메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages

Bicistronic lentiviruses containing a viral 2A cleavage sequence reliably co-express two proteins and restore vision to an animal model of LCA1

Author keywords

[No Author keywords available]

Indexed keywords

BICISTRONIC LENTIVIRUS VECTOR; GUANYLATE CYCLASE; GUANYLATE CYCLASE 1; LENTIVIRUS VECTOR; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; PHOTOPROTEIN;

EID: 79957627793     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020553     Document Type: Article
Times cited : (32)

References (47)
  • 1
    • 0033947697 scopus 로고    scopus 로고
    • Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy
    • Ali RR, Sarra GM, Stephens C, Alwis MD, Bainbridge JW, et al. (2000) Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nat Genet 25: 306-310.
    • (2000) Nat Genet , vol.25 , pp. 306-310
    • Ali, R.R.1    Sarra, G.M.2    Stephens, C.3    Alwis, M.D.4    Bainbridge, J.W.5
  • 2
    • 27244446791 scopus 로고    scopus 로고
    • Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP
    • Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, et al. (2005) Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Invest Ophthalmol Vis Sci 46: 3039-3045.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3039-3045
    • Pawlyk, B.S.1    Smith, A.J.2    Buch, P.K.3    Adamian, M.4    Hong, D.H.5
  • 3
    • 0038335879 scopus 로고    scopus 로고
    • Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy
    • Schlichtenbrede FC, da CL, Stephens C, Smith AJ, Georgiadis A, et al. (2003) Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med 5: 757-764.
    • (2003) J Gene Med , vol.5 , pp. 757-764
    • Schlichtenbrede, F.C.1    da, C.L.2    Stephens, C.3    Smith, A.J.4    Georgiadis, A.5
  • 4
    • 44249120315 scopus 로고    scopus 로고
    • Effect of gene therapy on visual function in Leber's congenital amaurosis
    • Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, et al. (2008) Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med 358: 2231-2239.
    • (2008) N Engl J Med , vol.358 , pp. 2231-2239
    • Bainbridge, J.W.1    Smith, A.J.2    Barker, S.S.3    Robbie, S.4    Henderson, R.5
  • 5
    • 70349105559 scopus 로고    scopus 로고
    • Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year
    • Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, et al. (2009) Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year. Hum Gene Ther 20: 999-1004.
    • (2009) Hum Gene Ther , vol.20 , pp. 999-1004
    • Cideciyan, A.V.1    Hauswirth, W.W.2    Aleman, T.S.3    Kaushal, S.4    Schwartz, S.B.5
  • 7
    • 77649242176 scopus 로고    scopus 로고
    • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration
    • Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, et al. (2010) Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 18: 643-650.
    • (2010) Mol Ther , vol.18 , pp. 643-650
    • Simonelli, F.1    Maguire, A.M.2    Testa, F.3    Pierce, E.A.4    Mingozzi, F.5
  • 9
    • 17344366357 scopus 로고    scopus 로고
    • Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
    • Redmond TM, Yu S, Lee E, Bok D, Hamasaki D, et al. (1998) Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet 20: 344-351.
    • (1998) Nat Genet , vol.20 , pp. 344-351
    • Redmond, T.M.1    Yu, S.2    Lee, E.3    Bok, D.4    Hamasaki, D.5
  • 10
    • 0026502611 scopus 로고
    • Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells
    • Gao H, Hollyfield JG, (1992) Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 33: 1-17.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 1-17
    • Gao, H.1    Hollyfield, J.G.2
  • 11
    • 0028360657 scopus 로고
    • The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator
    • Dizhoor AM, Lowe DG, Olshevskaya EV, Laura RP, Hurley JB, (1994) The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator. Neuron 12: 1345-1352.
    • (1994) Neuron , vol.12 , pp. 1345-1352
    • Dizhoor, A.M.1    Lowe, D.G.2    Olshevskaya, E.V.3    Laura, R.P.4    Hurley, J.B.5
  • 12
    • 0036196823 scopus 로고    scopus 로고
    • Photoreceptor specific guanylate cyclases in vertebrate phototransduction
    • Koch KW, Duda T, Sharma RK, (2002) Photoreceptor specific guanylate cyclases in vertebrate phototransduction. Mol Cell Biochem 230: 97-106.
    • (2002) Mol Cell Biochem , vol.230 , pp. 97-106
    • Koch, K.W.1    Duda, T.2    Sharma, R.K.3
  • 13
    • 16144363583 scopus 로고    scopus 로고
    • Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis
    • Perrault I, Rozet JM, Calvas P, Gerber S, Camuzat A, et al. (1996) Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis. Nat Genet 14: 461-464.
    • (1996) Nat Genet , vol.14 , pp. 461-464
    • Perrault, I.1    Rozet, J.M.2    Calvas, P.3    Gerber, S.4    Camuzat, A.5
  • 14
    • 0032477872 scopus 로고    scopus 로고
    • A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype
    • Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W, (1998) A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A 95: 1271-1276.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1271-1276
    • Semple-Rowland, S.L.1    Lee, N.R.2    Van Hooser, J.P.3    Palczewski, K.4    Baehr, W.5
  • 15
    • 33745608443 scopus 로고    scopus 로고
    • Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness
    • Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, et al. (2006) Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med 3: e201.
    • (2006) PLoS Med , vol.3
    • Williams, M.L.1    Coleman, J.E.2    Haire, S.E.3    Aleman, T.S.4    Cideciyan, A.V.5
  • 16
    • 77955629913 scopus 로고    scopus 로고
    • Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Muller cells
    • Semple-Rowland SL, Coggin WE, Geesey M, Eccles KS, Abraham L, et al. (2010) Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Muller cells. Mol Vis 16: 916-934.
    • (2010) Mol Vis , vol.16 , pp. 916-934
    • Semple-Rowland, S.L.1    Coggin, W.E.2    Geesey, M.3    Eccles, K.S.4    Abraham, L.5
  • 18
    • 85047698266 scopus 로고    scopus 로고
    • Improved co-expression of multiple genes in vectors containing internal ribosome entry sites (IRESes) from human genes
    • Wong ET, Ngoi SM, Lee CG, (2002) Improved co-expression of multiple genes in vectors containing internal ribosome entry sites (IRESes) from human genes. Gene Ther 9: 337-344.
    • (2002) Gene Ther , vol.9 , pp. 337-344
    • Wong, E.T.1    Ngoi, S.M.2    Lee, C.G.3
  • 19
    • 0034170820 scopus 로고    scopus 로고
    • IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector
    • Mizuguchi H, Xu Z, Ishii-Watabe A, Uchida E, Hayakawa T, (2000) IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector. Mol Ther 1: 376-382.
    • (2000) Mol Ther , vol.1 , pp. 376-382
    • Mizuguchi, H.1    Xu, Z.2    Ishii-Watabe, A.3    Uchida, E.4    Hayakawa, T.5
  • 20
    • 35548962799 scopus 로고    scopus 로고
    • Targeted expression of two proteins in neural retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters
    • Semple-Rowland SL, Eccles KS, Humberstone EJ, (2007) Targeted expression of two proteins in neural retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters. Mol Vis 13: 2001-2011.
    • (2007) Mol Vis , vol.13 , pp. 2001-2011
    • Semple-Rowland, S.L.1    Eccles, K.S.2    Humberstone, E.J.3
  • 21
    • 0033030109 scopus 로고    scopus 로고
    • Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy
    • de Felipe P, Martin V, Cortes ML, Ryan M, Izquierdo M, (1999) Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy. Gene Ther 6: 198-208.
    • (1999) Gene Ther , vol.6 , pp. 198-208
    • de Felipe, P.1    Martin, V.2    Cortes, M.L.3    Ryan, M.4    Izquierdo, M.5
  • 22
  • 23
    • 68949216338 scopus 로고    scopus 로고
    • Highly efficient multicistronic lentiviral vectors with peptide 2A sequences
    • Ibrahimi A, Vande VG, Reumers V, Toelen J, Thiry I, et al. (2009) Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Hum Gene Ther 20: 845-860.
    • (2009) Hum Gene Ther , vol.20 , pp. 845-860
    • Ibrahimi, A.1    Vande, V.G.2    Reumers, V.3    Toelen, J.4    Thiry, I.5
  • 24
    • 2342471959 scopus 로고    scopus 로고
    • Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector
    • Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, et al. (2004) Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol 22: 589-594.
    • (2004) Nat Biotechnol , vol.22 , pp. 589-594
    • Szymczak, A.L.1    Workman, C.J.2    Wang, Y.3    Vignali, K.M.4    Dilioglou, S.5
  • 25
    • 10744229841 scopus 로고    scopus 로고
    • Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells
    • Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, et al. (2003) Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther 7: 827-838.
    • (2003) Mol Ther , vol.7 , pp. 827-838
    • Yu, X.1    Zhan, X.2    D'Costa, J.3    Tanavde, V.M.4    Ye, Z.5
  • 26
    • 38049000861 scopus 로고    scopus 로고
    • Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons
    • Gascon S, Paez-Gomez JA, az-Guerra M, Scheiffele P, Scholl FG, (2008) Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. J Neurosci Methods 168: 104-112.
    • (2008) J Neurosci Methods , vol.168 , pp. 104-112
    • Gascon, S.1    Paez-Gomez, J.A.2    az-Guerra, M.3    Scheiffele, P.4    Scholl, F.G.5
  • 27
    • 0037501357 scopus 로고    scopus 로고
    • Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide
    • de Felipe P, Hughes LE, Ryan MD, Brown JD, (2003) Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide. J Biol Chem 278: 11441-11448.
    • (2003) J Biol Chem , vol.278 , pp. 11441-11448
    • de Felipe, P.1    Hughes, L.E.2    Ryan, M.D.3    Brown, J.D.4
  • 28
    • 76649115600 scopus 로고    scopus 로고
    • Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences
    • de Felipe P, Luke GA, Brown JD, Ryan MD, (2010) Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences. Biotechnol J 5: 213-223.
    • (2010) Biotechnol J , vol.5 , pp. 213-223
    • de Felipe, P.1    Luke, G.A.2    Brown, J.D.3    Ryan, M.D.4
  • 29
    • 0018817711 scopus 로고
    • Optokinetic nystagmus in the domestic pigeon. Effects of foveal lesions
    • Conley M, Fite KV, (1980) Optokinetic nystagmus in the domestic pigeon. Effects of foveal lesions. Brain Behav Evol 17: 89-102.
    • (1980) Brain Behav Evol , vol.17 , pp. 89-102
    • Conley, M.1    Fite, K.V.2
  • 30
    • 0021049577 scopus 로고
    • Optokinetic nystagmus in progressive retinal degeneration
    • Komenda JK, Fite KV, (1983) Optokinetic nystagmus in progressive retinal degeneration. Behav Neurosci 97: 928-936.
    • (1983) Behav Neurosci , vol.97 , pp. 928-936
    • Komenda, J.K.1    Fite, K.V.2
  • 31
    • 0014425514 scopus 로고
    • Optomotor responses to monocular stimulation: relation to visual system organization
    • Tauber ES, Atkin A, (1968) Optomotor responses to monocular stimulation: relation to visual system organization. Science 160: 1365-1367.
    • (1968) Science , vol.160 , pp. 1365-1367
    • Tauber, E.S.1    Atkin, A.2
  • 32
    • 0035005706 scopus 로고    scopus 로고
    • The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences
    • Donnelly ML, Hughes LE, Luke G, Mendoza H, ten DE, et al. (2001) The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. J Gen Virol 82: 1027-1041.
    • (2001) J Gen Virol , vol.82 , pp. 1027-1041
    • Donnelly, M.L.1    Hughes, L.E.2    Luke, G.3    Mendoza, H.4    ten, D.E.5
  • 33
    • 0025934319 scopus 로고
    • Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence
    • Ryan MD, King AM, Thomas GP, (1991) Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence. J Gen Virol 72 (Pt 11): 2727-2732.
    • (1991) J Gen Virol , vol.72 , Issue.Pt 11 , pp. 2727-2732
    • Ryan, M.D.1    King, A.M.2    Thomas, G.P.3
  • 34
    • 0028058011 scopus 로고
    • Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein
    • Ryan MD, Drew J, (1994) Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein. EMBO J 13: 928-933.
    • (1994) EMBO J , vol.13 , pp. 928-933
    • Ryan, M.D.1    Drew, J.2
  • 35
    • 65649098724 scopus 로고    scopus 로고
    • Production of multicistronic HIV-1 based lentiviral vectors
    • Chinnasamy N, Shaffer J, Chinnasamy D, (2009) Production of multicistronic HIV-1 based lentiviral vectors. Methods Mol Biol 515: 137-150.
    • (2009) Methods Mol Biol , vol.515 , pp. 137-150
    • Chinnasamy, N.1    Shaffer, J.2    Chinnasamy, D.3
  • 36
    • 4344649387 scopus 로고    scopus 로고
    • Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences
    • de Felipe P, Ryan MD, (2004) Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences. Traffic 5: 616-626.
    • (2004) Traffic , vol.5 , pp. 616-626
    • de Felipe, P.1    Ryan, M.D.2
  • 37
    • 78649347326 scopus 로고    scopus 로고
    • Functional expression of secreted proteins from a bicistronic retroviral cassette based on FMDV 2A can be position-dependent
    • Rothwell DG, Crossley R, Bridgeman JS, Sheard V, Zhang Y, et al. (2010) Functional expression of secreted proteins from a bicistronic retroviral cassette based on FMDV 2A can be position-dependent. Hum Gene Ther 21: 1631-1637.
    • (2010) Hum Gene Ther , vol.21 , pp. 1631-1637
    • Rothwell, D.G.1    Crossley, R.2    Bridgeman, J.S.3    Sheard, V.4    Zhang, Y.5
  • 38
    • 22744444388 scopus 로고    scopus 로고
    • Stable antibody expression at therapeutic levels using the 2A peptide
    • Fang J, Qian JJ, Yi S, Harding TC, Tu GH, et al. (2005) Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol 23: 584-590.
    • (2005) Nat Biotechnol , vol.23 , pp. 584-590
    • Fang, J.1    Qian, J.J.2    Yi, S.3    Harding, T.C.4    Tu, G.H.5
  • 39
    • 54549106702 scopus 로고    scopus 로고
    • Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
    • Yang S, Cohen CJ, Peng PD, Zhao Y, Cassard L, et al. (2008) Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. Gene Ther 15: 1411-1423.
    • (2008) Gene Ther , vol.15 , pp. 1411-1423
    • Yang, S.1    Cohen, C.J.2    Peng, P.D.3    Zhao, Y.4    Cassard, L.5
  • 40
    • 77950369833 scopus 로고    scopus 로고
    • Efficient downregulation of multiple mRNA targets with a single shRNA-expressing lentiviral vector
    • Chumakov SP, Kravchenko JE, Prassolov VS, Frolova EI, Chumakov PM, (2010) Efficient downregulation of multiple mRNA targets with a single shRNA-expressing lentiviral vector. Plasmid 63: 143-149.
    • (2010) Plasmid , vol.63 , pp. 143-149
    • Chumakov, S.P.1    Kravchenko, J.E.2    Prassolov, V.S.3    Frolova, E.I.4    Chumakov, P.M.5
  • 41
    • 0037844873 scopus 로고    scopus 로고
    • Evidence for a mechanism of recombination during reverse transcription dependent on the structure of the acceptor RNA
    • Moumen A, Polomack L, Unge T, Veron M, Buc H, et al. (2003) Evidence for a mechanism of recombination during reverse transcription dependent on the structure of the acceptor RNA. J Biol Chem 278: 15973-15982.
    • (2003) J Biol Chem , vol.278 , pp. 15973-15982
    • Moumen, A.1    Polomack, L.2    Unge, T.3    Veron, M.4    Buc, H.5
  • 42
    • 0035259827 scopus 로고    scopus 로고
    • Retroviral recombination: what drives the switch?
    • Negroni M, Buc H, (2001) Retroviral recombination: what drives the switch? Nat Rev Mol Cell Biol 2: 151-155.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 151-155
    • Negroni, M.1    Buc, H.2
  • 43
    • 78650918670 scopus 로고    scopus 로고
    • Restoration of Cone Vision in the CNGA3(-/-) Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
    • Michalakis S, Muhlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, et al. (2010) Restoration of Cone Vision in the CNGA3(-/-) Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function. Mol Ther 18: 2057-2063.
    • (2010) Mol Ther , vol.18 , pp. 2057-2063
    • Michalakis, S.1    Muhlfriedel, R.2    Tanimoto, N.3    Krishnamoorthy, V.4    Koch, S.5
  • 44
    • 77955332214 scopus 로고    scopus 로고
    • Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of leber congenital amaurosis
    • Pawlyk BS, Bulgakov OV, Liu X, Xu X, Adamian M, et al. (2010) Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of leber congenital amaurosis. Hum Gene Ther 21: 993-1004.
    • (2010) Hum Gene Ther , vol.21 , pp. 993-1004
    • Pawlyk, B.S.1    Bulgakov, O.V.2    Liu, X.3    Xu, X.4    Adamian, M.5
  • 45
    • 36048993980 scopus 로고    scopus 로고
    • Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos
    • Provost E, Rhee J, Leach SD, (2007) Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos. Genesis 45: 625-629.
    • (2007) Genesis , vol.45 , pp. 625-629
    • Provost, E.1    Rhee, J.2    Leach, S.D.3
  • 46
    • 36549081718 scopus 로고    scopus 로고
    • Generation of 2A Peptide-linked Multicistronic Vectors
    • In: Friedmann T, Rossi JJ, editors, Cold Spring Harbor, Cold Spring Harbor Laboratory Press
    • Szymczak AL, Vignali KM, Vignali DA, (2007) Generation of 2A Peptide-linked Multicistronic Vectors. In: Friedmann T, Rossi JJ, editors. Gene transfer: delivery and expression of DNA and RNA: a laboratory manual Cold Spring Harbor Cold Spring Harbor Laboratory Press pp. 137-147.
    • (2007) Gene Transfer: Delivery and Expression of DNA and RNA: A Laboratory Manual , pp. 137-147
    • Szymczak, A.L.1    Vignali, K.M.2    Vignali, D.A.3
  • 47
    • 4644310251 scopus 로고    scopus 로고
    • Cone cell survival and downregulation of GCAP1 protein in the retinas of GC1 knockout mice
    • Coleman JE, Zhang Y, Brown GA, Semple-Rowland SL, (2004) Cone cell survival and downregulation of GCAP1 protein in the retinas of GC1 knockout mice. Invest Ophthalmol Vis Sci 45: 3397-3403.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3397-3403
    • Coleman, J.E.1    Zhang, Y.2    Brown, G.A.3    Semple-Rowland, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.