Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 14105-14113

  Gloyn, Anna L ^a,b   Odili, Stella ^c   Zelent, Dorothy ^c   Buettger, Carol ^c   Castleden, Harriet A J ^b   Steele, Anna M ^b   Stride, Amanda ^b   Shiota, Chyio ^d   Magnuson, Mark A ^d   Lorini, Renata ^e   D'Annunzio, Giuseppe ^e   Stanley, Charles A ^f   Kwagh, Jae ^f   Van Schaftingen, Emile ^g   Veiga Da Cunha, Maria ^g   Barbetti, Fabrizio ^h   Dunten, Pete ⁱ   Han, Yi ⁱ   Grimsby, Joseph ⁱ   Taub, Rebecca ⁱ   Ellard, Sian ^b   Hattersley, Andrew T ^b   Matschinsky, Franz M ^c,j   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b PENINSULA MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF GENOA   (Italy)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g DE DUVE INSTITUTE   (Belgium)

^h BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

ⁱ Hoffman La Roche Department of Metabolic Diseases   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; DISEASES; DRUG PRODUCTS; GLUCOSE SENSORS; MUTAGENESIS; STRUCTURAL ANALYSIS; VAN DER WAALS FORCES;

GLUCOKINASE (GCK); HYPERGLYCEMIA; PHARMACOLOGICAL ACTIVATOR; PUTATIVE ENDOGENOUS ACTIVATOR;

ENZYMES;

GLUCOKINASE; GLUTATHIONE TRANSFERASE; RECOMBINANT ENZYME; REGULATOR PROTEIN; RO 0281675; UNCLASSIFIED DRUG; VALINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY; ENZYME ACTIVATION; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; FAMILY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; HYPERGLYCEMIA; INFANT; MALE; MATURITY ONSET DIABETES MELLITUS; MOLECULAR INTERACTION; PRIORITY JOURNAL; THERMOSTABILITY; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING SITES; CARRIER PROTEINS; CHILD; DIABETES MELLITUS, TYPE 2; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVATION; ENZYME STABILITY; FEMALE; GLUCOKINASE; GLUCOSE; HUMANS; HYPERGLYCEMIA; INFANT, NEWBORN; MALE; MODELS, MOLECULAR; PEDIGREE; POINT MUTATION; PREGNANCY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS;

EID: 20244377376     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413146200     Document Type: Article

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