메뉴 건너뛰기




Volumn 11, Issue 7, 2011, Pages 879-889

Immunotherapeutic modulation of the suppressive liver and tumor microenvironments

Author keywords

Liver microenvironment; Myeloid derived suppressor cells; Regulatory dendritic cells; Regulatory T cells; Tumor immunotherapy; Tumor associated macrophages

Indexed keywords

ALPHA INTERFERON; CCL1 CHEMOKINE; CD11B ANTIGEN; CD40 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; CHLORDANE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 27; INTERLEUKIN 6; MACROPHAGE DERIVED CHEMOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NATURAL KILLER CELL RECEPTOR NKG2D; NITRIC OXIDE; RANTES; REACTIVE OXYGEN METABOLITE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 79958056343     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.12.024     Document Type: Review
Times cited : (38)

References (173)
  • 1
    • 67650750880 scopus 로고    scopus 로고
    • The liver as a lymphoid organ
    • Crispe IN. The liver as a lymphoid organ. Annu Rev Immunol 2009;27:147-63.
    • (2009) Annu Rev Immunol , vol.27 , pp. 147-163
    • Crispe, I.N.1
  • 2
    • 0030200095 scopus 로고    scopus 로고
    • Role of Kupffer cells in the induction of tolerance after liver transplantation
    • DOI 10.1006/jsre.1996.0288
    • Sato K, Yabuki K, Haba T, Maekawa T. Role of Kupffer cells in the induction of tolerance after liver transplantation. J Surg Res 1996;63:433-8. (Pubitemid 26239411)
    • (1996) Journal of Surgical Research , vol.63 , Issue.2 , pp. 433-438
    • Sato, K.1    Yabuki, K.2    Haba, T.3    Maekawa, T.4
  • 3
    • 51349131121 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
    • You Q, Cheng L, Kedl RM, Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology 2008;48:978-90.
    • (2008) Hepatology , vol.48 , pp. 978-990
    • You, Q.1    Cheng, L.2    Kedl, R.M.3    Ju, C.4
  • 4
    • 46049112678 scopus 로고    scopus 로고
    • Role of Kupffer cells in the induction of tolerance of orthotopic liver transplantation in rats
    • DOI 10.1002/lt.21450
    • Chen Y, Liu Z, Liang S, Luan X, Long F, Chen J, Peng Y, Yan L, Gong J. Role of Kupffer cells in the induction of tolerance of orthotopic liver transplantation in rats. Liver Transpl 2008;14:823-36. (Pubitemid 351895512)
    • (2008) Liver Transplantation , vol.14 , Issue.6 , pp. 823-836
    • Chen, Y.1    Liu, Z.2    Liang, S.3    Luan, X.4    Long, F.5    Chen, J.6    Peng, Y.7    Yan, L.8    Gong, J.9
  • 6
    • 76549127740 scopus 로고    scopus 로고
    • Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase
    • Yan ML, Wang YD, Tian YF, Lai ZD, Yan LN. Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase. World J Gastroenterol 2010;16:636-40.
    • (2010) World J Gastroenterol , vol.16 , pp. 636-640
    • Yan, M.L.1    Wang, Y.D.2    Tian, Y.F.3    Lai, Z.D.4    Yan, L.N.5
  • 8
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res 2009;69:8067-75.
    • (2009) Cancer Res , vol.69 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 12
  • 13
    • 14044269485 scopus 로고    scopus 로고
    • Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12
    • Pillarisetty VG, Katz SC, Bleier JI, Shah AB, Dematteo RP. Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12. J Immunol 2005;174:2612-8. (Pubitemid 40279674)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 2612-2618
    • Pillarisetty, V.G.1    Katz, S.C.2    Bleier, J.I.3    Shah, A.B.4    DeMatteo, R.P.5
  • 14
    • 1642495750 scopus 로고    scopus 로고
    • Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition
    • Pillarisetty VG, Shah AB, Miller G, Bleier JI, DeMatteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004;172:1009-17. (Pubitemid 38113760)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 1009-1017
    • Pillarisetty, V.G.1    Shah, A.B.2    Miller, G.3    Bleier, J.I.4    DeMatteo, R.P.5
  • 16
    • 42249092204 scopus 로고    scopus 로고
    • Dendritic cells are required for effective cross-presentation in the murine liver
    • DOI 10.1002/hep.22167
    • Plitas G, Burt BM, Stableford JA, Nguyen HM, Welles AP, DeMatteo RP. Dendritic cells are required for effective cross-presentation in the murine liver. Hepatology 2008;47:1343-51. (Pubitemid 351547920)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1343-1351
    • Plitas, G.1    Burt, B.M.2    Stableford, J.A.3    Nguyen, H.M.4    Welles, A.P.5    DeMatteo, R.P.6
  • 22
    • 13544263583 scopus 로고    scopus 로고
    • Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin
    • De Creus A, Abe M, Lau AH, Hackstein H, Raimondi G, Thomson AW. Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol 2005;174:2037-45. (Pubitemid 40223946)
    • (2005) Journal of Immunology , vol.174 , Issue.4 , pp. 2037-2045
    • De Creus, A.1    Abe, M.2    Lau, A.H.3    Hackstein, H.4    Raimondi, G.5    Thomson, A.W.6
  • 23
    • 33748860233 scopus 로고    scopus 로고
    • Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses
    • DOI 10.1002/eji.200535767
    • Abe M, Tokita D, Raimondi G, Thomson AW. Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses. Eur J Immunol 2006;36:2483-93. (Pubitemid 44420604)
    • (2006) European Journal of Immunology , vol.36 , Issue.9 , pp. 2483-2493
    • Abe, M.1    Tokita, D.2    Raimondi, G.3    Thomson, A.W.4
  • 24
    • 0346366990 scopus 로고    scopus 로고
    • Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody
    • Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 2003;171:6466-77. (Pubitemid 37532075)
    • (2003) Journal of Immunology , vol.171 , Issue.12 , pp. 6466-6477
    • Asselin-Paturel, C.1    Brizard, G.2    Pin, J.-J.3    Briere, F.4    Trinchieri, G.5
  • 26
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • DOI 10.1038/ni1141
    • Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004;5:1219-26. (Pubitemid 41057736)
    • (2004) Nature Immunology , vol.5 , Issue.12 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.-J.3
  • 28
    • 73349122911 scopus 로고    scopus 로고
    • NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation
    • Castellaneta A, Sumpter TL, Chen L, Tokita D, Thomson AW. NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation. J Immunol 2009;183:6922-32.
    • (2009) J Immunol , vol.183 , pp. 6922-6932
    • Castellaneta, A.1    Sumpter, T.L.2    Chen, L.3    Tokita, D.4    Thomson, A.W.5
  • 30
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • Ozao-Choy J, Ma G, Kao J, Wang GX, Meseck M, Sung M, Schwartz M, Divino CM, Pan PY, Chen SH. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res 2009;69:2514-22.
    • (2009) Cancer Res , vol.69 , pp. 2514-2522
    • Ozao-Choy, J.1    Ma, G.2    Kao, J.3    Wang, G.X.4    Meseck, M.5    Sung, M.6    Schwartz, M.7    Divino, C.M.8    Pan, P.Y.9    Chen, S.H.10
  • 32
    • 0028236866 scopus 로고
    • Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen
    • DOI 10.1084/jem.179.6.1823
    • Lu L, Woo J, Rao AS, Li Y, Watkins SC, Qian S, Starzl TE, Demetris AJ, Thomson AW. Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med 1994;179:1823-34. (Pubitemid 24155663)
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.6 , pp. 1823-1834
    • Lu, L.1    Woo, J.2    Rao, A.S.3    Li, Y.4    Watkins, S.C.5    Qian, S.6    Starzl, T.E.7    Demetris, A.J.8    Thomson, A.W.9
  • 33
    • 33847752705 scopus 로고    scopus 로고
    • Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion
    • DOI 10.1002/hep.21457
    • Kingham TP, Chaudhry UI, Plitas G, Katz SC, Raab J, DeMatteo RP. Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion. Hepatology 2007;45:445-54. (Pubitemid 46374601)
    • (2007) Hepatology , vol.45 , Issue.2 , pp. 445-454
    • Kingham, T.P.1    Chaudhry, U.I.2    Plitas, G.3    Katz, S.C.4    Raab, J.5    DeMatteo, R.P.6
  • 34
    • 77956639937 scopus 로고    scopus 로고
    • Generation of cellular immune responses to HCV NS5 protein through in vivo activation of dendritic cells
    • Wintermeyer P, Gehring S, Eken A, Wands JR. Generation of cellular immune responses to HCV NS5 protein through in vivo activation of dendritic cells. J Viral Hepat 2010;17:705-13.
    • (2010) J Viral Hepat , vol.17 , pp. 705-713
    • Wintermeyer, P.1    Gehring, S.2    Eken, A.3    Wands, J.R.4
  • 35
    • 77349124883 scopus 로고    scopus 로고
    • Origin and development of dendritic cells
    • Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev 2010;234:45-54.
    • (2010) Immunol Rev , vol.234 , pp. 45-54
    • Liu, K.1    Nussenzweig, M.C.2
  • 36
    • 67650638850 scopus 로고    scopus 로고
    • Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
    • Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A. Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 2009;113:6277-87.
    • (2009) Blood , vol.113 , pp. 6277-6287
    • Swee, L.K.1    Bosco, N.2    Malissen, B.3    Ceredig, R.4    Rolink, A.5
  • 40
    • 1842555499 scopus 로고    scopus 로고
    • Functional impairment of dendritic cells caused by murine hepatocellular carcinoma
    • Lee WC, Chiang YJ, Wang HC, Wang MR, Lia SR, Chen MF. Functional impairment of dendritic cells caused by murine hepatocellular carcinoma. J Clin Immunol 2004;24:145-54.
    • (2004) J Clin Immunol , vol.24 , pp. 145-154
    • Lee, W.C.1    Chiang, Y.J.2    Wang, H.C.3    Wang, M.R.4    Lia, S.R.5    Chen, M.F.6
  • 41
    • 35448992438 scopus 로고    scopus 로고
    • Hepatoma cells inhibit the differentiation and maturation of dendritic cells and increase the production of regulatory T cells
    • DOI 10.1016/j.imlet.2007.09.003, PII S0165247807002064
    • Li L, Li SP, Min J, Zheng L. Hepatoma cells inhibit the differentiation and maturation of dendritic cells and increase the production of regulatory T cells. Immunol Lett 2007;114:38-45. (Pubitemid 47625596)
    • (2007) Immunology Letters , vol.114 , Issue.1 , pp. 38-45
    • Li, L.1    Li, S.-P.2    Min, J.3    Zheng, L.4
  • 43
    • 35748978808 scopus 로고    scopus 로고
    • Taming cancer by inducing immunity via dendritic cells
    • DOI 10.1111/j.1600-065X.2007.00575.x
    • Palucka AK, Ueno H, Fay JW, Banchereau J. Taming cancer by inducing immunity via dendritic cells. Immunol Rev 2007;220:129-50. (Pubitemid 350045575)
    • (2007) Immunological Reviews , vol.220 , Issue.1 , pp. 129-150
    • Palucka, A.K.1    Ueno, H.2    Fay, J.W.3    Banchereau, J.4
  • 44
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • DOI 10.1038/nature06175, PII NATURE06175
    • Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007;449:419-26. (Pubitemid 47509552)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 46
    • 33845625311 scopus 로고    scopus 로고
    • + T cells with PD-1-dependent regulatory activities
    • DOI 10.1111/j.1365-2567.2006.02479.x
    • Jinushi M, Takehara T, Tatsumi T, Yamaguchi S, Sakamori R, Hiramatsu N, Kanto T, Ohkawa K, Hayashi N. Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology 2007;120:73-82. (Pubitemid 44950472)
    • (2006) Immunology , vol.120 , Issue.1 , pp. 73-82
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Yamaguchi, S.4    Sakamori, R.5    Hiramatsu, N.6    Kanto, T.7    Ohkawa, K.8    Hayashi, N.9
  • 48
    • 38449083230 scopus 로고    scopus 로고
    • A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: Superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10
    • Chen YX, Man K, Ling GS, Chen Y, Sun BS, Cheng Q, Wong OH, Lo CK, Ng IO, Chan LC, Lau GK, Lin CL, Huang F, Huang FP. A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10. J Immunol 2007;179:6009-15.
    • (2007) J Immunol , vol.179 , pp. 6009-6015
    • Chen, Y.X.1    Man, K.2    Ling, G.S.3    Chen, Y.4    Sun, B.S.5    Cheng, Q.6    Wong, O.H.7    Lo, C.K.8    Ng, I.O.9    Chan, L.C.10    Lau, G.K.11    Lin, C.L.12    Huang, F.13    Huang, F.P.14
  • 49
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res 2005;65:3437-46. (Pubitemid 40524630)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 51
    • 67650422616 scopus 로고    scopus 로고
    • The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression
    • Ilkovitch D, Lopez DM. The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression. Cancer Res 2009;69:5514-21.
    • (2009) Cancer Res , vol.69 , pp. 5514-5521
    • Ilkovitch, D.1    Lopez, D.M.2
  • 54
    • 38049181485 scopus 로고    scopus 로고
    • Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
    • Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 2008;111:219-28.
    • (2008) Blood , vol.111 , pp. 219-228
    • Pan, P.Y.1    Wang, G.X.2    Yin, B.3    Ozao, J.4    Ku, T.5    Divino, C.M.6    Chen, S.H.7
  • 55
    • 77954399377 scopus 로고    scopus 로고
    • Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    • Sander LE, Sackett SD, Dierssen U, Beraza N, Linke RP, Muller M, Blander JM, Tacke F, Trautwein C. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J Exp Med 2010;207:1453-64.
    • (2010) J Exp Med , vol.207 , pp. 1453-1464
    • Sander, L.E.1    Sackett, S.D.2    Dierssen, U.3    Beraza, N.4    Linke, R.P.5    Muller, M.6    Blander, J.M.7    Tacke, F.8    Trautwein, C.9
  • 58
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol 2009;182:240-9.
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 59
    • 58949086448 scopus 로고    scopus 로고
    • Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    • Nausch N, Galani IE, Schlecker E, Cerwenka A. Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 2008;112:4080-9.
    • (2008) Blood , vol.112 , pp. 4080-4089
    • Nausch, N.1    Galani, I.E.2    Schlecker, E.3    Cerwenka, A.4
  • 60
    • 77957932965 scopus 로고    scopus 로고
    • Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver
    • Cripps JG, Wang J, Maria A, Blumenthal I, Gorham JD. Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver. Hepatology 2010;52:1350-9.
    • (2010) Hepatology , vol.52 , pp. 1350-1359
    • Cripps, J.G.1    Wang, J.2    Maria, A.3    Blumenthal, I.4    Gorham, J.D.5
  • 61
    • 77955471251 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells and myeloid-derived suppressor cells: Potential for regulation and therapy of liver auto- and alloimmunity
    • Natarajan S, Thomson AW. Tolerogenic dendritic cells and myeloid-derived suppressor cells: potential for regulation and therapy of liver auto- and alloimmunity. Immunobiology 2010;215:698-703.
    • (2010) Immunobiology , vol.215 , pp. 698-703
    • Natarajan, S.1    Thomson, A.W.2
  • 63
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • DOI 10.1172/JCI31422
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 2007;117:1155-66. (Pubitemid 46718400)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 64
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009;86:1065-73.
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 69
    • 77953720628 scopus 로고    scopus 로고
    • In situ regulation of DC subsets and T cells mediates tumor regression in mice
    • Ali OA, Emerich D, Dranoff G, Mooney DJ. In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Transl Med 2009;1:8ra19.
    • (2009) Sci Transl Med , vol.1
    • Ali, O.A.1    Emerich, D.2    Dranoff, G.3    Mooney, D.J.4
  • 70
    • 70349741039 scopus 로고    scopus 로고
    • Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I
    • Liu Q, Zhang C, Sun A, Zheng Y, Wang L, Cao X. Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J Immunol 2009;182:6207-16.
    • (2009) J Immunol , vol.182 , pp. 6207-6216
    • Liu, Q.1    Zhang, C.2    Sun, A.3    Zheng, Y.4    Wang, L.5    Cao, X.6
  • 72
    • 77956599685 scopus 로고    scopus 로고
    • PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
    • Muthuswamy R, Mueller-Berghaus J, Haberkorn U, Reinhart TA, Schadendorf D, Kalinski P. PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells. Blood 2010;116:1454-9.
    • (2010) Blood , vol.116 , pp. 1454-1459
    • Muthuswamy, R.1    Mueller-Berghaus, J.2    Haberkorn, U.3    Reinhart, T.A.4    Schadendorf, D.5    Kalinski, P.6
  • 76
    • 77953468036 scopus 로고    scopus 로고
    • Directing dendritic cell immunotherapy towards successful cancer treatment
    • Sabado RL, Bhardwaj N. Directing dendritic cell immunotherapy towards successful cancer treatment. Immunotherapy 2010;2:37-56.
    • (2010) Immunotherapy , vol.2 , pp. 37-56
    • Sabado, R.L.1    Bhardwaj, N.2
  • 77
    • 77955771348 scopus 로고    scopus 로고
    • GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- Bone marrow progenitor cells into myeloid-derived suppressor cells
    • Morales JK, Kmieciak M, Knutson KL, Bear HD, Manjili MH. GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res Treat 2010;123:39-49.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 39-49
    • Morales, J.K.1    Kmieciak, M.2    Knutson, K.L.3    Bear, H.D.4    Manjili, M.H.5
  • 78
    • 0346888498 scopus 로고    scopus 로고
    • + T Cells
    • DOI 10.1016/S0065-2776(03)81008-8
    • Hori S, Takahashi T, Sakaguchi S. Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol 2003;81:331-71. (Pubitemid 38009046)
    • (2003) Advances in Immunology , vol.81 , pp. 331-371
    • Hori, S.1    Takahashi, T.2    Sakaguchi, S.3
  • 83
    • 77957025756 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    • Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W. Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 2010;33:313-25.
    • (2010) Immunity , vol.33 , pp. 313-325
    • Xu, L.1    Kitani, A.2    Stuelten, C.3    McGrady, G.4    Fuss, I.5    Strober, W.6
  • 84
    • 61349195299 scopus 로고    scopus 로고
    • Increased intratumoral FOXP3-positive regulatory immune cells during interleukin-2 treatment in metastatic renal cell carcinoma
    • Jensen HK, Donskov F, Nordsmark M, Marcussen N, von der Maase H. Increased intratumoral FOXP3-positive regulatory immune cells during interleukin-2 treatment in metastatic renal cell carcinoma. Clin Cancer Res 2009;15:1052-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 1052-1058
    • Jensen, H.K.1    Donskov, F.2    Nordsmark, M.3    Marcussen, N.4    Von Der Maase, H.5
  • 85
    • 64849098858 scopus 로고    scopus 로고
    • NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment
    • Mailloux AW, Young MR. NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment. J Immunol 2009;182:2753-65.
    • (2009) J Immunol , vol.182 , pp. 2753-2765
    • Mailloux, A.W.1    Young, M.R.2
  • 88
    • 45549102822 scopus 로고    scopus 로고
    • Cutting edge: Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells
    • Chen X, Subleski JJ, Kopf H, Howard OM, Mannel DN, Oppenheim JJ. Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+ CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells. J Immunol 2008;180:6467-71.
    • (2008) J Immunol , vol.180 , pp. 6467-6471
    • Chen, X.1    Subleski, J.J.2    Kopf, H.3    Howard, O.M.4    Mannel, D.N.5    Oppenheim, J.J.6
  • 90
    • 47549114487 scopus 로고    scopus 로고
    • Combinations of tumor-specific CD8+ CTLs and anti-CD25 mAb provide improved immunotherapy
    • Ohmura Y, Yoshikawa K, Saga S, Ueda R, Kazaoka Y, Yamada S. Combinations of tumor-specific CD8+ CTLs and anti-CD25 mAb provide improved immunotherapy. Oncol Rep 2008;19:1265-70.
    • (2008) Oncol Rep , vol.19 , pp. 1265-1270
    • Ohmura, Y.1    Yoshikawa, K.2    Saga, S.3    Ueda, R.4    Kazaoka, Y.5    Yamada, S.6
  • 92
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999;59:3128-33. (Pubitemid 29316012)
    • (1999) Cancer Research , vol.59 , Issue.13 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 94
    • 75149139044 scopus 로고    scopus 로고
    • Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer
    • Saha A, Chatterjee SK. Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer. Scand J Immunol 2010;71:70-82.
    • (2010) Scand J Immunol , vol.71 , pp. 70-82
    • Saha, A.1    Chatterjee, S.K.2
  • 96
    • 33745306869 scopus 로고    scopus 로고
    • IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
    • Knutson KL, Dang Y, Lu H, Lukas J, Almand B, Gad E, Azeke E, Disis ML. IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice. J Immunol 2006;177:84-91. (Pubitemid 43939119)
    • (2006) Journal of Immunology , vol.177 , Issue.1 , pp. 84-91
    • Knutson, K.L.1    Dang, Y.2    Lu, H.3    Lukas, J.4    Almand, B.5    Gad, E.6    Azeke, E.7    Disis, M.L.8
  • 97
    • 36148939150 scopus 로고    scopus 로고
    • IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
    • DOI 10.1182/blood-2007-06-094615
    • Litzinger MT, Fernando R, Curiel TJ, Grosenbach DW, Schlom J, Palena C. IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 2007;110:3192-201. (Pubitemid 350106311)
    • (2007) Blood , vol.110 , Issue.9 , pp. 3192-3201
    • Litzinger, M.T.1    Fernando, R.2    Curiel, T.J.3    Grosenbach, D.W.4    Schlom, J.5    Palena, C.6
  • 99
    • 33646239606 scopus 로고    scopus 로고
    • Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- Lymphocytes is thymus and proliferation independent
    • Valzasina B, Piconese S, Guiducci C, Colombo MP. Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent. Cancer Res 2006;66:4488-95.
    • (2006) Cancer Res , vol.66 , pp. 4488-4495
    • Valzasina, B.1    Piconese, S.2    Guiducci, C.3    Colombo, M.P.4
  • 100
    • 77953624643 scopus 로고    scopus 로고
    • Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses
    • Hoelzinger DB, Smith SE, Mirza N, Dominguez AL, Manrique SZ, Lustgarten J. Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses. J Immunol 2010;184:6833-42.
    • (2010) J Immunol , vol.184 , pp. 6833-6842
    • Hoelzinger, D.B.1    Smith, S.E.2    Mirza, N.3    Dominguez, A.L.4    Manrique, S.Z.5    Lustgarten, J.6
  • 104
    • 50949085390 scopus 로고    scopus 로고
    • Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death
    • Reardon C, Wang A, McKay DM. Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J Immunol 2008;180:8316-26.
    • (2008) J Immunol , vol.180 , pp. 8316-8326
    • Reardon, C.1    Wang, A.2    McKay, D.M.3
  • 105
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 2001;193:727-40.
    • (2001) J Exp Med , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 106
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA, Pollard JW. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS ONE 2009;4:e6562.
    • (2009) PLoS ONE , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6    Lang, R.A.7    Pollard, J.W.8
  • 108
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 2008;181:5791-802.
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 109
    • 77955549860 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: More mechanisms for inhibiting antitumor immunity
    • Ostrand-Rosenberg S. Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother 2010;59:1593-600.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1593-1600
    • Ostrand-Rosenberg, S.1
  • 110
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res 2009;69:1553-60.
    • (2009) Cancer Res , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1    Ernstoff, M.S.2    Hernandez, C.3    Atkins, M.4    Zabaleta, J.5    Sierra, R.6    Ochoa, A.C.7
  • 111
    • 31344474166 scopus 로고    scopus 로고
    • Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression
    • DOI 10.1016/j.semcancer.2005.07.005, PII S1044579X05000581, The Inflamation-Cancer Linkage: A Double-Edged Sword
    • Serafini P, Borrello I, Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 2006;16:53-65. (Pubitemid 43139709)
    • (2006) Seminars in Cancer Biology , vol.16 , Issue.1 , pp. 53-65
    • Serafini, P.1    Borrello, I.2    Bronte, V.3
  • 113
    • 77953541622 scopus 로고    scopus 로고
    • Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma + vaccination model
    • Jia W, Jackson-Cook C, Graf MR. Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma + vaccination model. J Neuroimmunol 2010;223:20-30.
    • (2010) J Neuroimmunol , vol.223 , pp. 20-30
    • Jia, W.1    Jackson-Cook, C.2    Graf, M.R.3
  • 114
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-arginine metabolism
    • DOI 10.1038/nri1668
    • Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005;5:641-54. (Pubitemid 41113195)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.8 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 116
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J Immunol 2010;184:3106-16.
    • (2010) J Immunol , vol.184 , pp. 3106-3116
    • Nagaraj, S.1    Schrum, A.G.2    Cho, H.I.3    Celis, E.4    Gabrilovich, D.I.5
  • 118
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells
    • Hanson EM, Clements VK, Sinha P, Ilkovitch D, Ostrand-Rosenberg S. Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells. J Immunol 2009;183:937-44.
    • (2009) J Immunol , vol.183 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3    Ilkovitch, D.4    Ostrand-Rosenberg, S.5
  • 119
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009;182:4499-506.
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 120
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004;25:677-86. (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 121
    • 2342565892 scopus 로고    scopus 로고
    • Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    • DOI 10.1016/j.semcancer.2003.10.001, PII S1044579X03000968
    • Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M, Sica A. Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors. Semin Cancer Biol 2004;14:155-60. (Pubitemid 38586740)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.3 , pp. 155-160
    • Mantovani, A.1    Allavena, P.2    Sozzani, S.3    Vecchi, A.4    Locati, M.5    Sica, A.6
  • 122
    • 33745587776 scopus 로고    scopus 로고
    • Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1-type immune response
    • DOI 10.1111/j.1349-7006.2006.00231.x
    • Kondo T, Nakazawa H, Ito F, Hashimoto Y, Osaka Y, Futatsuyama K, Toma H, Tanabe K. Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1-type immune response. Cancer Sci 2006;97:780-6. (Pubitemid 43983791)
    • (2006) Cancer Science , vol.97 , Issue.8 , pp. 780-786
    • Kondo, T.1    Nakazawa, H.2    Ito, F.3    Hashimoto, Y.4    Osaka, Y.5    Futatsuyama, K.6    Toma, H.7    Tanabe, K.8
  • 123
    • 34247576659 scopus 로고    scopus 로고
    • Expression of CXCR3 on mononuclear cells and CXCR3 ligands in patients with metastatic renal cell carcinoma in response to systemic IL-2 therapy
    • DOI 10.1097/CJI.0b013e31802e089a, PII 0000237120070500000006
    • Reckamp KL, Figlin RA, Moldawer N, Pantuck AJ, Belldegrun AS, Burdick MD, Strieter RM. Expression of CXCR3 on mononuclear cells and CXCR3 ligands in patients with metastatic renal cell carcinoma in response to systemic IL-2 therapy. J Immunother 2007;30:417-24. (Pubitemid 46684431)
    • (2007) Journal of Immunotherapy , vol.30 , Issue.4 , pp. 417-424
    • Reckamp, K.L.1    Figlin, R.A.2    Moldawer, N.3    Pantuck, A.J.4    Belldegrun, A.S.5    Burdick, M.D.6    Strieter, R.M.7
  • 124
    • 22244477360 scopus 로고    scopus 로고
    • Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas
    • DOI 10.1007/s00262-004-0646-1
    • Cozar JM, Canton J, Tallada M, Concha A, Cabrera T, Garrido F, Ruiz-Cabello Osuna F. Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas. Cancer Immunol Immunother 2005;54:858-66. (Pubitemid 40991328)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.9 , pp. 858-866
    • Cozar, J.M.1    Canton, J.2    Tallada, M.3    Concha, A.4    Cabrera, T.5    Garrido, F.6    Ruiz-Cabello, O.F.7
  • 127
    • 78649598159 scopus 로고    scopus 로고
    • Pivotal advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells
    • Eruslanov E, Daurkin I, Ortiz J, Vieweg J, Kusmartsev S. Pivotal advance: tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells. J Leukoc Biol 2010;88:839-48.
    • (2010) J Leukoc Biol , vol.88 , pp. 839-848
    • Eruslanov, E.1    Daurkin, I.2    Ortiz, J.3    Vieweg, J.4    Kusmartsev, S.5
  • 128
    • 0036498542 scopus 로고    scopus 로고
    • Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions
    • Harizi H, Juzan M, Pitard V, Moreau JF, Gualde N. Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 2002;168:2255-63.
    • (2002) J Immunol , vol.168 , pp. 2255-2263
    • Harizi, H.1    Juzan, M.2    Pitard, V.3    Moreau, J.F.4    Gualde, N.5
  • 132
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • DOI 10.1158/0008-5472.CAN-06-4174
    • Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res 2007;67:4507-13. (Pubitemid 46815102)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 133
    • 65449143259 scopus 로고    scopus 로고
    • Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2
    • Zhang Y, Liu Q, Zhang M, Yu Y, Liu X, Cao X. Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. J Immunol 2009;182:3801-8.
    • (2009) J Immunol , vol.182 , pp. 3801-3808
    • Zhang, Y.1    Liu, Q.2    Zhang, M.3    Yu, Y.4    Liu, X.5    Cao, X.6
  • 135
    • 67149115417 scopus 로고    scopus 로고
    • Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4
    • Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 2009;85:996-1004.
    • (2009) J Leukoc Biol , vol.85 , pp. 996-1004
    • Bunt, S.K.1    Clements, V.K.2    Hanson, E.M.3    Sinha, P.4    Ostrand-Rosenberg, S.5
  • 136
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • DOI 10.1158/0008-5472.CAN-07-2354
    • Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 2007;67:10019-26. (Pubitemid 47621253)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 139
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol 2008;181:4666-75.
    • (2008) J Immunol , vol.181 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3    Freeze, H.H.4    Ostrand-Rosenberg, S.5    Srikrishna, G.6
  • 140
    • 33846479526 scopus 로고    scopus 로고
    • IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
    • Watkins SK, Egilmez NK, Suttles J, Stout RD. IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol 2007;178:1357-62. (Pubitemid 46154605)
    • (2007) Journal of Immunology , vol.178 , Issue.3 , pp. 1357-1362
    • Watkins, S.K.1    Egilmez, N.K.2    Suttles, J.3    Stout, R.D.4
  • 141
    • 70350529527 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: In situ reprogramming of tumor-associated macrophages
    • Stout RD, Watkins SK, Suttles J. Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J Leukoc Biol 2009;86:1105-9.
    • (2009) J Leukoc Biol , vol.86 , pp. 1105-1109
    • Stout, R.D.1    Watkins, S.K.2    Suttles, J.3
  • 142
    • 78650956146 scopus 로고    scopus 로고
    • Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumourassociated macrophages
    • Buhtoiarov IN, Sondel PM, Wigginton JM, Buhtoiarova TN, Yanke EM, Mahvi DA, Rakhmilevich AL. Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumourassociated macrophages. Immunology 2010;132:226-39.
    • (2010) Immunology , vol.132 , pp. 226-239
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Wigginton, J.M.3    Buhtoiarova, T.N.4    Yanke, E.M.5    Mahvi, D.A.6    Rakhmilevich, A.L.7
  • 143
    • 0033562982 scopus 로고    scopus 로고
    • + T cell responses by dysregulating antigen-presenting cell maturation
    • Bronte V, Chappell DB, Apolloni E, Cabrelle A, Wang M, Hwu P, Restifo NP. Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation. J Immunol 1999;162:5728-37. (Pubitemid 29314923)
    • (1999) Journal of Immunology , vol.162 , Issue.10 , pp. 5728-5737
    • Bronte, V.1    Chappell, D.B.2    Apolloni, E.3    Cabrelle, A.4    Wang, M.5    Hwu, P.6    Restifo, N.P.7
  • 145
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • Ko JS, Rayman P, Ireland J, Swaidani S, Li G, Bunting KD, Rini B, Finke JH, Cohen PA. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res 2010;70:3526-36.
    • (2010) Cancer Res , vol.70 , pp. 3526-3536
    • Ko, J.S.1    Rayman, P.2    Ireland, J.3    Swaidani, S.4    Li, G.5    Bunting, K.D.6    Rini, B.7    Finke, J.H.8    Cohen, P.A.9
  • 152
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 153
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the Janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    • DOI 10.1158/0008-5472.CAN-05-0529
    • Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 2005;65:9525-35. (Pubitemid 41508023)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3    Muro-Cacho, C.4    Sebti, S.M.5    Gabrilovich, D.I.6
  • 154
    • 25444513779 scopus 로고    scopus 로고
    • A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
    • DOI 10.1074/jbc.M502694200
    • Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J Biol Chem 2005;280:32979-88. (Pubitemid 41368347)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.38 , pp. 32979-32988
    • Turkson, J.1    Zhang, S.2    Mora, L.B.3    Burns, A.4    Sebti, S.5    Jove, R.6
  • 156
    • 75149179545 scopus 로고    scopus 로고
    • Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
    • Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, Divino CM, Chen SH. Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer. Cancer Res 2010;70:99-108.
    • (2010) Cancer Res , vol.70 , pp. 99-108
    • Pan, P.Y.1    Ma, G.2    Weber, K.J.3    Ozao-Choy, J.4    Wang, G.5    Yin, B.6    Divino, C.M.7    Chen, S.H.8
  • 160
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: Suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 2010;16:4583-94.
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3    Sahakian, E.4    Wei, S.5    Djeu, J.Y.6
  • 161
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 2007;179:977-83.
    • (2007) J Immunol , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 163
    • 25144466458 scopus 로고    scopus 로고
    • + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • DOI 10.1158/1078-0432.CCR-05-0883
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res 2005;11:6713-21. (Pubitemid 41339014)
    • (2005) Clinical Cancer Research , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 164
    • 0035020048 scopus 로고    scopus 로고
    • Phase III trial of cisplatin/gemcitabine with or without vinorelbine or paclitaxel in advanced non-small cell lung cancer
    • Comella P. Phase III trial of cisplatin/gemcitabine with or without vinorelbine or paclitaxel in advanced non-small cell lung cancer. Semin Oncol 2001;28:7-10. (Pubitemid 32476738)
    • (2001) Seminars in Oncology , vol.28 , Issue.2 SUPPL. 7 , pp. 7-10
    • Comella, P.1
  • 165
    • 16644386065 scopus 로고    scopus 로고
    • Gemcitabine-containing regimens vs others in first-line treatment of NSCLC
    • Williston Park
    • Natale RB. Gemcitabine-containing regimens vs others in first-line treatment of NSCLC. Oncology (Williston Park) 2004;18:27-31.
    • (2004) Oncology , vol.18 , pp. 27-31
    • Natale, R.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.