Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3243-3247

  Alagille, David ^a   Dacosta, Herve ^a   Chen, Yelin ^b   Hemstapat, Kamondanai ^b   Rodriguez, Alice ^b   Baldwin, Ronald M ^c   Conn, Jeffrey P ^b   Tamagnan, Gilles D ^a  

^a INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antagonist; Glutamate; mGluR5; MPEP

Indexed keywords

(2 METHYLTHIAZOL 4 YL)ETHYNYL; (5 METHYLPYRIDINV 2 YL)ETHYNYL; (6 METHYLPYRIDIN 2 YL)ETHYNYL; (PYRIDIN 2 YL)ETHYNYL; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; IMIPRAMINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; MORPHINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DETERMINATION; DRUG SCREENING; HIPPOCAMPUS; IC 50; IN VITRO STUDY; MOUSE; NEUROTRANSMISSION; NONHUMAN; POSTOPERATIVE PAIN; RAT; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION;

ACETYLENE; ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; LIGANDS; MICE; MOLECULAR STRUCTURE; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79956067404     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.047     Document Type: Article

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31. 50 values were calculated from nonlinear curve fitting using GraphPad Prism v. 4.01 and of three separate experiments, presented as the mean ± standard error of the mean (SEM).
32. 50, which was obtained from nonlinear curve fitting by GraphPad Prism v. 4.01 from three separate experiments in duplicates.