Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Chen, Muhan ^a   Huang, Jian Dong ^a   Deng, Hong K ^b   Dong, Suisui ^a   Deng, Wen ^a   Tsang, Sze L ^a   Huen, Michael S Y ^a   Chen, Leilei ^a   Zan, Tong ^b   Zhu, Gui Xia ^a   Guan, Xin Yuan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b PEKING UNIVERSITY   (China)

Author keywords

Chromosome instability; EIF 5A2 aging; Oncogene; Transgenic mouse

Indexed keywords

COMPLEMENTARY DNA; INITIATION FACTOR; INITIATION FACTOR 5A2; UNCLASSIFIED DRUG; EIF 5A2; EIF-5A2;

AGING; ANAPHASE; ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY WEIGHT; BONE MALFORMATION; BONE RADIOGRAPHY; CALCIFICATION; CARCINOGENESIS; CELL AGING; CELL COUNT; CELL DIVISION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EUKARYOTIC TRANSLATION INITIATION FACTOR 5A2 GENE; FIBROBLAST; GENE ACTIVATION; GENE OVEREXPRESSION; GENE REPRESSION; GROWTH RATE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KYPHOSIS; LIFESPAN; METAPHASE; MOLECULAR GENETICS; MOUSE; NONHUMAN; ONCOGENE; OSTEOPOROSIS; PHENOTYPE; TRANSGENIC MOUSE; WOUND HEALING IMPAIRMENT; ANIMAL; BONE; CELL TRANSFORMATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; PREGNANCY; RADIOGRAPHY;

AGING; ANIMALS; BONE AND BONES; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, TRANSGENIC; PEPTIDE INITIATION FACTORS; PHENOTYPE; PREGNANCY;

EID: 79957512522     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-199     Document Type: Article

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