Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 16871-16878

  Norrgård, Malena A ^a   Hellman, Ulf ^a   Mannervik, Bengt ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE SUBSTRATES; AROMATIC SUBSTITUTIONS; CATALYTIC ACTIVITY; CATALYTIC FUNCTIONS; CHEMICAL REAGENTS; CYS RESIDUES; DIFFERENT EFFECTS; ENZYME SPECIFICITY; FUNCTIONAL PROPERTIES; GLUTATHIONE TRANSFERASE; LARGE-SCALE PRODUCTION; MODIFIED PROTEINS; MUTANT ENZYMES; NATURAL PROTEINS; PRIMARY STRUCTURES; RECOMBINANT PROTEIN; SIDE-CHAINS; SIMPLE SUBSTITUTION; SITE DIRECTED MUTAGENESIS; SUBSTRATE-BINDING SITES; WILD-TYPE ENZYMES;

AMINO ACIDS; BINDING SITES; CATALYST ACTIVITY; CHEMICAL MODIFICATION; ENZYMES; MASS SPECTROMETRY; PROTEINS; SCANNING;

SUBSTRATES;

ALANINE; CYSTEINE; GLUTATHIONE TRANSFERASE; TYROSINE;

ALKYLATION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR CLONING; NITROSYLATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ALANINE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CYSTEINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; MASS SPECTROMETRY; METHIONINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 79955775737     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.230078     Document Type: Article

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