Generation of cellular immune responses to HCV NS5 protein through in vivo activation of dendritic cells

Journal of Viral Hepatitis

Volumn 17, Issue 10, 2010, Pages 705-713

  Wintermeyer, P ^a,b   Gehring, S ^a,c   Eken, A ^a   Wands, J R ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

cellular immune response; cytotoxicity; dendritic cells; hepatitis C virus

Indexed keywords

B7 ANTIGEN; CD11B ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; DENDRITIC CELL VACCINE; FLT3 LIGAND; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 2; NONSTRUCTURAL PROTEIN 5; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CANCER INHIBITION; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL EXPANSION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HYDRODYNAMICS BASED TRANSFECTION; IMMUNIZATION; MOUSE; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; VACCINE PRODUCTION;

ANIMALS; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; GENE EXPRESSION PROFILING; INTERFERON-GAMMA; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; UP-REGULATION; VIRAL HEPATITIS VACCINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77956639937     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01228.x     Document Type: Article

References (35)

1. Hsu EK, Murray KF. Hepatitis B and C in children. Nat Clin Pract Gastroenterol Hepatol 2008 5: 311 320.
2. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392: 245 252.
3. Caux C, Massacrier C, Vanbervliet B et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994 180: 1263 1272.
4. Gehring S, Gregory SH, Wintermeyer P, Aloman C, Wands Jr. Generation of immune responses against hepatitis C virus by dendritic cells containing NS5 protein-coated microparticles. Clin Vaccine Immunol 2009 16: 163 171.
5. Encke J, Findeklee J, Geib J, Pfaff E, Stremmel W. Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection. Clin Exp Immunol 2005 142: 362 369.
6. Kuzushita N, Gregory SH, Monti NA, Carlson R, Gehring S, Wands Jr. Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens. Gastroenterology 2006 130: 453 464.
7. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001 194: 1395 1406.
8. Chisari FV. Unscrambling hepatitis C virus-host interactions. Nature 2005 436: 930 932.
9. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005 5: 215 229.
10. Auffermann-Gretzinger S, Keeffe EB, Levy S. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 2001 97: 3171 3176.
11. Bain C, Fatmi A, Zoulim F, Zarski JP, Trepo C, Inchauspe G. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001 120: 512 524.
12. Aloman C, Gehring S, Wintermeyer P, Kuzushita N, Wands Jr. Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction. Gastroenterology 2007 132: 698 708.
13. Gehring S, Gregory SH, Wintermeyer P, San Martin M, Aloman C, Wands Jr. Generation and characterization of an immunogenic dendritic cell population. J Immunol Methods 2008 332: 18 30.
14. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006 6: 476 483.
15. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999 6: 1258 1266.
16. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2002 2: 77 84. (Pubitemid 37323231)
17. Jiang W, Swiggard WJ, Heufler C et al. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995 375: 151 155.
18. Bonifaz LC, Bonnyay DP, Charalambous A et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med 2004 199: 815 824.
19. Shurin MR, Pandharipande PP, Zorina TD et al. FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol 1997 179: 174 184.
20. He Y, Pimenov AA, Nayak JV, Plowey J, Falo LD Jr. , Huang L. Intravenous injection of naked DNA encoding secreted flt3 ligand dramatically increases the number of dendritic cells and natural killer cells in vivo. Hum Gene Ther 2000 11: 547 554.
21. Pulendran B, Lingappa J, Kennedy MK et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J Immunol 1997 159: 2222 2231.
22. Maraskovsky E, Brasel K, Teepe M et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996 184: 1953 1962.
23. Cerundolo V, Hermans IF, Salio M. Dendritic cells: a journey from laboratory to clinic. Nat Immunol 2004 5: 7 10.
24. Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005 5: 296 306.
25. Dubsky P, Ueno H, Piqueras B, Connolly J, Banchereau J, Palucka AK. Human dendritic cell subsets for vaccination. J Clin Immunol 2005 25: 551 572.
26. Ludewig B, Ehl S, Karrer U, Odermatt B, Hengartner H, Zinkernagel RM. Dendritic cells efficiently induce protective antiviral immunity. J Virol 1998 72: 3812 3818.
27. Charalambous A, Oks M, Nchinda G, Yamazaki S, Steinman RM. Dendritic cell targeting of survivin protein in a xenogeneic form elicits strong CD4+ T cell immunity to mouse survivin. J Immunol 2006 177: 8410 8421.
28. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002 196: 1627 1638.
29. Aarntzen EH, Figdor CG, Adema GJ, Punt CJ, de Vries IJ. Dendritic cell vaccination and immune monitoring. Cancer Immunol Immunother 2008 57: 1559 1568.
30. Banchereau J, Schuler-Thurner B, Palucka AK, Schuler G. Dendritic cells as vectors for therapy. Cell 2001 106: 271 274.
31. Wintermeyer P, Wands Jr. Vaccines to prevent chronic hepatitis C virus infection: current experimental and preclinical developments. J Gastroenterol 2007 42: 424 432.
32. O'Hagan DT, Singh M, Ulmer JB. Microparticle-based technologies for vaccines. Methods 2006 40: 10 19.
33. O'Hagan DT, Singh M, Dong C et al. Cationic microparticles are a potent delivery system for a HCV DNA vaccine. Vaccine 2004 23: 672 680.
34. Waeckerle-Men Y, Allmen EU, Gander B et al. Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine 2006 24: 1847 1857.
35. Chakravarty PK, Guha C, Alfieri A et al. Flt3L therapy following localized tumor irradiation generates long-term protective immune response in metastatic lung cancer: its implication in designing a vaccination strategy. Oncology 2006 70: 245 254.