Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes

GLIA

Volumn 25, Issue 3, 1999, Pages 270-281

  Ye, Zu Cheng ^a   Sontheimer, Harald ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Glia; Glutamate transport; Glutamate uptake; Neurotoxicity; Synaptic transmission

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1-AMINO-1,3-DICARBOXYCYCLOPENTANE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; CYCLOLEUCINE; DRUG DERIVATIVE; GLUTAMIC ACID; METABOTROPIC RECEPTOR; NEUROPROTECTIVE AGENT;

ANIMAL; ARTICLE; ASTROCYTE; CELL CULTURE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; HIPPOCAMPUS; METABOLISM; NEWBORN; PHYSIOLOGY; RAT; SECRETION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLOLEUCINE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; NA(+)-K(+)-EXCHANGING ATPASE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0033083661     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(19990201)25:3<270::AID-GLIA7>3.0.CO;2-V     Document Type: Article

References (68)

1. Amos BJ, Chesler M. 1998. Characterization of an intracellular alkaline shift in rat astrocytes triggered by metabotropic glutamate receptors. J Neurophysiol 79:695-703.
2. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG. 1997. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci USA 94:4155-4160.
3. Attwell D, Barbour B, Szatkowski M. 1993. Nonvesicular release of neurotransmitter. Neuron 11:401-407.
4. Baba A, Saga H, Hashimoto H. 1993. Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes. Neurosci Lett 149:182-184.
5. Benveniste H, Drejer J, Schousboe A, Diemer NH. 1984. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369-1374.
6. Boss V, Boaten AS. 1995. An L-cysteine sulfinic acid-sensitive metabotropic receptor mediates increased cAMP accumulation in hippocampal slices. Neurosci Lett 184:1-4.
7. Boss V, Nutt KM, Conn PJ. 1994. L-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase-D activity. Mol Pharmacol 45:1177-1182.
8. Bruno V, Sureda FX, Storto M, Casabona G, Caruso A, Knopfel T, Kuhn R, Nicoletti F. 1997. The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling. J Neurosci 17:1891-1897.
9. Bushell TJ, Jane DE, Tse HW, Watkins JC, Garthwaite J, Collingridge GL. 1996. Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br J Pharmacol 117:1457-1462.
10. Cai ZH, Kimelberg HK. 1997. Glutamate receptor-mediated calcium responses in acutely isolated hippocampal astrocytes. Glia 21:380-389.
11. Casabona G, Genazzani AA, Di Stefano M, Sortino MA, Nicoletti F. 1992. Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices. J Neurochem 59:1161-1163.
12. Choi DW, Rothman SM. 1990. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13:171-182.
13. Cholewinski AJ, Reid JC, McDermott AM, Wilkin GP. 1989. Purification of astroglial-cell cultures from rat spinal cord: the use of D-valine to inhibit fibroblast growth. Neurochem Int 15:365-369.
14. Estin C, Vernadakis A. 1986. Primary glial cells and brain fibroblasts: interactions in culture. Brain Res Bull 16:723-731.
15. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. 1995. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375:599-603.
16. Forsythe ID, Clements JD. 1990. Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones. J Physiol (Lond) 429:1-16.
17. Fosse VM, Kolstad J, Fonnum F. 1986. A bioluminescence method for the measurement of L-glutamate: applications to the study of changes in the release of L-glutamate from lateral geniculate nucleus and superior colliculus after visual cortex ablation in rats. J Neurochem 47:340-349.
18. Gegelashvili G, Schousboe A. 1997. High-affinity glutamate transporters: Regulation of expression and activity. Mol Pharmacol 52:6-15.
19. Genazzani AA, Casabona G, L'Episcopo MR, Condorelli DF, Dell'Albani P, Shinozaki H, Nicoletti F. 1993. Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices. Brain Res 622:132-138.
20. Gilbert SF, Migeon BR. 1975. D-Valine as a selective agent for normal human and rodent epithelial cells in culture. Cell 5:11-17.
21. Griffiths R, Dunlop J, Gorman A, Senior J, Grieve A. 1994. L-transPyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol 47:267-274.
22. Hayashi Y, Sekiyama N, Nakanishi S, Jane DE, Sunter DC, Birse EF, Udvarhelyi PM, Watkins JC. 1994. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci 14:3370-3377.
23. Isaacson JS, Nicoll RA. 1993. The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus. J Neurophysiol 70:2187-2191.
24. Ito I, Kohda A, Tanabe S, Hirose E, Hayashi M, Mitsunaga S, Sugiyama H. 1992. 3,5-dihydroxyphenyl-glycine: A potent agonist of metabotropic glutamate receptors. NeuroReport 3:1013-1016.
25. Izumi Y, Clifford DB, Zorumski CF. 1992. Low concentrations of N-methyl-D-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices. Neurosci Lett 137:245-248.
26. Jane DE, Jones PL, Pook PC, Tse HW, Watkins JC. 1994. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. Br J Pharmacol 112:809-816.
27. Kanai Y, Hediger MA. 1992. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360:467-471.
28. Kawabata S, Tsutsumi R, Kohara A, Yamaguchi T, Nakanishi S, Okada M. 1996. Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors. Nature 383:89-92.
29. Keinanen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH. 1990. A family of AMPA-selective glutamate receptors. Science 249:556-560.
30. Kemp MC, Jane DE, Tse HW, Roberts PJ. 1996. Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur J Pharmacol 309:79-85.
31. Levi G, Patrizio M. 1992. Astrocyte heterogeneity: Endogenous amino acid levels and release evoked by non-N-methyl-D-aspartate receptor agonists and by potassium-induced swelling in type-1 and type-2 astrocytes. J Neurochem 58:1943-1952.
32. Lindsay RM, Barber PC, Sherwood MR, Zimmer J, Raisman G. 1982. Astrocyte cultures from adult rat brain: derivation, characterization, and neurotrophic properties of pure astroglial cells from corpus callosum. Brain Res 243:329-343.
33. Longuemare MC, Swanson RA. 1995. Excitatory amino acid release from astrocytes during energy failure by reversal of sodium-dependent uptake. J Neurosci Res 40:379-386.
34. Manahan-Vaughan D. 1997. Group 1 and 2 metabotropic glutamate receptors play differential roles in hippocampal long-term depression and long-term potentiation in freely moving rats. J Neurosci 17:3303-3311.
35. Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. 1991. Sequence and expression of a metabotropic glutamate receptor. Nature 349:760-765.
36. Mennerick S, Zorumski CF. 1994. Glial contributions to excitatory neurotransmission in cultured hippocampal cells. Nature 368: 59-62.
37. Miller S, Cotman CW, Bridges RJ. 1992. 1-Aminocyclopentane-1,3-dicarboxylic acid induces glutamine synthetase activity in cultured astrocytes. J Neurochem 58:1967-1970.
38. Miller S, Romano C, Cotman CW. 1995. Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. J Neurosci 15:6103-6109.
39. Nicholls D, Attwell D. 1990. The release and uptake of excitatory amino acids. Trends Pharmacol Sci 11:462-468.
40. Nicoletti F, Bruno V, Copani A, Casabona G, Knopfel T. 1996. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19:267-271.
41. Ogata T, Nakamura Y, Shibata T, Kataoka K. 1992. Release of excitatory amino acids from cultured hippocampal astrocytes induced by a hypoxic-hypoglycemic stimulation. J Neurochem 58:1957-1959.
42. Ottersen OP. 1989. Quantitative electron microscopic immunocytochemistry of neuroactive amino acids. Anat Embryol 180:1-15.
43. Patneau DK, Mayer ML. 1990. Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J Neurosci 10:2385-2399.
44. Petralia RS, Wang YX, Niedzielski AS, Wenthold RJ. 1996. The metabotropic glutamate receptors, mGLUR2 and mGLUR3, show unique postsynaptic, presynaptic, and glial localizations. Neuroscience 71:949-976.
45. Pin JP, Duvoisin R. 1995. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology 34:1-26.
46. Pines G, Danbolt NC, Bjoras M, Zhang Y, Bendahan A, Eide L, Koepsell H, Storm-Mathisen J, Seeberg E, Kanner BI. 1992. Cloning and expression of a rat brain L-glutamate transporter. Nature 360:464-467.
47. Porter JT, McCarthy KD. 1996. Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals. J Neurosci 16:5073-5081.
48. Prezeau L, Carrette J, Helpap B, Curry K, Pin JP, Bockaert J. 1994. Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Mol Pharmacol 45:570-577.
49. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang YF, Schielke JP, Welty DF. 1996. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675-686.
50. 3H]-D-aspartate from primary astrocyte cultures in response to raised external potassium. J Neurosci 16:7803-7811.
51. Schoepp DD, Conn PJ. 1993. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14:13-20.
52. Stein E, Cox JA, Seeburg PH, Verdoorn TA. 1992. Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes. Mol Pharmacol 42:864-871.
53. +-dependent glutamate/ aspartate transporter from rat brain. Proc Natl Acad Sci USA 89:10955-10959.
54. Swanson RA, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC. 1997. Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci 17:932-940.
55. Szatkowski M, Barbour B, Attwell D. 1990. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348:443-446.
56. Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. 1993. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci 13:1372-1378.
57. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K. 1997. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699-1702.
58. Testa CM, Catania MV, Young AB. 1994. Anatomical distribution of metabotropic glutamate receptors in mammalian brain. In: Conn PJ, Patel J, editors. The metabotropic glutamate receptors. Totowa, NJ: Humana Press, Inc. p 99-123.
59. Velasco I, Tapia R, Massieu L. 1996. Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures. J Neurosci Res 44:551-561.
60. Volterra A, Bezzi P, Rizzini BL, Trotti D, Ullensvang K, Danbolt NC, Racagni G. 1996. The competitive transport inhibitor L-transpyrrolidine-2,4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. Eur J Neurosci 8:2019-2028.
61. Winder DG, Conn PJ. 1995. Metabotropic glutamate receptor (mGLUR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGLUR. J Neurochem 64:592-599.
62. Winder DG, Conn PJ. 1996. Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication. J Neurosci Res 46:131-137.
63. Winder DG, Ritch PS, Gereau RW, 4th, Conn PJ. 1996. Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus. J Physiol (Lond.) 494:743-755.
64. Ye ZC, Sontheimer H. 1996. Cytokine modulation of glial glutamate uptake: A possible involvement of nitric oxide. NeuroReport 7:2181-2185.
65. Ye ZC, Sontheimer H. 1997. Modulation of extracellular glutamate via stimulation of astrocytic metabotropic glutamate receptors. Soc Neurosci Abstr 23:1791.
66. Ye ZC, Sontheimer H. 1998. Astrocytes protect neurons from neurotoxic injury by serum glutamate. Glia 22:237-248.
67. Zerangue N, Kavanaugh MP. 1996. Flux coupling in a neuronal glutamate transporter. Nature 383:634-637.
68. Zorumski CF, Mennerick S, Que J. 1996. Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons. J Physiol (Lond.) 494:465-477.