Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts

BMB Reports

Volumn 43, Issue 3, 2010, Pages 205-211

  Ahn, Jun Ho ^a   Eum, Ki Hwan ^a   Lee, Michael ^a  

^a SolarLight Ltd   (South Korea)

Author keywords

Feedback regulation; Paclitaxel; Protein interaction; Raf 1 kinase; Spry2

Indexed keywords

EID: 77953491252     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.3.205     Document Type: Article

References (25)

1. Sasaki, A., Taketomi, T., Kato, R., Saeki, K., Nonami, A., Sasaki, M., Kuriyama, M., Saito, N., Shibuya, M. and Yoshimura, A. (2003) Mammalian Sprouty4 suppresses Rasindependent ERK activation by binding to Raf1. Nat. Cell. Biol. 5, 427-432.
2. Yusoff, P., Lao, D. H., Ong, S. H., Wong, E. S. M., Lim, J., Lo, T. L., Leong, F., Fong, C. W. and Guy, G. R. (2002) Sprouty2 inhibits the Ras/MAP Kinase pathway by inhibiting the activation of Raf. J. Biol. Chem. 277, 3195-3201.
3. Lito, P., Mets, B. D., Kleff, S., O'Reilly, S., Maher, V. M. and McCormick, J. J. (2008) Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogenetransformed human fibroblasts. J. Biol. Chem. 283, 2002-2009.
4. Kim, H. J. and Bar-Sagi, D. (2004) Modulation of signalling by Sprouty: a developing story. Nat. Rev. Mol. Cell Biol. 5, 441-450.
5. Mason, J. M., Morrison, D. J., Basson, M. A. and Licht, J. D. (2006) Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol. 16, 45-54.
6. Kolch, W. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351, 289-305.
7. Marshall, M. S. (1995) Ras target proteins in eucaryotic cells. FASEB J. 9, 1311-1318.
8. Luo, Z., Diaz, B., Marshall, M. S. and Avruch, J. (1997) An intact Raf zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ. Mol. Cell. Biol. 17, 46-53.
9. Dhillon, A. S. and Kolch, W. (2002) Untying the regulation of the Raf-1 kinase. Arch. Biochem. Biophys. 404, 3-9.
10. Diaz, B., Barnard, D., Filson, A., MacDonald, S., King, A. and Marshall, M. (1997) Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol. Cell. Biol. 17, 4509-4516.
11. Fabian, J. R., Daar, I. O. and Morrison, D. K. (1993) Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 13, 7170-7179.
12. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D. and Rapp, U. R. (1993) Protein kinase C alpha activates Raf-1 by direct phosphorylation. Nature 364, 249-252.
13. Reich, A., Sapir, A. and Shilo, B. (1999) Sprouty is a general inhibitor of receptor tyrosine kinase signaling. Development 126, 4139-4147.
14. Lee, M. (2006) Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2. Biochem. Biophys. Res. Commun. 350, 450-456.
15. Blagosklonny, M. V., Giannakakou, P., El-Deiry, W. S., Kingston, D. G., Higgs, P. I., Neckers, L. and Fojo, T. (1997) Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res. 57, 130-135.
16. Cheung, H. W., Ling, M. T., Tsao, S. W., Wong, Y. C. and Wang, X. (2004) Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells. Carcinogenesis 25, 881-887.
17. Improta-Brears, T., Ghosh, S. and Bell, R. M. (1999) Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine. J. Cell Biochem. 198, 171-178.
18. Ahn, J. H., Eum, K. H. and Lee, M. (2009) The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts. Mol. Cell. Biochem. 332, 189- 197.
19. Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z. X., Ferrans, V. J., Howard, B. H. and Finkel, T. (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936-7940.
20. Mason, J. M., Morrison, D. J., Bassit, B., Dimri, M., Band, H., Licht, J. D. and Gross, I. (2004) Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol. Biol. Cell 15, 2176-2188.
21. Lao, D. H., Yusoff, P., Chandramouli, S., Philp, R. J., Fong, C. W., Jackson, R. A., Saw, T. Y., Yu, C. Y. and Guy, G. R. (2007) Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation. J. Biol. Chem. 282, 9117-9126.
22. Impagnatiello, M. A., Weitzer, S., Gannon, G., Compagni, A., Cotten, M. and Christofori, G. (2001) Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. J. Cell. Biol. 152, 1087-1098.
23. Chandramouli, S., Yu, C. Y., Yusoff, P., Lao, D. H., Leong, H. F., Mizuno, K. and Guy, G. R. (2008) Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. J. Biol. Chem. 283, 1679-1691.
24. Li, X., Wheldon, L. and Heath, J. K. (2003) Sprouty: a controversial role in receptor tyrosine kinase signalling pathways. Biochem. Soc. Trans. 31, 1445-1446.
25. Park, Y. P., Choi, S. C., Kim, B. Y., Kim, J. T., Song, E. Y., Kang, S. H., Yoon, D. Y., Paik, S. G., Kim, K. D., Kim, J. W. and Lee, H. G. (2008) Induction of Mac-2BP by nerve growth factor is regulated by the PI3K/Akt/NF-kB-dependent pathway in the HEK293 cell line. BMB Rep. 41, 784-789.