Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I

Journal of Immunology

Volumn 182, Issue 10, 2009, Pages 6207-6216

  Liu, Qiuyan ^a   Zhang, Chaoxiong ^a   Sun, Anna ^b   Zheng, Yuanyuan ^a   Wang, Li ^b   Cao, Xuetao ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; CD11 ANTIGEN; INTERLEUKIN 10; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; ARGINASE; CD11B ANTIGEN; CYTOKINE; HLA ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOLOGY; CANCER TISSUE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; DENDRITE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG CANCER; MICROENVIRONMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUMOR CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; LEWIS CARCINOMA; METABOLISM; TRANSGENIC MOUSE; TUMOR ESCAPE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD11B; ARGINASE; BLOTTING, WESTERN; CARCINOMA, LEWIS LUNG; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; TUMOR ESCAPE;

EID: 70349741039     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803926     Document Type: Article

References (46)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271-296.
2. Steinman, R. M., and J. Banchereau. 2007. Taking dendritic cells into medicine. Nature 449: 419-426.
3. Melief, C. J. 2008. Cancer immunotherapy by dendritic cells. Immunity 29: 372-383.
4. Vulink, A., K. J. Radford, C. Melief, and D. N. Hart. 2008. Dendritic cells in cancer immunotherapy. Adv Cancer Res. 99: 363-407.
5. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21: 685-711.
6. + regulatory T cells. J. Immunol. 177: 3806-3813.
7. + regulatory T cells. J. Cell. Mol. Med. 12: 690-700.
8. + T cell tolerance. J. Exp. Med. 196: 1627-1638.
9. Munn, D. H., M. D. Sharma, J. R. Lee, K. G. Jhaver, T. S. Johnson, D. B. Keskin, B. Marshall, P. Chandler, S. J. Antonia, R. Burgess, Jr., C. L. Slingluff, and A. L. Mellor. 2002. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297: 1867-1870.
10. Wakkach, A., N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18: 605-617. (Pubitemid 36588578)
11. Chorny, A., E. Gonzalez-Rey, A. Fernandez-Martin, D. Pozo, D. Ganea, and M. Delgado. 2005. Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders. Proc. Natl. Acad. Sci. USA 102: 13562-13567. (Pubitemid 41420888)
12. Sato, K., N. Yamashita, N. Yamashita, M. Baba, and T. Matsuyama. 2003. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 18: 367-379. (Pubitemid 36351516)
13. Adorini, L. 2003. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes. Ann. NY Acad. Sci. 987: 258-261. (Pubitemid 36584031)
14. + dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. J. Immunol. 181: 2483-2493.
15. Zhang, M., H. Tang, Z. Guo, H. An, X. Zhu, W. Song, J. Guo, X. Huang, T. Chen, J. Wang, and X. Cao. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5: 1124-1133. (Pubitemid 39549626)
16. Tang, H., Z. Guo, M. Zhang, J. Wang, G. Chen, and X. Cao. 2006. Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10. Blood 108: 1189-1197. (Pubitemid 44232014)
17. Xia, S., Z. Guo, X. Xu, H. Yi, Q. Wang, and X. Cao. 2008. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells maintaining liver tolerance. Blood 112: 3175-3185.
18. Li, Q., Z. Guo, X. Xu, S. Xia, and X. Cao. 2008. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur. J. Immunol. 38: 2751-2761.
19. Kim, R., M. Emi, K. Tanabe, and K. Arihiro. 2006. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res. 66: 5527-5536. (Pubitemid 43927099)
20. Rabinovich, G. A., D. Gabrilovich, and E. M. Sotomayor. 2007. Immunosuppressive strategies that are mediated by tumor cells. Annu. Rev. Immunol. 25: 267-296.
21. Zou, W. 2005. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5: 263-274. (Pubitemid 40488632)
22. Shurin, M. R., G. V. Shurin, L. A. Okshin, Z. R. Yurkovetsky, D. W. Gutkin, G. Chatta, H. Zhong, B. Han, and R. L. Ferris. 2006. Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies? Cancer Metastasis Rev. 25: 333-356.
23. Kusmartsev, S., and D. I. Gabrilovich. 2006. Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer. Cancer Metastasis Rev. 25: 323-331. (Pubitemid 44922353)
24. Lin, W. W., and M. A. Karin. 2007. Cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117: 1175-1183. (Pubitemid 46718402)
25. Todryk, S., A. A. Melcher, N. Hardwick, E. Linardakis, A. Bateman, M. P. Colombo, A. Stoppacciaro, and R. G. Vile. 1999. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J. Immunol. 63: 1398-1408. (Pubitemid 29352760)
26. Bell, D., P. Chomarat, D. Broyles, G. Netto, G. M. Harb, S. Lebecque, J. Valladeau, J. Davoust, K. A. Palucka, and J. Banchereau. 1999. In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190: 1417-1426.
27. + T cells that facilitate tumor development. J. Exp. Med. 204: 1037-1047.
28. + regulatory T cell proliferation. J. Exp. Med. 202: 919-929.
29. Chomarat, P., J. Banchereau, J. Avoust, and A. K. Palucka. 2000. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. 1: 510-514.
30. Yang, X., J. J. Letterio, R. J. Lechleider, L. Chen, R. Hayman, H. Gu, A. B. Roberts, and C. Deng. 1999 Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J. 18: 1280-1291. (Pubitemid 29110312)
31. Guo, Z., M. Zhang, H. An, W. Chen, S. Liu, J. Guo, Y. Yu, and X. Cao. 2003. Fas ligation induces IL-1β-dependent maturation and IL-1β-independent survival of dendritic cells: different roles of ERK and NF-κB signaling pathways. Blood 102: 4441-4447. (Pubitemid 37494108)
32. Wang, L., Q. Liu, Q. Sun, C. Zhang, T. Chen, and X. Cao. 2008. TLR4 signaling in cancer cells promotes chemoattraction of immature dendritic cells via autocrine CCL20. Biochem. Biophys. Res. Commun. 366: 852-856.
33. Munder, M., H. Schneider, C. Luckner, T. Giese, C. D. Langhans, J. M. Fuentes, P. Kropf, I. Mueller, A. Kolb, M. Modolell, and A. D. Ho. 2006. Suppression of T-cell functions by human granulocyte arginase. Blood 108: 1627-1634.
34. Bronte, V., P. Serafini, A. Mazzoni, D. M. Segal, and P. Zanovello. 2003. L-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol. 24: 302-306. (Pubitemid 36694880)
35. + myeloid suppressor cells cause T cell dysfunction after traumatic stress. J. Immunol. 176: 2085-2094.
36. Ferrone, S., and T. L. Whiteside. 2007. Tumor microenvironment and immune escape. Surg. Oncol. Clin. North Am. 16: 755-774.
37. Fricke, I., and D. I. Gabrilovich. 2006. Dendritic cells and tumor microenvironment: a dangerous liaison. Immunol. Invest. 35: 459-483. (Pubitemid 44266783)
38. Drake, C. G., E. Jaffee, and D. M. Pardoll. 2006. Mechanisms of immune evasion by tumors. Adv. Immunol. 90: 51-81.
39. Gajewski, T. F., Y. Meng, and H. Harlin. 2006. Immune suppression in the tumor microenvironment. J. Immunother. 29: 233-240.
40. Dhodapkar, M. V., K. M. Dhodapkar, and A. K. Palucka. 2008. Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ. 15: 39-50.
41. + regulatory T cell proliferation. J. Exp. Med. 202: 919-929.
42. - down-regulation and apoptosis of T cells through oxygen-dependent pathways. J. Immunol. 181: 3089-3098.
43. Svensson, M., A. Maroof, M. Ato, and P. M. Kaye. 2004. Stromal cells direct local differentiation of regulatory dendritic cells. Immunity 21: 805-816. (Pubitemid 39626671)
44. Popov, A., and J. L. Schultze. 2008. IDO-expressing regulatory dendritic cells in cancer and chronic infection. J. Mol. Med. 86: 145-160. (Pubitemid 351172124)
45. Kusmartsev, S., and D. I. Gabrilovich. 2006. Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol. Immunother. 55: 237-245. (Pubitemid 41683212)
46. Bronte, V., E. Apolloni, A. Cabrelle, R. Ronca, P. Serafini, P. Zamboni, N. P. Restifo, and P. Zanovello. 2000. Identification of a CD11b(+)/Gr-1(+)/ CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96: 3838-3846.