Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: A randomized trial

Malaria Journal

Volumn 7, Issue , 2008, Pages

  Gürkov, Robert ^a   Eshetu, Teferi ^a,b   Miranda, Isabel Barreto ^a   Berens Riha, Nicole ^a   Mamo, Yoseph ^b   Girma, Tsinuel ^b   Krause, Eike ^a   Schmidt, Michael ^a   Hempel, John Martin ^a   Löscher, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JIMMA UNIVERSITY   (Ethiopia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ATOVAQUONE PLUS PROGUANIL; QUININE; ARTEMETHER; ARTEMISININ DERIVATIVE; ATOVAQUONE; BENFLUMETOL; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; PROGUANIL;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANOREXIA; ARTHRALGIA; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIARRHEA; DISTORTION PRODUCT OTOACOUSTIC EMISSION; DRUG EFFICACY; DRUG TOLERABILITY; EVOKED BRAIN STEM RESPONSE; FEMALE; FEVER; FOLLOW UP; HEADACHE; HEARING LOSS; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MYALGIA; NAUSEA; NYSTAGMUS; OTOTOXICITY; PURE TONE AUDIOMETRY; RANDOMIZED CONTROLLED TRIAL; SHIVERING; THORAX PAIN; TINNITUS; VERTIGO; VOMITING; AUDIOMETRY; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; ETHIOPIA; MIDDLE AGED; PERCEPTION DEAFNESS;

ADOLESCENT; ADULT; ARTEMISININS; ATOVAQUONE; AUDIOMETRY; CHILD; CHLOROGUANIDE; ETHANOLAMINES; ETHIOPIA; FEMALE; FLUORENES; HEARING LOSS, SENSORINEURAL; HUMANS; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; QUININE;

EID: 53249086183     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-7-179     Document Type: Article

References (34)

1. Antimalarial treatment policies for P. falciparum and P. vivaxby country in WHO Africa region. P Olumese, Anti-Malarial Drug Policies: AFRO Global AMDP Database 2007 http://www.who.int/malaria/amdp/amdp_afro.htm 17356587
2. Guidelines for the treatment of malaria (NLM classification: WC 770). World Health Organization (WHO), 2007 http://www.who.int/malaria/docs/ TreatmentGuidelines2006.pdf
3. Ataxia and slurred speech after artesunate treatment for falciparum malaria. LG Miller CB Panosian, N Engl J Med 1997 336 1328 10.1056/ NEJM199705013361818 9132599
4. Neurotoxicity of artemisinin: possible counseling and treatment of side effects. Z Elias E Bonnet B Marchou P Massip, Clin Infect Dis 1999 28 1330 1331 10.1086/517789 10451183
5. Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether. S Toovey A Jamieson, Trans R Soc Trop Med Hyg 2004 98 261 267 10.1016/j.trstmh.2003.11.001 15109547
6. Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. R Price M van Vugt L Phaipun C Luxemburger J Simpson R McGready F ter Kuile A Kham T Chongsuphajaisiddhi NJ White F Nosten, Am J Trop Med Hyg 1999 60 547 555 10348227
7. A case-control auditory evaluation of patients treated with artemether-lumefantrine. R Hutagalung H Htoo P Nwee J Arunkamomkiri J Zwang VI Carrara E Ashley P Singhasivanon NJ White F Nosten, Am J Trop Med Hyg 2006 74 211 214 16474072
8. Clinical and neurophysiological study of the effects of multiple doses of artemisinin on brain-stem function in Vietnamese patients. E Kissinger TT Hien NT Hung ND Nam NL Tuyen BV Dinh C Mann NH Phu PP Loc JA Simpson NJ White JJ Farrar, Am J Trop Med Hyg 2000 63 48 55 11357994
9. A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria. M van Vugt BJ Angus RN Price C Mann JA Simpson C Poletto SE Htoo S Looareesuwan NJ White F Nosten, Am J Trop Med Hyg 2000 62 65 69 10761725
10. Chloroquine ototoxicity. R Bortoli M Santiago, Clin Rheumatol 2007 26 1809 1810 10.1007/s10067-007-0662-6 17594118
11. Mefloquine and ototoxicity: a report of 3 cases. M Fusetti A Eibenstein V Corridore S Hueck S Chiti-Batelli, Clin Ter 1999 150 379 382 10687269
12. Clinical and experimental histological studies on effects of salicylate and quinine on the ear. J Falbe-Hansen, Acta otolaryngologica 1941 44 1 216
13. Mapping Malaria Risk in the Highlands of Africa. J Cox M Craig D Le Sueur B Sharp, MARA/HIMAL Technical Report 1999 http://www.lshtm.ac.uk/dcvbu/himal/ Documents/HIMALReport.pdf
14. Malaria diagnosis and treatment guidelines for health workers in Ethiopia. Federal Democratic Republic of Ethiopia MoHAAE, 2 2007
15. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster, Trans R Soc Trop Med Hyg 2000 94 Suppl 1 S1 90 10.1016/S0035-9203(00)90300-6 11103309
16. A clinical sign of canal paresis. GM Halmagyi IS Curthoys, Arch Neurol 1988 45 737 739 3390028
17. Pure-tone threshold estimation from extrapolated distortion product otoacoustic emission I/O-functions in normal and cochlear hearing loss ears. P Boege T Janssen, J Acoust Soc Am 2002 111 1810 1818 10.1121/1.1460923 12002865
18. Weighted DPOAE input/output-functions: a tool for automatic assessment of hearing loss in clinical application. JA Oswald T Janssen, Z Med Phys 2003 13 93 98 12868334
19. Determination of genetic variation within Plasmodium falciparumby using enzymatically amplified DNA from filter paper disks impregnated with whole blood. KC Kain DE Lanar, J Clin Microbiol 1991 29 1171 1174 1864936
20. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. G Snounou S Viriyakosol XP Zhu W Jarra L Pinheiro VE do Rosario S Thaithong KN Brown, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
21. The use of PCR genotyping in the assessment of recrudescence or reinfection after antimalarial drug treatment. G Snounou HP Beck, Parasitol Today 1998 14 462 467 10.1016/S0169-4758(98)01340-4 17040849
22. Plasmodium falciparum: extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea. I Felger L Tavul S Kabintik V Marshall B Genton M Alpers HP Beck, Exp Parasitol 1994 79 106 116 10.1006/expr.1994.1070 7914494
23. Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness. K Mugittu M Adjuik G Snounou F Ntoumi W Taylor H Mshinda P Olliaro HP Beck, Trop Med Int Health 2006 11 1350 1359 10.1111/j.1365-3156.2006.01688.x 16930256
24. Guidelines for the audiologic management of individuals receiving cochleotoxic drug therapy. American Speech-Language-Hearing Association, ASHA 1994 36 suppl 12 11 19
25. JW Hall III, Handbook of Auditory Evoked Responses Allyn & Bacon 1992
26. Effects of weight, age, and time on artemether-lumefantrine associated ototoxicity and evidence of irreversibility. S Toovey, Travel Med Infect Dis 2006 4 71 76 10.1016/j.tmaid.2005.02.003 16887727
27. Are currently deployed artemisinins neurotoxic? S Toovey, Toxicol Lett 2006 166 95 104 10.1016/j.toxlet.2006.06.001 16828992
28. Artemisinin derivatives: toxic for laboratory animals, safe for humans? T Gordi EI Lepist, Toxicol Lett 2004 147 99 107 10.1016/j.toxlet.2003.12.009 14757313
29. Neuropathological assessment of artemether-treated severe malaria. TT Hien GD Turner NT Mai NH Phu D Bethell WF Blakemore JB Cavanagh A Dayan I Medana RO Weller NP Day NJ White, Lancet 2003 362 295 296 10.1016/S0140-6736(03)13974- 8 12892962
30. Neurotoxic mode of action of artemisinin. G Schmuck E Roehrdanz RK Haynes R Kahl, Antimicrob Agents Chemother 2002 46 821 827 11850267 10.1128/AAC.46.3.821-827.2002
31. No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria. MB McCall AJ Beynon EA Mylanus AJ van der Ven RW Sauerwein, Trans R Soc Trop Med Hyg 2006 100 1098 1104 10.1016/j.trstmh.2006. 02.017 16808940
32. Further observations concerning the toxic effects of streptomycin and quinine on the auditory organ of guinea pigs. L Ruedi W Furrer F Lüthy G Nager B Tschirren, Laryngoscope 1952 62 333 351 10.1288/00005537-195204000-00001 14928708
33. The influence of exercise-induced temperature elevations on the auditory brain-stem response (ABR). CJ Thomas JD Jones PD Scott ME Rosenberg, Clin Otolaryngol Allied Sci 1991 16 138 141 10.1111/j.1365-2273.1991.tb01962.x 2070528
34. [Effect of body temperature changes on evoked potentials]. H Tachibana M Takeda M Sugita J Kondo M Miyauchi A Matsuoka, Rinsho Byori 1990 38 1383 1386 Japanese 2082039