Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer

Journal of Steroid Biochemistry and Molecular Biology

Volumn 125, Issue 1-2, 2011, Pages 57-65

  Thomas, James L ^a   Bucholtz, Kevin M ^b   Kacsoh, Balint ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCER UNIVERSITY   (United States)

Author keywords

3 Hydroxysteroid dehydrogenase; Breast cancer; Enzyme inhibitor; MCF 7 tumor cell; Short chain dehydrogenase reductase

Indexed keywords

17 HYDROXYPREGNENOLONE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; ALDOSTERONE SYNTHASE; AROMATASE; CYTOCHROME P450 17; EPOSTANE; ESTRADIOL; HYDROCORTISONE; PRASTERONE; PREGNENOLONE; STEROID 21 MONOOXYGENASE; SULFOTRANSFERASE; TESTOSTERONE; TRILOSTANE;

BINDING AFFINITY; BREAST TUMOR; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; MICHAELIS MENTEN KINETICS; POSTMENOPAUSE; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

3-HYDROXYSTEROID DEHYDROGENASES; BREAST NEOPLASMS; CELL LINE; FEMALE; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN CONFORMATION; STEROIDS;

EID: 79957679997     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.08.003     Document Type: Review

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