-
1
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham,R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
2
-
-
3943107573
-
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
-
Sancar,A., Lindsey-Boltz,L.A., Unsal-Kacmaz,K. and Linn,S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem., 73, 39-85.
-
(2004)
Annu. Rev. Biochem
, vol.73
, pp. 39-85
-
-
Sancar, A.1
Lindsey-Boltz, L.A.2
Unsal-Kacmaz, K.3
Linn, S.4
-
3
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich,K.A. and Cortez,D. (2008) ATR: An essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol., 9, 616-627.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
4
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun,T.S., Pacek,M., Yee,M.C., Walter,J.C. and Cimprich,K.A. (2005) Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev., 19, 1040-1052.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
5
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri,A., Falck,J., Lukas,C., Bartek,J., Smith,G.C., Lukas,J. and Jackson,S.P. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol., 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
6
-
-
33646777679
-
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
-
Myers,J.S. and Cortez,D. (2006) Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem., 281, 9346-9350.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 9346-9350
-
-
Myers, J.S.1
Cortez, D.2
-
7
-
-
33751256575
-
DNA nucleotide excision repair-dependent signaling to checkpoint activation
-
Marini,F., Nardo,T., Giannattasio,M., Minuzzo,M., Stefanini,M., Plevani,P. and Falconi,M.M. (2006) DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc. Natl Acad. Sci. USA, 103, 17325-17330.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 17325-17330
-
-
Marini, F.1
Nardo, T.2
Giannattasio, M.3
Minuzzo, M.4
Stefanini, M.5
Plevani, P.6
Falconi, M.M.7
-
8
-
-
34247354227
-
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
-
Matsumoto,M., Yaginuma,K., Igarashi,A., Imura,M., Hasegawa,M., Iwabuchi,K., Date,T., Mori,T., Ishizaki,K., Yamashita,K. et al. (2007) Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells. J. Cell Sci., 120, 1104-1112.
-
(2007)
J. Cell Sci
, vol.120
, pp. 1104-1112
-
-
Matsumoto, M.1
Yaginuma, K.2
Igarashi, A.3
Imura, M.4
Hasegawa, M.5
Iwabuchi, K.6
Date, T.7
Mori, T.8
Ishizaki, K.9
Yamashita, K.10
-
9
-
-
53349143167
-
Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1
-
Stiff, T., Cerosaletti, K., Concannon, P., O'Driscoll, M. and Jeggo, P.A. (2008) Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1. Hum. Mol. Genet., 17, 3247-3253.
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 3247-3253
-
-
Stiff, T.1
Cerosaletti, K.2
Concannon, P.3
O'Driscoll, M.4
Jeggo, P.A.5
-
10
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou,L. and Elledge,S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
11
-
-
34247257202
-
The structural determinants of checkpoint activation
-
MacDougall,C.A., Byun,T.S., Van,C., Yee,M.C. and Cimprich,K.A. (2007) The structural determinants of checkpoint activation. Genes Dev., 21, 898-903.
-
(2007)
Genes Dev
, vol.21
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
12
-
-
0037076402
-
Preferential binding of ATR protein to UV-damaged DNA
-
Unsal-Kacmaz,K., Makhov,A.M., Griffith,J.D. and Sancar,A. (2002) Preferential binding of ATR protein to UV-damaged DNA. Proc. Natl Acad. Sci. USA, 99, 6673-6678.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 6673-6678
-
-
Unsal-Kacmaz, K.1
Makhov, A.M.2
Griffith, J.D.3
Sancar, A.4
-
13
-
-
33645223728
-
Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences
-
Jiang,G. and Sancar,A. (2006) Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences. Mol. Cell Biol., 26, 39-49.
-
(2006)
Mol. Cell Biol
, vol.26
, pp. 39-49
-
-
Jiang, G.1
Sancar, A.2
-
14
-
-
34548060929
-
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
-
Choi,J.H., Lindsey-Boltz,L.A. and Sancar,A. (2007) Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc. Natl Acad. Sci. USA, 104, 13301-13306.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 13301-13306
-
-
Choi, J.H.1
Lindsey-Boltz, L.A.2
Sancar, A.3
-
15
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai,A., Lee,J., Yoo,H.Y. and Dunphy,W.G. (2006) TopBP1 activates the ATR-ATRIP complex. Cell, 124, 943-955.
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
16
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka,J., Niedziela-Majka,A. and Burgers,P.M. (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell, 24, 891-901.
-
(2006)
Mol. Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
17
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee,J.H. and Paull,T.T. (2004) Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science, 304, 93-96.
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
18
-
-
17644409069
-
ATM activation by DNA doublestrand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee,J.H. and Paull,T.T. (2005) ATM activation by DNA doublestrand breaks through the Mre11-Rad50-Nbs1 complex. Science, 308, 551-554.
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
19
-
-
0029840823
-
Recognition of DNA adducts by human nucleotide excision repair. Evidence for a thermodynamic probing mechanism
-
Gunz,D., Hess,M.T. and Naegeli,H. (1996) Recognition of DNA adducts by human nucleotide excision repair. Evidence for a thermodynamic probing mechanism. J. Biol. Chem., 271, 25089-25098.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 25089-25098
-
-
Gunz, D.1
Hess, M.T.2
Naegeli, H.3
-
20
-
-
0033575865
-
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA
-
Yamane,K. and Tsuruo,T. (1999) Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene, 18, 5194-5203.
-
(1999)
Oncogene
, vol.18
, pp. 5194-5203
-
-
Yamane, K.1
Tsuruo, T.2
-
21
-
-
27544460716
-
Identification and functional analysis of TopBP1 and its homologs
-
Garcia,V., Furuya,K. and Carr,A.M. (2005) Identification and functional analysis of TopBP1 and its homologs. DNA Repair, 4, 1227-1239.
-
(2005)
DNA Repair
, vol.4
, pp. 1227-1239
-
-
Garcia, V.1
Furuya, K.2
Carr, A.M.3
-
22
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes,D.A., Glick,G.G., Zhao,R. and Cortez,D. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev., 22 1478-1489.
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
23
-
-
35748967571
-
Rapid activation of ATM on DNA flanking double-strand breaks
-
You,Z., Bailis,J.M., Johnson,S.A., Dilworth,S.M. and Hunter,T. (2007) Rapid activation of ATM on DNA flanking double-strand breaks. Nat. Cell Biol., 9, 1311-1318.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 1311-1318
-
-
You, Z.1
Bailis, J.M.2
Johnson, S.A.3
Dilworth, S.M.4
Hunter, T.5
-
24
-
-
33747493040
-
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1
-
Hashimoto,Y., Tsujimura,T., Sugino,A. and Takisawa,H. (2006) The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells, 11, 993-1007.
-
(2006)
Genes Cells
, vol.11
, pp. 993-1007
-
-
Hashimoto, Y.1
Tsujimura, T.2
Sugino, A.3
Takisawa, H.4
-
25
-
-
33646119403
-
Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
-
Yan,S., Lindsay,H.D. and Michael,W.M. (2006) Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. J. Cell Biol., 173, 181-186.
-
(2006)
J. Cell Biol
, vol.173
, pp. 181-186
-
-
Yan, S.1
Lindsay, H.D.2
Michael, W.M.3
-
26
-
-
58149102035
-
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
-
Navadgi-Patil, V.M. and Burgers, P.M. (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J. Biol. Chem., 283, 35853-35859.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 35853-35859
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
27
-
-
57749099248
-
Dpb11 activates the Mec1-Ddc2 complex
-
Mordes,D.A., Nam,E.A. and Cortez,D. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc. Natl Acad. Sci. USA, 105, 18730-18734.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 18730-18734
-
-
Mordes, D.A.1
Nam, E.A.2
Cortez, D.3
-
28
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix,S., Wagner,J.M., Kobayashi,M., Yamamoto,K. and Karnitz,L.M. (2007) The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev., 21, 1472-1477.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
29
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee,J., Kumagai,A. and Dunphy,W.G. (2007) The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem., 282, 28036-28044.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
30
-
-
42949130159
-
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
-
Bonilla,C.Y., Melo,J.A. and Toczyski,D.P. (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell, 30, 267-276.
-
(2008)
Mol. Cell
, vol.30
, pp. 267-276
-
-
Bonilla, C.Y.1
Melo, J.A.2
Toczyski, D.P.3
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