Detection and quantitation of IgG 1 hinge aspartate isomerization: A rapid degradation in stressed stability studies

Analytical Chemistry

Volumn 81, Issue 17, 2009, Pages 7454-7459

  Hambly, David M ^a   Banks, Douglas D ^a   Scavezze, Joanna L ^a   Siska, Christine C ^a   Gadgil, Himanshu S ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; APPARENT RATE CONSTANT; ASPARTATES; ASPARTIC ACIDS; CHARACTERIZATION METHODS; ELEVATED TEMPERATURE; FC REGION; HIGH EFFICIENCY; INCUBATION PERIODS; PEPTIDE MAPPING; PROCESS DEVELOPMENT; PRODUCT CONSISTENCY; RAPID DEGRADATION; REVERSED PHASE; STABILITY STUDY; STORAGE CONDITION; STORAGE TEMPERATURES; TERMINAL SIDES;

ACTIVATION ENERGY; AMINES; AMINO ACIDS; DEGRADATION; ELECTRON TRANSITIONS; ISOMERIZATION; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; RATE CONSTANTS;

ISOMERS;

ASPARTIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; LYSINE; MONOCLONAL ANTIBODY;

ARTICLE; HINGE REGION; ISOMERIZATION; PEPTIDE MAPPING; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; STORAGE TEMPERATURE; TEMPERATURE SENSITIVITY;

ASPARTIC ACID; DRUG STORAGE; HOT TEMPERATURE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; ISOMERISM; MASS SPECTROMETRY; MODELS, MOLECULAR; PEPTIDE MAPPING; PROTEIN STABILITY;

EID: 69749112012     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901258g     Document Type: Article

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