Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation

Journal of Bone and Mineral Research

Volumn 16, Issue 11, 2001, Pages 2082-2091

  Bi, Yanming ^a   Seabold, Joscelyn M ^a,b   Kaar, Scott G ^a   Ragab, Ashraf A ^a   Goldberg, Victor M ^a   Anderson, James M ^a   Greenfield, Edward M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endotoxin; Implant loosening; Osteoclast differentiation; Osteolysis; Toll like receptors

Indexed keywords

ENDOTOXIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MUTANT PROTEIN; TITANIUM; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE PROSTHESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPROSTHESIS LOOSENING; HUMAN; HUMAN CELL; IMPLANT; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PHAGOCYTOSIS;

EID: 0034782843     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.11.2082     Document Type: Article

References (76)

1. Current concepts in orthopaedic biomaterials and implant fixation
2. The response to particulate debris
3. The biologic effects of implant materials
4. Periprosthetic osteolysis in total hip arthroplasty: The role of particulate wear debris
5. Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts
6. A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles
7. Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobaltchromium-alloy and high-density-polyethylene particles
8. Arthroplasty implant biomaterial particle associated macrophages differentiate into lacunar bone resorbing cells
9. Polymethylmethacrylate-induced inflammatory macrophages resorb bone
10. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis
11. A study of implant failure in the Wagner resurfacing arthroplasty
12. Prosthetic synovitis
13. Bone formation and bone resorption in failed total joint arthroplasties: Histomorphometric analysis with histochemical and immunohistochemical technique
14. Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells
15. Polymethylmethacrylate-induced release of bone resorbing factors
16. Macrophages stimulate bone resorption when they phagocytose particles
17. Bone resorption activity of particulatestimulated macrophages
18. Role of tumor necrosis factor alpha in particulate-induced bone resorption
19. Response of three murine macrophage populations to particulate debris: Bone resorption in organ cultures
20. Activation of osteoclast-mediated bone resorption by the supernatant from a rabbit synovial cell line in response to polyethylene particles
21. Joint fluid from patients with failed total hip arthroplasty stimulates pit formation by mouse osteoclasts on dentin slices
22. Size and shape of biomaterial wear debris
23. Composition and morphology of wear debris in failed uncemented total hip replacement
24. The histological effects of the implantation of different sizes of polyethylene particles in the rabbit tibia
25. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces
26. Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
27. Bacterial colonization of orthopaedic fixation devices in the absence of clinical infection
28. Bacterial growth associated with metallic implants in dogs
29. Incidence of infection and analysis of contributing factors in revision joint arthroplasty over a two-year period
30. Radiodense lines and subclinical infection in pediatric hip surgery
31. The inflammatory response to particulate wear debris in total hip arthroplasty
32. A four-year prospective study on microbial ecology of explanted prosthetic hips in 52 patients with "aseptic" prosthetic joint loosening
33. The significance of positive cultures from orthopaedic fixation devices in the absence of clinical infection
34. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty
35. Improved detection of infection in hip replacements
36. Polymerase chain reaction detection of bacterial infection in total knee arthroplasty
37. Detection of prosthetic hip infection at revision arthroplasty by immunofluorescence microscopy and PCR amplification of the bacterial 16S rRNA gene
38. Antibiotic prophylaxis in total hip arthroplasty
39. Establishment of a new perchloric acid treatment method to allow determination of the total endotoxin content in human plasma by the limulus test and clinical application
40. Possible pathogenic role of endotoxin in Reye's syndrome
41. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice
42. 3, PTH, IL-1, IL-6, and TNF
43. Osteoclast differentiation requires ascorbic acid
44. Interleukin-4 induces foreign body giant cells from human monocytes/macrophages
45. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
46. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
47. Endotoxin detection
48. The use of polymyxin B and C3H/HeJ mouse spleen cells as criteria for endotoxin contamination
49. Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: Analysis of Chromosome 4 markers surrouding the Lps gene
50. Induction of CD14 expression in LPSn, LPSd and tumor necrosis factor receptor-deficient mice
51. The role of adherent endotoxin in stimulation of osteoclast differentiation by orthopaedic wear particles
52. Polymyxin B use does not ensure endotoxin-free solution
53. Induction of human interleukin-1 production by polymyxin B
54. Polymyxin-B stimulates tumor necrosis factor-alpha production by human peripheral blood mononuclear cells
55. Stimulation of cytokine production by titanium wear particles is due to adherent endotoxin
56. Adsorbed endotoxin mediates differential effects on particle-induced stimulation of cytokine and chemokine release
57. Macrophage cytokine response to particles and lipopolysaccharide in vitro
58. Decontaminating particles exposed to bacterial endotoxin (LPS)
59. The effect of particle wear debris on nuclear factor kappa B activation in differentiated THP-1 cells
60. Adherent endotoxins are necessary for particle-induced bone resorption in a rat model
61. Bone resorptive cytokines produced in response to wear particles induce osteoclast differentiation by stimulating ODF/OPGL expression by mesenchymal support cells
62. Toll, a new piece in the puzzle of innate immunity
63. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
64. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
65. Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin
66. Toll-like receptor 4 (TLR4)deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
67. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide
68. Outside-in signaling by lipopolysaccharide through a tailless integrin
69. Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers Infect Immun
70. Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-KB activation and TNF production induced by lipopolysaccharide and Group B Streptococcal cell walls
71. Signaling pathways for tumor necrosis factor-α and interluekin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro
72. Pin tract infections: Silver vs uncoated pins
73. Use of fibrinolytic agents to coat wire implants to decrease infection
74. The prevention of prosthetic infection using a cross-linked albumin coating in a rabbit model
75. Anti-infective efficacy of antiseptic-coated intramedullary nails