Estrogen production via the aromatase enzyme in breast carcinoma: Which cell type is responsible?

Journal of Steroid Biochemistry and Molecular Biology

Volumn 61, Issue 3-6, 1997, Pages 267-271

  Santen, R J ^a   Santner, S J ^b   Pauley, R J ^b   Tait, L ^b   Kaseta, J ^b   Demers, L M ^c   Hamilton, C ^c   Yue, W ^a   Wang, J P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE;

BREAST CANCER; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; STROMA CELL;

MINK CELL FOCUS-FORMING VIRUS; MUS MUSCULUS;

EID: 0031126015     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00211-7     Document Type: Conference Paper

References (20)

1. 4-androstenedione to estrone in normal males and nonpregnant normal, castrate and adrenalectomized females. J. Clin. Endocr. 27:1967;1103-1111.
2. Longcope C., Kato T., Horton R. Conversion of blood androgens to estrogens in normal adult men and women. J. Clin. Invest. 48:1969;2191-2201.
3. Santner S.J., Feil P.D., Santen R.J. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J. Clin. Endocr. Metab. 59:1984;29-33.
4. Adams J.B., Li K. Biosynthesis of 17β-oestradiol in human breast carcinoma tissue and a novel method for its characterization. Br. J. Cancer. 31:1975;429-433.
5. Reed M.J., Owen A.M., Lai L.C., Coldham N.G., Ghilchik M.W., Shaikh N.A., James V.H.T. In situ oestrone synthesis in normal breast and breast tumour tissues: effect of treatment with 4-hydroxyandrostenedione. Int. J. Cancer. 44:1989;233-237.
6. Thijssen J.H.H., Daroszewski J., Milewicz A., Blankenstein M.A. Local aromatase activity in human breast tissues. J. Steroid Biochem. Molec. Biol. 44:1993;577-582.
7. Santen R.J., Martel J., Hoagland M., Naftolin F., Roa L., Harada N., Hafer L., Zaino R., Santner S.J. Stromal spindle cells contain aromatase in human breast tumors. J. Clin. Endocr. Metab. 79:1994;627-632.
8. Santner S.J., Pauley R.J., Tait L., Kasseta J., Santen R.J. Breast cancer stromal cell aromatase expression. J. Clin. Endocr. Metab. 82:1997;200-208.
9. Tilson-Mallett N., Santner S.J., Feil P.D., Santen R.J. Biological significance of aromatase activity in human breast tumors. J. Clin. Endocr. Metab. 57:1983;1125-1128.
10. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning, A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, New York.
11. Chomcyznski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analyt. Biochem. 162:1987;156-159.
12. Yue W., Zhou D., Chen S., Brodie A. A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene. Cancer Res. 54:1994;5092-5095.
13. Yue W., Wang J., Savinov A., Brodie A. The effects of aromatase inhibitors on growth of mammary tumors in a nude mouse model. Cancer Res. 55:1995;3073-3077.
14. Ronnov-Jlessen L., Petersen O.W., Koteliansky V.E., Bissell M.J. The origin of myofibroblasts in breast cancer. J. Clin. Invest. 95:1995;859-873.
15. Lu Q., Nakmura J., Savinov A., Yue W., Weisz J., Dabbs D.J., Wolz G., Brodie A. Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology. 137:1996;3061-3068.
16. Barsky S.H., Gopalakrishna R. Increased invasion and spontaneous metastasis of BL6 melanoma with inhibition of the desmoplastic response in C57 Bl/6 mice. Cancer Res. 47:1987;1663-1667.
17. Simpson E.R., Merrill J.C., Hollub A.J., Graham-Lorence S., Mendelson C.R. Regulation of estrogen biosynthesis by human adipose cells. Endocr. Rev. 10:1989;136-148.
18. Reed M.J., Topping L., Coldham N.G., Purohit A., Ghilchik M.W., James V.H.T. Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors. J. Steroid Biochem. Molec. Biol. 44:1993;589-596.
19. Bulun S.E., Simpson E.R. Regulation of aromatase expression in human tissues. Breast Cancer Res. Treat. 30:1994;19-29.
20. Berstein L., Santen R.J., Santner S.J. Three-component model of oestrogen formation and regulation of intratumoural oestrogen pool in breast neoplasms. Med. Hypoth. 45:1995;588-589.