An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Moura Alves, Pedro ^a   Neves Costa, Ana ^a   Raquel, Helena ^a   Pacheco, Teresa Raquel ^a   D'Almeida, Bruno ^a   Rodrigues, Raquel ^a   Cadima Couto, Iris ^a   Chora, Ângelo ^a   Oliveira, Mariana ^b   Gama Carvalho, Margarida ^a,b   Hacohen, Nir ^c,d   Moita, Luis F ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROTEIN SFRS3; REGULATOR PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA BINDING PROTEIN; SFRS3 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ESCHERICHIA COLI; GENE FUNCTION; GENE IDENTIFICATION; GENETIC REGULATION; IMMUNOREGULATION; LOSS OF FUNCTION MUTATION; NONHUMAN; PROTEIN SYNTHESIS REGULATION; RNA SPLICING; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MONOCYTE; REPORTER GENE; REPRODUCIBILITY; SECRETION;

VERTEBRATA;

CASPASE 1; CELL LINE; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, REPORTER; HUMANS; INTERLEUKIN-1BETA; MONOCYTES; NF-KAPPA B; REPRODUCIBILITY OF RESULTS; RNA SPLICING; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 79956068797     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019829     Document Type: Article

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