The guanylhydrazone CNI-1493: An inhibitor with dual activity against malaria - Inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

Parasitology Research

Volumn 102, Issue 6, 2008, Pages 1177-1184

  Specht, Sabine ^a   Sarite, Salem Ramadan ^a   Hauber, Ilona ^b   Hauber, Joachim ^b   Görbig, Ulf F ^c   Meier, Chris ^c   Bevec, Dorian ^d   Hoerauf, Achim ^a   Kaiser, Annette ^a,e  

^a UNIVERSITY OF BONN   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d mondoBIOTECH   (Switzerland)

^e BONN RHEIN SIEG UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; DEOXYHYPUSINE SYNTHASE; HYPUSINE; SEMAPIMOD; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN MALARIA; CATALYSIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG INHIBITION; HOST CELL; IC 50; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN PROCESSING;

ANIMALS; ANTIMALARIALS; ENZYME INHIBITORS; HYDRAZONES; INHIBITORY CONCENTRATION 50; MALARIA; MICE; MICE, INBRED C57BL; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EUKARYOTA; MUS; PLASMODIUM (APICOMPLEXA); PLASMODIUM BERGHEI;

EID: 42049114073     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-008-0891-x     Document Type: Article

References (29)

1. Atkins MB, Redman B, Mier J, Gollob J, Weber J, Sosman J, MacPherson BL, Plasse T (2001) A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma. Clin Cancer Res 7:486-492
2. Bevec D, Jaschke H Oft M, Wöhl T, Himmelspach M, Pacher A, Schebesta M, Koettnitz K, Drobovnok M, Csonga R, Lottspeich F Hauber J (1996) Inhibition of HIV-1 Replication in lymphocytes by mutants of Rev cofactor eIF-5a. Science 271:1858-1860
3. Bianchi M, Bloom O, Raabe T, Cohen PS, Chesney J, Sherry B, Schmidtmaverova H, Calandra T, Zhang X, Bukrinsky M, Ulrich P, Cerami A, Tracey KJ (1996) Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 183:927-936
4. Caraglia M, Marra M, Giuberti G, D' Alessandro AM Baldi A, Tassone P, Venuta S, Tagliaferri P, Abbruzzese A (2003) The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-a and EGF in human cancer cells. J Biochem 133:757-765
5. Clark IA, Budd AC, Alleva LM, Cowden WB (2006) Human malarial disease: a consequence of inflammatory cytokine release. Malaria J 5:85
6. Cohen PS, Nakashtri H, Dennis J, Caragine T, Bianchi M, Cerami A, Tracey KJ (1996) CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. PNAS 93:3967-3971
7. Danese S, Semeraro S, Armuzzi A, Papa A, Gasbarrini A (2006) Biological therapies for inflammatory bowel disease: research drives clinics. Mini Rev Med Chem 6:771-784
8. Gimenez F, Barraud de Lagerie S, Fernandez C, Pino P, Mazier D (2003) Tumor necrosis factor alpha in the pathogenesis of cerebral malaria. Cell Mol Life Scien 60:1623-1635
9. Haider N, Eschbach ML, Dias Sde S, Gilberger TW, Walter RD, Luersen K (2005) The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterization of the polyamine synthesis enzyme. Mol Biochem Parasitol 142:224-236
10. Hauber I, Bevec D, Heukeshoven J, Kratzer F, Hom F, Choidas A, Harrer T, Hauber J (2005) Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. J Clin Invest 115:76-85
11. Kaiser A, Gottwald A, Maier W, Seitz HM (2003) Targeting enzymes involved in spermidine metabolism of parasitic protozoa-a possible new strategy for anti-parasitic treatment. Parasitol Research 91:508-516
12. Kaiser A, Hammels I, Gottwald A, Nassar M, Zaghloul MS, Motaal BA, Hauber J, Hoerauf A (2007) Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium faciparum: an enzyme with dual enzymatic properties. Bioorg Biomed Chem 15:6200-6207
13. Löwenberg M, Verhaar A, Van den Blink B, Ten Kate F, Van Deventer S, Peppelenbosch M, Hommes D (2005) Specific inhibition of c-Raf activity by semapimod induces remission in severe Crohn's disease. J Immun 175:2293-3000
14. Lou J, Lucas R, Grau GE (2001) Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clin Microbiol Rev 14:810-820
15. Lucas R, Juillard P, Decoster E, Redard M, Burger D Donati Y, Giroud C, Monso-Hinard C, De Kesel T, Buurman WA, Moore MW, Dayer JM, Fiers W, Bluethmann H, Grau GE (1997) Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. Eur J Immunol 27:1719-1725
16. Molony MB, Pawluk AR, Ackland NR (1990) Plasmodium falciparum growth in deep culture. Trans R Soc Trop Med Hyg 84:516-518
17. Müller S, Da'dara A, Lürsen K, Wrenger C, Das Gupta R, Madhubala R, Walter RD (2000) In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase. J Biol Chem 275:8097-8102
18. Njuguna JT, Nassar M, Hoerauf A, Kaiser AE (2006) Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax. BMC Microbiol 16:91-98
19. Park MH (2006) The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic initiation factor 5A (eIF5A). J Biochem 139:1-9
20. Sasaki K, Abid MR, Miazaki M (1997) Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae. FEBS Lett 121:769-778
21. Schütz S, Chemnitz J, Spillner C, Frohme M, Hauber J, Kehlenbach RH (2006) Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway. J Mol Biol 358:997-1009
22. Sitaraman SV, Hoteit M, Gewirtz AT (2003) CNI-1493. Curr Opin Investig Drugs 11:1363-1368
23. Schofield L, Grau GE (2005) Immunological Processes in malaria pathogenesis. Nature Rev Immun 5:722-735
24. Sommer MN, Bevec D, Klebl B, Flicke B, Holscher K, Freudenreich T, Hauber I, Hauber J, Mett H (2004) Screening assay for the identification of deoxyhypusine synthase inhibitors. J Biomol Screen 9:434-438
25. Trager W, Williams J (1992) Extracellular (axenic) development in vitro of the erythrocytic cycle of P. falciparum. Proc Natl Acad Sci U S A 89:5351-5355
26. Taylor CA, Senchyna M, Flanagan J, Joyce EM, Cliché DO, Boone AN, Culp-Stewart S, Thompson JE (2004) Role of eIF5A in TNF-alpha-mediated apoptosis of lamina cribrosa cells. Invest Ophthalmol Vis Sci 45:3568-3576
27. Umland TC, Wolff EC, Park MH, Davies DR (2004) A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme×NAD×inhibitor ternary complex. J Biol Chem 27:28697-28705
28. Wang TW, Zhang CG, Wu W, Nowack LM, Madey E, Thompson JE (2005) Antisense suppression of deoxyhypusine synthase in tomato delays fruit softening and alters growth and development. Plant Physiol 138:1372-1382
29. Zanelli CF, Maragno AL Gregio AP, Komili S, Pandolfi JR, Mestriner CA, Lustri WR, Valentini SR (2006) EIF5A binds to translational machinery components and affects translation in yeast. Biochem Biophys Res Commun 348:1358-1366