메뉴 건너뛰기




Volumn 6, Issue , 2011, Pages

Neuroprotective effects of ginsenosides Rh1 and Rg2 on neuronal cells

Author keywords

[No Author keywords available]

Indexed keywords

GINSENOSIDE; GINSENOSIDE RH 2; GINSENOSIDES RH1; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOPAMINE; UNCLASSIFIED DRUG;

EID: 79955988875     PISSN: None     EISSN: 17498546     Source Type: Journal    
DOI: 10.1186/1749-8546-6-19     Document Type: Article
Times cited : (19)

References (59)
  • 1
    • 0037379324 scopus 로고    scopus 로고
    • Genetic and environmental factors in the cause of Parkinson's disease
    • Warner TT, Schapira AH. Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol 2003, 53(Suppl 3):16-25.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3 , pp. 16-25
    • Warner, T.T.1    Schapira, A.H.2
  • 2
    • 44949138796 scopus 로고    scopus 로고
    • A review of Parkinson's disease
    • 10.1093/bmb/ldn013, 18398010
    • Davie CA. A review of Parkinson's disease. Br Med Bull 2008, 86:109-127. 10.1093/bmb/ldn013, 18398010.
    • (2008) Br Med Bull , vol.86 , pp. 109-127
    • Davie, C.A.1
  • 3
    • 33646849308 scopus 로고    scopus 로고
    • 6-Hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cδ
    • Hanrott K, Gudmunsen L, O'Neill MJ, Wonnacott S. 6-Hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cδ. J Biol Chem 2006, 281:5373-5382.
    • (2006) J Biol Chem , vol.281 , pp. 5373-5382
    • Hanrott, K.1    Gudmunsen, L.2    O'Neill, M.J.3    Wonnacott, S.4
  • 4
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease
    • Linert W, Herlinger E, Jameson RF, Kienzl E, Jellinger K, Youdim MB. Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease. Biochim Biophys Acta 1996, 1316:160-168.
    • (1996) Biochim Biophys Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3    Kienzl, E.4    Jellinger, K.5    Youdim, M.B.6
  • 5
    • 0028914437 scopus 로고
    • Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine
    • 10.1021/jm00006a010, 7699708
    • Napolitano A, Crescenzi O, Pezzella A, Prota G. Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine. J Med Chem 1995, 38:917-922. 10.1021/jm00006a010, 7699708.
    • (1995) J Med Chem , vol.38 , pp. 917-922
    • Napolitano, A.1    Crescenzi, O.2    Pezzella, A.3    Prota, G.4
  • 6
    • 0342369569 scopus 로고    scopus 로고
    • Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease
    • Soto-Otero R, Méndez-Alvarez E, Hermida-Ameijeiras A, Muñoz-Patiño AM, Labandeira-Garcia JL. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem 2000, 74:1605-1612.
    • (2000) J Neurochem , vol.74 , pp. 1605-1612
    • Soto-Otero, R.1    Méndez-Alvarez, E.2    Hermida-Ameijeiras, A.3    Muñoz-Patiño, A.M.4    Labandeira-Garcia, J.L.5
  • 7
    • 0034646802 scopus 로고    scopus 로고
    • Extracellular toxicity of 6-hydroxydopamine on PC12 cells
    • 10.1016/S0304-3940(00)00948-4, 10754220
    • Blum D, Torch S, Nissou MF, Benabid AL, Verna JM. Extracellular toxicity of 6-hydroxydopamine on PC12 cells. Neurosci Lett 2000, 283:193-196. 10.1016/S0304-3940(00)00948-4, 10754220.
    • (2000) Neurosci Lett , vol.283 , pp. 193-196
    • Blum, D.1    Torch, S.2    Nissou, M.F.3    Benabid, A.L.4    Verna, J.M.5
  • 8
    • 72149127646 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways
    • 10.1016/j.jep.2009.09.038, 19799986
    • Ge KL, Chen WF, Xie JX, Wong MS. Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways. J Ethnopharmacol 2010, 127:118-123. 10.1016/j.jep.2009.09.038, 19799986.
    • (2010) J Ethnopharmacol , vol.127 , pp. 118-123
    • Ge, K.L.1    Chen, W.F.2    Xie, J.X.3    Wong, M.S.4
  • 9
    • 47149114009 scopus 로고    scopus 로고
    • Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway
    • 10.1016/j.ijdevneu.2008.03.009, 18462913
    • Li Z, Hu Y, Zhu Q, Zhu J. Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway. Int J Dev Neurosci 2008, 26:635-640. 10.1016/j.ijdevneu.2008.03.009, 18462913.
    • (2008) Int J Dev Neurosci , vol.26 , pp. 635-640
    • Li, Z.1    Hu, Y.2    Zhu, Q.3    Zhu, J.4
  • 10
    • 52049104485 scopus 로고    scopus 로고
    • Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine
    • 10.1111/j.1471-4159.2008.05588.x, 18665912
    • Rodriguez-Blanco J, Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez C. Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine. J Neurochem 2008, 107:127-140. 10.1111/j.1471-4159.2008.05588.x, 18665912.
    • (2008) J Neurochem , vol.107 , pp. 127-140
    • Rodriguez-Blanco, J.1    Martín, V.2    Herrera, F.3    García-Santos, G.4    Antolín, I.5    Rodriguez, C.6
  • 12
    • 3142621044 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid
    • 10.1254/jphs.FMJ04001X4, 15215638
    • Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 2004, 95:153-157. 10.1254/jphs.FMJ04001X4, 15215638.
    • (2004) J Pharmacol Sci , vol.95 , pp. 153-157
    • Hasegawa, H.1
  • 13
    • 51349086818 scopus 로고    scopus 로고
    • Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium
    • 10.1111/j.1745-7254.2008.00868.x, 18718179
    • Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin 2008, 29:1103-1108. 10.1111/j.1745-7254.2008.00868.x, 18718179.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1103-1108
    • Chen, C.F.1    Chiou, W.F.2    Zhang, J.T.3
  • 14
    • 0034868729 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1)
    • 10.1055/s-2001-16488, 11509974
    • Rudakewich M, Ba F, Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med 2001, 67:533-537. 10.1055/s-2001-16488, 11509974.
    • (2001) Planta Med , vol.67 , pp. 533-537
    • Rudakewich, M.1    Ba, F.2    Benishin, C.G.3
  • 15
    • 0042530357 scopus 로고    scopus 로고
    • Protective effect of ginsenoside Rg1 on MPP+-induced apoptosis in SHSY5Y cells
    • 10.1007/s00702-003-0005-y, 12898340
    • Chen XC, Fang F, Zhu YG, Chen LM, Zhou YC, Chen Y. Protective effect of ginsenoside Rg1 on MPP+-induced apoptosis in SHSY5Y cells. J Neural Transm 2003, 110:835-845. 10.1007/s00702-003-0005-y, 12898340.
    • (2003) J Neural Transm , vol.110 , pp. 835-845
    • Chen, X.C.1    Fang, F.2    Zhu, Y.G.3    Chen, L.M.4    Zhou, Y.C.5    Chen, Y.6
  • 16
    • 11844268081 scopus 로고    scopus 로고
    • Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress
    • 10.1111/j.1745-7254.2005.00019.x, 15659115
    • Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM. Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol Sin 2005, 26:56-62. 10.1111/j.1745-7254.2005.00019.x, 15659115.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 56-62
    • Chen, X.C.1    Zhou, Y.C.2    Chen, Y.3    Zhu, Y.G.4    Fang, F.5    Chen, L.M.6
  • 17
    • 70449535513 scopus 로고    scopus 로고
    • Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells
    • 10.1016/j.taap.2009.09.009, 19781563
    • Hwang YP, Jeong HG. Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. Toxicol Appl Pharmacol 2010, 242:18-28. 10.1016/j.taap.2009.09.009, 19781563.
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 18-28
    • Hwang, Y.P.1    Jeong, H.G.2
  • 18
    • 0842265668 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP+-affected mesencephalic dopaminergic cells
    • 10.1007/s00702-003-0063-1, 14714214
    • Radad K, Gille G, Moldzio R, Saito H, Ishige K, Rausch WD. Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP+-affected mesencephalic dopaminergic cells. J Neural Transm 2004, 111:37-45. 10.1007/s00702-003-0063-1, 14714214.
    • (2004) J Neural Transm , vol.111 , pp. 37-45
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Ishige, K.5    Rausch, W.D.6
  • 19
    • 4344622460 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate
    • 10.1016/j.brainres.2004.06.030, 15328030
    • Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 2004, 1021:41-53. 10.1016/j.brainres.2004.06.030, 15328030.
    • (2004) Brain Res , vol.1021 , pp. 41-53
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Rausch, W.D.5
  • 20
    • 70350062072 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway
    • 10.1111/j.1476-5381.2009.00361.x, 2765594, 19703168
    • Xu L, Chen WF, Wong MS. Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway. Br J Pharmacol 2009, 158:738-748. 10.1111/j.1476-5381.2009.00361.x, 2765594, 19703168.
    • (2009) Br J Pharmacol , vol.158 , pp. 738-748
    • Xu, L.1    Chen, W.F.2    Wong, M.S.3
  • 21
    • 0036743094 scopus 로고    scopus 로고
    • Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells
    • 10.1021/np0201117, 12350149
    • Zou K, Zhu S, Meselhy MR, Tohda C, Cai S, Komatsu K. Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J Nat Prod 2002, 65:1288-1292. 10.1021/np0201117, 12350149.
    • (2002) J Nat Prod , vol.65 , pp. 1288-1292
    • Zou, K.1    Zhu, S.2    Meselhy, M.R.3    Tohda, C.4    Cai, S.5    Komatsu, K.6
  • 22
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2008, 55:1-99.
    • (2008) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 23
    • 33748809553 scopus 로고    scopus 로고
    • Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
    • 10.1016/j.febslet.2006.08.044, 16962103
    • Tansakul P, Shibuya M, Kushiro T, Ebizuka Y. Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett 2006, 580:5143-5149. 10.1016/j.febslet.2006.08.044, 16962103.
    • (2006) FEBS Lett , vol.580 , pp. 5143-5149
    • Tansakul, P.1    Shibuya, M.2    Kushiro, T.3    Ebizuka, Y.4
  • 24
    • 79959507089 scopus 로고    scopus 로고
    • Wild Rose College and Wholistic Clinic
    • Wild Rose College and Wholistic Clinic. , http://www.wrc.net/wrcnet_content/herbalresources/materiamedica/materiamedica.aspx?mmid=15
  • 25
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: cellular and molecular biology
    • 10.1210/er.20.3.321, 10368774
    • McKenna NJ, Lanz RB, O'Malley BW. Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 1999, 20:321-344. 10.1210/er.20.3.321, 10368774.
    • (1999) Endocr Rev , vol.20 , pp. 321-344
    • McKenna, N.J.1    Lanz, R.B.2    O'Malley, B.W.3
  • 27
    • 1442323686 scopus 로고    scopus 로고
    • Minireview: A plethora of estrogen receptors in the brain: where will it end?
    • Toran-Allerand CD. Minireview: A plethora of estrogen receptors in the brain: where will it end?. Endocrinology 2004, 145:1069-1074.
    • (2004) Endocrinology , vol.145 , pp. 1069-1074
    • Toran-Allerand, C.D.1
  • 28
    • 0035852657 scopus 로고    scopus 로고
    • Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    • 10.1073/pnas.041483198, 29363, 11172057
    • Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 2001, 98:1952-1957. 10.1073/pnas.041483198, 29363, 11172057.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1952-1957
    • Dubal, D.B.1    Zhu, H.2    Yu, J.3    Rau, S.W.4    Shughrue, P.J.5    Merchenthaler, I.6    Kindy, M.S.7    Wise, P.M.8
  • 29
    • 27644508001 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: critical role of the A/B domain of the receptor
    • 10.1677/jme.1.01826, 16216907
    • Mérot Y, Ferrière F, Debroas E, Flouriot G, Duval D, Saligaut C. Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: critical role of the A/B domain of the receptor. J Mol Endocrinol 2005, 35:257-267. 10.1677/jme.1.01826, 16216907.
    • (2005) J Mol Endocrinol , vol.35 , pp. 257-267
    • Mérot, Y.1    Ferrière, F.2    Debroas, E.3    Flouriot, G.4    Duval, D.5    Saligaut, C.6
  • 31
    • 0033118387 scopus 로고    scopus 로고
    • Stable transfection of PC12 cells with estrogen receptor (ERalpha): protective effects of estrogen on cell survival after serum deprivation
    • 10.1002/(SICI)1097-4547(19990401)56:1<99::AID-JNR13>3.0.CO;2-G, 10213481
    • Gollapudi L, Oblinger MM. Stable transfection of PC12 cells with estrogen receptor (ERalpha): protective effects of estrogen on cell survival after serum deprivation. J Neurosci Res 1999, 56:99-108. 10.1002/(SICI)1097-4547(19990401)56:1<99::AID-JNR13>3.0.CO;2-G, 10213481.
    • (1999) J Neurosci Res , vol.56 , pp. 99-108
    • Gollapudi, L.1    Oblinger, M.M.2
  • 32
    • 0037233177 scopus 로고    scopus 로고
    • Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway
    • 10.1210/en.2002-220698, 12488359
    • Mize AL, Shapiro RA, Dorsa DM. Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway. Endocrinology 2003, 144:306-312. 10.1210/en.2002-220698, 12488359.
    • (2003) Endocrinology , vol.144 , pp. 306-312
    • Mize, A.L.1    Shapiro, R.A.2    Dorsa, D.M.3
  • 33
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • 10.1038/sj.onc.1210392, 17496909
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007, 26:3100-3112. 10.1038/sj.onc.1210392, 17496909.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 34
    • 38149085101 scopus 로고    scopus 로고
    • Regulatory mechanisms of mitogen-activated kinase signaling
    • 10.1007/s00018-007-7012-3, 17726577
    • Zhang Y, Dong C. Regulatory mechanisms of mitogen-activated kinase signaling. Cell Mol Life Sci 2007, 64:2771-2789. 10.1007/s00018-007-7012-3, 17726577.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2771-2789
    • Zhang, Y.1    Dong, C.2
  • 35
    • 0034111152 scopus 로고    scopus 로고
    • Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts
    • Wang YZ, Bonner JC. Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts. Am J Respir Cell Mol Biol 2000, 22:590-596.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 590-596
    • Wang, Y.Z.1    Bonner, J.C.2
  • 36
    • 0032527705 scopus 로고    scopus 로고
    • The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival
    • 1219585, 9657968
    • Wang X, Martindale JL, Liu Y, Holbrook NJ. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 1998, 333:291-300. 1219585, 9657968.
    • (1998) Biochem J , vol.333 , pp. 291-300
    • Wang, X.1    Martindale, J.L.2    Liu, Y.3    Holbrook, N.J.4
  • 37
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • 10.1126/science.270.5240.1326, 7481820
    • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331. 10.1126/science.270.5240.1326, 7481820.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 38
    • 0034697364 scopus 로고    scopus 로고
    • Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
    • 10.1074/jbc.275.16.12200, 10766856
    • Stanciu M, Wang Y, Kentor R, Burke N, Watkins S, Kress G, Reynolds I, Klann E, Angiolieri MR, Johnson JW, DeFranco DB. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 2000, 275:12200-12206. 10.1074/jbc.275.16.12200, 10766856.
    • (2000) J Biol Chem , vol.275 , pp. 12200-12206
    • Stanciu, M.1    Wang, Y.2    Kentor, R.3    Burke, N.4    Watkins, S.5    Kress, G.6    Reynolds, I.7    Klann, E.8    Angiolieri, M.R.9    Johnson, J.W.10    DeFranco, D.B.11
  • 39
    • 2442608520 scopus 로고    scopus 로고
    • ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3
    • 10.1083/jcb.200403028, 2172179, 15123736
    • Subramaniam S, Zirrgiebel U, von Bohlen, Halbach O, Strelau J, Laliberté C, Kaplan DR, Unsicker K. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol 2004, 165:357-369. 10.1083/jcb.200403028, 2172179, 15123736.
    • (2004) J Cell Biol , vol.165 , pp. 357-369
    • Subramaniam, S.1    Zirrgiebel, U.2    von Bohlen3    Halbach, O.4    Strelau, J.5    Laliberté, C.6    Kaplan, D.R.7    Unsicker, K.8
  • 40
    • 77953304307 scopus 로고    scopus 로고
    • Inhibition of extracellular signal-regulated kinases (ERK)1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-κB-regulated antiapoptotic mechanisms
    • Lu K, Liang CL, Liliang PC, Yang CH, Cho CL, Weng HC, Tsai YD, Wang KW, Chen HJ. Inhibition of extracellular signal-regulated kinases (ERK)1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-κB-regulated antiapoptotic mechanisms. J Neurochem 2010, 114:237-246.
    • (2010) J Neurochem , vol.114 , pp. 237-246
    • Lu, K.1    Liang, C.L.2    Liliang, P.C.3    Yang, C.H.4    Cho, C.L.5    Weng, H.C.6    Tsai, Y.D.7    Wang, K.W.8    Chen, H.J.9
  • 41
    • 0034648063 scopus 로고    scopus 로고
    • Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
    • 10.1016/S0304-3940(00)01229-5, 10876086
    • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 2000, 288:163-166. 10.1016/S0304-3940(00)01229-5, 10876086.
    • (2000) Neurosci Lett , vol.288 , pp. 163-166
    • Satoh, T.1    Nakatsuka, D.2    Watanabe, Y.3    Nagata, I.4    Kikuchi, H.5    Namura, S.6
  • 42
    • 0037216665 scopus 로고    scopus 로고
    • Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis
    • 10.1124/jpet.102.040246, 12490588
    • Wang X, Wang H, Xu L, Rozanski DJ, Sugawara T, Chan PH, Trzaskos JM, Feuerstein GZ. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 2003, 304:172-178. 10.1124/jpet.102.040246, 12490588.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 172-178
    • Wang, X.1    Wang, H.2    Xu, L.3    Rozanski, D.J.4    Sugawara, T.5    Chan, P.H.6    Trzaskos, J.M.7    Feuerstein, G.Z.8
  • 43
    • 0028225403 scopus 로고
    • An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells
    • Lustig RH, Hua P, Yu W, Ahmad FJ, Baas PW. An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells. J Neurosci 1994, 14:3945-3957.
    • (1994) J Neurosci , vol.14 , pp. 3945-3957
    • Lustig, R.H.1    Hua, P.2    Yu, W.3    Ahmad, F.J.4    Baas, P.W.5
  • 44
    • 47849085831 scopus 로고    scopus 로고
    • Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells
    • 10.1016/j.tox.2008.04.001, 18756631
    • Ossola B, Kääräinen TM, Raasmaja A, Männistö PT. Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Toxicology 2008, 250:1-8. 10.1016/j.tox.2008.04.001, 18756631.
    • (2008) Toxicology , vol.250 , pp. 1-8
    • Ossola, B.1    Kääräinen, T.M.2    Raasmaja, A.3    Männistö, P.T.4
  • 46
    • 34247230363 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    • 10.1016/j.jep.2006.12.015, 17257792
    • Li N, Liu B, Dluzen DE, Jin Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J Ethnopharmacol 2007, 111:458-463. 10.1016/j.jep.2006.12.015, 17257792.
    • (2007) J Ethnopharmacol , vol.111 , pp. 458-463
    • Li, N.1    Liu, B.2    Dluzen, D.E.3    Jin, Y.4
  • 47
    • 0037462036 scopus 로고    scopus 로고
    • In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes
    • 10.1021/jf026228i, 12696936
    • Liu ZQ, Luo XY, Liu GZ, Chen YP, Wang ZC, Sun YX. In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. J Agric Food Chem 2003, 51:2555-2558. 10.1021/jf026228i, 12696936.
    • (2003) J Agric Food Chem , vol.51 , pp. 2555-2558
    • Liu, Z.Q.1    Luo, X.Y.2    Liu, G.Z.3    Chen, Y.P.4    Wang, Z.C.5    Sun, Y.X.6
  • 48
    • 57649129461 scopus 로고    scopus 로고
    • Protective effect of ginsenosides Rg(2) and Rh(1) on oxidation-induced impairment of erythrocyte membrane properties
    • Samukawa K, Suzuki Y, Ohkubo N, Aoto M, Sakanaka M, Mitsuda N. Protective effect of ginsenosides Rg(2) and Rh(1) on oxidation-induced impairment of erythrocyte membrane properties. Biorheology 2008, 45:689-700.
    • (2008) Biorheology , vol.45 , pp. 689-700
    • Samukawa, K.1    Suzuki, Y.2    Ohkubo, N.3    Aoto, M.4    Sakanaka, M.5    Mitsuda, N.6
  • 49
    • 0037728660 scopus 로고    scopus 로고
    • A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells
    • 10.1016/S0960-0760(03)00067-0, 12732291
    • Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 2003, 84:463-468. 10.1016/S0960-0760(03)00067-0, 12732291.
    • (2003) J Steroid Biochem Mol Biol , vol.84 , pp. 463-468
    • Lee, Y.1    Jin, Y.2    Lim, W.3    Ji, S.4    Choi, S.5    Jang, S.6    Lee, S.7
  • 50
    • 34250891417 scopus 로고    scopus 로고
    • 6-Hydroxydopamine induces mitochondrial ERK activation
    • 10.1016/j.freeradbiomed.2007.04.028, 2023873, 17602953
    • Kulich SM, Horbinski C, Patel M, Chu CT. 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic Biol Med 2007, 43:372-383. 10.1016/j.freeradbiomed.2007.04.028, 2023873, 17602953.
    • (2007) Free Radic Biol Med , vol.43 , pp. 372-383
    • Kulich, S.M.1    Horbinski, C.2    Patel, M.3    Chu, C.T.4
  • 51
    • 38049005109 scopus 로고    scopus 로고
    • Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells
    • 10.1002/jnr.21478, 17847117
    • Lin E, Cavanaugh JE, Leak RK, Perez RG, Zigmond MJ. Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells. J Neurosci Res 2008, 86:108-117. 10.1002/jnr.21478, 17847117.
    • (2008) J Neurosci Res , vol.86 , pp. 108-117
    • Lin, E.1    Cavanaugh, J.E.2    Leak, R.K.3    Perez, R.G.4    Zigmond, M.J.5
  • 52
    • 0036345583 scopus 로고    scopus 로고
    • Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng
    • 10.1210/jc.87.8.3691, 12161497
    • Chan RY, Chen WF, Dong A, Guo D, Wong MS. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab 2002, 87:3691-3695. 10.1210/jc.87.8.3691, 12161497.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3691-3695
    • Chan, R.Y.1    Chen, W.F.2    Dong, A.3    Guo, D.4    Wong, M.S.5
  • 53
    • 3242708348 scopus 로고    scopus 로고
    • Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding
    • 10.1210/jc.2003-031823, 15240639
    • Cho J, Park W, Lee S, Ahn W, Lee Y. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 2004, 89:3510-3515. 10.1210/jc.2003-031823, 15240639.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3510-3515
    • Cho, J.1    Park, W.2    Lee, S.3    Ahn, W.4    Lee, Y.5
  • 54
    • 38649129855 scopus 로고    scopus 로고
    • Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway
    • 10.1016/j.jsbmb.2007.06.005, 17936617
    • Lau WS, Chan RY, Guo DA, Wong MS. Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway. J Steroid Biochem Mol Biol 2008, 108:64-71. 10.1016/j.jsbmb.2007.06.005, 17936617.
    • (2008) J Steroid Biochem Mol Biol , vol.108 , pp. 64-71
    • Lau, W.S.1    Chan, R.Y.2    Guo, D.A.3    Wong, M.S.4
  • 55
    • 0041308144 scopus 로고    scopus 로고
    • Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells
    • 10.1007/BF03179933, 12568360
    • Lee YJ, Jin YR, Lim WC, Park WK, Cho JY, Jang S, Lee SK. Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res 2003, 26:58-63. 10.1007/BF03179933, 12568360.
    • (2003) Arch Pharm Res , vol.26 , pp. 58-63
    • Lee, Y.J.1    Jin, Y.R.2    Lim, W.C.3    Park, W.K.4    Cho, J.Y.5    Jang, S.6    Lee, S.K.7
  • 56
    • 0036838768 scopus 로고    scopus 로고
    • Protective effects of estrogen and selective estrogen receptor modulators in the brain
    • 10.1095/biolreprod.102.003848, 12390866
    • Dhandapani KM, Brann DW. Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 2002, 67:1379-1385. 10.1095/biolreprod.102.003848, 12390866.
    • (2002) Biol Reprod , vol.67 , pp. 1379-1385
    • Dhandapani, K.M.1    Brann, D.W.2
  • 57
    • 0019048612 scopus 로고
    • HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. 2nd communication
    • 10.1055/s-2008-1074929, 7413841
    • Soldati F, Sticher O. HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. 2nd communication. Planta Med 1980, 39:348-357. 10.1055/s-2008-1074929, 7413841.
    • (1980) Planta Med , vol.39 , pp. 348-357
    • Soldati, F.1    Sticher, O.2
  • 58
    • 21344437013 scopus 로고    scopus 로고
    • Evidence that the tertiary structure of 20(S)-ginsenoside Rg(3) with tight hydrophobic packing near the chiral center is important for Na(+) channel regulation
    • 10.1016/j.bbrc.2005.06.026, 15979567
    • Kang DI, Lee JY, Yang JY, Jeong SM, Lee JH, Nah SY, Kim Y. Evidence that the tertiary structure of 20(S)-ginsenoside Rg(3) with tight hydrophobic packing near the chiral center is important for Na(+) channel regulation. Biochem Biophys Res Commun 2005, 333:1194-1201. 10.1016/j.bbrc.2005.06.026, 15979567.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 1194-1201
    • Kang, D.I.1    Lee, J.Y.2    Yang, J.Y.3    Jeong, S.M.4    Lee, J.H.5    Nah, S.Y.6    Kim, Y.7
  • 59
    • 65749114119 scopus 로고    scopus 로고
    • 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity
    • 10.1016/j.bmcl.2009.04.054, 19428246
    • Liu J, Shiono J, Shimizu K, Yu H, Zhang C, Jin F, Kondo R. 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity. Bioorg Med Chem Lett 2009, 19:3320-3323. 10.1016/j.bmcl.2009.04.054, 19428246.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 3320-3323
    • Liu, J.1    Shiono, J.2    Shimizu, K.3    Yu, H.4    Zhang, C.5    Jin, F.6    Kondo, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.