Gene replacement therapy rescues photoreceptor degeneration in a murine model of leber congenital amaurosis lacking RPGRIP

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 9, 2005, Pages 3039-3045

  Pawlyk, Basil S ^a   Smith, Alexander J ^b   Buch, Prateek K ^b   Adamian, Michael ^a   Hong, Dong Hyun ^a   Sandberg, Michael A ^a   Ali, Robin R ^b   Li, Tiansen ^a  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EYE PROTEIN; GUANOSINE TRIPHOSPHATASE; OPSIN; PARVOVIRUS VECTOR; PROTEIN; PROTEIN RBGR; PROTEIN RPGRIP; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; RPGR PROTEIN, HUMAN; RPGRIP1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRORETINOGRAM; EXPRESSION VECTOR; FOLLOW UP; GENE; GENE EXPRESSION SYSTEM; GENE REPLACEMENT THERAPY; IMMUNOHISTOCHEMISTRY; LEBER CONGENITAL AMAUROSIS; MICROSCOPY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROMOTER REGION; RPGRIP GENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT; ADENO ASSOCIATED VIRUS; ANIMAL; BLINDNESS; DISEASE MODEL; ELECTRORETINOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENE THERAPY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; RETINA DEGENERATION; ULTRASTRUCTURE;

ANIMALS; BLINDNESS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; MICE; MICE, KNOCKOUT; OPSIN; PHOTORECEPTORS, VERTEBRATE; PROMOTER REGIONS (GENETICS); PROTEINS; RETINAL DEGENERATION; TRANSFECTION;

EID: 27244446791     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0371     Document Type: Article

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