Structural basis for the selective inhibition of human 3β-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells

Molecular and Cellular Endocrinology

Volumn 301, Issue 1-2, 2009, Pages 174-182

  Thomas, James L ^a   Bucholtz, Kevin M ^b   Sun, Jingping ^a   Mack, Vance L ^a   Kacsoh, Balint ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCER UNIVERSITY   (United States)

Author keywords

3 Hydroxysteroid dehydrogenase; Breast cancer; Enzyme inhibitor; MCF 7 tumor cell

Indexed keywords

17BETA ACETOXY TRILOSTANE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; EPOSTANE; LETROZOLE; OXIDOREDUCTASE INHIBITOR; PRASTERONE; TRILOSTANE; UNCLASSIFIED DRUG;

ARTICLE; BREAST TUMOR; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

3-HYDROXYSTEROID DEHYDROGENASES; ARGININE; AROMATASE INHIBITORS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COENZYMES; DEHYDROEPIANDROSTERONE; DIHYDROTESTOSTERONE; ENZYME INHIBITORS; ESTRADIOL; ESTRONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KINETICS; MUTANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 60249089535     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.09.029     Document Type: Article

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