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Torphy JT: Phosphodiesterase isoenzymes. Molecular targets for novel antiasthma agents. J Resp Crit Care Med 1998, 157:351-370. This is an excellent review of the phosphodiesterase isozymes covering their molecular biology, mechanistic effects, in vitro and in vivo biology.
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Biochem Biophys Res Commun
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McLaughlin MM, Cieslinski LB, Burman M, Torphy TJ, Livi GP: A low Km rolipram-sensitive, cAMP-specific phosphodiesterase from human brain: Cloning and expression of cDNA, biochemical characterization of recombinant protein and tissue distribution of mRNA. J Biol Chem 1993, 268:6470-6476.
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Owens RJ, Lumb S, Rees-Milton K, Russell A, Baldock D, Lang V, Crabbe T, Ballersteros M, Perry MJ: Molecular cloning and expression of a human phosphodiesterase 4C. Cell Signal 1997, 9:575-585.
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12
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Bolger GB, Erdogan S, Jones RE, Loughney K, Scotland G, Hoffman R, Wilkinson I, Farrell C, Houslay MD: Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. Biochem J 1997, 328:539-548.
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Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3
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Hustun E, Lumb S, Russell A, CAtterall C, Ross AH, Steele MR, Bolger GB, Perry MJ, Owens RJ, Houslay MD: Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Biochem J 1997, 328:549-558.
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14
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Cyclic nucleotide phosphodiesterase 4 subtypes are differently expressed by primary keratinocytes and human epidermoid cell lines
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Chujor CS, Hammerschmid F, Lam C: Cyclic nucleotide phosphodiesterase 4 subtypes are differently expressed by primary keratinocytes and human epidermoid cell lines. J Invest Dermatol 1998, 110:287-291.
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Phosphodiesterase 4B gene transcription is activated by lipopolysaccharide and inhibited by interleukin-10 in human monocytes
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Ma D, Wu P, Egan RW, Billah MM, Wang P: Phosphodiesterase 4B gene transcription is activated by lipopolysaccharide and inhibited by interleukin-10 in human monocytes. Mol Pharmacol 1999, 55:50-57. This paper covers the activation of one of the subtypes of PDE 4, namely 4B, by LPS indicating its potential role in inflammatory disorders. The paper also describes the inhibition of IL-10 in human monocytes.
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Mol Pharmacol
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Ma, D.1
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Characterization of the rolipram sensitive, cyclic AMP-specific phosphodiesterases: Identification and differential expression of immunologically distinct forms in the rat brain
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Iona S, Cuomo M, Bushnik T, Sette C, Hess M, Shelton ER, Conti M: Characterization of the rolipram sensitive, cyclic AMP-specific phosphodiesterases: Identification and differential expression of immunologically distinct forms in the rat brain. Mot Pharmacol 1998, 53:23-32. This study uses monoclonal and polyclonal antibodies to each of the PDE 4 subtypes to characterise their localisation in different regions of the rat brain.
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Mot Pharmacol
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Iona, S.1
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Conti, M.7
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17
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0032584673
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Subcellular localization of the rolipram sensitive, cAMP-specific phosphodiesterases Differential targeting and activation of the splicing variants derived from the PDE4D gene
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Jin SL, Bushnik T, LAn L, Conti M: Subcellular localization of the rolipram sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene. J Biol Chem 1998, 273:19672-19678. Data in this paper show that three PDE 4D splicing variants are targeted to discrete subcellular compartments and that hormonal activation causes temporal activation.
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J Biol Chem
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Jin, S.L.1
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Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 i mitogen-stimulated and leukemic human lymphocytes
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Jiang X, Paskind M, Weltzien R, Epstein PM: Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 i mitogen-stimulated and leukemic human lymphocytes. Cell Biochem Biophys 1998, 28:135-160.
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Jiang, X.1
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19
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Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE-3 and inducing PDE4D1 and PDE4D2 splice variants as well as down regulating a novel PDE4A splice variant
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Erdogan S, Houslay M: Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE-3 and inducing PDE4D1 and PDE4D2 splice variants as well as down regulating a novel PDE4A splice variant Biochem J 1997, 321:165-175.
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Erdogan, S.1
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Takahashi M, Terwilliger R, Lane C, Mezes PS, Conti M, Duman RS: Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterases 4A and 4B isoforms. J Neurosci 1999, 19:610-618.
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cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of ser-54: Generation of a molecular model
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Hoffman R, Wilkinson IR, McCallum JF, Engels P, Houslay MD: cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of ser-54: Generation of a molecular model. Biochem J 1998, 333:139-149.
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22
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0030702945
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Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities
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Rocque WJ, Tian G, Wiseman JS, Holmes WD, Zajac-Thompson I, Willard DH, Patel IR, Wisely GB, Clay WC, Kadwell SH et al.: Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities. Biochemistry 1997, 36:14250-14261.
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Rocque, W.J.1
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23
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0032584089
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Stimulation of p70S6 kinase via a growth hormone controlled phosphatidylinositol 3-kinase pathway leads to the activation of PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes
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Mackenzie SJ, Yarwood SJ, Peden AH, Bolger GB, Vernon RG, Houslay MD: Stimulation of p70S6 kinase via a growth hormone controlled phosphatidylinositol 3-kinase pathway leads to the activation of PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes. Proc Natl Acad Sci USA 1998, 95:3549-3554. The involvement of PDE4A5 in cellular differentiation stimulated by growth hormone is described in this paper.
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Proc Natl Acad Sci USA
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Mackenzie, S.J.1
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24
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Induction of phosphodiesterase 3B, 4A4, 4D1, 4D2, and 4D3 in jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonist. Potential role in beta2-adrenoreceptor desensitization
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Seybold J, Newton R, Wright L, Finney PA, Suttorp N, Barnes PJ, Adcock IM, Giembycz MA: Induction of phosphodiesterase 3B, 4A4, 4D1, 4D2, and 4D3 in jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonist. Potential role in beta2-adrenoreceptor desensitization. J Biol Chem 1998, 273:20575-20588.
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Essayan DM, Kagey-Sobotka A, Lichtenstein LM, Huang S-K: Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Pharmacol Exp Ther 1997, 282:505-512.
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Essayan DM, Huang S-K, Kagey-Sobotka A, Lichtenstein MD: Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen driven proliferation and cytokine gene expression. J Allergy Clin Immunol 1997, 99:28-37.
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Kaminuma O, Mori A, Wada K, Kikkawa H, IKezama K, Okudaira H: A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkat cells. Immunopharmacology 1998, 38:247-252.
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Essayan DM, Kagey-Sobotka A, Lichenstein LM, Huang S-K: Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergan-specific human T lymphocyte clones. Biochem Pharmacol 1997, 53:1055-1060.
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Gantner F, Gotz C, Gekeler V, SChudt C, Wendel A, Hatzelmann A: Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation. Br J Pharmacol 1998, 123:1031-1038.
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Crocker IC, Ohia SE, Charch MK, Towley RG: Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. J Allergy Clin Immunol 1998, 102:797-804.
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Gantner F, Tenor H, Gekeler V, Schudt C, Wendel A, Hatzelmann A: Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals; a comparative study. J Allergy Clin Immunol 1997, 100:527-535.
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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a low affinity phosphodiesterase 4 conformer
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Souness JE, Griffin M, Maslen C, Ebsworth K, Scott LC, Pollock K, Palfreyman MN, Karlsson J-A: Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a low affinity phosphodiesterase 4 conformer. Br J Pharmacol 1996, 118:649-658.
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Bigler A, Sigmund B, Emmerich U, Baumann KH, Hartmann G, Endres S: Anti-inflammatory activities of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol 1998, 63:101-107.
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In vitro differentiation of human monocytes to macrophages: Change of PDE profile and its relationship to suppression of tumor necrosis factor-α release by PDE inhibitors
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Gantner F, Kupferschmidt R, Schudt C, Wendel A, Hatzelmann A: In vitro differentiation of human monocytes to macrophages: Change of PDE profile and its relationship to suppression of tumor necrosis factor-α release by PDE inhibitors. Br J Pharmacol 1997, 121:221-231.
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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-a and leukotriene B4 in novel human whole blood assay
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Brideau C, Van Standen C, Styler A, Rodger IW, Chan CC: The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-a and leukotriene B4 in novel human whole blood assay. Br J Pharmacol 1999, 126:979-988.
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Rose RJ, Lui H, Palmer D, Maurice DH: Cyclic AMP-mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity. Br J Pharmacol 1997, 122:233-240.
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Santamaria L, Palacios JM, Beleta J: Inhibition of eotaxin-mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram. Br J Pharmacol 1997, 121:1150-1154.
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