Reversal effect of Raf-1/Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell line

Oral Oncology

Volumn 45, Issue 11, 2009, Pages 991-997

  Dong, Yan ^a   Shao, Shujuan ^a   Hu, Jun ^a   Yang, Peiman ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Double RNAi; KBv200 cell line; Multidrug resistance; Raf 1 Mdr 1

Indexed keywords

MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; RAF PROTEIN; SMALL INTERFERING RNA; VINCRISTINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-RAF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; VINCRISTINE;

EID: 70349974713     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2009.05.642     Document Type: Article

References (31)

1. Jin W., Scotto K.W., Hait W.N., and Yang J.M. Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells. Biochem Pharmacol 74 (2007) 851-859
2. Kaszubiak A., Kupstat A., Müller U., Hausmann R., Holm P.S., and Laqe H. Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1. Biochem Biophys Res Commun 357 (2007) 295-301
3. Xu B.H., Gupta V., and Singh S.V. Mitomycin C sensitivity in human bladder cancer cells: possible role of glutathione and glutathione transferase in resistance. Arch Biochem Biophys 308 (1994) 164-170
4. Garcia M., Alaniz L., Lopes E., Blanco G., Hajos S., and Alvarez E. Inhibition of NF-κB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leuk Res 29 (2005) 1425-1434
5. Zhu Q., and Center M.S. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. Cancer Res 54 (1994) 4488-4494
6. Krishnamachary N., and Cencer M.S. The MRP gene associated with a non-P-glycol-protein multidrug resistance encodes a 190-Kda membrane bound glycoprotein. Cancer Res 53 (1993) 3658-3661
7. Cho Y., and Kim M. Expression of multidrug resistance-related genes in oral squamous cell carcinomas. Oral Oncol 37 8 (2001) 652-659
8. Grunt C.E., Valdimarsson G., Hipfner D.R., Almquist K.C., Cole S.P., and Deeley R.G. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54 (1994) 357-384
9. Shelton J.G., Steelman L.S., Lee J.T., Knapp S.L., Blalock W.L., and Moye P.W. Effects of the Raf/MEK/ERK and PI3K signal transduction pathways on the abrogation of cytokine dependence and prevention of apoptosis in hematopoietic cells. Oncogene 22 (2003) 2478-2492
10. Mallon R., Feldberg L.R., Kim S.C., Collins K., Wojciechowicz D., and Hollander I. An enzyme-linked immunosorbent assay for the Raf/MEK1/MAPK signaling cascade. Anal Biochem 294 (2001) 48-54
11. Chang F., Steelman L.S., Lee J.T., Shelton J.G., Navolanic P.M., and Blalock W.L. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17 (2003) 1263-1293
12. Weinstein-Oppenheimer C.R., Blalock W.L., Steelman L.S., Chang F., and McCubrey J.A. The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors. Pharmacol Ther 88 (2000) 229-279
13. Thompson N., and Lyons J. Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 5 (2005) 350-356
14. Lee J.T., and McCubrey J.A. The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 16 (2002) 486-507
15. Lee H., Tian B., Sedivy J., Wans J., and Kim M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology 131 (2006) 1208-1217
16. Keller E.T., Fu Z., Yeung K., and Brennan M. Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. Cancer Lett 207 (2004) 131-137
17. Park S.J., Kim Y.Y., Ju J.W., Han B.G., Park S.I., and Park B.J. Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation. Biochem Biophys Res Commun 289 (2001) 1205-1210
18. Steelman L.S., Pohnert S.C., Shelton J.G., Franklin R.A., Bertrand F.E., and McCubrey J.A. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18 (2004) 189-218
19. Li N., Greenblatt D.Y., Jaskula-Sztul R., Xue M.X., Kunnimalaiyaan M., and Chen H. Focal adhesion kinase (FAK) is a downstream effector of the Raf-1 signal transduction pathway in gastrointestinal carcinoid cancer cells. J Surg Res 144 (2008) 239
20. Weinstein-Oppenheimer C.R., Henríquez-Roldán C.F., Davis J.M., Navolanic P.M., Saleh O.A., and Steelman L.S. Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin. Clin Cancer Res 7 (2001) 2898-2907
21. Davis J.M., Navolanic P.M., Weinstein-Oppenheimer C.R., Steelman L.S., Hu W., and Konopleva M. Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance. Clin Cancer Res 9 (2003) 1161-1170
22. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
23. Elbashir S.M., Harborth J., Weber K., and Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26 (2002) 199-213
24. Cioca D.P., Aoki Y., and Kiyosawa K. RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines. Cancer Gene Ther 10 (2003) 125-133
25. Leung R.K., and Whittaker P.A. RNA interference. From gene silencing to gene-specific therapeutics. Pharmacol Ther 107 (2005) 222-239
26. Carsten C., Edith G., Sabine H., Joerg-Christian T., Ernst W., and Roland G. Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis. Brain Res 1125 (2006) 147-154
27. Vérène S., Alain L., and Béatrice J. Modulation of MDR1 gene expression in multidrug resistant MCF7 cells by low concentrations of small interfering RNAs. Biochem Pharmacol 70 (2005) 1424-1430
28. Wu H., Hait W.N., and Yang J.M. Small interfering RNA-induced suppression of MDR1 restores sensitivity to multidrug-resistant cancer cells. Cancer Res 63 (2003) 1515-1519
29. Gao Y., Xiong D., Liu H., Peng H., Shao X., Xu Y., et al. Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein×anti -CD3 diabody. Leukemia 18 (2004) 513-520
30. Moscow J.A., Schneider E., Ivy S.P., and Cowan K.H. Multidrug resistance. Cancer Chemother Biol Response Modif 17 (1997) 139-177
31. Gottesman M.M., and Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Rev Biochem 62 (1993) 385-427