Confusion of concepts in mixture toxicology

Food and Chemical Toxicology

Volumn 34, Issue 11-12, 1996, Pages 1025-1031

  Konemann W H ^a   Pieters, M N ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT; ENVIRONMENTAL CHEMICAL;

DOSE RESPONSE; DRUG MIXTURE; HUMAN; MAMMAL; MODEL; NOMENCLATURE; NONHUMAN; SHORT SURVEY; STATISTICS;

EID: 0030292266     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(97)00070-7     Document Type: Article

References (27)

1. Ariëns E. J., Simonis A. M. and Offermeier J. (1976) Introduction to General Toxicology. Revised printing. Academic Press, London.
2. Ashford J. R. (1981) General models for the joint action of drugs. Biometrics 37, 457-474.
3. Ashford J. R. and Cobby J. M. (1974) A system of models for the action of drugs applied singly or jointly to biological organisms. Biometrics 30, 11-31.
4. Berenbaum M. C. (1985) The expected effect of a combination of agents: the general solution. Journal of Theoretical Biology 114, 413-431.
5. Berenbaum M. C. (1989) What is synergy?. Pharmacological Reviews 41, 93-141.
6. Bliss C. I. (1939) The toxicity of poisons applied jointly. Annals of Applied Biology 26, 585-615.
7. Deneer J. W., Sinnige T. L., Seinen W. and Hermens J. L. M. (1988) The joint acute toxicity to Daphnia magna of industrial organic chemicals at low concentrations. Aquatic Toxicology 12, 33-38.
8. EIFAC (1987) Water Quality Criteria for European Freshwater Fish. Revised report on combined effects on freshwater fish and aquatic life of mixtures of toxicants in water (Technical Paper 37, rev. 1.), Rome.
9. Finney D. J. (1942) The analysis of toxicity tests on mixtures of poisons. Annals of Applied Biology 29, 82-94.
10. Finney D. J. (1971) Probit Analysis. Cambridge University Press, Cambridge.
11. Hermens J., Broekhuyzen E., Canton J. H. and Wegman R. (1985a) Quantitative structure activity relationships and mixture toxicity studies of alcohols and chlorohydrocarbons: effects on growth of Daphnia magna. Aquatic Toxicology 6, 209-217.
12. Hermens J., Canton J. H., Steyger N. and Wegman R. (1984a) Joint effect of a mixture of 14 chemicals on mortality and inhibition of reproduction of Daphnia magna. Aquatic Toxicology 5, 315-322.
13. Hermens J. and Leeuwangh P. (1982) Joint toxicity of mixtures of 8 and 24 chemicals to the guppy (Poecilia reticulata). Ecotoxicology and Environmental Safety 6, 302-310.
14. Hermens J., Leeuwangh P. and Musch A. (1984b) Quantitative structure activity relationships and mixture toxicity studies of chloro-and alkylanilines at an acute lethal toxicity level to the guppy (Poecilia reticulata). Ecotoxicology and Environmental Safety 8, 388-394.
15. Hermens J., Leeuwangh P, and Musch A. (1985b) Joint toxicity of mixtures of groups of organic aquatic pollutants to the guppy (Poecilia reticulata). Ecotoxicology and Environmental Safety 9, 321-326.
16. Hewlett P. S. and Placket R. L. (1959) A unified theory for quantal responses to mixtures of drugs: non-interactive action. Biometrics 15, 591-610.
17. Hewlett P. S. and Placket R. L. (1964) A unified theory for quantal responses to mixtures of drugs: competitive action. Biometrics 20, 566-575.
18. Jonker D., Jones M. A., van Bladeren P. J., Woutersen R. A., Til H. P. and Feron V. J. (1993) Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. Food and Chemical Toxicology 31, 45-52.
19. Jonker D., Woutersen R. A., van Bladeren P. J., Til H. P. and Feron V. J. (1990) 4-Week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds. Food and Chemical Toxicology 28, 623-631.
20. Kodell R. L. and Pounds J. G. (1991) Assessing the toxicity of mixtures of chemicals. In Statistics in Toxicology. Edited by D. Krewski and C. Franklin. pp. 559-591. Gordon and Breach, New York.
21. Könemann W. H. (1981) Fish toxicity tests with mixtures of more than two chemicals: a proposal for a quantitative approach and experimental results. Toxicology 19, 229-238.
22. Mehendale H. M. (1990) Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism. Medical Hypotheses 33, 289-299.
23. Placket R. L. and Hewlett P. S. (1952) Quantal responses to mixtures of poisons. Journal of the Royal Statistical Society, Series B 14, 143-163.
24. Placket R. L. and Hewlett P. S. (1963) A unified theory for quantal responses to mixtures of drugs: the fitting of data of certain models for two non-interactive drugs with complete positive correlation of tolerances. Biometrics 19, 517-531.
25. Placket R. L. and Hewlett P. S. (1967) A comparison of two approaches to the construction of models for quantal responses to mixtures of drugs. Biometrics 23, 27-44.
26. Soni M. G. and Mehendale H. M. (1991) Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies. Toxicology and Applied Pharmacology 108, 58-66.
27. US EPA. (1986) Guidelines for the health risk assessment of chemical mixtures. US Environmental Protection Agency. Federal Register 51, 34014-34025.