Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles

Biomaterials

Volumn 32, Issue 24, 2011, Pages 5535-5542

  Pearl, Jeremy I ^a   Ma, Ting ^a   Irani, Afraaz R ^a   Huang, Zhinong ^a   Robinson, William H ^b   Smith, Robert L ^a   Goodman, Stuart B ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immune response; Osteolysis; Polymethylmethacrylate; Wear debris

Indexed keywords

ASEPTIC LOOSENING; BONE LOSS; GENE EXPRESSION DATA; IMMUNE RESPONSE; IN-VIVO; INFLAMMATORY RESPONSE; INNATE IMMUNITY; MOLECULAR PATTERNS; MURINE MACROPHAGES; MYELOID DIFFERENTIATION FACTOR 88; ORTHOPEDIC IMPLANT; OSTEOLYSIS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; PERIPROSTHETIC OSTEOLYSIS; PMMA PARTICLE; THERAPEUTIC TARGETS; TLR SIGNALING; TOLL-LIKE RECEPTORS; WEAR DEBRIS; WEAR PARTICLES; WILD TYPES;

GENE EXPRESSION; IMPLANTS (SURGICAL); INTERFERONS; MACROPHAGES; POLYESTERS; SIGNALING;

DEBRIS;

MYELOID DIFFERENTIATION FACTOR 88; POLY(METHYL METHACRYLATE); TIR DOMAIN CONTAINING ADAPTER INDUCING INTERFERON BETA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE PROSTHESIS; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; ORTHOPEDICS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE; CELLS, CULTURED; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; POLYMETHYL METHACRYLATE; POLYMYXIN B; PROSTHESES AND IMPLANTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; MUS;

EID: 79957896683     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.046     Document Type: Article

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