Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 19118-19126

  Beer, Nicola L ^a   Van De Bunt, Martijn ^a   Colclough, Kevin ^b   Lukacs, Christine ^c   Arundel, Paul ^d   Chik, Constance L ^e   Grimsby, Joseph ^c   Ellard, Sian ^f   Gloyn, Anna L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^c HOFFMANN LA ROCHE INC   (United States)

^d SHEFFIELD CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF ALBERTA   (Canada)

^f UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC ACTIVATOR; BETA CELL; CATALYSIS RATE; GLOBAL PROBLEMS; GLUCOKINASE; GLUCOKINASE ACTIVITY; GLUCOSE METABOLISM; HEPATOCYTES; IN-VITRO ASSAYS; MATURITY-ONSET DIABETES OF THE YOUNG; NATURALLY OCCURRING; PHARMACOLOGICAL MANIPULATION; RECOMBINANT PROTEIN; REGULATORY PROTEIN; RELATIVE ACTIVITIES; THERAPEUTIC STRATEGY; TYPE-2 DIABETES; WILD TYPES;

GLUCOSE; INSULIN; PROTEINS;

CHEMICAL ACTIVATION;

CHLOROTHIAZIDE; DIAZOXIDE; GLUCOKINASE; GLUCOSE; HYDROCHLOROTHIAZIDE; TRIACYLGLYCEROL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CASE REPORT; CATALYSIS; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; ETHNICITY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; HYPERINSULINEMIC HYPOGLYCEMIA; HYPERTRICHOSIS; HYPOGLYCEMIA; IN VITRO STUDY; MALE; MATURITY ONSET DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SYMPTOM; TREATMENT DURATION; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 2; GLUCOKINASE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INFANT, NEWBORN; LIVER; MALE; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY;

EID: 79956320989     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.223362     Document Type: Article

References (70)

1. Zimmet, P., Alberti, K. G., and Shaw, J. (2001) Nature 414, 782-787
2. Coghlan, M., and Leighton, B. (2008) Expert Opin. Investig. Drugs 17, 145-167
3. Matschinsky, F. M. (2009) Nat. Rev. Drug Discov. 8, 399-416
4. Matschinsky, F. M., and Porte, D. (2010) F1000 Med. Rep. 2, 43
5. Osbak, K. K., Colclough, K., Saint-Martin, C., Beer, N. L., Bellanné-Chantelot, C., Ellard, S., and Gloyn, A. L. (2009) Hum. Mutat. 30, 1512-1526
6. Barbetti, F., Cobo-Vuilleumier, N., Dionisi-Vici, C., Toni, S., Ciampalini, P., Massa, O., Rodriguez-Bada, P., Colombo, C., Lenzi, L., Garcia-Gimeno, M. A., Bermudez-Silva, F. J., Rodriguez de Fonseca, F., Banin, P., Aledo, J. C., Baixeras, E., Sanz, P., and Cuesta-Muñoz, A. L. (2009) Mol. Endocrinol. 23, 1983-1989
7. Christesen, H. B., Jacobsen, B. B., Odili, S., Buettger, C., Cuesta-Munoz, A., Hansen, T., Brusgaard, K., Massa, O., Magnuson, M. A., Shiota, C., Matschinsky, F. M., and Barbetti, F. (2002) Diabetes 51, 1240-1246
8. Christesen, H. B., Tribble, N. D., Molven, A., Siddiqui, J., Sandal, T., Brusgaard, K., Ellard, S., Njølstad, P. R., Alm, J., Brock Jacobsen, B., Hussain, K., and Gloyn, A. L. (2008) Eur. J. Endocrinol. 159, 27-34
9. Cuesta-Muñoz, A. L., Huopio, H., Otonkoski, T., Gomez-Zumaquero, J. M., Näntö-Salonen, K., Rahier, J., López-Enriquez, S., García-Gimeno, M. A., Sanz, P., Soriguer, F. C., and Laakso, M. (2004) Diabetes 53, 2164-2168
10. Glaser, B., Kesavan, P., Heyman, M., Davis, E., Cuesta, A., Buchs, A., Stanley, C. A., Thornton, P. S., Permutt, M. A., Matschinsky, F. M., and Herold, K. C. (1998) N. Engl. J. Med. 338, 226-230
11. Gloyn, A. L., Noordam, K., Willemsen, M. A., Ellard, S., Lam, W. W., Campbell, I. W., Midgley, P., Shiota, C., Buettger, C., Magnuson, M. A., Matschinsky, F. M., and Hattersley, A. T. (2003) Diabetes 52, 2433-2440
12. Kassem, S., Bhandari, S., Rodríguez-Bada, P., Motaghedi, R., Heyman, M., García-Gimeno, M. A., Cobo-Vuilleumier, N., Sanz, P., Maclaren, N. K., Rahier, J., Glaser, B., and Cuesta-Muñoz, A. L. (2010) N. Engl. J. Med. 362, 1348-1350
13. Meissner, T., Marquard, J., Cobo-Vuilleumier, N., Maringa, M., Rodríguez-Bada, P., García-Gimeno, M. A., Baixeras, E., Weber, J., Olek, K., Sanz, P., Mayatepek, E., and Cuesta-Muñoz, A. L. (2009) Horm. Metab. Res. 41, 320-326
14. Sayed, S., Langdon, D. R., Odili, S., Chen, P., Buettger, C., Schiffman, A. B., Suchi, M., Taub, R., Grimsby, J., Matschinsky, F. M., and Stanley, C. A. (2009) Diabetes 58, 1419-1427
15. Wabitsch, M., Lahr, G., Van de Bunt, M., Marchant, C., Lindner, M., von Puttkamer, J., Fenneberg, A., Debatin, K. M., Klein, R., Ellard, S., Clark, A., and Gloyn, A. L. (2007) Diabet. Med. 24, 1393-1399
16. Froguel, P., Vaxillaire, M., Sun, F., Velho, G., Zouali, H., Butel, M. O., Lesage, S., Vionnet, N., Clément, K., Fougerousse, F., Tanizawa, Y., Weissenbach, J., Beckmann, J. S., Lathrop, G. M., Passa, P. H., Permutt, M. A., and Cohen, D. (1992) Nature 356, 162-164
17. Hattersley, A. T., Turner, R. C., Permutt, M. A., Patel, P., Tanizawa, Y., Chiu, K. C., O'Rahilly, S., Watkins, P. J., and Wainscoat, J. S. (1992) Lancet 339, 1307-1310
18. Njølstad, P. R., Sagen, J. V., Bjørkhaug, L., Odili, S., Shehadeh, N., Bakry, D., Sarici, S. U., Alpay, F., Molnes, J., Molven, A., Søvik, O., and Matschinsky, F. M. (2003) Diabetes 52, 2854-2860
19. Njølstad, P. R., Søvik, O., Cuesta-Muñoz, A., Bjørkhaug, L., Massa, O., Barbetti, F., Undlien, D. E., Shiota, C., Magnuson, M. A., Molven, A., Matschinsky, F. M., and Bell, G. I. (2001) N. Engl. J. Med. 344, 1588-1592
20. Porter, J. R., Shaw, N. J., Barrett, T. G., Hattersley, A. T., Ellard, S., and Gloyn, A. L. (2005) J. Pediatr. 146, 131-133
21. Rubio-Cabezas, O., Díaz González, F., Aragonés, A., Argente, J., and Campos-Barros, A. (2008) Pediatr. Diabetes 9, 245-249
22. Turkkahraman, D., Bircan, I., Tribble, N. D., Akçurin, S., Ellard, S., and Gloyn, A. L. (2008) J. Pediatr. 153, 122-126
23. Weedon, M. N., Clark, V. J., Qian, Y., Ben-Shlomo, Y., Timpson, N., Ebrahim, S., Lawlor, D. A., Pembrey, M. E., Ring, S., Wilkin, T. J., Voss, L. D., Jeffery, A. N., Metcalf, B., Ferrucci, L., Corsi, A. M., Murray, A., Melzer, D., Knight, B., Shields, B., Smith, G. D., Hattersley, A. T., Di Rienzo, A., and Frayling, T. M. (2006) Am. J. Hum. Genet. 79, 991-1001
24. Weedon, M. N., Frayling, T. M., Shields, B., Knight, B., Turner, T., Metcalf, B. S., Voss, L., Wilkin, T. J., McCarthy, A., Ben-Shlomo, Y., Davey Smith, G., Ring, S., Jones, R., Golding, J., Byberg, L., Mann, V., Axelsson, T., Syvänen, A. C., Leon, D., and Hattersley, A. T. (2005) Diabetes 54, 576-581
25. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y. D., Chines, P., Clarke, R., Coin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N., de Geus, E. J., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A. L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Martínez-Larrad, M. T., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., Palmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigurethsson, G., Sijbrands, E. J., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvänen, A. C., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., van Dijk, K. W., van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C., Yarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J., Meneton, P., Magnusson, P. K., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L, Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M. R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C., and Barroso, I. (2010) Nat. Genet. 42, 105-116
26. Matschinsky, F. M. (1990) Diabetes 39, 647-652
27. Matschinsky, F. M. (2002) Diabetes 51, Suppl. 3, S394-S404
28. McKerrecher, D., Johnstone, C., Caulkett, P. W. R., James, R., Jones, C. D., Hargreaves, R. B., Hayter, B. R., Currie, G. S., Allen, J. V., and Gaskin, H. (April 7, 2004) European Patent (EP) 1404335, World Intellectual Property Organization Patent (WO) 03000267
29. Array BioPharma Inc. (2009) Glucokinase Activator ARRY-403: Phase I Single Ascending Dose Top-Line Results, Array BioPharma Inc., Boulder, CO
30. Bonadonna, R. C., Heise, T., Arbet-Engels, C., Kapitza, C., Avogaro, A., Grimsby, J., Zhi, J., Grippo, J. F., and Balena, R. (2010) J. Clin. Endocrinol. Metab. 95, 5028-5036
31. Bonadonna, R. C., Kapitza, C., Heinse, T., Avogaro, A., Boldrin, M., Grimsby, J., Mulligan, M. E., Arbet-Engels, C., and Balena, R. (2008) Diabetologia 51, Suppl. 1, S371 (Abstr. 927)
32. Brocklehurst, K. J., Payne, V. A., Davies, R. A., Carroll, D., Vertigan, H. L., Wightman, H. J., Aiston, S., Waddell, I. D., Leighton, B., Coghlan, M. P., and Agius, L. (2004) Diabetes 53, 535-541
33. Castelhano, A. L., Dong, H., Fyfe, M. C., Gardner, L. S., Kamikozawa, Y., Kurabayashi, S., Nawano, M., Ohashi, R., Procter, M. J., Qiu, L., Rasamison, C. M., Schofield, K. L., Shah, V. K., Ueta, K., Williams, G. M., Witter, D., and Yasuda, K. (2005) Bioorg. Med. Chem. Lett. 15, 1501-1504
34. Grimsby, J., Sarabu, R., Corbett, W. L., Haynes, N. E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., Marcus, L., Qi, L., Spence, C. L., Tengi, J., Magnuson, M. A., Chu, C. A., Dvorozniak, M. T., Matschinsky, F. M., and Grippo, J. F. (2003) Science 301, 370-373
35. McKerrecher, D., Allen, J. V., Bowker, S. S., Boyd, S., Caulkett, P. W., Currie, G. S., Davies, C. D., Fenwick, M. L., Gaskin, H., Grange, E., Hargreaves, R. B., Hayter, B. R., James, R., Johnson, K. M., Johnstone, C., Jones, C. D., Lackie, S., Rayner, J. W., and Walker, R. P. (2005) Bioorg. Med. Chem. Lett. 15, 2103-2106
36. McKerrecher, D., Allen, J. V., Caulkett, P. W., Donald, C. S., Fenwick, M. L., Grange, E., Johnson, K. M., Johnstone, C., Jones, C. D., Pike, K. G., Rayner, J. W., and Walker, R. P. (2006) Bioorg. Med. Chem. Lett. 16, 2705-2709
37. Holland, G. W., Sarabu, R., Kester, R. F., Haynes, N. E., Bizzarro, F. T., Corbett, W. L., Grippo, J. F., and Mahaney, P. E. (October 6, 2004) European Patent (EP) 1169312, World Intellectual Property Organization Patent (WO) 0058293
38. Zhai, S., Mulligan, M. E., Grimsby, J., Arbet-Engels, C., Boldrin, M., Balena, R., and Zhi, J. (2008) Diabetologia 51, Suppl. 1, S372, Abstr. 928
39. Zhi, J., Zhai, S., Mulligan, M. E., Grimsby, J., Arbet-Engels, C., Boldrin, M., and Balena, R. (2008) Diabetologia 51, Suppl. 1, S23 (Abstr. 42)
40. Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., and Nagata, Y. (2004) Structure 12, 429-438
41. Pal, P., and Miller, B. G. (2009) Biochemistry 48, 814-816
42. Liang, Y., Kesavan, P., Wang, L. Q., Niswender, K., Tanizawa, Y., Permutt, M. A., Magnuson, M. A., and Matschinsky, F. M. (1995) Biochem. J. 309, 167-173
43. Beer, N. L., Tribble, N. D., McCulloch, L. J., Roos, C., Johnson, P. R., Orho-Melander, M., and Gloyn, A. L. (2009) Hum. Mol. Genet. 18, 4081-4088
44. Brocklehurst, K. J., Davies, R. A., and Agius, L. (2004) Biochem. J. 378, 693-697
45. Gloyn, A. L., Odili, S., Zelent, D., Buettger, C., Castleden, H. A., Steele, A. M., Stride, A., Shiota, C., Magnuson, M. A., Lorini, R., d'Annunzio, G., Stanley, C. A., Kwagh, J., van Schaftingen, E., Veiga-da-Cunha, M., Barbetti, F., Dunten, P., Han, Y., Grimsby, J., Taub, R., Ellard, S., Hattersley, A. T., and Matschinsky, F. M. (2005) J. Biol. Chem. 280, 14105-14113
46. Davis, E. A., Cuesta-Muñoz, A., Raoul, M., Buettger, C., Sweet, I., Moates, M., Magnuson, M. A., and Matschinsky, F. M. (1999) Diabetologia 42, 1175-1186
47. Gloyn, A. L., Odili, S., Buettger, C., Njolstad, P., Shiota, C., Magnuson, M. A., and Matschinsky, F. M. (2004) in Glucokinase and Glycaemic Disease: from Basics to Novel Therapeutics (Matschinsky, F. M., and Magnuson, M. A., eds) pp. 92-109, Karger, Basel
48. Bruce, S. (2000) Am. J. Hum. Biol. 12, 542-551
49. Liang, Y., Najafi, H., Smith, R. M., Zimmerman, E. C., Magnuson, M. A., Tal, M., and Matschinsky, F. M. (1992) Diabetes 41, 792-806
50. Lynedjian, P. (2004) in Glucokinase and Glycaemic Disease: from Basics to Novel Therapeutics (Matschinsky, F. M., and Magnuson, M. A., eds) pp. 156-166, Karger, Basel
51. Alvarez, E., Roncero, I., Chowen, J. A., Vázquez, P., and Blázquez, E. (2002) J. Neurochem. 80, 45-53
52. Baltrusch, S., Lenzen, S., Okar, D. A., Lange, A. J., and Tiedge, M. (2001) J. Biol. Chem. 276, 43915-43923
53. Bjørkhaug, L., Molnes, J., Søvik, O., Njølstad, P. R., and Flatmark, T. (2007) J. Biol. Chem. 282, 22757-22764
54. Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C. Y., Krauss, S., Ranger, A. M., Datta, S. R., Greenberg, M. E., Licklider, L. J., Lowell, B. B., Gygi, S. P., and Korsmeyer, S. J. (2003) Nature 424, 952-956
55. Danial, N. N., Walensky, L. D., Zhang, C. Y., Choi, C. S., Fisher, J. K., Molina, A. J., Datta, S. R., Pitter, K. L., Bird, G. H., Wikstrom, J. D., Deeney, J. T., Robertson, K., Morash, J., Kulkarni, A., Neschen, S., Kim, S., Greenberg, M. E., Corkey, B. E., Shirihai, O. S., Shulman, G. I., Lowell, B. B., and Korsmeyer, S. J. (2008) Nat. Med. 14, 144-153
56. Massa, L., Baltrusch, S., Okar, D. A., Lange, A. J., Lenzen, S., and Tiedge, M. (2004) Diabetes 53, 1020-1029
57. Shiota, C., Coffey, J., Grimsby, J., Grippo, J. F., and Magnuson, M. A. (1999) J. Biol. Chem. 274, 37125-37130
58. Van Schaftingen, E., and Veiga da Cunha, M. (2004) in Glucokinase and Glycaemic Disease: from Basics to Novel Therapeutics (Matschinsky, F. M., and Magnuson, M. A., eds) pp. 193-207, Karger, Basel
59. Arden, C., Trainer, A., de la Iglesia, N., Scougall, K. T., Gloyn, A. L., Lange, A. J., Shaw, J. A., Matschinsky, F. M., and Agius, L. (2007) Diabetes 56, 1773-1782
60. Sagen, J. V., Odili, S., Bjørkhaug, L., Zelent, D., Buettger, C., Kwagh, J., Stanley, C., Dahl-Jørgensen, K., de Beaufort, C., Bell, G. I., Han, Y., Grimsby, J., Taub, R., Molven, A., Søvik, O., Njølstad, P. R., and Matschinsky, F. M. (2006) Diabetes 55, 1713-1722
61. Burke, C. V., Buettger, C. W., Davis, E. A., McClane, S. J., Matschinsky, F. M., and Raper, S. E. (1999) Biochem. J. 342, 345-352
62. Miller, S. P., Anand, G. R., Karschnia, E. J., Bell, G. I., LaPorte, D. C., and Lange, A. J. (1999) Diabetes 48, 1645-1651
63. Slosberg, E. D., Desai, U. J., Fanelli, B., St Denny, I., Connelly, S., Kaleko, M., Boettcher, B. R., and Caplan, S. L. (2001) Diabetes 50, 1813-1820
64. Heredia, V. V., Carlson, T. J., Garcia, E., and Sun, S. (2006) J. Biol. Chem. 281, 40201-40207
65. Baltrusch, S., Francini, F., Lenzen, S., and Tiedge, M. (2005) Diabetes 54, 2829-2837
66. Grimsby, J., Coffey, J. W., Dvorozniak, M. T., Magram, J., Li, G., Matschinsky, F. M., Shiota, C., Kaur, S., Magnuson, M. A., and Grippo, J. F. (2000) J. Biol. Chem. 275, 7826-7831
67. Zawalich, W. S., Rognstad, R., Pagliara, A. S., and Matschinsky, F. M. (1977) J. Biol. Chem. 252, 8519-8523
68. O'Doherty, R. M., Lehman, D. L., Télémaque-Potts, S., and Newgard, C. B. (1999) Diabetes 48, 2022-2027
69. Grimsby, J., and Grippo, J. F. (2004) in Glucokinase and Glycaemic Disease: from Basics to Novel Therapeutics (Matschinsky, F. M., and Magnuson, M. A., eds) pp. 360-378, Karger, Basel
70. Massa, O., Meschi, F., Cuesta-Munoz, A., Caumo, A., Cerutti, F., Toni, S., Cherubini, V., Guazzarotti, L., Sulli, N., Matschinsky, F. M., Lorini, R., Iafusco, D., and Barbetti, F. (2001) Diabetologia 44, 898-905