Ibudilast: A non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall

Cardiovascular Drug Reviews

Volumn 19, Issue 3, 2001, Pages 215-225

  Kishi, Yukio ^a   Ohta, Seiko ^a   Kasuya, Natsuko ^a   Sakita, Shinya ^b   Ashikaga, Takashi ^b   Isobe, Mitsuaki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Yokohama Minami Kyosai Hospital   (Japan)

Author keywords

Asthma; Cerebrovascular disease; Endothelial cells; Ibudilast; Leukotriene D4; Nitric oxide; Pentoxifylline; Phosphodiesterase; Platelets; Prostacyclin; Rolipram; Smooth muscle cells; SRS A; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE TRIPHOSPHATE; BETA THROMBOGLOBULIN; COLLAGEN; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYTOKINE; DIPYRIDAMOLE; IBUDILAST; INOSITOL PHOSPHATE; ISOBUTYLMETHYLXANTHINE; LEUKOTRIENE D4; NITRIC OXIDE; OXYGEN; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; PROSTACYCLIN; PROTEIN TYROSINE KINASE; ROLIPRAM; SLOW REACTING SUBSTANCE; THROMBOCYTE FACTOR 4;

ALLERGIC ENCEPHALOMYELITIS; ALLERGIC REACTION; ANTIINFLAMMATORY ACTIVITY; ARTERY THROMBOSIS; ASTHMA; BLOOD CELL; BLOOD VESSEL WALL; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION; VASODILATATION;

EID: 0035676125     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2001.tb00066.x     Document Type: Review

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