Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 8, 2005, Pages 3251-3255

  Mathis, Alexander ^a   Wild, Peter ^a   Boettger, Erik C ^a   Kapel, Christian M O ^b   Deplazes, Peter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CLARITHROMYCIN; LARGE SUBUNIT RIBOSOMAL RNA; MACROLIDE; MITOCHONDRIAL RNA; RIBOSOME RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; DRUG TARGETING; ECHINOCOCCUS MULTILOCULARIS; ELECTRON MICROSCOPY; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; ECHINOCOCCUS MULTILOCULARIS; MACROLIDES; MICROSCOPY, ELECTRON; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PARASITIC SENSITIVITY TESTS; PEPTIDYL TRANSFERASES; RIBOSOMES; RNA, RIBOSOMAL; SEQUENCE ANALYSIS, DNA;

EID: 23044437944     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.8.3251-3255.2005     Document Type: Article

References (36)

1. Ammann, R. W., and J. Eckert. 1996. Cestodes. Echinococcus. Gastroenterol. Clin. N. Am. 25:655-689.
2. Araujo, F. G., D. R. Guptill, and J. S. Remington. 1988. Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii. Antimicrob. Agents Chemother. 32:755-757.
3. Beckers, C. J., D. S. Roos, R. G. Donald, B. J. Luft, J. C. Schwab, Y. Cao, and K. A. Joiner. 1995. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. J. Clin. Investig. 95:367-376.
4. Boettger, E. C., B. Springer, T. Prammananan, Y. Kidan, and P. Sander. 2001. Structural basis for selectivity and toxicity of ribosomal antibiotics. EMBO Rep. 2:318-323.
5. Botero, D. 1970. Paromomycin as effective treatment of Taenia infections. Am. J. Trop. Med. Hyg. 19:234-237.
6. Camps, M., G. Arrizabalaga, and J. Boothroyd. 2002. An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii. Mol. Microbiol. 43:1309-1318.
7. Clough, B., M. Strath, P. Preiser, P. Denny, and I. R. Wilson. 1997. Thiostrepton binds to malarial plastid rRNA. FEBS Lett. 406:123-125.
8. Derouin, F. 2001. Anti-toxoplasmosis drugs. Curr. Opin. Investig. Drugs 2:1368-1374.
9. Eckert, J., and P. Deplazes. 2004. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin. Microbiol. Rev. 17:107-135.
10. Eckert, J., M. A. Gemmell, F.-X. Meslin, and Z. S. Pawlowski (ed.). 2001. WHO/OIE manual on echinococcosis in humans and animals: a public health problem of global concern. Office International des Epizootics, Paris, France.
11. Eckert, J., R. C. Thompson, S. A. Michael, L. M. Kumaratilake, and H. M. el-Sawah. 1989. Echinococcus granulosus of camel origin: development in dogs and parasite morphology. Parasitol. Res. 75:536-544.
12. Fichera, M. E., and D. S. Roos. 1997. A plastid organelle as a drug target in apicomplexan parasites. Nature 390:407-409.
13. Ginsburg, H., A. A. Divo, T. G. Geary, M. T. Boland, and J. B. Jensen. 1986. Effects of mitochondrial inhibitors on intraerythrocytic Plasmodium falciparum in in vitro cultures. J. Protozool. 33:121-125.
14. Hemphill, A., M. Stettler, M. Walker, M. Siles-Lucas, R. Fink, and B. Gottstein. 2002. Culture of Echinococcus multilocularis metacestodes: an alternative to animal use. Trends Parasitol. 18:445-451.
15. Hoerau, A., O. Adjei, and D. W. Buttner. 2002. Antibiotics for the treatment of onchocerciasis and other filarial infections. Curr. Opin. Investig. Drugs 3:533-537.
16. Ingold, K., P. Bigler, W. Thormann, T. Cavaliero, B. Gottstein, and A. Hemphill. 1999. Efficacies of albendazole sulfoxide and albendazole sulfone against in vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob. Agents Chemother. 43:1052-1061.
17. Kapel, C. M. O., P. R. Torgerson, R. C. A. Thompson, and P. Deplazes. Int. J. Parasitol., in press.
18. Kern, P. 2003. Echinococcus granulosus infection: clinical presentation, medical treatment and outcome. Langenbeck's Arch. Surg. 388:413-420.
19. Kiatfuengfoo, R., T. Suthiphongchai, P. Prapunwattana, and Y. Yuthavong. 1989. Mitochondria as the site of action of tetracycline on Plasmodium falciparum. Mol. Biochem. Parasitol. 34:109-115.
20. Krolewiecki, A., S. Leon, P. Scott, and D. Abraham. 2002. Activity of azithromycin against Leishmania major in vitro and in vivo. Am. J. Trop. Med. Hyg. 67:273-277.
21. Mathis, A., P. Wild, P. Deplazes, and E. C. Boettger. 2004. The mitochondrial ribosome of the protozoan Acanthamoeba castellanii is the target for macrolide antibiotics. Mol. Biochem. Parasitol. 135:223-227.
22. McFadden, G. I., and D. S. Roos. 1999. Apicomplexan plastids as drug targets. Trends Microbiol. 7:328-333.
23. McManus, M. C., and C. Bryant. 1995. Biochemistry, physiology and molecular biology of Echinococcus, p. 135-181. In R. C. A. Thompson and A. J. Lymbery (ed.), Echinococcosis and hydatid disease. CAB International, Wallingford, United Kingdom.
24. Pfister, P., M. Risch, D. E. Brodersen, and E. C. Bottger. 2003. Role of 16S rRNA helix 44 in ribosomal resistance to hygromycin B. Antimicrob. Agents Chemother. 47:1496-1502.
25. Pukrittayakamee, S., R. Clemens, A. Chantra, A. Nontprasert, T. Luknam, S. Looareesuwan, and N. J. White. 2001. Therapeutic responses to antibacterial drugs in vivax malaria. Trans. R. Soc. Trop. Med. Hyg. 95:524-528.
26. Reuter, S., M. Merkle, K. Brehm, P. Kern, and B. Manfras. 2003. Effect of amphotericin B on larval growth of Echinococcus multilocularis. Antimicrob. Agents Chemother. 47:620-625.
27. Rodriguez-Fonseca, C., R. Amils, and R. A. Garrett. 1995. Fine structure of the peptidyl transfease centre on 23S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes. J. Mol. Biol. 247:224-235.
28. Roos, D. S. 1999. The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites: some additional thoughts. Parasitol. Today 15:41.
29. Sadiq, S. T., K. W. Glasgow, C. J. Drakeley, O. Muller, B. M. Greenwood, D. C. Mabey, and R. L. Bailey. 1995. Effects of azithromycin on malariometric indices in The Gambia. Lancet 346:881-882.
30. Salem, H. H., and G. al-Allaf. 1967. Paromomycin and Taenia saginata. Lancet ii:1360.
31. Sander, P., T. Prammananan, A. Meier, K. Frischkorn, and E. C. Bottger. 1997. The role of ribosomal RNAs in macrolide resistance. Mol. Microbiol. 26:469-480.
32. Stettler, M., R. Fink, M. Walker, B. Gottstein, T. G. Geary, J. F. Rossignol, and A. Hemphill. 2003. In vitro parasiticidal effect of nitazoxanide against Echinococcus multilocularis metacestodes. Antimicrob. Agents Chemother. 47:467-474.
33. Stettler, M., J. F. Rossignol, R. Fink, M. Walker, B. Gottstein, M. Merli, R. Theurillat, W. Thormann, E. Dricot, R. Segers, and A. Hemphill. 2004. Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. Int. J. Parasitol. 34:615-624.
34. Taylor, W. R., T. L. Richie, D. J. Fryauff, H. Picarima, C. Ohrt, D. Tang, D. Braitman, G. S. Murphy, H. Widjaja, E. Tjitra, A. Ganjar, T. R. Jones, H. Basri, and J. Berman. 1999. Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. Clin. Infect. Dis. 28:74-81.
35. Uip, D. E., A. L. Lima, V. S. Amato, M. Boulos, V. A. Neto, and D. Bem David. 1998. Roxithromycin treatment for diarrhoea caused by Cryptosporidium spp. in patients with AIDS. J. Antimicrob. Chemother. 41:93-97.
36. Van der Auwera, G., S. Chappelle, and R. de Wachter. 1994. Structure of the large ribosomal subunit RNA of Phytophthora megasperma, and phytogeny of oomycetes. FEBS Lett. 338:133-136.