Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells

Molecular Therapy

Volumn 7, Issue 6, 2003, Pages 827-838

  Yu, Xiaobing ^a   Zhan, Xiangcan ^a,b   D'Costa, Jenice ^a   Tanavde, Vivek M ^a   Ye, Zhaohui ^a   Peng, Tien ^a   Malehorn, Matthew T ^a   Yang, Xiaoming ^b   Civin, Curt I ^a   Cheng, Linzhao ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bicistronic vectors; Gene therapy; Gene transfer; Hematopoietic stem progenitor cells; IRES; Lentiviral vectors; NOD SCID mice; Transplantation models

Indexed keywords

CD34 ANTIGEN; ELONGATION FACTOR 1ALPHA; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; PHOSPHOGLYCERATE KINASE; RETROVIRUS VECTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG TARGETING; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; MOUSE; NONHUMAN; PROGENY; PROMOTER REGION; REPORTER GENE;

ANIMALIA; CYTOMEGALOVIRUS; LENTIVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 10744229841     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00104-7     Document Type: Article

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