Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 954-958

  Guo, Li Jun ^a   Wei, Cheng Xi ^a   Jia, Jing Hao ^a   Zhao, Li Ming ^a   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

1,2,4 Triazolo 4,3 a quinoline; 3 Mercaptopropionic acid; Anticonvulsant; Isoniazid; Maximal electroshock; Neurotoxicity; Pentylenetetrazole; Quinoline; Strychnine; Thiosemicarbazide; Triazole

Indexed keywords

3 MERCAPTOPROPIONIC ACID; 5 (2 BROMOBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (2 CHLOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (2 FLUOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (2,4 DICHLOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (2,6 DICHLOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (3 CHLOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (3 FLUOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (4 BROMOBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (4 CHLOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (4 FLUOROBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 (4 METHYLBENZYLOXY)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 BENZYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 BUTOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 DODECYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 ETHOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 HEPTYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 HEXYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 METHOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 OCTYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 PENTYLOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 5 PROPOXY[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; 7 BENZYLOXYL 4,5 DIHYDRO[1,2,4]TRIAZOLO[4,3 A]QUINOLINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; ISONIAZID; PENTETRAZOLE; QUINOLINE DERIVATIVE; STRYCHNINE; THIOSEMICARBAZIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NEUROTOXICITY; NONHUMAN; ROTAROD TEST; SEIZURE;

ANIMALS; ANTICONVULSANTS; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; QUINOLINES; SEIZURES;

EID: 60549109247     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.07.010     Document Type: Article

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