-
1
-
-
77953577584
-
The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy
-
Abrams, S. L., Steelman, L. S., Shelton, J. G., Wong, E. W., Chap-pell, W. H., Basecke, J., Stivala, F., Donia, M., Nicoletti, F., Libra, M., Martelli, A. M. and McCubrey, J. A. (2010) The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell Cycle 9, 1781-1791.
-
(2010)
Cell Cycle
, vol.9
, pp. 1781-1791
-
-
Abrams, S.L.1
Steelman, L.S.2
Shelton, J.G.3
Wong, E.W.4
Chap-Pell, W.H.5
Basecke, J.6
Stivala, F.7
Donia, M.8
Nicoletti, F.9
Libra, M.10
Martelli, A.M.11
McCubrey, J.A.12
-
2
-
-
70450257737
-
The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts
-
Ahn, J. H., Eum, K. H. and Lee, M. (2009) The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts. Mol. Cell. Biochem. 332, 189-197.
-
(2009)
Mol. Cell. Biochem
, vol.332
, pp. 189-197
-
-
Ahn, J.H.1
Eum, K.H.2
Lee, M.3
-
3
-
-
77953491252
-
Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts
-
Ahn, J. H., Eum, K. H. and Lee, M. (2010) Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts. BMB Rep. 43, 205-211.
-
(2010)
BMB Rep
, vol.43
, pp. 205-211
-
-
Ahn, J.H.1
Eum, K.H.2
Lee, M.3
-
4
-
-
0027439693
-
Selective Regulation of Expression of Protein Kinase C (PKC) Isoenzymes In Multidrug-resistant MCF-7 Cells. Functional Signifi Cance of Enhanced Expression of PKC alpha
-
Blobe, G. C., Sachs, C. W., Khan, W. A., Fabbro, D., Stabel, S., Wetsel, W. C., Obeid, L. M., Fine, R. L. and Hannun, Y. A. (1993) Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional signifi cance of enhanced expression of PKC alpha. J. Biol. Chem. 268, 658-664.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 658-664
-
-
Blobe, G.C.1
Sachs, C.W.2
Khan, W.A.3
Fabbro, D.4
Stabel, S.5
Wetsel, W.C.6
Obeid, L.M.7
Fine, R.L.8
Hannun, Y.A.9
-
5
-
-
0028881514
-
Interaction of tamoxifen with the multidrug resistance P-glycoprotein
-
Callaghan, R. and Higgins, C. F. (1995) Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br. J. Cancer 71, 294-299.
-
(1995)
Br. J. Cancer
, vol.71
, pp. 294-299
-
-
Callaghan, R.1
Higgins, C.F.2
-
6
-
-
2342435822
-
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis
-
Chatterjee, D., Bai, Y., Wang, Z., Beach, S., Mott, S., Roy, R., Braastad, C., Sun, Y., Mukhopadhyay, A., Aggarwal, B. B., Darnowski, J., Pantazis, P., Wyche, J., Fu, Z., Kitagwa, Y., Keller, E. T., Sedivy, J. M. and Yeung, K. C. (2004) RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J. Biol. Chem. 279, 17515-17523.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 17515-17523
-
-
Chatterjee, D.1
Bai, Y.2
Wang, Z.3
Beach, S.4
Mott, S.5
Roy, R.6
Braastad, C.7
Sun, Y.8
Mukhopadhyay, A.9
Aggarwal, B.B.10
Darnowski, J.11
Pantazis, P.12
Wyche, J.13
Fu, Z.14
Kitagwa, Y.15
Keller, E.T.16
Sedivy, J.M.17
Yeung, K.C.18
-
7
-
-
0027221138
-
A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase
-
Cornwell, M. M. and Smith, D. E. (1993) A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase. J. Biol. Chem. 268, 15347-15350.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 15347-15350
-
-
Cornwell, M.M.1
Smith, D.E.2
-
8
-
-
0037342272
-
Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance
-
Davis, J. M., Navolanic, P. M., Weinstein-Oppenheimer, C. R., Steelman, L. S., Hu, W., Konopleva, M., Blagosklonny, M. V., McCubrey, J. A. (2003) Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance. Clin. Cancer Res. 9, 1161-1170.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 1161-1170
-
-
Davis, J.M.1
Navolanic, P.M.2
Weinstein-Oppenheimer, C.R.3
Steelman, L.S.4
Hu, W.5
Konopleva, M.6
Blagosklonny, M.V.7
McCubrey, J.A.8
-
9
-
-
70349974713
-
Reversal effect of Raf-1/ Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell line
-
Dong, Y., Shao, S., Hu, J. and Yang, P. (2009) Reversal effect of Raf-1/ Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell line. Oral Oncol. 45, 991-997.
-
(2009)
Oral Oncol
, vol.45
, pp. 991-997
-
-
Dong, Y.1
Shao, S.2
Hu, J.3
Yang, P.4
-
10
-
-
0036176510
-
Mechanisms of cancer drug resistanace
-
Gottesman, M. M. (2002) Mechanisms of cancer drug resistanace. Annu. Rev. Med. 53, 615-627.
-
(2002)
Annu Rev. Med
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
11
-
-
0030027552
-
Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide
-
Gupta, K. P., Ward, N. E., Gravitt, K. R., Bergman, P. J. and O'Brian, C. A. (1996) Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide. J. Biol. Chem. 271, 2102-2111.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 2102-2111
-
-
Gupta, K.P.1
Ward, N.E.2
Gravitt, K.R.3
Bergman, P.J.4
O'Brian, C.A.5
-
12
-
-
0032559228
-
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
-
Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. and Krasnow, M. A. (1998) Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263.
-
(1998)
Cell
, vol.92
, pp. 253-263
-
-
Hacohen, N.1
Kramer, S.2
Sutherland, D.3
Hiromi, Y.4
Krasnow, M.A.5
-
13
-
-
0029964257
-
Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
-
Haldar, S., Chintapalli, J. and Croce, C. M. (1996) Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res. 56, 1253-1255.
-
(1996)
Cancer Res
, vol.56
, pp. 1253-1255
-
-
Haldar, S.1
Chintapalli, J.2
Croce, C.M.3
-
14
-
-
0025934998
-
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffi nity labeling of P-glycoprotein
-
Jaffrezou, J. P., Herbert, J. M., Levade, T., Gau, M. N., Chatelain, P. and Laurent, G. (1991) Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffi nity labeling of P-glycoprotein. J. Biol. Chem. 266, 19858-19864.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 19858-19864
-
-
Jaffrezou, J.P.1
Herbert, J.M.2
Levade, T.3
Gau, M.N.4
Chatelain, P.5
Laurent, G.6
-
15
-
-
4944264724
-
Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab
-
Jazirehi, A. R., Vega, M. I., Chatterjee, D., Goodglick, L. and Bonavida, B. (2004) Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab. Cancer Res. 64, 7117-7126.
-
(2004)
Cancer Res
, vol.64
, pp. 7117-7126
-
-
Jazirehi, A.R.1
Vega, M.I.2
Chatterjee, D.3
Goodglick, L.4
Bonavida, B.5
-
16
-
-
0030048861
-
Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter
-
Kim, S. H., SH, L., NH, K., CD, K. and BS, C. (1996) Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter. Cancer Lett. 98, 199-205.
-
(1996)
Cancer Lett
, vol.98
, pp. 199-205
-
-
Kim, S.H.1
Sh, L.2
Nh, K.3
Cd, K.4
Bs, C.5
-
17
-
-
0030803378
-
Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter
-
Lee, L. F., Haskill, J. S., Mukaida, N., Matsushima, K. and Ting, J. P. (1997) Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter. Mol. Cell. Biol. 17, 5097-5105.
-
(1997)
Mol. Cell Biol
, vol.17
, pp. 5097-5105
-
-
Lee, L.F.1
Haskill, J.S.2
Mukaida, N.3
Matsushima, K.4
Ting, J.P.5
-
18
-
-
33749354298
-
Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2
-
Lee, M. (2006) Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2. Biochem. Biophys. Res. Commun. 350, 450-456.
-
(2006)
Biochem Biophys. Res. Commun
, vol.350
, pp. 450-456
-
-
Lee, M.1
-
19
-
-
77957851560
-
The differences in biological properties between parental and v-Ha-ras transformed NIH3T3 cells
-
Lee, M., Ahn, J. H. and Eum, K. H. (2009) The differences in biological properties between parental and v-Ha-ras transformed NIH3T3 cells. Cancer Res. Treat. 41, 93-99.
-
(2009)
Cancer Res. Treat
, vol.41
, pp. 93-99
-
-
Lee, M.1
Ahn, J.H.2
Eum, K.H.3
-
20
-
-
0037431072
-
Down-regulation of Raf- 1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells
-
Lee, M., Koh, W. S. and Han, S. S. (2003) Down-regulation of Raf- 1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells. Cancer Lett. 193, 57-64.
-
(2003)
Cancer Lett
, vol.193
, pp. 57-64
-
-
Lee, M.1
Koh, W.S.2
Han, S.S.3
-
21
-
-
0028825531
-
Ras target proteins in eukaryotic cells
-
Marshall, M. S. (1995) Ras target proteins in eukaryotic cells. FASEB J. 9, 1311-1318.
-
(1995)
FASEB J
, vol.9
, pp. 1311-1318
-
-
Marshall, M.S.1
-
22
-
-
41949114548
-
Taxanes, microtubules and chemoresistant breast cancer
-
McGrogan, B. T., Gilmartin, B., Carney, D. N. and McCann, A. (2008) Taxanes, microtubules and chemoresistant breast cancer. Biochim. Biophys. Acta 1785, 96-132.
-
(2008)
Biochim. Biophys. Acta
, pp. 96-132
-
-
McGrogan, B.T.1
Gilmartin, B.2
Carney, D.N.3
McCann, A.4
-
23
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer, K. E. and Pritchard, C. A. (2003) Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta 1653, 25-40.
-
(2003)
Biochim. Biophys. Acta
, vol.1653
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
24
-
-
33745746815
-
Pharmacological strategies for overcoming multidrug resistance
-
Nobili, S., Landini, I., Giglioni, B. and Mini, E. (2006) Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 7, 861-879.
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 861-879
-
-
Nobili, S.1
Landini, I.2
Giglioni, B.3
Mini, E.4
-
25
-
-
0038613087
-
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
-
Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. and Yoshimura, A. (2003) Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat. Cell Biol. 5, 427-432.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 427-432
-
-
Sasaki, A.1
Taketomi, T.2
Kato, R.3
Saeki, K.4
Nonami, A.5
Sasaki, M.6
Kuriyama, M.7
Saito, N.8
Shibuya, M.9
Yoshimura, A.10
-
26
-
-
0034808394
-
Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin
-
Weinstein-Oppenheimer, C. R., Henríquez-Roldán, C. F., Davis, J. M., Navolanic, P. M., Saleh, O. A., Steelman, L. S., Franklin, R. A., Robinson, P. J., McMahon, M. and McCubrey, J. A. (2001) Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin. Clin. Cancer Res. 7, 2898-2907.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 2898-2907
-
-
Weinstein-Oppenheimer, C.R.1
Henríquez-Roldán, C.F.2
Davis, J.M.3
Navolanic, P.M.4
Saleh, O.A.5
Steelman, L.S.6
Franklin, R.A.7
Robinson, P.J.8
McMahon, M.9
McCubrey, J.A.10
-
27
-
-
67650656774
-
Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: Evaluation of current strategies
-
Wu, C. P., Calcagno, A. M. and Ambudkar, S. V. (2008) Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr. Mol. Pharmacol. 1, 93-105.
-
(2008)
Curr. Mol. Pharmacol
, vol.1
, pp. 93-105
-
-
Wu, C.P.1
Calcagno, A.M.2
Ambudkar, S.V.3
-
28
-
-
0033539167
-
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
-
Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Katsanakis, K. D., Rose, D. W., Mischak, H., Sedivy, J. M. and Kolch, W. (1999) Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401, 173-177.
-
(1999)
Nature
, vol.401
, pp. 173-177
-
-
Yeung, K.1
Seitz, T.2
Li, S.3
Janosch, P.4
McFerran, B.5
Kaiser, C.6
Fee, F.7
Katsanakis, K.D.8
Rose, D.W.9
Mischak, H.10
Sedivy, J.M.11
Kolch, W.12
-
29
-
-
0024421664
-
Reversal mechanism of multidrug resistance by verapamil: Direct binding of verapamil to P-glycoprotein on specifi c sites and transport of verapamil outward across the plasma membrane of K562/ADM cells
-
Yusa, K. and Tsuruo, T. (1989) Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specifi c sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res. 49, 5002-5006.
-
(1989)
Cancer Res
, vol.49
, pp. 5002-5006
-
-
Yusa, K.1
Tsuruo, T.2
-
30
-
-
0036479310
-
Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf
-
Yusoff, P., Lao, D. H., Ong, S. H., Wong, E. S., Lim, J., Lo, T. L., Leong, H. F., Fong, C. W. and Guy, G. R. (2002) Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf. J. Biol. Chem. 277, 3195-3201.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 3195-3201
-
-
Yusoff, P.1
Lao, D.H.2
Ong, S.H.3
Wong, E.S.4
Lim, J.5
Lo, T.L.6
Leong, H.F.7
Fong, C.W.8
Guy, G.R.9
-
31
-
-
0035833318
-
Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria
-
Zhong, J., Troppmair, J. and Rapp, U. R. (2001) Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria. Oncogene 20, 4807-4816.
-
(2001)
Oncogene
, vol.20
, pp. 4807-4816
-
-
Zhong, J.1
Troppmair, J.2
Rapp, U.R.3
|