Triazoles: As potential bioactive agents

International Journal of Pharmaceutical Sciences Review and Research

Volumn 8, Issue 1, 2011, Pages 161-169

  Siddiqui, Nadeem ^a   Ahsan, Waquar ^a   Alam, M Shamsher ^a   Ali, Ruhi ^a   Jain, Sanjay ^b   Azad, Bishmillah ^a   Akhtar, Jawaid ^a  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Anticancer; Anticonvulsant; Antimalarial; Antimicrobial; Triazole

Indexed keywords

1 (4 PHENYL 5 THIOXOL [1,2,4]TRIAZOL 3 YL)METHYL 5 OXO [1,2,4]TRIAZOLE DERIVATIVE; 1 (5 PHENYLAMINO [1,3,4]THIADIAZOL 2 YL)METHYL 5 OXO [1,2,4]TRIAZOLE; 1 [1,3,4 THIADIAZOL 2 YL] 3 METHYLTHIO 6,7 DIHYDROBENZO[C]THIOPHEN 4(5H) ONE; 1,3,4 THIADIAZOL 2 YLMETHYL 1,2,4 TRIAZOLE; 2,3,4,6 TETRA O ACETYL ALPHA GLUCOPYRANOSYL BROMIDE; 3 AMINO 7 (2,6 DICHLOROBENZYL) 6 METHYLTRIAZOLO[4,3 B]PYRIDAZINE; 3 ETHYL 4 (4 OCTYLOXYPHENYL) 4H 1,2,4 TRIAZOLE; 4 ALKYL ARYL 2,4 DIHYDRO 5 [[6 (4 BROMOPHENYL)IMIDAZOL[2,1 B]THIAZOL 3 YL]METHYL] 3H 1,2,4 TRIAZOLE 3 THIONE; 4 AMINO 5 (4,5,6,7 TETRAHYDRO 1 BENZOTHIEN 2 YL) 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 AMINO 5 (5 PHENYLTHIEN 2 YL) 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 AMINO N [(1 (2,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL] 4 AMINOBENZENESULFONAMIDE; 4 AMINO N [(1 DODECYL 1H 1,2,3 TRIZOL 4 YL)METHYL]BENZENESULFONAMIDE; 4 AMINO N [[1 (2,4 DIFLUROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]BENZENESULFONAMIDE; 4 ETHYL 5 (4,5,6,7 TETRAHYDRO 1 BENZOTHIEN 2 YL) 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4,5 DIPHENYL 2H 1,2,4 TRIAZOL 3(4H) ONE; 5 BENZYLOXY [1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 HEXYLOXY [1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 7 (4 FLUOROBENZYLOXY) 4,5 DIHYDRO [1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 7 BENZYLOXY 4,5 DIHYDRO [1,2,4]THIAZOLO[4,3 A]QUINOLINE 1(2H) ONE; 8 CHLORO 6 (2 FLUOROPHENYL) 1 (ARYL) 4H [1,2,4]TRIAZOLO[4,3 A][1,4]BENZODIAZEPINE; ANTHRAQUINONE DERIVATIVE; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; COUMARIN; N ETHYL 5 (4,5,6,7 TETRAHYDRO 1 BENZOTHIEN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; SULFANILAMIDE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; HUMAN; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; REVIEW; SEIZURE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THREE DIMENSIONAL IMAGING;

EID: 79957641538     PISSN: None     EISSN: 0976044X     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Siddiqui N, Ahsan W, Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening, European Journal of Medicinal Chemistry, 45, 2010, 1536-43.
2. Narayana B, Raj KKV, Ashalatha BV, Kumari NS, Synthesis of some new substituted triazolo [4,3-a][1,4] benzodiazepine derivatives as potent anticonvulsants, European Journal of Medicinal Chemistry, 41, 2006, 417-22.
3. Shalini M, Yogeeswari P, Sriram D, Stables JP, Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one, Biomedicine Pharmacotherapy, 63, 2009, 187-193.
4. Küçükgüzel I, Küçükgüzel SG, Rollas S, Ötük-Sanis G, Özdemir O, Bayrak I, Altug T, Stables JP, Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity. IL Farmaco 59, 2004, 893-901.
5. Moreau S, Coudert P, Rubat C, Vallee-Goyet D, Gardette D, Gramain JC, Couquelet J, Synthesis and Anticonvulsant Properties of Triazolo- and Imidazopyridazinyl Carboxamides and Carboxylic Acids, Bioorganic and Medicinal Chemistry, 6, 1998, 983-991.
6. Chen J, Sun XY, Chai KY, Lee JS, Song MS, Quana ZS, Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)-3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3- a]quinolines, Bioorganic and Medicinal Chemistry, 15, 2007, 6775-6781.
7. Xie ZF, Chai KY, Piao HR, Kwak KC, Quan ZS, 2005, Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines, Bioorganic and Medicinal Chemistry Letters, 15, 4803-4805.
8. Guo LJ, Wei CX, Jia JH, Zhao LM, Quan ZS, Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity, European Journal of Medicinal Chemistry, 44, 2009, 954-958.
9. Jin HG, Sun XY, Chai KY, Piao HR, Quan ZS, Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro- [1,2,4]triazolo[4,3-a]quinoline-1(2H)-ones, Bioorganic and Medicinal Chemistry, 14, 2006, 6868-6873.
10. Zhang J, Redman N, Litke AP, Zeng J, Zhan J, Chan KY, Chang, CT, Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs, Bioorganic and Medicinal Chemistry, 19, 2011, 498-503.
11. Shi Y, Zhau C, Synthesis and evaluation of a class of new Coumarin triazole derivatives as potential antimicrobial agents, Bioorganic and Medicinal Chemistry Letters, 21, 2011, 956-960.
12. Wang X, Wan K, Zhou C, Synthesis of novel sulfanilamidederived 1, 2, 3-triazoles and their evaluation for antibacterial and antifungal activities, European Journal of Medicinal Chemistry, 45, 2010, 4631-4639.
13. Bay HA, Quaddouri B, Guaadaoui A, Touzani R, Benchat N, Hamal A, Taleb M, Bellaoui, M, Kadiri SE, Synthesis and Biological Activity of New Triazole Compounds, Drug Design Discovery, 7, 2010, 41-45.
14. Khalil N.SAM, Efficient synthesis, structure, and antimicrobial activity of some novel N- and S-β-dglucosides of 5-pyridin-3-yl-1,2,4-triazoles, Carbohydrate Research, 341, 2006, 2187-2199.
15. Demirbas N, Karaoglu SA, Demirbas A, Sancak K, Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives, European Journal of Medicinal Chemistry, 39, 2004, 793-804.
16. Demirbas A, Sahin D, Demirbas N, Karaoglu SA, Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities, European Journal of Medicinal Chemistry, 44, 2009, 2896-2903.
17. Tehranchian S, Akbarzadeh T, Fazeli MR, Jamalifar H, Shafiee A, Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones, Bioorganic and Medicinal Chemistry Letters, 15, 2005, 1023-1025.
18. Guzeldemirci NU, Kucukbasmaci O, Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety, European Journal of Medicinal Chemistry, 4, 2010, 63-68.
19. Chandrika PM, Yakaiah T, Gayatri G, Kumar KP, Narsaiah B, Murthy USN, Rao, ARR, Click chemistry: Studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation-Theoretical and experimental validation, European Journal of Medicinal Chemistry, 45, 2010, 78-84.
20. Yan S, Liu Y, Chen Y, Liu L, Lin J, An efficient one-pot synthesis of heterocycle-fused 1, 2, 3-triazole derivatives as anti-cancer agents, Bioorganic and Medicinal Chemistry Letters, 20, 2010, 5225-5228.
21. Banday AH, Shameem SA, Gupta BD, Kumar HMS, D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation. Steroids, 75, 2010, 801-804.
22. Ibrahim DA, Synthesis and biological evaluation of 3,6- disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as a novel class of potential anti-tumor agents, European Journal of Medicinal Chemistry, 44, 2009, 2776-2781.
23. Mavrova AT, Wesselinova D, Tsenov YA, Denkova P, Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells, European Journal of Medicinal Chemistry, 44, 2009, 63-69.
24. Kaplancikli ZA, Özdemir A, Turan-Zitouni G, Altintop MD, Can OD, New pyrazoline derivatives and their antidepressant activity, 45, European Journal of Medicinal Chemistry, 4383-4387.
25. Varvaresou A, Siatra-Papastaikoudi T, Tsotinis A, Tsantili-Kakoulidou A. Vamvakides, A, Synthesis, lipophilicity and biological evaluation of indole-containing derivatives of 1,3,4-thiadiazole and 1,2,4-triazole, IL Farmaco, 53, 1998, 320-326.
26. Shehry MF, Abu-Hashem A, El-Telbani EM, Synthesis of 3- ((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents, European Journal of Medicinal Chemistry, 45, 2010, 1906-1911.
27. Hunashal RD, Ronad PM, Maddi VS, Satyanarayana D, Kamadod MA, Synthesis, Anti-inflammatory and Analgesic Activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1,2,4-Triazol-3-ylthio] Acetic Acid Derivatives, 2011, 10.1016/j.arabjc.01.003
28. Tozkoparan B, Gökhan N, Aktay G, Yesilada E, Ertan M, 6- Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-onessubstituted with ibuprofen: synthesis, characterizationand evaluation of anti-inflammatory activity, European Journal of Medicinal Chemistry, 35, 2000, 743-750.
29. Tripathi RP, Yadav AK, Ajay A, Bisht SS, Chaturvedi V, Sinha SK, Application of Huisgen (3 + 2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobenzofuran-2-ylmethyl [1,2,3]-triazoles and their antitubercular evaluations, European Journal of Medicinal Chemistry, 45, 2010, 142-148.
30. Patel NB, Khan IH, Rajani SD, Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles, European Journal of Medicinal Chemistry, 45, 2010, 4293-4299.
31. Kumar GVS, Rajendraprasad Y, Mallikarjuna BP, Chandrashekar SM, Kistayya, C, Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercularagents, European Journal of Medicinal Chemistry, 45, 2010, 2063-2074.
32. Shiradkar M, Kumar GVS, Dasari V, Tatikonda S, Akula KC, Shah R, Clubbed triazoles: A novel approach to antitubercular drugs, European Journal of Medicinal Chemistry, 42, 2007, 807-816.
33. Shiradkar MR, Murahari KK, Gangadasu HR, Suresh T, Kalyan CA, Panchal D, Kaur R, Burange P, Ghogare J, Mokale V, Raut M., Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents, Bioorganic and Medicinal Chemistry, 15, 2007, 3997-4008.
34. Yu J, Wua Q, Zhang Q, Liu Y, Li Y, Zhou Z, Synthesis and antitumor activity of novel 20, 30-dideoxy-20, 30-diethane thionucleosides bearing 1, 2, 3-triazole residues, Bioorganic and Medicinal Chemistry Letters, 20, 2010, 240-243.
35. Al-Soud YA, Al-Dweri MN, Al-Masoudi N.A, Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives, IL Farmaco, 59, 2004, 775-783.
36. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K, Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds, Bioorganic and Medicinal Chemistry, 18, 2010, 8243-8256.
37. Vlahakis JZ, Lazar C, Crandall IE, Szarek, WA, Anti-Plasmodium activity of imidazolium and triazolium salts, Bioorganic and Medicinal Chemistry, 18, 2010, 6184-6196.