메뉴 건너뛰기




Volumn 30, Issue 4, 2011, Pages 483-498

Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): A novel target for an additional therapy

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTEMISONE; ARTESUNATE; CHLOROQUINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MEFLOQUINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PRIMAQUINE; PROGUANIL; QUININE; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 79956049009     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-010-1122-9     Document Type: Review
Times cited : (11)

References (172)
  • 2
    • 75649132295 scopus 로고    scopus 로고
    • The role of platelets in the pathogenesis of cerebral malaria
    • Cox D, McConkey S (2010) The role of platelets in the pathogenesis of cerebral malaria. Cell Mol Life Sci 67:557-568
    • (2010) Cell Mol Life Sci , vol.67 , pp. 557-568
    • Cox, D.1    McConkey, S.2
  • 3
    • 65249181659 scopus 로고    scopus 로고
    • Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells
    • Hora R, Bridges DJ, Craig A, Sharma A (2009) Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells. J Biol Chem 284:6260-6269
    • (2009) J Biol Chem , vol.284 , pp. 6260-6269
    • Hora, R.1    Bridges, D.J.2    Craig, A.3    Sharma, A.4
  • 4
    • 35648975301 scopus 로고    scopus 로고
    • CD44, a signal receptor for the inhibition of the cytoadhesion of CD36-binding Plasmodium falciparum-infected erythrocytes by CSA-binding infected erythrocytes
    • DOI 10.1016/j.micinf.2007.07.011, PII S1286457907002687
    • Jurzynski C, Gysin J, Pouvelle B (2007) CD44, a signal receptor for the inhibition of the cytoadhesion of CD36-binding Plasmodium falciparum-infected erythrocytes by CSA-binding infected erythrocytes. Microbes Infect 9:1463-1470 (Pubitemid 350019584)
    • (2007) Microbes and Infection , vol.9 , Issue.12-13 , pp. 1463-1470
    • Jurzynski, C.1    Gysin, J.2    Pouvelle, B.3
  • 5
    • 34447267252 scopus 로고    scopus 로고
    • Neural cell adhesion molecule, a new cytoadhesion receptor for Plasmodium falciparum-infected erythrocytes capable of aggregation
    • DOI 10.1128/IAI.01852-06
    • Pouvelle B, Matarazzo V, Jurzynski C, Nemeth J, Ramharter M, Rougon G, Gysin J (2007) Cell adhesion molecule, a new cytoadhesion receptor for Plasmodium falciparum-infected erythrocytes capable of aggregation. Infect Immun 75:3516-3522 (Pubitemid 47040953)
    • (2007) Infection and Immunity , vol.75 , Issue.7 , pp. 3516-3522
    • Pouvelle, B.1    Matarazzo, V.2    Jurzynski, C.3    Nemeth, J.4    Ramharter, M.5    Rougon, G.6    Gysin, J.7
  • 8
    • 0035820184 scopus 로고    scopus 로고
    • The role of tumour necrosis factor-alpha in the pathogenesis of complicated falciparum malaria
    • Odeh M (2001) The role of tumour necrosis factor-alpha in the pathogenesis of complicated falciparum malaria. Cytokine 14:8-11
    • (2001) Cytokine , vol.14 , pp. 8-11
    • Odeh, M.1
  • 9
    • 42049114073 scopus 로고    scopus 로고
    • The guanylhydrazone CNI-1493: An inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase
    • Specht S, Sarite SR, Hauber I, Hauber J, Görbig UF, Meier C, Bevec D, Hoerauf A, Kaiser A (2008) The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase. Parasitol Res 102:1177-1184
    • (2008) Parasitol Res , vol.102 , pp. 1177-1184
    • Specht, S.1    Sarite, S.R.2    Hauber, I.3    Hauber, J.4    Görbig, U.F.5    Meier, C.6    Bevec, D.7    Hoerauf, A.8    Kaiser, A.9
  • 10
    • 70350752494 scopus 로고    scopus 로고
    • Triclosan inhibit the growth of the late liver-stage of Plasmodium
    • Singh AP, Surolia N, Surolia A (2009) Triclosan inhibit the growth of the late liver-stage of Plasmodium. IUBMB Life 61:923-928
    • (2009) IUBMB Life , vol.61 , pp. 923-928
    • Singh, A.P.1    Surolia, N.2    Surolia, A.3
  • 11
    • 68149097061 scopus 로고    scopus 로고
    • The role of PPARs in MDR - A lesson from embryonic development
    • Konieczna A, Lichnovka R, Erdosova B, Ehrmann J (2009) The role of PPARs in MDR - a lesson from embryonic development. Neoplasma 56:279-283
    • (2009) Neoplasma , vol.56 , pp. 279-283
    • Konieczna, A.1    Lichnovka, R.2    Erdosova, B.3    Ehrmann, J.4
  • 12
    • 70349111436 scopus 로고    scopus 로고
    • Emerging roles of peroxisome proliferator-activated receptor-β/ δ in inflammation
    • Bishop-Bailey D, Bystrom J (2009) Emerging roles of peroxisome proliferator-activated receptor-β/δ in inflammation. Pharmacol Ther 124:141-150
    • (2009) Pharmacol Ther , vol.124 , pp. 141-150
    • Bishop-Bailey, D.1    Bystrom, J.2
  • 15
    • 42549114387 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
    • DOI 10.1038/labinvest.2008.20, PII LABINVEST200820
    • Lin J, Chen A (2008) Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 88:529-540 (Pubitemid 351581455)
    • (2008) Laboratory Investigation , vol.88 , Issue.5 , pp. 529-540
    • Lin, J.1    Chen, A.2
  • 16
    • 77950798963 scopus 로고    scopus 로고
    • Curcumin improves sclerosing cholangitis in Mdr2-/- Mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation
    • Baghdasaryan A, Claudel T, Kosters A, Gumhold J, Silbert D, Thüringer A, Leski K, Fickert P, Karpen SJ, Trauner M (2010) Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 59:521-530
    • (2010) Gut , vol.59 , pp. 521-530
    • Baghdasaryan, A.1    Claudel, T.2    Kosters, A.3    Gumhold, J.4    Silbert, D.5    Thüringer, A.6    Leski, K.7    Fickert, P.8    Karpen, S.J.9    Trauner, M.10
  • 21
    • 55249086256 scopus 로고    scopus 로고
    • Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria
    • Weinberg JB, Lopansri BK, Mwaikambo E, Granger DL (2008) Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. Curr Opin Infect Dis 21:468-475
    • (2008) Curr Opin Infect Dis , vol.21 , pp. 468-475
    • Weinberg, J.B.1    Lopansri, B.K.2    Mwaikambo, E.3    Granger, D.L.4
  • 22
    • 60749123350 scopus 로고    scopus 로고
    • Cerebral malaria
    • Ohnishi K (2009) Cerebral malaria. Brain Nerve 61:122-128
    • (2009) Brain Nerve , vol.61 , pp. 122-128
    • Ohnishi, K.1
  • 24
    • 51249117284 scopus 로고    scopus 로고
    • Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: Role of IL-1beta and 15-HETE
    • Prato M, Gallo V, Giribaldi G, Arese P (2008) Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE. Malar J 157:8-17
    • (2008) Malar J , vol.157 , pp. 8-17
    • Prato, M.1    Gallo, V.2    Giribaldi, G.3    Arese, P.4
  • 28
    • 33747757697 scopus 로고    scopus 로고
    • Cerebral malaria: Role of microparticles and platelets in alterations of the blood-brain barrier
    • DOI 10.1016/j.ijpara.2006.02.005, PII S0020751906000634, Blood-Brain Barrier in Parasitic Disease
    • Combes V, Coltel N, Faille D, Wassmer SC, Grau GE (2006) Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. Int J Parasitol 36:541-546 (Pubitemid 44275316)
    • (2006) International Journal for Parasitology , vol.36 , Issue.5 , pp. 541-546
    • Combes, V.1    Coltel, N.2    Faille, D.3    Wassmer, S.C.4    Grau, G.E.5
  • 29
    • 0031849928 scopus 로고    scopus 로고
    • Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment
    • DOI 10.1016/S0163-7258(98)00008-4, PII S0163725898000084
    • Newton CRJC, Krishna S (1998) Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther 79:1-53 (Pubitemid 28318261)
    • (1998) Pharmacology and Therapeutics , vol.79 , Issue.1 , pp. 1-53
    • Newton, C.R.J.C.1    Krishna, S.2
  • 30
    • 0026662199 scopus 로고
    • Possible central role of nitric oxide in conditions clinically similar to cerebral malaria
    • Clark IA, Rockett KA, Cowden WB (1992) Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Lancet 340:894-896
    • (1992) Lancet , vol.340 , pp. 894-896
    • Clark, I.A.1    Rockett, K.A.2    Cowden, W.B.3
  • 32
    • 79956032591 scopus 로고    scopus 로고
    • Malaria: Severe, life-threatening
    • (Online) July 2007
    • Omari AA, Garner P (2007) Malaria: severe, life-threatening. Clin Evid (Online) July 2007, p 913
    • (2007) Clin Evid , pp. 913
    • Omari, A.A.1    Garner, P.2
  • 33
    • 70349757024 scopus 로고    scopus 로고
    • Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages
    • Helmers AJ, Gowda DC, Kain KC, Liles WC (2009) Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. Am J Trop Med Hyg 81:631-637
    • (2009) Am J Trop Med Hyg , vol.81 , pp. 631-637
    • Helmers, A.J.1    Gowda, D.C.2    Kain, K.C.3    Liles, W.C.4
  • 34
    • 0036717905 scopus 로고    scopus 로고
    • Role of the tumor necrosis factor receptor 2 (TNFR2) in cerebral malaria in mice
    • Piguet PF, Kan CD, Vesin C (2002) Role of the tumor necrosis factor receptor 2 (TNFR2) in cerebral malaria in mice. Lab Invest 82:1155-1166 (Pubitemid 35014849)
    • (2002) Laboratory Investigation , vol.82 , Issue.9 , pp. 1155-1166
    • Piguet, P.F.1    Kan, C.D.2    Vesin, C.3
  • 35
    • 65449140616 scopus 로고    scopus 로고
    • Genetic characterization and evolutionary inference of TNF-alpha through computational analysis
    • Awasthi G, Singh S, Dash AP, Das A (2008) Genetic characterization and evolutionary inference of TNF-alpha through computational analysis. Braz J Infect Dis 12:374-379
    • (2008) Braz J Infect Dis , vol.12 , pp. 374-379
    • Awasthi, G.1    Singh, S.2    Dash, A.P.3    Das, A.4
  • 36
    • 77956260871 scopus 로고    scopus 로고
    • TNF family members and malaria: Old observations, new insights and future directions
    • Randall LM, Engwerda CR (2010) TNF family members and malaria: old observations, new insights and future directions. Exp Parasitol 126:326-331
    • (2010) Exp Parasitol , vol.126 , pp. 326-331
    • Randall, L.M.1    Engwerda, C.R.2
  • 39
    • 77957660950 scopus 로고    scopus 로고
    • Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions
    • Jambou R, Combes V, Jambou MJ, Weksler BB, Couraud PO, Grau GE (2010) Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions. PLoS Pathog 29:e1001021
    • (2010) PLoS Pathog , vol.29
    • Jambou, R.1    Combes, V.2    Jambou, M.J.3    Weksler, B.B.4    Couraud, P.O.5    Grau, G.E.6
  • 42
    • 0036295560 scopus 로고    scopus 로고
    • The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier
    • Dietrich JB (2002) The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol 128:58-68
    • (2002) J Neuroimmunol , vol.128 , pp. 58-68
    • Dietrich, J.B.1
  • 44
    • 0026580223 scopus 로고
    • Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus
    • Ockenhouse CF, Betageri R, Springer TA, Staunton DE (1992) Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Cell 68:63-69
    • (1992) Cell , vol.68 , pp. 63-69
    • Ockenhouse, C.F.1    Betageri, R.2    Springer, T.A.3    Staunton, D.E.4
  • 46
    • 25644448837 scopus 로고    scopus 로고
    • Inhibition of endothelial activation: A new way to treat cerebral malaria?
    • Wassmer SC, Cianciolo GJ, Combes V, Grau GE (2005) Inhibition of endothelial activation: a new way to treat cerebral malaria? PLoS Med 2:e245
    • (2005) PLoS Med , vol.2
    • Wassmer, S.C.1    Cianciolo, G.J.2    Combes, V.3    Grau, G.E.4
  • 47
    • 0030842615 scopus 로고    scopus 로고
    • Expression of major histocompatibility complex antigens on mouse brain microvascular endothelial cells in relation to susceptibility to cerebral malaria
    • Monso-Hinard C, Lou JN, Behr C, Juillard P, Grau GE (1997) Expression of major histocompatibility complex antigens on mouse brain microvascular endothelial cells in relation to susceptibility to cerebral malaria. Immunology 92:53-59 (Pubitemid 27380881)
    • (1997) Immunology , vol.92 , Issue.1 , pp. 53-59
    • Monso-Hinard, C.1    Lou, J.N.2    Behr, C.3    Juillard, P.4    Grau, G.E.5
  • 48
    • 0034024232 scopus 로고    scopus 로고
    • Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria
    • Chen L, Zhang Z, Sendo F (2000) Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria. Clin Exp Immunol 120:125-133 (Pubitemid 30176909)
    • (2000) Clinical and Experimental Immunology , vol.120 , Issue.1 , pp. 125-133
    • Chen, L.1    Zhang, Z.-H.2    Sendo, F.3
  • 49
    • 0034950275 scopus 로고    scopus 로고
    • Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria
    • DOI 10.1016/S1383-5769(01)00063-0, PII S1383576901000630
    • Chen L, Sendo F (2001) Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria. Parasitol Int 50:139-143 (Pubitemid 32600949)
    • (2001) Parasitology International , vol.50 , Issue.2 , pp. 139-143
    • Chen, L.1    Sendo, F.2
  • 50
    • 0028281484 scopus 로고
    • Role of neutrophil-endothelial cell adhesion in inflammatory disorders
    • DOI 10.1016/0883-9441(94)90032-9
    • Korthuis RJ, Anderson DC, Granger DN (1994) Role of neutrophil- endothelial cell adhesion in inflammatory disorders. J Crit Care 9:47-71 (Pubitemid 24095050)
    • (1994) Journal of Critical Care , vol.9 , Issue.1 , pp. 47-71
    • Korthuis, R.J.1    Anderson, D.C.2    Granger, D.N.3
  • 51
    • 18844416133 scopus 로고    scopus 로고
    • + T cell proliferation
    • DOI 10.1016/j.jneuroim.2005.02.009, PII S0165572805000780
    • Pais TF, Chatterjee S (2005) Brain macrophage activation in murine cerebral malaria precedes accumulation of leukocytes and CD8+ T cell proliferation. J Neuroimmunol 163:73-83 (Pubitemid 40692950)
    • (2005) Journal of Neuroimmunology , vol.163 , Issue.1-2 , pp. 73-83
    • Pais, T.F.1    Chatterjee, S.2
  • 54
    • 0023099495 scopus 로고
    • Killing of Plasmodium falciparum by Eosinophil secretory products
    • Waters LS, Taverne J, Tai PC, Spry CJ, Targett GA, Playfair JH (1987) Killing of Plasmodium falciparum by eosinophil secretory products. Infect Immun 55:877-881 (Pubitemid 17035420)
    • (1987) Infection and Immunity , vol.55 , Issue.4 , pp. 877-881
    • Waters, L.S.1    Taverne, J.2    Tai, P.-C.3
  • 56
    • 0027077974 scopus 로고
    • The importance of T cell homing and the spleen in reaching a balance between malaria immunity and immunopathology: The moulding of immunity by early exposure to cross-reactive organisms
    • Good MF, Currier J (1992) The importance of T cell homing and the spleen in reaching a balance between malaria immunity and immunopathology: the moulding of immunity by early exposure to cross-reactive organisms. Immunol Cell Biol 70:405-410 (Pubitemid 23032827)
    • (1992) Immunology and Cell Biology , vol.70 , Issue.6 , pp. 405-410
    • Good, M.F.1    Currier, J.2
  • 59
    • 52449086058 scopus 로고    scopus 로고
    • Induction of blood brain barrier tight junction protein alterations by CD8 T cells
    • Suidan GL, Mcdole JR, Chen Y, Pirko I, Johnson AJ (2008) Induction of blood brain barrier tight junction protein alterations by CD8 T cells. PLoS ONE 22:e3037
    • (2008) PLoS ONE , vol.22
    • Suidan, G.L.1    Mcdole, J.R.2    Chen, Y.3    Pirko, I.4    Johnson, A.J.5
  • 60
    • 0031081063 scopus 로고    scopus 로고
    • Early activation of microglia in the pathogenesis of fatal murine cerebral malaria
    • DOI 10.1002/(SICI)1098-1136(199702)19:2<91::AID-GLIA1>3.0.CO;2-C
    • Medana IM, Hunt NH, Chan-Ling T (1997) Early activation of microglia in the pathogenesis of fatal murine cerebral malaria. Glia 19:91-103 (Pubitemid 27098815)
    • (1997) GLIA , vol.19 , Issue.2 , pp. 91-103
    • Medana, I.M.1    Hunt, N.H.2    Chan-Ling, T.3
  • 61
    • 0030984307 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: Evidence for production by microglia and astrocytes
    • Medana IM, Hunt NH, Chaudhri G (1997) Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes. Am J Pathol 150:1473-1486 (Pubitemid 27152664)
    • (1997) American Journal of Pathology , vol.150 , Issue.4 , pp. 1473-1486
    • Medana, I.M.1    Hunt, N.H.2    Chaudhri, G.3
  • 63
    • 0031012981 scopus 로고    scopus 로고
    • Resistance to cerebral malaria in tumor necrosis factor-alpha/beta- deficient mice is associated with a reduction of intercellular adhesion molecule-1 up- Regulation and T helper type 1 response
    • Rudin W, Eugster HP, Bordmann G, Bonato J, Müller M, Yamage M, Ryffel B (1997) Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am J Pathol 150(1):257-266 (Pubitemid 27027115)
    • (1997) American Journal of Pathology , vol.150 , Issue.1 , pp. 257-266
    • Rudin, W.1    Eugster, H.-P.2    Bordmann, G.3    Bonato, J.4    Muller, M.5    Yamage, M.6    Ryffel, B.7
  • 65
    • 33646584526 scopus 로고    scopus 로고
    • Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria
    • DOI 10.1016/j.ijpara.2005.12.005, PII S002075190500425X
    • Potter S, Chan-Ling T, Ball HJ, Mansour H, Mitchell A, Maluish L, Hunt NH (2006) Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol 36:485-496 (Pubitemid 43728781)
    • (2006) International Journal for Parasitology , vol.36 , Issue.4 , pp. 485-496
    • Potter, S.1    Chan-Ling, T.2    Ball, H.J.3    Mansour, H.4    Mitchell, A.5    Maluish, L.6    Hunt, N.H.7
  • 66
    • 29644445600 scopus 로고    scopus 로고
    • Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum
    • DOI 10.1128/IAI.74.1.645-653.2006
    • Wassmer SC, Combes V, Candal FJ, Juhan-Vague I, Grau GE (2006) Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infect Immun 74:645-653 (Pubitemid 43023120)
    • (2006) Infection and Immunity , vol.74 , Issue.1 , pp. 645-653
    • Wassmer, S.C.1    Combes, V.2    Candal, F.J.3    Juhan-Vague, I.4    Grau, G.E.5
  • 67
    • 77649221389 scopus 로고    scopus 로고
    • Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation
    • Couper KN, Barnes T, Hafalla JC, Combes V, Ryffel B, Secher T, Grau GE, Riley EM, de Souza JB (2010) Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. PLoS Pathog 29:e1000744
    • (2010) PLoS Pathog , vol.29
    • Couper, K.N.1    Barnes, T.2    Hafalla, J.C.3    Combes, V.4    Ryffel, B.5    Secher, T.6    Grau, G.E.7    Riley, E.M.8    De Souza, J.B.9
  • 70
    • 0037460705 scopus 로고    scopus 로고
    • Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production
    • DOI 10.1016/S0140-6736(03)12564-0
    • Lopansri BK, Anstey NM, Weinberg JB, Stoddard GJ, Hobbs MR, Levesque MC, Mwaikambo ED, Granger DL (2003) Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet 361:676-678 (Pubitemid 36246553)
    • (2003) Lancet , vol.361 , Issue.9358 , pp. 676-678
    • Lopansri, B.K.1    Anstey, N.M.2    Weinberg, J.B.3    Stoddard, G.J.4    Hobbs, M.R.5    Levesque, M.C.6    Mwaikambo, E.D.7    Granger, D.L.8
  • 71
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • DOI 10.1038/364626a0
    • Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, SingelDJ, Stamler JS (1993)Aredox-basedmechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364:626-632 (Pubitemid 23274719)
    • (1993) Nature , vol.364 , Issue.6438 , pp. 626-632
    • Lipton, S.A.1    Choi, Y.-B.2    Pan, Z.-H.3    Lei, S.Z.4    Chen, H.-S.V.5    Sucher, N.J.6    Loscalzo, J.7    Singel, D.J.8    Stamler, J.S.9
  • 73
    • 0033747107 scopus 로고    scopus 로고
    • Increased plasma levels of histidine and histamine in falciparum malaria: Relevance to severity of infection
    • Enwonwu CO, Afolabi BM, Salako LO, Idigbe EO, Bashirelah N (2000) Increased plasma levels of histidine and histamine in falciparum malaria: relevance to severity of infection. J Neural Transm 107:1273-1287
    • (2000) J Neural Transm , vol.107 , pp. 1273-1287
    • Enwonwu, C.O.1    Afolabi, B.M.2    Salako, L.O.3    Idigbe, E.O.4    Bashirelah, N.5
  • 74
    • 57749099137 scopus 로고    scopus 로고
    • Evidence of artemisinin-resistant malaria in Western Cambodia
    • Accessed 24 November 2010
    • Noedl H, Youry Se, Schaecher K, Smith BL, Socheat D, Fukuda MM (2008) Evidence of artemisinin-resistant malaria in Western Cambodia . N Engl J Med 359;24. www.nejm.org. http://content.nejm.org/cgi/reprint/359/24/2619.pdf. Accessed 24 November 2010
    • (2008) N Engl J Med , vol.359 , pp. 24
    • Noedl, H.1    Se, Y.2    Schaecher, K.3    Smith, B.L.4    Socheat, D.5    Fukuda, M.M.6
  • 75
    • 70349260815 scopus 로고    scopus 로고
    • Seventy-five years of Resochin® in the fight against malaria
    • Jensen M, Mehlhorn H (2009) Seventy-five years of Resochin® in the fight against malaria. Parasitol Res 105:609-627
    • (2009) Parasitol Res , vol.105 , pp. 609-627
    • Jensen, M.1    Mehlhorn, H.2
  • 76
    • 77949617633 scopus 로고    scopus 로고
    • WHO, Geneva Accessed 24 November 2010
    • WHO (2009) World malaria report 2009. WHO, Geneva. http://www.who.int/ malaria/world-malaria-report-2009/en/index.html. Accessed 24 November 2010
    • (2009) World Malaria Report 2009
  • 77
    • 12144260299 scopus 로고    scopus 로고
    • Routine anticonvulsants for treating cerebral malaria
    • CD002152
    • Meremikwu MM, Marson AG (2002) Routine anticonvulsants for treating cerebral malaria. Cochrane Database Syst Rev 2: CD002152
    • (2002) Cochrane Database Syst Rev , vol.2
    • Meremikwu, M.M.1    Marson, A.G.2
  • 78
    • 0025272890 scopus 로고
    • Treatment of malaria - 1990
    • Panisko DM, Keystone JS (1990) Treatment of malaria - 1990. Drugs 39:160-189 (Pubitemid 120032391)
    • (1990) Drugs , vol.39 , Issue.2 , pp. 160-189
    • Panisko, D.M.1    Keystone, J.S.2
  • 81
    • 0013561990 scopus 로고
    • Canadian recommendations for the prevention and treatment of malaria among international travellers
    • Committee to Advice on Tropical Medicine and Travel
    • Committee to Advice on Tropical Medicine and Travel (1995) Canadian recommendations for the prevention and treatment of malaria among international travellers. CCDR 21S3:1-18
    • (1995) CCDR , vol.21 S3 , pp. 1-18
  • 85
    • 34248169388 scopus 로고    scopus 로고
    • Immunomodulatory therapy associated to anti-parasite drugs as a way to prevent severe forms of malaria
    • Muniz-Junqueira MI (2007) Immunomodulatory therapy associated to anti-parasite drugs as a way to prevent severe forms of malaria. Curr Clin Pharmacol 2:59-73
    • (2007) Curr Clin Pharmacol , vol.2 , pp. 59-73
    • Muniz-Junqueira, M.I.1
  • 86
    • 33750634271 scopus 로고    scopus 로고
    • An edible vaccine for malaria using transgenic tomatoes of varying sizes, shapes and colors to carry different antigens
    • DOI 10.1016/j.mehy.2006.04.079, PII S0306987706005317
    • Chowdhury K, Bagasra O (2007) An edible vaccine for malaria using transgenic tomatoes of varying sizes, shapes and colors to carry different antigens. Med Hypotheses 68:22-30 (Pubitemid 44692051)
    • (2006) Medical Hypotheses , vol.68 , Issue.1 , pp. 22-30
    • Chowdhury, K.1    Bagasra, O.2
  • 87
    • 77953805104 scopus 로고    scopus 로고
    • Exploring novel targets for antimalarial drug discovery: Plasmodial protein kinases
    • Jirage D, Keenan SM, Waters NC (2010) Exploring novel targets for antimalarial drug discovery: plasmodial protein kinases. Infect Disord Drug Targets 10(3):134-146
    • (2010) Infect Disord Drug Targets , vol.10 , Issue.3 , pp. 134-146
    • Jirage, D.1    Keenan, S.M.2    Waters, N.C.3
  • 88
    • 77953857808 scopus 로고    scopus 로고
    • Targeting Plasmodium falciparum purine salvage enzymes: A look at structure-based drug development
    • Donaldson T, Kim K (2010) Targeting Plasmodium falciparum purine salvage enzymes: a look at structure-based drug development. Infect Disord Drug Targets 10(3):191-199
    • (2010) Infect Disord Drug Targets , vol.10 , Issue.3 , pp. 191-199
    • Donaldson, T.1    Kim, K.2
  • 90
    • 77954029768 scopus 로고    scopus 로고
    • Transporters as mediators of drug resistance in Plasmodium falciparum
    • doi:10.1016/j.ijpara.2010.04.001
    • Sanchez CP, Dave A, Stein WD, Lanzer M (2010) Transporters as mediators of drug resistance in Plasmodium falciparum. Int J Parasitol. doi:10.1016/j.ijpara.2010.04.001
    • (2010) Int J Parasitol
    • Sanchez, C.P.1    Dave, A.2    Stein, W.D.3    Lanzer, M.4
  • 91
    • 0003989708 scopus 로고    scopus 로고
    • World Health Organization, Geneva, 534 WHO/CDC/DRS/2001.4
    • Bloland PB (2001) Drug resistance in malaria. World Health Organization, Geneva, 534 WHO/CDC/DRS/2001.4
    • (2001) Drug Resistance in Malaria
    • Bloland, P.B.1
  • 93
    • 1642474428 scopus 로고    scopus 로고
    • History, Dynamics, and Public Health Importance of Malaria Parasite Resistance
    • DOI 10.1128/CMR.17.1.235-254.2004
    • Talisuna AO, Bloland P, D'Alessandro U (2004) History, dynamics, and public health importance of malaria parasite resistance. Clin Microbiol Rev 17:235-254 (Pubitemid 38120936)
    • (2004) Clinical Microbiology Reviews , vol.17 , Issue.1 , pp. 235-254
    • Talisuna, A.O.1    Bloland, P.2    D'Alessandro, U.3
  • 94
    • 33750000361 scopus 로고    scopus 로고
    • Malaria treatment failures after artemisinin-based therapy in three expatriates: Could improved manufacturer information help to decrease the risk of treatment failure?
    • doi:10.1186/1475-2875-5-81
    • Jackson Y, Chappuis F, Loutan L, Taylor W (2006) Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?Malar J 5:81. doi:10.1186/1475-2875-5-81
    • (2006) Malar J , vol.5 , pp. 81
    • Jackson, Y.1    Chappuis, F.2    Loutan, L.3    Taylor, W.4
  • 97
    • 34447568519 scopus 로고    scopus 로고
    • Cardiotoxicity of antimalarial drugs
    • White NJ (2007) Cardiotoxicity of antimalarial drugs. Lancet Infect Dis 7:549-558
    • (2007) Lancet Infect Dis , vol.7 , pp. 549-558
    • White, N.J.1
  • 98
    • 63249124480 scopus 로고    scopus 로고
    • Headache and malaria: A brief review
    • Wiwanitkit V (2009) Headache and malaria: a brief review. Acta Neurol Taiwan 18:56-59
    • (2009) Acta Neurol Taiwan , vol.18 , pp. 56-59
    • Wiwanitkit, V.1
  • 101
    • 0029866818 scopus 로고    scopus 로고
    • The safety of antimalarial drugs in pregnancy
    • Phillips-Howard PA, Wood D (1996) The safety of antimalarial drugs in pregnancy. Drug Saf 14:131-145 (Pubitemid 26086050)
    • (1996) Drug Safety , vol.14 , Issue.3 , pp. 131-145
    • Phillips-Howard, P.A.1    Wood, D.2
  • 103
    • 52449119596 scopus 로고    scopus 로고
    • Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion for acute malaria
    • Busari O, Busari O (2008) Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion for acute malaria. J Natl Med Assoc 100:1063-1065
    • (2008) J Natl Med Assoc , vol.100 , pp. 1063-1065
    • Busari, O.1    Busari, O.2
  • 104
    • 0018357503 scopus 로고
    • Extrapyramidal syndrome following chloroquine therapy
    • Singhi S, Singhi P, Singh M (1979) Extrapyramidal syndrome following chloroquine therapy. Indian J Pediatr 46:58-60 (Pubitemid 9201969)
    • (1979) Indian Journal of Pediatrics , vol.46 , Issue.373 , pp. 58-60
    • Singhi, S.1    Singhi, P.2    Singh, M.3
  • 105
    • 39249083840 scopus 로고    scopus 로고
    • Chorea in a 29-year-old Nigerian following antimalarial treatment with artesunate
    • Busari OA, Oligbu G (2008) Chorea in a 29-year-old Nigerian following antimalarial treatment with artesunate. Int J Infect Dis 12:221-223
    • (2008) Int J Infect Dis , vol.12 , pp. 221-223
    • Busari, O.A.1    Oligbu, G.2
  • 108
    • 58149187879 scopus 로고    scopus 로고
    • High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency
    • Fanello CI, Karema C, Avellino P, Bancone G, Uwimana A, Lee SJ, d'Alessandro U, Modiano D (2008) High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PLoS ONE 3:e4031
    • (2008) PLoS ONE , vol.3
    • Fanello, C.I.1    Karema, C.2    Avellino, P.3    Bancone, G.4    Uwimana, A.5    Lee, S.J.6    D'Alessandro, U.7    Modiano, D.8
  • 109
    • 0035319794 scopus 로고    scopus 로고
    • Effect of Intravenous Quinine on Capillary Glucose Levels in Malaria
    • Gupta GB, Varma S (2001) Effect of intravenous quinine on capillary glucose levels in malaria. J Assoc Physicians India 49:426-429 (Pubitemid 33641643)
    • (2001) Journal of Association of Physicians of India , vol.49 , Issue.APR , pp. 426-429
    • Gupta, G.B.1    Varma, S.2
  • 110
    • 0006946190 scopus 로고    scopus 로고
    • Neurotoxicity and artemisinin compounds do the observations in animals justify limitation of clinical use?
    • Dyan AD (1998) Neurotoxicity and artemisinin compounds do the observations in animals justify limitation of clinical use? Med Trop Mars 58:32-37
    • (1998) Med Trop Mars , vol.58 , pp. 32-37
    • Dyan, A.D.1
  • 115
    • 76449100708 scopus 로고    scopus 로고
    • PPARs: Diverse regulators in energy metabolism and metabolic diseases
    • Wang YX (2010) PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 20:124-137
    • (2010) Cell Res , vol.20 , pp. 124-137
    • Wang, Y.X.1
  • 116
    • 36049034344 scopus 로고    scopus 로고
    • Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms
    • DOI 10.1016/j.it.2007.09.003, PII S147149060700244X
    • Straus DS, Glass CK (2007) Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 28:551-558 (Pubitemid 350101420)
    • (2007) Trends in Immunology , vol.28 , Issue.12 , pp. 551-558
    • Straus, D.S.1    Glass, C.K.2
  • 117
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • DOI 10.1038/83336
    • Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM (2001) PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 7:48-52 (Pubitemid 32095641)
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 119
    • 27944505915 scopus 로고    scopus 로고
    • PPARs in diseases: Control mechanisms of inflammation
    • DOI 10.2174/092986705774462905
    • Kostadinova R, Wahli W, Michalik L (2005) PPARs in diseases: control mechanisms of inflammation. Curr Med Chem 12:2995-3009 (Pubitemid 41672488)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.25 , pp. 2995-3009
    • Kostadinova, R.1    Wahli, W.2    Michalik, L.3
  • 120
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • DOI 10.1146/annurev.med.53.082901.104018
    • Berger J, Moller DE (2002) The mechanisms of action of PPARs. Annu Rev Med 53:409-435 (Pubitemid 34177889)
    • (2002) Annual Review of Medicine , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 121
    • 28944432295 scopus 로고    scopus 로고
    • PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats
    • DOI 10.1007/s11064-005-8341-y
    • Gelinas DS, McLaurin J (2005) PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats. Neurochem Res 2005:1369-1375 (Pubitemid 41784472)
    • (2005) Neurochemical Research , vol.30 , Issue.11 , pp. 1369-1375
    • Gelinas, D.S.1    McLaurin, J.2
  • 122
    • 19544388947 scopus 로고    scopus 로고
    • PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia
    • DOI 10.1097/00001756-200505310-00010
    • Lee JH, Joe EH, Jou I (2005) PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia. NeuroReport 16:829-833 (Pubitemid 40733794)
    • (2005) NeuroReport , vol.16 , Issue.8 , pp. 829-833
    • Lee, J.H.1    Joe, E.-H.2    Jou, I.3
  • 123
    • 59649111988 scopus 로고    scopus 로고
    • PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury
    • Collino M, Patel NS, Thiemermann C (2005) PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury. Ther Adv Cardiovasc Dis 2:179-197
    • (2005) Ther Adv Cardiovasc Dis , vol.2 , pp. 179-197
    • Collino, M.1    Patel, N.S.2    Thiemermann, C.3
  • 124
    • 52049083897 scopus 로고    scopus 로고
    • Cortical expression of peroxisome proliferator-activated receptor-alpha after human brain contusion
    • Feng D, Zhang Y, Chen G (2008) Cortical expression of peroxisome proliferator-activated receptor-alpha after human brain contusion. J Int Med Res 36:783-791
    • (2008) J Int Med Res , vol.36 , pp. 783-791
    • Feng, D.1    Zhang, Y.2    Chen, G.3
  • 125
    • 27244452751 scopus 로고    scopus 로고
    • Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts neuroprotective effects in traumatic brain injury
    • DOI 10.1016/j.neulet.2005.06.019
    • Besson VC, Chen XR, Plotkine M, Marchand-Verrecchia C (2005) Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts europrotective effects in traumatic brain injury. Neurosci Lett 388:7-12 (Pubitemid 41569361)
    • (2005) Neuroscience Letters , vol.388 , Issue.1 , pp. 7-12
    • Besson, V.C.1    Chen, X.R.2    Plotkine, M.3    Marchand-Verrecchia, C.4
  • 126
    • 34547118091 scopus 로고    scopus 로고
    • Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury
    • DOI 10.1089/neu.2006.0216
    • Chen XR, Besson VC, Palmier B, Garcia Y, Plotkine M, Marchand-Leroux C (2007) Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. J Neurotrauma 24:1119-1131 (Pubitemid 47106286)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.7 , pp. 1119-1131
    • Chen, X.R.1    Besson, V.C.2    Palmier, B.3    Garcia, Y.4    Plotkine, M.5    Marchand-Leroux, C.6
  • 128
    • 72049114712 scopus 로고    scopus 로고
    • Activation of peroxisome proliferatoractivated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema
    • Morgenweck J, Abdel-Aleem OS, McNamara KC, Donahue RR, Badr MZ, Taylor BK Activation of peroxisome proliferatoractivated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. Neuropharmacology 58(2):337-345
    • Neuropharmacology , vol.58 , Issue.2 , pp. 337-345
    • Morgenweck, J.1    Abdel-Aleem, O.S.2    McNamara, K.C.3    Donahue, R.R.4    Badr, M.Z.5    Taylor, B.K.6
  • 129
    • 0035336185 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum- parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages
    • Serghides L, Kain KC (2001) Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. J Immunol 166:6742-6748 (Pubitemid 32467218)
    • (2001) Journal of Immunology , vol.166 , Issue.11 , pp. 6742-6748
    • Serghides, L.1    Kain, K.C.2
  • 131
    • 43049164121 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats
    • Sun H, Huang Y, Yu X, Li Y, Yang J, Li R, Deng Y, Zhao G (2008) Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. Int J Dev Neurosci 26:505-515
    • (2008) Int J Dev Neurosci , vol.26 , pp. 505-515
    • Sun, H.1    Huang, Y.2    Yu, X.3    Li, Y.4    Yang, J.5    Li, R.6    Deng, Y.7    Zhao, G.8
  • 132
    • 38449085356 scopus 로고    scopus 로고
    • Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists
    • DOI 10.2741/2802
    • Kapadia R, Yi JH, Vemuganti R (2008) Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 13:1813-1826 (Pubitemid 351599735)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.5 , pp. 1813-1826
    • Kapadia, R.1    Yi, J.-H.2    Vemuganti, R.3
  • 133
    • 16844374020 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats
    • DOI 10.1016/j.biopsych.2005.01.007
    • García-Bueno B, Madrigal JL, Lizasoain I, Moro MA, Lorenzo P, Leza JC (2005) Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Biol Psychiatry 57:885-894 (Pubitemid 40488357)
    • (2005) Biological Psychiatry , vol.57 , Issue.8 , pp. 885-894
    • Garcia-Bueno, B.1    Madrigal, J.L.M.2    Lizasoain, I.3    Moro, M.A.4    Lorenzo, P.5    Leza, J.C.6
  • 134
    • 70349671387 scopus 로고    scopus 로고
    • Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats
    • Wang CX, Ding X, Noor R, Pegg C, He C, Shuaib A (2009) Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats. J Cereb Blood Flow Metab 29:1683-1694
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1683-1694
    • Wang, C.X.1    Ding, X.2    Noor, R.3    Pegg, C.4    He, C.5    Shuaib, A.6
  • 135
    • 38449085356 scopus 로고    scopus 로고
    • Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists
    • DOI 10.2741/2802
    • Hyong A, Kapadia R, Yi JH, Vemuganti R (2008) Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 13:1813-1826 (Pubitemid 351599735)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.5 , pp. 1813-1826
    • Kapadia, R.1    Yi, J.-H.2    Vemuganti, R.3
  • 136
    • 44649087641 scopus 로고    scopus 로고
    • Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents
    • Hyong A, Jadhav V, Lee S, Tong W, Rowe J, Zhang JH, Tang J (2008) Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res 1215:218-224
    • (2008) Brain Res , vol.1215 , pp. 218-224
    • Hyong, A.1    Jadhav, V.2    Lee, S.3    Tong, W.4    Rowe, J.5    Zhang, J.H.6    Tang, J.7
  • 137
    • 44049097234 scopus 로고    scopus 로고
    • Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists
    • Bernardo A, Minghetti L (2008) Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists. PPAR Res 2008:864-140
    • (2008) PPAR Res , vol.2008 , pp. 864-1140
    • Bernardo, A.1    Minghetti, L.2
  • 139
    • 43949121783 scopus 로고    scopus 로고
    • PPAR-gamma, microglial cells, and ocular inflammation: New venues for potential therapeutic approaches
    • Malchiodi-Albedi F, Matteucci A, Bernardo A, Minghetti L (2008) PPAR-gamma, microglial cells, and ocular inflammation: new venues for potential therapeutic approaches. PPAR Res 2008:295-784
    • (2008) PPAR Res , vol.2008 , pp. 295-784
    • Malchiodi-Albedi, F.1    Matteucci, A.2    Bernardo, A.3    Minghetti, L.4
  • 140
    • 70049086389 scopus 로고    scopus 로고
    • Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: A randomized, double-blind, placebo-controlled trial
    • Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, Kain KC (2009) Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 49:841-849
    • (2009) Clin Infect Dis , vol.49 , pp. 841-849
    • Boggild, A.K.1    Krudsood, S.2    Patel, S.N.3    Serghides, L.4    Tangpukdee, N.5    Katz, K.6    Wilairatana, P.7    Liles, W.C.8    Looareesuwan, S.9    Kain, K.C.10
  • 141
    • 68249152624 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells
    • Bernardo A, Bianchi D, Magnaghi V, Minghetti L (2009) Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. J Neuropathol Exp Neurol 68:97-808
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 97-808
    • Bernardo, A.1    Bianchi, D.2    Magnaghi, V.3    Minghetti, L.4
  • 142
    • 33744994576 scopus 로고    scopus 로고
    • PPARgamma as a therapeutic target in central nervous system diseases
    • DOI 10.1016/j.neuint.2006.03.020, PII S019701860600163X, Molecular Mechanisms of Neuroinflammation
    • Sundararajan S, Jiang Q, Heneka M, Landreth G (2006) PPARgamma as a therapeutic target in central nervous system diseases. Neurochem Int 49:136-144 (Pubitemid 43867071)
    • (2006) Neurochemistry International , vol.49 , Issue.2 , pp. 136-144
    • Sundararajan, S.1    Jiang, Q.2    Heneka, M.3    Landreth, G.4
  • 143
    • 70349499011 scopus 로고    scopus 로고
    • Modulation of transcription by the peroxisome proliferator-activated receptor β/γ-binding RNA aptamer in colon cancer cells
    • Kwak H, Hwang I, Kim JH, Kim MY, Yang JS, Jeong S (2009) Modulation of transcription by the peroxisome proliferator-activated receptor β/γ-binding RNA aptamer in colon cancer cells. Mol Cancer Ther 8:2664-2673
    • (2009) Mol Cancer Ther , vol.8 , pp. 2664-2673
    • Kwak, H.1    Hwang, I.2    Kim, J.H.3    Kim, M.Y.4    Yang, J.S.5    Jeong, S.6
  • 147
    • 33744519163 scopus 로고    scopus 로고
    • PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    • DOI 10.1016/j.yjmcc.2006.03.422, PII S0022282806000873
    • Ding G, Cheng L, Qin Q, Frontin S, Yang Q (2006) PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol 40:821-828 (Pubitemid 43817042)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.40 , Issue.6 , pp. 821-828
    • Ding, G.1    Cheng, L.2    Qin, Q.3    Frontin, S.4    Yang, Q.5
  • 148
    • 9144251051 scopus 로고    scopus 로고
    • Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression
    • DOI 10.1038/sj.emboj.7600437
    • Tan NS, Michalik L, Di-Poï N, Ng CY, Mermod N, Roberts AB, Desvergne B, Wahli W (2004) Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. EMBO J 23:4211-4221 (Pubitemid 39546159)
    • (2004) EMBO Journal , vol.23 , Issue.21 , pp. 4211-4221
    • Tan, N.S.1    Michalik, L.2    Di-Poi, N.3    Ng, C.Y.4    Mermod, N.5    Roberts, A.B.6    Desvergne, B.7    Wahli, W.8
  • 150
    • 70249113348 scopus 로고    scopus 로고
    • A PPAR β/δ agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease
    • Kalinin S, Richardson JC, Feinstein DL (2009) A PPAR β/δ agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res 6:431-437
    • (2009) Curr Alzheimer Res , vol.6 , pp. 431-437
    • Kalinin, S.1    Richardson, J.C.2    Feinstein, D.L.3
  • 152
    • 66449124004 scopus 로고    scopus 로고
    • Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
    • Defaux A, Zurich MG, Braissant O, Honegger P, Monnet-Tschudi F (2009) Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. J Neuroinflammation 7:6-15
    • (2009) J Neuroinflammation , vol.7 , pp. 6-15
    • Defaux, A.1    Zurich, M.G.2    Braissant, O.3    Honegger, P.4    Monnet-Tschudi, F.5
  • 153
    • 50949105881 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor â/ä inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2
    • Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M (2008) Activation of peroxisome proliferator-activated receptor â/ä inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. Diabetes 57:2149-2157
    • (2008) Diabetes , vol.57 , pp. 2149-2157
    • Rodríguez-Calvo, R.1    Serrano, L.2    Coll, T.3    Moullan, N.4    Sánchez, R.M.5    Merlos, M.6    Palomer, X.7    Laguna, J.C.8    Michalik, L.9    Wahli, W.10    Vázquez- Carrera, M.11
  • 154
    • 77950530988 scopus 로고    scopus 로고
    • Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated
    • Tripathi AK, Sha W, Shulaev V, Stins MF, Sullivan DJ Jr (2009) Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium. Blood 114:4243-4252
    • (2009) Blood , vol.114 , pp. 4243-4252
    • Tripathi, A.K.1    Sha, W.2    Shulaev, V.3    Stins, M.F.4    Sullivan Jr., D.J.5
  • 155
    • 70349849654 scopus 로고    scopus 로고
    • PPARdelta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- Mice
    • Lim HJ, Park JH, Lee S, Choi HE, Lee KS, Park HY (2009) PPARdelta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice. Eur J Pharmacol 622:45-51
    • (2009) Eur J Pharmacol , vol.622 , pp. 45-51
    • Lim, H.J.1    Park, J.H.2    Lee, S.3    Choi, H.E.4    Lee, K.S.5    Park, H.Y.6
  • 156
    • 39749176168 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor ̂/̈ activation improves angiotensin II-induced cardiac hypertrophy in vitro
    • DOI 10.1080/10641960801945840, PII 790775260
    • Sheng L, Ye P, Liu YX, Han CG, Zhang ZY (2008) Peroxisome proliferator-activated receptor â/ä activation improves angiotensin II-induced cardiac hypertrophy in vitro. Clin Exp Hypertens 30:109-119 (Pubitemid 351302225)
    • (2008) Clinical and Experimental Hypertension , vol.30 , Issue.2 , pp. 109-119
    • Sheng, L.1    Ye, P.2    Liu, Y.-X.3    Han, C.-G.4    Zhang, Z.-Y.5
  • 157
    • 77954496807 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis
    • Kanakasabai S, Chearwae W, Walline CC, Iams W, Adams SM, Bright JJ (2010) Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis. Immunology 130 (4):572-588
    • (2010) Immunology , vol.130 , Issue.4 , pp. 572-588
    • Kanakasabai, S.1    Chearwae, W.2    Walline, C.C.3    Iams, W.4    Adams, S.M.5    Bright, J.J.6
  • 159
    • 70450200765 scopus 로고    scopus 로고
    • PPAR delta-mediated macrophage activation: A matter of fat
    • Schug TT, Li X (2009) PPAR delta-mediated macrophage activation: a matter of fat. Dis Model Mech 10:421-422
    • (2009) Dis Model Mech , vol.10 , pp. 421-422
    • Schug, T.T.1    Li, X.2
  • 162
    • 67949095966 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta} 1/Smad3
    • Kim HJ, Kim MY, Jin H, Kim HJ, Kang SS, Kim HJ, Lee JH, Chang KC, Hwang JY, Yabe-Nishimura C, Kim JH, Seo HG (2009) Peroxisome proliferator-activated receptor delta regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta} 1/Smad3. Circ Res 105:16-24
    • (2009) Circ Res , vol.105 , pp. 16-24
    • Kim, H.J.1    Kim, M.Y.2    Jin, H.3    Kim, H.J.4    Kang, S.S.5    Kim, H.J.6    Lee, J.H.7    Chang, K.C.8    Hwang, J.Y.9    Yabe-Nishimura, C.10    Kim, J.H.11    Seo, H.G.12
  • 165
  • 167
    • 51849123779 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor β/δ (PPARβ/γ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression
    • Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM (2008) Ligand activation of peroxisome proliferator-activated receptor β/δ (PPARβ/γ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci 105:418-428
    • (2008) Toxicol Sci , vol.105 , pp. 418-428
    • Shan, W.1    Palkar, P.S.2    Murray, I.A.3    McDevitt, E.I.4    Kennett, M.J.5    Kang, B.H.6    Isom, H.C.7    Perdew, G.H.8    Gonzalez, F.J.9    Peters, J.M.10
  • 168
    • 77749237175 scopus 로고    scopus 로고
    • Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
    • Cabrales P, Zanini GM, Meays D, Frangos JA, Carvalho LJ (2010) Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. Am J Pathol 176:1306-1315
    • (2010) Am J Pathol , vol.176 , pp. 1306-1315
    • Cabrales, P.1    Zanini, G.M.2    Meays, D.3    Frangos, J.A.4    Carvalho, L.J.5
  • 169
    • 55949111070 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor /β/δ in the brain: Facts and hypothesis
    • Hall MG, Quignodon L, Desvergne B (2008) Peroxisome proliferator- activated receptor /β/δ in the brain: facts and hypothesis. PPAR Res 2008(2008):780452
    • (2008) PPAR Res , vol.2008 , Issue.2008 , pp. 780452
    • Hall, M.G.1    Quignodon, L.2    Desvergne, B.3
  • 170
    • 77449141973 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) /β/δ: A new potential therapeutic target for the treatment of metabolic syndrome
    • Coll T, Rodrïguez-Calvo R, Barroso E, Serrano L, Eyre E, Palomer X, Vázquez-Carrera M (2009) Peroxisome proliferator-activated receptor (PPAR) /β/δ: a new potential therapeutic target for the treatment of metabolic syndrome. Curr Mol Pharmacol 2:46-55
    • (2009) Curr Mol Pharmacol , vol.2 , pp. 46-55
    • Coll, T.1    Rodrïguez-Calvo, R.2    Barroso, E.3    Serrano, L.4    Eyre, E.5    Palomer, X.6    Vázquez-Carrera, M.7
  • 171
    • 18944390448 scopus 로고    scopus 로고
    • PPARalpha activators may be good candidates as anti-aging agents
    • Erol A (2005) PPARalpha activators may be good candidates as anti-aging agents. Med Hypotheses 65:35-38
    • (2005) Med Hypotheses , vol.65 , pp. 35-38
    • Erol, A.1
  • 172
    • 67651154149 scopus 로고    scopus 로고
    • The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome
    • Huang TH, Teoh AW, Lin BL, Lin DS, Roufogalis B (2009) The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome. Pharmacol Res 60:195-206
    • (2009) Pharmacol Res , vol.60 , pp. 195-206
    • Huang, T.H.1    Teoh, A.W.2    Lin, B.L.3    Lin, D.S.4    Roufogalis, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.