Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3307-3312

  Allcock, Robert W ^a   Blakli, Haakon ^a   Jiang, Zhong ^a   Johnston, Karen A ^a   Morgan, Keith M ^a   Rosair, Georgina M ^a   Iwase, Kazuhiko ^b   Kohno, Yasushi ^b   Adams, David R ^a  

^a HERIOT WATT UNIVERSITY   (United Kingdom)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cyclic 3 ,5 nucleotide phosphodiesterase (PDE); Ibudilast; PDE3 inhibitors; PDE4 inhibitors; Respiratory disease

Indexed keywords

6 (PYRAZOLO[1,5 A]PYRIDIN 3 YL)PYRIDAZIN 3(2H) ONES; IBUDILAST; IMAZODAN; KCA 965; MILRINONE; NITROGEN; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PYRAZOLOPYRIDINE DERIVATIVE; PYRIDAZINONE DERIVATIVE; ROFLUMILAST; UNCLASSIFIED DRUG; ZARDAVERINE;

ARTICLE; ASTHMA; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; ENZYME ACTIVATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PYRAZOLES; PYRIDAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TEPROTIDE;

EID: 79956135813     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.021     Document Type: Article

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