Modulation of transcription by the peroxisome proliferator-activated receptor δ-binding RNA aptamer in colon cancer cells

Molecular Cancer Therapeutics

Volumn 8, Issue 9, 2009, Pages 2664-2673

  Kwak, Hoyun ^a   Hwang, Injoo ^a   Jee, Ho Kim ^a   Mee, Young Kim ^a   Ji, Sun Yang ^a   Jeong, Sunjoo ^a  

^a Dankook University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; CYCLOOXYGENASE 2; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; VASCULOTROPIN A;

ARTICLE; CANCER CELL CULTURE; COLON ADENOCARCINOMA; COLON CARCINOGENESIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REPORTER GENE; RNA BINDING; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR PROMOTION;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BETA CATENIN; CELL PROLIFERATION; CLONING, MOLECULAR; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DNA PRIMERS; HCT116 CELLS; HUMANS; PPAR DELTA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70349499011     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0214     Document Type: Article

References (42)

1. Wang D, Dubois RN. Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res 2008;2008:931074. (Pubitemid 351842211)
2. Wang D, Dubois RN. Inflammatory mediators and nuclear receptor signaling in colorectal cancer. Cell Cycle 2007;6:682-685 (Pubitemid 46535680)
3. Michalik L, Desvergne B, Wahli W. Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer 2004;4:61-70. (Pubitemid 38082154)
4. Park BH, Vogelstein B, Kinzler KW. Genetic disruption of PPAR decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci U S A 2001;98:2598-2603 (Pubitemid 32209528)
5. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor accelerates intestinal adenoma growth. Nat Med 2004;10:245-247 (Pubitemid 38667613)
6. Park BH, Breyer B, He TC. Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer. Curr Opin Oncol 2001;13:78-83. (Pubitemid 32060049)
7. He TC, Chan TA, Vogelstein B, Kinzler KW. PPAR-δ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999;99:335-345 (Pubitemid 29519912)
8. Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/β-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 2005;26:898-915.
9. Han C, Lim K, Xu L, Li G, Wu T. Regulation of Wnt/β-catenin pathway by cPLA2́ and PPARδ. J Cell Biochem 2008;105:534-545
10. Buchanan FG, DuBois RN. Connecting COX-2 and Wnt in cancer. Cancer Cell 2006;9:6-8.
11. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkindn JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin- β-catenin signaling axis. Science 2005;310:1504-1510
12. Wang D, Wang H, Shi Q, et al. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ. Cancer Cell 2004;6:285-295
13. Xu L, Han C, Lim K, Wu T. Cross-talk between peroxisome proliferator-activated receptor δ and cytosolic phospholipase A2́/cyclooxygenase-2/prostaglandin E2 signaling pathways in human hepatocellular carcinoma cells. Cancer Res 2006;66:11859-11868 (Pubitemid 46094198)
14. 2 signaling pathways for human cholangiocarcinoma cell growth. J Biol Chem 2006;281:33982-33996
15. Gupta RA, Tan J, Krause WF, et al. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer. Proc Natl Acad Sci U S A 2000;97:13275-13280
16. Glinghammar B, Skogsberg J, Hamsten A, Ehrenborg E. PPARδ activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2003;308:361-368 (Pubitemid 36937188)
17. Wang D, Wang H, Guo Y, et al. Crosstalk between peroxisome proliferator-activated receptor δ and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 2006;103:19069-19074 (Pubitemid 350002829)
18. von Rahden BHA., Stein H.J., Pühringer F, et al. Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. Cancer Res 2005;65:5038-5044 (Pubitemid 40827311)
19. +/min mice. Proc Natl Acad Sci U S A 2007;104:10625-10630
20. Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 2000;61:6050-6054 (Pubitemid 32762538)
21. Easwaran V, Lee SH, Inge L, et al. β-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 2003;63:3145-3153 (Pubitemid 36735866)
22. Barak Y, Liao D, He W, et al. Effects of peroxisome proliferator- activated receptor δ on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 2002;99:303-308 (Pubitemid 34060358)
23. Harman FS, Nicol CJ, Marin HE, Ward JM, Gonzalez FJ, Peters JM. Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis. Nat Med 2004;10:481-483 (Pubitemid 38667905)
24. Reed KR, Sansom OJ, Hayes AJ, et al. PPARd status and Apc-mediated tumorigenesis in the mouse intestine. Oncogene 2004;23:8992-8996
25. Choi KH, Park MW, Lee SY, et al. Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. Mol Cancer Ther 2006;5:2428-2434
26. Lee HK, Choi YS, Park YA, Jeong S. Modulation of oncogenic transcription and alternative splicing by β-catenin and an RNA aptamer in colon cancer cells. Cancer Res 2006;66:10560-10566 (Pubitemid 44799779)
27. Saunders MA, Sansores-Garcia L, Gilroy DW, Wu KK. Selective suppression of CCAAT/enhancer-binding protein β binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem 2001;276:18897-18904 (Pubitemid 37411209)
28. Kwon HS, Shin HC, Kim JS. Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels. Nucleic Acids Res 2005;33:e74.
29. Kim MY, Jeong S. Inhibition of the functions of the nucleocapsid protein of human immunodeficiency virus-1 by an RNA aptamer. Biochem Biophys Res Commun 2004;320:1181-1186 (Pubitemid 38916668)
30. Park MW, Choi KH, Jeong S. Inhibition of the DNA binding by the TCF-1 binding RNA aptamer. Biochem Biophys Res Commun 2005;330:11-17 (Pubitemid 40403023)
31. Lee HK, Kwak HY, Hur J, et al. β-Catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. Cancer Res 2007;67:9315-9321 (Pubitemid 47535920)
32. Michalik L, Desvergne B, Wahli W. Peroxisome proliferator-activated receptors β/δ: emerging roles for a previously neglected third family member. Curr Opin Lipidol 2003;14:129-135
33. Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B. Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002;10:721-733 (Pubitemid 35335629)
34. Piqueras L, Reynolds AR, Hodivala-Dilke KM, et al. Activation of PPARβ/δ induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol 2007;27:63-69 (Pubitemid 46370477)
35. Stephen RL, Gustafsson MCU, Jarvis M, et al. Activation of peroxisome proliferator-activated receptor δ stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Res 2004;64:3162-3170 (Pubitemid 38581418)
36. Zeng L, Geng Y, Tretiakova M, Yu X, Sicinski P, Kroll TG. Peroxisome proliferator-activated receptor-δ induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Res 2008;68:6578-6586
37. Martinasso G, Oraldi M, Trombetta A, et al. Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines. PPAR Res 2007;2007:93416. (Pubitemid 46609369)
38. Hollingshead HE, Killins RL, Borland MG, et al. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis 2007;28:2641-2649
39. Kim DJ, Bility MT, Billin AN, Willson TM, Gonzalez FJ, Peters JM. PPARβ/δ selectively induces differentiation and inhibits cell proliferation. Cell Death Differ 2006;13:53-60.
40. Shureiqi I, Jiang W, Zuo X, et al. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A 2003;100:9968-9973 (Pubitemid 37087052)
41. Borland MG, Foreman JE, Girroir EE, et al. Ligand activation of peroxisome proliferator-activated receptor-β/δ inhibits cell proliferation in human HaCaT keratinocytes. Mol Pharmacol 2008;74:1429-1442
42. Handeli S, Simon JA. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPAR δ activities. Mol Cancer Ther 2008;7:521-529