Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis

FEBS Letters

Volumn 435, Issue 1, 1998, Pages 69-73

  Kubo, Yoshihiro ^a   Yoshimichi, Murata ^a,b   Heinemann, Stefan H ^c  

^a Tokyo Metropol Inst for N   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c MAX PLANCK INSTITUTE   (Germany)

Author keywords

Cysteine; Inward rectifier; Mutagenesis; Pore topology; Potassium channel

Indexed keywords

AMINO ACID; CYSTEINE; POTASSIUM CHANNEL; REAGENT;

ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; MUTAGENESIS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RECORDING;

AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032508478     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01038-2     Document Type: Article

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