Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: Inhibition by novel non-steroidal steroid sulfatase inhibitors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 73, Issue 5, 2000, Pages 225-235

  Billich, Andreas ^a   Nussbaumer, Peter ^a   Lehr, Philipp ^a  

^a Research Institute of the Vienna   (Austria)

Author keywords

Breast cancer; Dehydropiandroesterone sulfate; Enzyme inhibition; Estrone sulfate; Steroid sulfatase

Indexed keywords

ENZYME INHIBITOR; ESTRONE SULFATE; PRASTERONE SULFATE; STERYL SULFATASE; STERYL SULFATASE INHIBITOR; SULFAMIC ACID 2 NONYL 4 OXO 4H CHROMEN 6 YL ESTER; SULFAMIC ACID 2 TERT BUTYL 4 OXO 4H CHROMEN 6 YL ESTER; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISOTOPE LABELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ARYLSULFATASES; BREAST NEOPLASMS; CELL DIVISION; DEHYDROEPIANDROSTERONE SULFATE; ENZYME INHIBITORS; ESTRONE; FEMALE; HUMANS; INDICATORS AND REAGENTS; KINETICS; MOLECULAR STRUCTURE; STERYL-SULFATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 0033734846     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(00)00077-7     Document Type: Article

References (48)

1. Importance of estrogen sulfates in breast cancer
2. Sulphatase inhibitors: The rationale for the development of a new endocrine therapy
3. Determination of hormonal steroid concentrations in biological extracts by high resolution fragmentography
4. Estrone and estradiol content in human breast tumors: Relationship to estradiol receptors
5. Endogenous oestradiol-17β concentration in breast tumors determined by mass fragmentography and by radioimmunoassay: Relationship to receptor content
6. Endogenous concentration and sub-cellular distribution of estrogens in normal and malignant breast tissue
7. Control and expression of oestrone sulphatase activities in human breast cancer
8. Concentration of unconjugated estrone and estradiol in peripheral plasma in nonpregnant women throughout the menstrual cycle, castrate and postmenopausal women and in men
9. In situ estrogen production via the estrone sulfatase pathway in breast tumors: Relative importance versus the aromatase pathway
10. Enzymatic control of estrogen production in human breast cancer: Relative significance of aromatase versus sulfatase pathway
11. Biosynthesis of 17β-oestradiol in human breast carcinoma tissue and a novel method for its characterization
12. Biologic significance of aromatase activity in human breast tumors
13. Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma
14. Estrone sulfate: A potential source of estradiol in human breast cancer tissues
15. Aromatase activity in normal breast and breast tumor tissue: In vivo and in vitro studies
16. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients
17. The plasma concentration of oestrone sulphate in postmenopausal women: Lack of diurnal variation, effect of ovariectomy, age and weight
18. Estrone sulphate: Production rate and metabolism in man
19. Stimulation of cell proliferation and estrogenic response by adrenal C19Δ5 steroids in the ZR-75-1 human breast cancer cell line
20. The interrelationship between plasma 5-ene adrenal androgens in normal women
21. Estrogenic effects of physiological concentrations of 5-androstene-3β,17β-diol and its metabolism in MCF-7 human breast cancer cells
22. Androstenedione and androst-5-ene-3β,17β-diol stimulate DMBA-induced mammary tumours-role of aromatase
23. Adrenal androgen secretion and metabolism in postmenopausal women
24. Uptake and concentration of steroid hormones in mammary tissues
25. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer
26. Plasma sex hormone levels and risk of breast cancer in postmenopausal women
27. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines
28. Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase
29. Development of potent non-estrogenic estrone sulfatase inhibitors
30. The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatases inhibitors with reduced oestrogenicity
31. Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17β-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: Combination of two substituents at positions C3 and C17β of estradiol
32. Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors
33. Uber das Hydrazidosulfamid
34. Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates
35. Synthesis and sulfatase inhibitory activities of nonsteroidal estrone sulfatase inhibitors
36. A monoclonal antibody to rat liver arylsulfatase C and its application in immunohistochemistry
37. Enzymic studies of sulphatases in tissues of the normal human and in metachromatic leukodystrophy with multiple sulphatase deficiencies: Arylsulphatases A, B and C, cerebroside sulphatase, psychosine sulphatase and steroid sulphatases
38. New colorimetric cytotoxicity assay for anticancer-drug screening
39. Inactivation of steroid sulfatase by an active site directed inhibitor, estrone 3-O-sulfamate
40. Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF-7 cell cultures
41. Biological effects of adrenal androgens on MCF-7 and BT-20 human breast cancer cells
42. Influence of dehydroepiandrosterone and 5-en-androstene-3 beta, 17 beta-diol on the growth of MCF-7 human breast cancer cells induced by 17 beta-estradiol
43. Dehydroepiandrosterone sulfate estrogenic action at its physiological plasma concentration in human breast cancer cell lines
44. C19 Steroids estrogenic activity in human breast cancer cell lines: Importance of dehydroepiandrosterone sulfate at physiological plasma concentration
45. Sulfamates of various estrogens-prodrugs with increased systemic and reduced hepatic estrogenicity at oral application
46. Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives
47. In vivo actvity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal nonestrogenic steroid sulfatase inhibitor
48. Aminoglutethimide: Review of pharmacology and clinical use