Expression of glutamate receptor subunits in human cancers

Histochemistry and Cell Biology

Volumn 132, Issue 4, 2009, Pages 435-445

  Stepulak, Andrzej ^a,b   Luksch, Hella ^b   Gebhardt, Christine ^c   Uckermann, Ortrud ^b   Marzahn, Jenny ^b   Sifringer, Marco ^c   Rzeski, Wojciech ^d,e   Staufner, Christian ^b   Brocke, Katja S ^b   Turski, Lechoslaw ^f   Ikonomidou, Chrysanthy ^g,h  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^e INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^f Solvay Pharmaceuticals Inc   (Netherlands)

^g UNIVERSITY OF WISCONSIN MADISON   (United States)

^h University of Wisconsin Health   (United States)

Author keywords

Cancer; Electrophysiology; Glutamate receptor; Immunocytochemistry; PCR

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; ASTROCYTOMA; BRAIN TISSUE; BREAST CARCINOMA; CANCER CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GLIOMA; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG CARCINOMA; MEDULLOBLASTOMA; MULTIPLE MYELOMA; NEOPLASM; NEUROBLASTOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; T CELL LEUKEMIA; THYROID CARCINOMA; TUMOR CELL LINE;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; BRAIN; CELL LINE, TUMOR; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; NEOPLASMS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; VALINE;

EID: 72849112674     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-009-0613-1     Document Type: Article

References (43)

1. M Abdul N Hoosein 2005 N-methyl-d-aspartate receptor in human prostate cancer J Membr Biol 205 125 128 16362500 10.1007/s00232-005-0777-0 1:CAS:528:DC%2BD2MXhtlWrsrjM (Pubitemid 41803689)
2. A Arcella G Carpinelli G Battaglia M D'Onofrio F Santoro RT Ngomba V Bruno P Casolini F Giangaspero F Nicoletti 2005 Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo Neuro Oncol 7 236 245 16053698 10.1215/S1152851704000961 1:CAS:528:DC%2BD2MXos1Cmtr8%3D (Pubitemid 41079133)
3. E Aronica B Yankaya GH Jansen S Leenstra CW van Veelen JA Gorter D Troost 2001 Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy Neuropathol Appl Neurobiol 27 223 237 11489142 10.1046/j.0305-1846.2001.00314.x 1:CAS:528:DC%2BD3MXmtVyls7s%3D (Pubitemid 32678675)
4. EA Cavalheiro JW Olney 2001 Glutamate antagonists: deadly liaisons with cancer Proc Natl Acad Sci USA 98 5947 5948 11371628 10.1073/pnas.121179198 1:CAS:528:DC%2BD3MXktVWlu7s%3D (Pubitemid 32488170)
5. HJ Chang BC Yoo SB Lim SY Jeong WH Kim JG Park 2005 Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance Clin Cancer Res 11 3288 3295 15867225 10.1158/1078-0432.CCR-04-1912 1:CAS:528:DC%2BD2MXjslOqtr4%3D (Pubitemid 40627877)
6. SW Choi SY Park SP Hong H Pai JY Choi SG Kim 2004 The expression of NMDA receptor 1 is associated with clinicopathological parameters and prognosis in the oral squamous cell carcinoma J Oral Pathol Med 33 533 537 15357673 10.1111/j.1600-0714.2004.00226.x 1:CAS:528:DC%2BD2cXpt1Gnsr4%3D (Pubitemid 39318463)
7. S Cull-Candy S Brickley M Farrant 2001 NMDA receptor subunits: diversity, development and disease Curr Opin Neurobiol 11 327 335 11399431 10.1016/S0959-4388(00)00215-4 1:CAS:528:DC%2BD3MXks1Oktbg%3D (Pubitemid 32524098)
8. JF de Groot Y Piao L Lu GN Fuller WK Yung 2008 Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation J Neurooncol 88 121 133 18317690 10.1007/s11060-008-9552-2
9. T Hayashi H Umemori M Mishina T Yamamoto 1999 The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn Nature 397 72 76 9892356 10.1038/16269 1:CAS:528:DyaK1MXns1Wqsg%3D%3D (Pubitemid 29038251)
10. E Hinoi T Takarada T Ueshima Y Tsuchihashi Y Yoneda 2004 Glutamate signaling in peripheral tissues Eur J Biochem 271 1 13 14686914 10.1046/j.1432-1033.2003.03907.x 1:CAS:528:DC%2BD2cXotFKitg%3D%3D (Pubitemid 38122160)
11. H Husi MA Ward JS Choudhary WB Blackstock SG Grant 2000 Proteomic analysis of NMDA receptor-adhesion protein signaling complexes Nat Neurosci 3 661 669 10862698 10.1038/76615 1:CAS:528:DC%2BD3cXkvFaqtrw%3D (Pubitemid 30437200)
12. L Iacovelli A Arcella G Battaglia S Pazzaglia E Aronica P Spinsanti A Caruso E De Smaele A Saran A Gulino M D'Onofrio F Giangaspero F Nicoletti 2006 Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas J Neurosci 26 8388 8397 16899734 10.1523/JNEUROSCI.2285-06.2006 1:CAS:528:DC%2BD28Xos1Kju70%3D (Pubitemid 44309853)
13. S Ishiuchi K Tsuzuki Y Yoshida N Yamada N Hagimura H Okado A Miwa H Kurihara Y Nakazao M Tamura T Sasaki S Ozawa 2002 Blockage of Ca(2+)-permeable AMPA receptor suppresses migration and induces apoptosis in human glioblastoma cells Nat Med 8 971 978 12172541 10.1038/nm746 1:CAS:528:DC%2BD38Xms1aitr0%3D (Pubitemid 35033701)
14. N Kalariti N Pissimissis M Koutsilieris 2005 The glutamatergic system outside the CNS and in cancer biology Expert Opin Investig Drugs 14 1487 1496 16307489 10.1517/13543784.14.12.1487 1:CAS:528:DC%2BD2MXht1Gks7vI (Pubitemid 41749194)
15. Y Kawahara K Ito H Sun I Kanazawa S Kwak 2003 Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain Eur J Neurosci 18 23 33 12859334 10.1046/j.1460-9568.2003.02718.x (Pubitemid 36920842)
16. K Keinanen W Wisden B Sommer P Werner A Herb TA Verdoorn B Sakmann PH Seeburg 1990 A family of AMPA-selective glutamate receptors Science 249 556 560 2166337 10.1126/science.2166337 1:CAS:528:DyaK3cXlt1KqtLg%3D
17. JN Kew JA Kemp 2005 Ionotropic and metabotropic glutamate receptor structure and pharmacology Psychopharmacology (Berl) 179 4 29 10.1007/s00213-005-2200-z 1:CAS:528:DC%2BD2MXjtV2itbY%3D (Pubitemid 40576690)
18. MS Kim X Chang JK Nagpal K Yamashita JH Baek S Dasqupta G Wu M Osada JH Woo WH Westra B Trink EA Ratovitski C Moon D Sidrawsky 2008 The N-methyl-d-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth Oncogene 27 2045 2054 17922030 10.1038/sj.onc.1210842 1:CAS:528:DC%2BD1cXjslWjtrw%3D
19. J Lerma AV Paternain A Rodriguez-Moreno JC López-García 2001 Molecular physiology of kainate receptors Physiol Rev 81 971 998 11427689 1:CAS:528:DC%2BD3MXlt1Oiu7Y%3D
20. JW Liu MS Kim J Nagpal K Yamashita L Poeta X Chang J Lee HL Park C Jeronimo WH Westra M Mori C Moon B Trink D Sidransky 2007 Quantitative hypermethylation of NMDAR2B in human gastric cancer Int J Cancer 121 1994 2000 17620329 10.1002/ijc.22934 1:CAS:528:DC%2BD2sXhtFSjsL%2FK (Pubitemid 47463162)
21. S Maas S Patt M Schrey A Rich 2001 Underediting of glutamate receptor GluR-B mRNA in malignant gliomas Proc Natl Acad Sci USA 98 14687 14692 11717408 10.1073/pnas.251531398 1:CAS:528:DC%2BD3MXptFCksbk%3D (Pubitemid 33121452)
22. DR Madden 2002 The structure and function of glutamate receptor ion channels Nat Rev Neurosci 3 91 101 11836517 10.1038/nrn725 1:CAS:528: DC%2BD38Xhslyju7k%3D (Pubitemid 135706578)
23. YE Marin S Chen 2004 Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development J Mol Med 82 735 749 15322701 10.1007/s00109-004-0566-8 1:CAS:528:DC%2BD2cXpt1Wqt70%3D (Pubitemid 40022267)
24. Y Nakajima H Iwakabe C Akazawa H Nawa R Shigemoto N Mizuno S Nakanishi 1993 Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for l-2-amino-4- phosphonobutyrate J Biol Chem 268 11868 11873 8389366 1:CAS:528: DyaK3sXlsFamt78%3D
25. F Nicoletti A Arcella L Iacovelli G Battaglia F Giangaspero D Melchiorri 2007 Metabotropic glutamate receptors: new targets for the control of tumor growth? Trends Pharmacol Sci 28 206 213 17433452 10.1016/j.tips.2007.03.008 1:CAS:528:DC%2BD2sXkvFGiur0%3D (Pubitemid 46671560)
26. M Nishi H Hinds HP Lu M Kawara Y Hayashi 2001 Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner J Neurosci 21 RC185 11717388 1:STN:280: DC%2BD3Mnns1Kgtw%3D%3D
27. R Pacheco T Gallart C Lluis R Franco 2007 Role of glutamate on T cell mediated immunity J Neuroimmunol 185 9 19 17303252 10.1016/j.jneuroim.2007.01. 003 1:CAS:528:DC%2BD2sXjs1Kqurk%3D (Pubitemid 46497434)
28. CL Palmer L Cotton JM Henley 2005 The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors Pharmacol Rev 57 253 257 15914469 10.1124/pr.57.2.7 1:CAS:528: DC%2BD2MXlsFejtLg%3D (Pubitemid 41043886)
29. SY Park SA Lee IH Han BC Yoo SH Lee JY Park IH Cha J Kim SW Choi 2007 Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma Oncol Rep 17 81 87 17143482
30. PM Pollock K Cohen-Solal R Sood J Namkoong JJ Martino A Koganti H Zhu C Robbins I Makalowska SS Shin Y Marin KG Roberts LM Yudt A Chen J Cheng A Incao HW Pinkett CL Graham K Dunn SM Crespo-Carbone KR Mackason KB Ryan D Sinsimer J Goydos KR Reuhl M Eckhaus PS Meltzer WJ Pavan JM Trent S Chen 2003 Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia Nat Genet 34 108 112 12704387 10.1038/ng1148 1:CAS:528:DC%2BD3sXjt1Ont7k%3D (Pubitemid 36548800)
31. G Popescu 2005 Mechanism-based targeting of NMDA receptor functions Cell Mol Life Sci 62 2100 2101 16132227 10.1007/s00018-005-5227-8 1:CAS:528:DC%2BD2MXhtFCgtLjL (Pubitemid 41291666)
32. W Rzeski L Turski C Ikonomidou 2001 Glutamate antagonists limit tumor growth Proc Natl Acad Sci USA 98 6372 6377 11331750 10.1073/pnas.091113598 1:CAS:528:DC%2BD3MXktVWktr0%3D (Pubitemid 32488244)
33. SS Shin JJ Martino S Chen 2008 Metabotropic glutamate receptors (mGlus) and cellular transformation Neuropharmacology 55 396 402 18554669 10.1016/j.neuropharm.2008.04.021 1:CAS:528:DC%2BD1cXhtVKisrnO
34. A Stepulak M Sifringer W Rzeski S Endesfelder A Gratopp EE Pohl P Bittigau U Felderhoff-Mueser AM Kaindl C Bührer HH Hansen M Stryjecka-Zimmer L Turski C Ikonomidou 2005 NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth Proc Natl Acad Sci USA 102 15605 15610 16230611 10.1073/pnas.0507679102 1:CAS:528:DC%2BD2MXht1ShtrbO (Pubitemid 41528103)
35. A Stepulak M Sifringer W Rzeski K Brocke A Gratopp EE Pohl L Turski C Ikonomidou 2007 AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth Cancer Biol Ther 6 1908 1915 18059166 1:CAS:528:DC%2BD1cXks1WjtLw%3D
36. T Takano JH Lin G Arcuino O Gao J Yang M Nedergaard 2001 Glutamate release promotes growth of malignant gliomas Nat Med 7 1010 1015 11533703 10.1038/nm0901-1010 1:CAS:528:DC%2BD3MXmvFOlsrw%3D (Pubitemid 32937380)
37. M Takeda M Haga H Yamada M Kinoshita M Otsuka S Tsuboi Y Moriyama 2000 Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells Neurosci Lett 294 97 100 11058796 10.1016/S0304-3940(00)01546-9 1:CAS:528:DC%2BD3cXovFSltLg%3D (Pubitemid 30780005)
38. Y Wang JP Durkin 1995 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-d-aspartate, activates mitogen-activated protein kinase through G-protein beta gamma subunits in rat cortical neurons J Biol Chem 270 22783 22787 7559406 10.1074/jbc.270.39.22783 1:CAS:528:DyaK2MXosFOqurk%3D
39. Y Wang DL Small DB Stanimirovic P Mortey JP Durkin 1997 AMPA receptor-mediated regulation of a Gi-protein in cortical neurons Nature 389 502 504 9333240 10.1038/39062 1:CAS:528:DyaK2sXmsFWqu7w%3D (Pubitemid 27435326)
40. K Watanabe T Kanno T Oshima H Miwa G Tashiro T Nishizaki 2008 The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells Biochem Biophys Res Commun 367 487 490 18178157 10.1016/j.bbrc.2007.12.167 1:CAS:528:DC%2BD1cXpsFyltA%3D%3D
41. EA Waxman DR Lynch 2005 N-methyl-d-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease Neuroscientist 11 37 49 15632277 10.1177/1073858404269012 1:CAS:528:DC%2BD2MXht1ylsrc%3D (Pubitemid 40223089)
42. BC Yoo E Jeon SH Hong YK Shin HJ Chang JG Park 2004 Metabotropic glutamate receptor 4-mediated 5-fluorouracil resistance in a human colon cancer cell line Clin Cancer Res 10 4176 4184 15217955 10.1158/1078-0432.CCR-1114-03 1:CAS:528:DC%2BD2cXltFWmu7k%3D (Pubitemid 38812498)
43. A Yoshioka N Ikegaki M Williams D Pleasure 1996 Expression of N-methyl-d-aspartate (NMDA) and non-NMDA glutamate receptor genes in neuroblastoma, medulloblastoma, and other cells lines J Neurosci Res 46 164 178 8915893 10.1002/(SICI)1097-4547(19961015)46:2<164::AID-JNR4>3.0.CO;2-F 1:CAS:528:DyaK28Xms1anur4%3D (Pubitemid 26367541)