Alteration of the Specificity of Malate Dehydrogenase by Chemical Modulation of an Active Site Arginine

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31151-31155

  Wright, S Kirk ^a   Viola, Ronald E ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; GENETIC ENGINEERING; OXIDATION;

MUTANTS; SITE-SPECIFIC MODULATIONS;

ENZYMES;

2 OXOGLUTARIC ACID; AMIDINE; AMINE; AMINO ACID DERIVATIVE; ARGININE; CYSTEINE; HYDROXYPYRUVIC ACID; MALATE DEHYDROGENASE; MALIC ACID; MUTANT PROTEIN; OXALOACETIC ACID; PYRUVIC ACID DERIVATIVE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; OXIDATION; PRIORITY JOURNAL; CHEMISTRY; METABOLISM; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ARGININE; BINDING SITES; CATALYSIS; MALATE DEHYDROGENASE; MUTAGENESIS, SITE-DIRECTED; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0035903146     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100892200     Document Type: Article

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