H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Blood

Volumn 117, Issue 19, 2011, Pages 5102-5111

  Iborra, Salvador ^a,e   Soto, Manuel ^a   Stark Aroeira, Luiz ^b   Castellano, Esther ^c   Alarcón, Balbino ^a   Alonso, Carlos ^a   Santos, Eugenio ^c   Fernández Malavé, Edgar ^d  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c Centro de Investigacion del Cancer   (Spain)

^d SCHOOL OF MEDICINE   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN H RAS; PROTEIN N RAS; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; THYMOCYTE;

EID: 79955955743     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-10-315770     Document Type: Article

References (50)

1. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol. 2002;2(12):933-944. (Pubitemid 37323214)
2. O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science. 2010;327(5969):1098-1102.
3. Olson MF, Marais R. Ras protein signalling. Semin Immunol. 2000;12(1):63-73. (Pubitemid 30114017)
4. Downward J, Graves JD, Warne PH, et al. Stimulation of p21ras upon T-cell activation. Nature. 1990;346(6286):719-723.
5. Ehrhardt A, David MD, Ehrhardt GR, et al. Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen. Mol Cell Biol. 2004;24(14):6311-6323. (Pubitemid 38891132)
6. Mor A, Campi G, Du G, et al. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol. 2007;9(6):713-719. (Pubitemid 47214735)
7. Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol. 2005;15(14):R563-R574. (Pubitemid 41026614)
8. Mor A, Philips MR. Compartmentalized Ras/MAPK signaling. Annu Rev Immunol. 2006;24:771-800.
9. Genot E, Cantrell DA. Ras regulation and function in lymphocytes. Curr Opin Immunol. 2000;12(3):289-294. (Pubitemid 30240538)
10. Scheele JS, Marks RE, Boss GR. Signaling by small GTPases in the immune system. Immunol Rev. 2007;218:92-101. (Pubitemid 47052300)
11. Swan KA, Alberola-Ila J, Gross JA, et al. Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J. 1995;14(2):276-285.
12. Yamashita M, Kimura M, Kubo M, et al. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A. 1999;96(3):1024-1029. (Pubitemid 29072177)
13. Feig LA. Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat Cell Biol. 1999;1(2):E25-E27.
14. Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci. 2005;118(Pt 5):843-846.
15. Esteban LM, Vicario-Abejon C, Fernandez-Salguero P, et al. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol. 2001;21(5):1444-1452. (Pubitemid 32156364)
16. Umanoff H, Edelmann W, Pellicer A, et al. The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A. 1995;92(5):1709-1713.
17. Johnson L, Greenbaum D, Cichowski K, et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997;11(19):2468-2481. (Pubitemid 27438829)
18. Kaye J, Hsu ML, Sauron ME, et al. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 1989;341(6244):746-749. (Pubitemid 19260889)
19. Hogquist KA, Jameson SC, Heath WR, et al. T cell receptor antagonist peptides induce positive selection. Cell. 1994;76(1):17-27. (Pubitemid 24035278)
20. Iborra S, Carrion J, Anderson C, et al. Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice. Infect Immun. 2005;73(9):5842-5852. (Pubitemid 41193021)
21. Sun Z, Arendt CW, Ellmeier W, et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000;404(6776):402-407. (Pubitemid 30164343)
22. Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126(1):131-138. (Pubitemid 13203451)
23. Perez de Castro I, Diaz R, Malumbres M, et al. Mice deficient for N-ras: impaired antiviral immune response and T-cell function. Cancer Res. 2003;63(7):1615-1622. (Pubitemid 36373652)
24. Alberola-Ila J, Forbush KA, Seger R, et al. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature. 1995;373(6515):620-623.
25. Szabo SJ, Sullivan BM, Peng SL, et al. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol. 2003;21:713-758. (Pubitemid 37174546)
26. Grogan JL, Mohrs M, Harmon B, et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 2001;14(3):205-215. (Pubitemid 32289286)
27. Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol. 2004;4(4):249-258. (Pubitemid 38478660)
28. Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100(6):655-669.
29. Lord GM, Rao RM, Choe H, et al. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005;106(10):3432-3439. (Pubitemid 41609178)
30. Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002;2(11):845-858. (Pubitemid 37328707)
31. Sypek JP, Chung CL, Mayor SE, et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med. 1993;177(6):1797-1802. (Pubitemid 23146148)
32. Chakir H, Campos-Neto A, Mojibian M, et al. IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response. Microbes Infect. 2003;5(4):241-249. (Pubitemid 36428713)
33. Zimmermann S, Egeter O, Hausmann S, et al. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J Immunol. 1998;160(8):3627-3630. (Pubitemid 28176060)
34. Mendez S, Tabbara K, Belkaid Y, et al. Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability. Infect Immun. 2003;71(9):5121-5129. (Pubitemid 37070755)
35. Sommer F, Meixner M, Mannherz M, et al. Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice. Int Immunol. 1998;10(12):1853-1861. (Pubitemid 28566047)
36. Plowman SJ, Williamson DJ, O'Sullivan MJ, et al. While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol. 2003;23(24):9245-9250. (Pubitemid 37499811)
37. Johnson L, Mercer K, Greenbaum D, et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 2001;410(6832):1111- 1116. (Pubitemid 32391044)
38. Daniels MA, Teixeiro E, Gill J, et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature. 2006;444(7120):724-729. (Pubitemid 44949596)
39. Usui T, Preiss JC, Kanno Y, et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med. 2006;203(3):755-766.
40. Berenson LS, Ota N, Murphy KM. Issues in Thelper 1 development-resolved and unresolved. Immunol Rev. 2004;202:157-174.
41. Sharp LL, Schwarz DA, Bott CM, et al. The influence of the MAPK pathway on T cell lineage commitment. Immunity. 1997;7(5):609-618. (Pubitemid 28156629)
42. Schulz EG, Mariani L, Radbruch A, et al. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity. 2009;30(5):673-683.
43. Constant SL, Dong C, Yang DD, et al. JNK1 is required for T cell-mediated immunity against Leishmania major infection. J Immunol. 2000;165(5):2671-2676. (Pubitemid 30660716)
44. Rodriguez-Viciana P, Sabatier C, McCormick F. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol. 2004;24(11):4943-4954. (Pubitemid 38668058)
45. Nakayama T, Yamashita M. The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin Immunol. 2010;22(5):303-309.
46. Roberts AW, Kim C, Zhen L, et al. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 1999;10(2):183-196. (Pubitemid 29115624)
47. Li B, Yu H, Zheng W, et al. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science. 2000;288(5474):2219-2222. (Pubitemid 30429608)
48. Croker BA, Handman E, Hayball JD, et al. Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol. 2002;80(3):231-240. (Pubitemid 34639373)
49. Castellano E, De Las RJ, Guerrero C, et al. Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses. Oncogene. 2007;26(6):917-933.
50. Reuter CW, Morgan MA, Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. 2000;96(5):1655-1669. (Pubitemid 30661043)