Tethering DNA damage checkpoint mediator proteins topoisomerase IIβ-binding protein 1 (TopBP1) and claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19229-19236

  Lindsey Boltz, Laura A ^a   Sancar, Aziz ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA-TELANGIECTASIA MUTATED; BINDING PROTEINS; CLASPIN; DNA DAMAGES; GENOMIC REGIONS; HUMAN CELLS; IN-VITRO; IN-VIVO; LAC REPRESSOR; MAMMALIAN CELLS; REPLICATION PROTEINS; SIGNALING PATHWAYS; SINGLE-STRANDED DNA; SYNERGISTIC ACTIVATION; TOPOISOMERASE II; ULTRA-VIOLET LIGHT;

CHEMICAL ACTIVATION; ENZYMES; ESCHERICHIA COLI; MAMMALS; PHOSPHORYLATION; PROTEINS; ULTRAVIOLET RADIATION;

DNA;

ATR PROTEIN; CHECKPOINT KINASE 1; CLASPIN; DNA; LAC REPRESSOR; PROTEIN; REPLICATION FACTOR A; TOPOISOMERASE IIBETA BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; GENOMICS; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; NONHUMAN; OPERATOR GENE; PRIORITY JOURNAL; RADIATION EXPOSURE; REPRESSOR GENE; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ESCHERICHIA COLI; HUMANS; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; ESCHERICHIA COLI; MAMMALIA;

EID: 79957624098     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.237958     Document Type: Article

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