935886 scopus 로고
    • Growth hormone prevents steroid-induced growth depression in health and uremia
    • Kovacs G, Fine RN, Worgall S, et al. Growth hormone prevents steroid-induced growth depression in health and uremia. Kidney Int 1991; 40: 1032-1040.
    • (1991) Kidney Int , vol.40 , pp. 1032-1040
    • Kovacs, G.1    Fine, R.N.2    Worgall, S.3
  • 194
    • 0033305271 scopus 로고    scopus 로고
    • Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-defcient adults
    • Woodhouse L, Asa S, Thomas S, Ezzat S. Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-defcient adults. J Clin Endocrinol Metab 1999; 84: 4570-4577.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 4570-4577
    • Woodhouse, L.1    Asa, S.2    Thomas, S.3    Ezzat, S.4
  • 196
    • 0035917828 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells
    • Kimura K, Kanda F, Okuda S, Chihara. K. Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells. Neurosci Lett 2001; 302: 154-156.
    • (2001) Neurosci. Lett , vol.302 , pp. 154-156
    • Kimura, K.1    Kanda, F.2    Okuda, S.3    Chihara, K.4
  • 197
    • 0021366032 scopus 로고
    • Increased proteolysis: An effect of increases in plasma cortisol within the physiologic range
    • Simmons P, Miles J, Gerich J, Hammond M. Increased proteolysis: an effect of increases in plasma cortisol within the physiologic range. J Clin Invest 1984; 73: 412-420.
    • (1984) J. Clin. Invest , vol.73 , pp. 412-420
    • Simmons, P.1    Miles, J.2    Gerich, J.3    Hammond, M.4
  • 198
    • 18144441273 scopus 로고
    • Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans
    • Beauftere B, Horber F, Schwenk W, et al. Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. Am J Physiol 1989; 257: E712-721.
    • (1989) Am. J. Physiol , vol.257
    • Beauftere, B.1    Horber, F.2    Schwenk, W.3
  • 201
    • 0019870157 scopus 로고
    • Hormonal regulation of protein degradation in skeletal and cardiac muscle
    • Tischler ME. Hormonal regulation of protein degradation in skeletal and cardiac muscle. Life Sci 1981; 28: 2569-2576.
    • (1981) Life Sci , vol.28 , pp. 2569-2576
    • Tischler, M.E.1
  • 202
    • 0023814696 scopus 로고
    • Physiological hypercortisolemia increases proteolysis, glutamme, and alanine production
    • Darmaun D, Matthews DE, Bier DM. Physiological hypercortisolemia increases proteolysis, glutamme, and alanine production. Am J Physiol 1988; 255: E366-373.
    • (1988) Am. J. Physiol , vol.255
    • Darmaun, D.1    Matthews, D.E.2    Bier, D.M.3
  • 204
    • 0035018506 scopus 로고    scopus 로고
    • Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action
    • Liu Z, Jahn LA, Long W, Fryburg DA, Wei L, Barrett EJ. Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action. J Clin Endocrinol Metab 2001; 86:2136-2143.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2136-2143
    • Liu, Z.1    Jahn, L.A.2    Long, W.3    Fryburg, D.A.4    Wei, L.5    Barrett, E.J.6
  • 205
    • 0031764205 scopus 로고    scopus 로고
    • Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition
    • Touati G, Prieur AM, Ruiz JC, Noel M, Czernichow P. Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition. J Clin Endocrinol Metab 1998; 83: 403-409.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 403-409
    • Touati, G.1    Prieur, A.M.2    Ruiz, J.C.3    Noel, M.4    Czernichow, P.5
  • 206
    • 0025330710 scopus 로고
    • Human growth hormone prevents the protein catabolic side effects of prednisone in humans
    • Horber F, Haymond M. Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 1990; 86: 265-272.
    • (1990) J. Clin. Invest , vol.86 , pp. 265-272
    • Horber, F.1    Haymond, M.2
  • 207
    • 0025818655 scopus 로고
    • Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans
    • Fryburg DA, Gelfand RA, Barrett EJ. Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol 1991; 260: E499-504.
    • (1991) Am. J. Physiol , vol.260
    • Fryburg, D.A.1    Gelfand, R.A.2    Barrett, E.J.3
  • 208
    • 0034919001 scopus 로고    scopus 로고
    • Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly
    • Trainer P, Drake W, Perry L, Taylor N, Besser G, Monson J. Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. J Clin Endocrinol Metab 2001; 86: 2989-2992.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2989-2992
    • Trainer, P.1    Drake, W.2    Perry, L.3    Taylor, N.4    Besser, G.5    Monson, J.6
  • 209
    • 85047683614 scopus 로고    scopus 로고
    • Minireview: 11β-hydroxysteroid dehydrogenase type 1 - A tissue-specific amplifier of glucocorticoid action
    • Seckl JR, Walker BR. Minireview: 11β-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action. Endocrinology 2001; 142: 1371-1376.
    • (2001) Endocrinology , vol.142 , pp. 1371-1376
    • Seckl, J.R.1    Walker, B.R.2
  • 210
    • 0034480518 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid-dehydrogenase isoforms: Tissue distribution and implications for clinical medicine
    • Diederich S, Quinkler M, Burkhardt P, Grossmann C, Bahr V, Oelkers W. 11Beta-hydroxysteroid-dehydrogenase isoforms: tissue distribution and implications for clinical medicine. Eur J Clin Invest 2000; 30(Suppl 3): 21-27.
    • (2000) Eur. J. Clin. Invest , vol.30 , Issue.SUPPL. 3 , pp. 21-27
    • Diederich, S.1    Quinkler, M.2    Burkhardt, P.3    Grossmann, C.4    Bahr, V.5    Oelkers, W.6
  • 213
    • 0032231654 scopus 로고    scopus 로고
    • Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess
    • Li A, Tedde R, Krozowski ZS, et al. Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess. Am J Hum Genet 1998; 63: 370-379.
    • (1998) Am. J. Hum. Genet , vol.63 , pp. 370-379
    • Li, A.1    Tedde, R.2    Krozowski, Z.S.3
  • 214
    • 0026095840 scopus 로고
    • The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
    • Tannin GM, Agarwal AK, Monder C, New MI, White PC. The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 1991; 266: 16653-16658.
    • (1991) J. Biol. Chem , vol.266 , pp. 16653-16658
    • Tannin, G.M.1    Agarwal, A.K.2    Monder, C.3    New, M.I.4    White, P.C.5
  • 216
    • 0033305631 scopus 로고    scopus 로고
    • Differentiation of adipose stromal cells: The roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase
    • Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 1999; 140: 3188-3196.
    • (1999) Endocrinology , vol.140 , pp. 3188-3196
    • Bujalska, I.J.1    Kumar, S.2    Hewison, M.3    Stewart, P.M.4
  • 217
    • 0031595976 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated
    • Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE. 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated. J Steroid Biochem Mol Biol 1998; 64: 251-260.
    • (1998) J. Steroid Biochem. Mol. Biol , vol.64 , pp. 251-260
    • Napolitano, A.1    Voice, M.W.2    Edwards, C.R.3    Seckl, J.R.4    Chapman, K.E.5
  • 218
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294:2166-2170.
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 219
    • 0031890042 scopus 로고    scopus 로고
    • The effect of growth hormone replacement therapy on the cortisol-cortisone interconversion in hypopituitary adults: Evidence for growth hormone modulation of extrarenal 11(β)-hydroxysteroid dehydrogenase activity
    • Gelding S, Taylor N, Wood P, et al. The effect of growth hormone replacement therapy on the cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11(β)-hydroxysteroid dehydrogenase activity. Clin Endocrinol (Oxford) 1998; 48: 153-162.
    • (1998) Clin. Endocrinol. (Oxford) , vol.48 , pp. 153-162
    • Gelding, S.1    Taylor, N.2    Wood, P.3
  • 220
    • 0034457930 scopus 로고    scopus 로고
    • Modulation of cortisol metabolism by low-dose growth hormone replacement in elderly hypopituitary patients
    • Toogood AA, Taylor NF, Shalet SM, Monson JP. Modulation of cortisol metabolism by low-dose growth hormone replacement in elderly hypopituitary patients. J Clin Endocrinol Metab 2000; 85: 1727-1730.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 1727-1730
    • Toogood, A.A.1    Taylor, N.F.2    Shalet, S.M.3    Monson, J.P.4
  • 221
    • 0035320623 scopus 로고    scopus 로고
    • Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    • Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001; 12: 118-122.
    • (2001) Trends Endocrinol. Metab , vol.12 , pp. 118-122
    • Kojima, M.1    Hosoda, H.2    Matsuo, H.3    Kangawa, K.4
  • 222
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 223
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosada H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000; 279: 909-913.
    • (2000) Biochem. Biophys. Res. Commun , vol.279 , pp. 909-913
    • Hosada, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 224
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-977.
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 225
    • 0030028275 scopus 로고    scopus 로고
    • Identification of a new G-protein-linked receptor for growth hormone secretagogues
    • Pong SS, Chaung LY, Dean DC, et al. Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol 1996; 10: 57-61.
    • (1996) Mol. Endocrinol , vol.10 , pp. 57-61
    • Pong, S.S.1    Chaung, L.Y.2    Dean, D.C.3
  • 226
    • 0040184557 scopus 로고    scopus 로고
    • Ghrelin strongly stimulates growth hormone release in humans
    • Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000; 85: 4908-4911.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 4908-4911
    • Takaya, K.1    Ariyasu, H.2    Kanamoto, N.3
  • 227
    • 0028239544 scopus 로고
    • Growth hormone-releasing activity of hexarelin in humans. A dose-response study
    • Imbimbo BP, Mant T, Edwards M, et al. Growth hormone-releasing activity of hexarelin in humans. A dose-response study. Eur J Clin Pharmacol 1994; 46: 421-425.
    • (1994) Eur. J. Clin. Pharmacol , vol.46 , pp. 421-425
    • Imbimbo, B.P.1    Mant, T.2    Edwards, M.3
  • 228
    • 0029809414 scopus 로고    scopus 로고
    • Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults - A clinical research center study
    • Chapman IM, Hartman ML, Pezzoli SS, Thorner MO. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults -- a clinical research center study. J Clin Endocrinol Metab 1996; 81: 2874-2880.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , pp. 2874-2880
    • Chapman, I.M.1    Hartman, M.L.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 229
    • 0027278470 scopus 로고
    • Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
    • Huhn WC, Hartman ML, Pezzoli SS, Thorner MO. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J Clin Endocrinol Metab 1993; 76: 1202-1208.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 1202-1208
    • Huhn, W.C.1    Hartman, M.L.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 230
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
    • Bowers CY, Momany FA, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984; 114: 1537-1545.
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3    Hong, A.4
  • 231
    • 0025159576 scopus 로고
    • Growth hormone-releasing hormone and growth hormone-releasing peptide as potential therapeutic modalities
    • Thorner MO, Vance ML, Rogol AD, et al. Growth hormone-releasing hormone and growth hormone-releasing peptide as potential therapeutic modalities. Acta Paediatrica Suppl 1990; 367: 29-32.
    • (1990) Acta Paediatrica Suppl , vol.367 , pp. 29-32
    • Thorner, M.O.1    Vance, M.L.2    Rogol, A.D.3
  • 233
    • 0033305790 scopus 로고    scopus 로고
    • The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin
    • [see comments]
    • Korbonits M, Kaltsas G, Perry LA, et al. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin [see comments]. J Clin Endocrinol Metab 1999; 84: 2489-2495.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 2489-2495
    • Korbonits, M.1    Kaltsas, G.2    Perry, L.A.3
  • 234
    • 8044230701 scopus 로고    scopus 로고
    • Adrenocorticotropin-and cortisol-releasing effect of hexarelin, a synthetic growth-hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome
    • Loche S, Colao A, Cappa M, et al. Adrenocorticotropin-and cortisol-releasing effect of hexarelin, a synthetic growth-hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome. J Clin Endocrinol Metab 1997; 82: 861-864.
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 861-864
    • Loche, S.1    Colao, A.2    Cappa, M.3
  • 235
    • 0030909925 scopus 로고    scopus 로고
    • Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats
    • Thomas GB, Fairhall KM, Robinson IC. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 1997; 138: 1585-1591.
    • (1997) Endocrinology , vol.138 , pp. 1585-1591
    • Thomas, G.B.1    Fairhall, K.M.2    Robinson, I.C.3
  • 236
    • 0030967950 scopus 로고    scopus 로고
    • Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat
    • Clark RG, Thomas GB, Mortensen DL, et al. Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat. Endocrinology 1997; 138: 4316-4323.
    • (1997) Endocrinology , vol.138 , pp. 4316-4323
    • Clark, R.G.1    Thomas, G.B.2    Mortensen, D.L.3
  • 237
    • 0029704368 scopus 로고    scopus 로고
    • Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland
    • Smith RG, Pong SS, Hickey SS, et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog Horm Res 1996; 51: 261-285.
    • (1996) Recent Prog. Horm. Res , vol.51 , pp. 261-285
    • Smith, R.G.1    Pong, S.S.2    Hickey, S.S.3
  • 238
    • 0032468862 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptor expression in human pituitary tumors
    • Skinner MM, Nass R, Lopes B, et al. Growth hormone secretagogue receptor expression in human pituitary tumors. J Clin Endocrinol Metab 1998; 83: 4314-4320.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 4314-4320
    • Skinner, M.M.1    Nass, R.2    Lopes, B.3
  • 239
    • 0031764975 scopus 로고    scopus 로고
    • Presence of growth hormone secretagogue receptor messenger ribonucleic acid in human pituitary tumors and rat GH3 cells
    • Adams EF, Huang B, Buchfelder M, et al. Presence of growth hormone secretagogue receptor messenger ribonucleic acid in human pituitary tumors and rat GH3 cells. J Clin Endocrinol Metab 1998; 83: 638-642.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 638-642
    • Adams, E.F.1    Huang, B.2    Buchfelder, M.3
  • 240
    • 15444346101 scopus 로고    scopus 로고
    • Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors
    • Korbonits M, Jacobs RA, Aylwin SJ, et al. Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. J Clin Endocrinol Metab 1998; 83: 3624-3630.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 3624-3630
    • Korbonits, M.1    Jacobs, R.A.2    Aylwin, S.J.3
  • 241
    • 0027980887 scopus 로고
    • L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion
    • Gertz BJ, Sciberras DG, Yogendran L, et al. L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion. J Clin Endocrinol Metab 1994; 79: 745-749.
    • (1994) J. Clin. Endocrinol. Metab , vol.79 , pp. 745-749
    • Gertz, B.J.1    Sciberras, D.G.2    Yogendran, L.3
  • 242
    • 0032491383 scopus 로고    scopus 로고
    • Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release
    • Torsello A, Luoni M, Schweiger F, et al. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Eur J Pharmacol 1998; 360: 123-129.
    • (1998) Eur. J. Pharmacol , vol.360 , pp. 123-129
    • Torsello, A.1    Luoni, M.2    Schweiger, F.3
  • 243
    • 0003250346 scopus 로고    scopus 로고
    • Evidence that the orexigenic effect of ghrelin is mediated by a distinct GHS-R subtype
    • Endocrine Society Meeting, Denver
    • Toth DW, Hellman PH, Gordon DA, et al. Evidence that the orexigenic effect of ghrelin is mediated by a distinct GHS-R subtype. In: Endocrine Society Meeting, Denver, 2001, P1-90.
    • (2001)
    • Toth, D.W.1    Hellman, P.H.2    Gordon, D.A.3
  • 244
    • 0034109729 scopus 로고    scopus 로고
    • Glucocorticoid regulation of growth hormone (GH) secretagogue-induced growth responses and GH secretagogue receptor expression in the rat
    • Thomas GB, Bennett PA, Carmignac DF, Robinson IC. Glucocorticoid regulation of growth hormone (GH) secretagogue-induced growth responses and GH secretagogue receptor expression in the rat. Growth Hormone & Igf Research 2000; 10: 45-52.
    • (2000) Growth Hormone & Igf Research , vol.10 , pp. 45-52
    • Thomas, G.B.1    Bennett, P.A.2    Carmignac, D.F.3    Robinson, I.C.4
  • 245
    • 0034809698 scopus 로고    scopus 로고
    • Hormonal regulation of the human ghrelin receptor gene transcription
    • Kaji H, Kishimoto M, Kirimura T, et al. Hormonal regulation of the human ghrelin receptor gene transcription. Biochem Biophys Res Commun 2001; 284: 660-666.
    • (2001) Biochem. Biophys. Res. Commun , vol.284 , pp. 660-666
    • Kaji, H.1    Kishimoto, M.2    Kirimura, T.3
  • 246
    • 0034998144 scopus 로고    scopus 로고
    • Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor
    • Petersenn S, Rasch AC, Penshorn M, Beil FU, Schulte HM. Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. Endocrinology 2001; 142: 2649-2659.
    • (2001) Endocrinology , vol.142 , pp. 2649-2659
    • Petersenn, S.1    Rasch, A.C.2    Penshorn, M.3    Beil, F.U.4    Schulte, H.M.5
  • 247
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
    • Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-345.
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 248
    • 0035430665 scopus 로고    scopus 로고
    • Ghrelin: An orexigenic and somatotrophic signal from the stomach
    • Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nature Reviews Neurosci 2001; 2: 551-560.
    • (2001) Nature Reviews Neurosci , vol.2 , pp. 551-560
    • Inui, A.1
  • 249
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 250
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000; 141: 4325-4328.
    • (2000) Endocrinology , vol.141 , pp. 4325-4328
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3
  • 251
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001; 50: 227-232.
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3


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