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Volumn 19, Issue 1, 1998, Pages 207-212

Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ANTIOXIDANT; BIS(2 HYDROXYPROPYL)NITROSAMINE; BUTYLATED HYDROXYANISOLE; CAFFEIC ACID; CATECHOL; DIETHYLNITROSAMINE; MEQUINOL; METHYLNITROSOUREA; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE;

EID: 0031820173     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.1.207     Document Type: Article
Times cited : (169)

References (37)
  • 2
    • 0022761966 scopus 로고
    • Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters
    • Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y. and Ito, N. (1986) Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. Carcinogenesis, 7, 1285-1289.
    • (1986) Carcinogenesis , vol.7 , pp. 1285-1289
    • Hirose, M.1    Inoue, T.2    Asamoto, M.3    Tagawa, Y.4    Ito, N.5
  • 3
    • 0023235633 scopus 로고
    • Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks
    • Hirose, M., Masuda, A., Imaida, K., Kagawa, M., Tsuda, H. and Ito, N. (1987) Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks. Japan. J. Cancer Res.(Gann), 78, 317-321.
    • (1987) Japan. J. Cancer Res.(Gann) , vol.78 , pp. 317-321
    • Hirose, M.1    Masuda, A.2    Imaida, K.3    Kagawa, M.4    Tsuda, H.5    Ito, N.6
  • 4
    • 0022631167 scopus 로고
    • Short-term effects of various phenols and acids on the Fischer 344 male rat forestomach epithelium
    • Rodrigues, C., Lok, E., Nera, E., Iverson, F., Page, D., Karpinski, K. and Clayson, D.B. (1986) Short-term effects of various phenols and acids on the Fischer 344 male rat forestomach epithelium. Toxicology, 38, 103-117.
    • (1986) Toxicology , vol.38 , pp. 103-117
    • Rodrigues, C.1    Lok, E.2    Nera, E.3    Iverson, F.4    Page, D.5    Karpinski, K.6    Clayson, D.B.7
  • 5
    • 0025933853 scopus 로고
    • Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N×C3H/HeN F1 mice
    • Hagiwara, A., Hirose, M., Takahashi, S., Ogawa, K., Shirai, T. and Ito, N. (1991) Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N×C3H/HeN F1 mice. Cancer Res., 51, 5655-5660.
    • (1991) Cancer Res. , vol.51 , pp. 5655-5660
    • Hagiwara, A.1    Hirose, M.2    Takahashi, S.3    Ogawa, K.4    Shirai, T.5    Ito, N.6
  • 6
    • 0027093470 scopus 로고
    • Forestomach neoplasm induction in F344 /DuCrj rats B6C3F1 mice exposed to sesamol
    • Tamano, S., Hirose, M., Tanaka, H., Asakawa, E., Ogawa, K. and Ito, N., (1992) Forestomach neoplasm induction in F344 /DuCrj rats B6C3F1 mice exposed to sesamol. Japan. J. Cancer Res., 83, 1279-1285.
    • (1992) Japan. J. Cancer Res. , vol.83 , pp. 1279-1285
    • Tamano, S.1    Hirose, M.2    Tanaka, H.3    Asakawa, E.4    Ogawa, K.5    Ito, N.6
  • 7
    • 0028040120 scopus 로고
    • Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats
    • Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S. and Ito, N. (1994) Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int. J. Cancer, 56, 146-152.
    • (1994) Int. J. Cancer , vol.56 , pp. 146-152
    • Asakawa, E.1    Hirose, M.2    Hagiwara, A.3    Takahashi, S.4    Ito, N.5
  • 10
    • 0023687087 scopus 로고
    • Modification of N-methyl-N′-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats
    • Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M. and Ito, N. (1988) Modification of N-methyl-N′-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Cancer Res., 48, 5310-5315.
    • (1988) Cancer Res. , vol.48 , pp. 5310-5315
    • Hirose, M.1    Fukushima, S.2    Kurata, Y.3    Tsuda, H.4    Tatematsu, M.5    Ito, N.6
  • 11
    • 0024437057 scopus 로고
    • Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine
    • Yamaguchi, S., Hirose, M., Fukushima, S., Hasegawa, R. and Ito, N. (1989) Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res., 49, 6015-6018.
    • (1989) Cancer Res. , vol.49 , pp. 6015-6018
    • Yamaguchi, S.1    Hirose, M.2    Fukushima, S.3    Hasegawa, R.4    Ito, N.5
  • 12
    • 0020960114 scopus 로고
    • Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats
    • Imaida, K., Fukushima, S., Shirai, T., Ohtani, M., Nakanishi, K. and Ito, N. (1983) Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats. Carcinogenesis, 4, 895-899.
    • (1983) Carcinogenesis , vol.4 , pp. 895-899
    • Imaida, K.1    Fukushima, S.2    Shirai, T.3    Ohtani, M.4    Nakanishi, K.5    Ito, N.6
  • 13
    • 0021210942 scopus 로고
    • Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol
    • Tsuda, H., Sakata, T., Shirai, T., Kurata, Y., Tamano, S. and Ito, N. (1984) Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol. Cancer Lett., 24, 19-27.
    • (1984) Cancer Lett. , vol.24 , pp. 19-27
    • Tsuda, H.1    Sakata, T.2    Shirai, T.3    Kurata, Y.4    Tamano, S.5    Ito, N.6
  • 14
    • 0021132033 scopus 로고
    • Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats
    • Imaida, K., Fukushima, S., Shirai, T., Masui, T., Ogiso, T. and Ito, N. (1984) Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats. Gann, 75, 769-775.
    • (1984) Gann , vol.75 , pp. 769-775
    • Imaida, K.1    Fukushima, S.2    Shirai, T.3    Masui, T.4    Ogiso, T.5    Ito, N.6
  • 15
    • 0023028961 scopus 로고
    • Epigenetic promoting effects of butylated hydroxyanisole
    • Williams, G.M., (1986) Epigenetic promoting effects of butylated hydroxyanisole. Food. Chem. Toxic., 24, 1163-1166.
    • (1986) Food. Chem. Toxic. , vol.24 , pp. 1163-1166
    • Williams, G.M.1
  • 16
    • 0024351624 scopus 로고
    • Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N′-nitro-N-nitrosoguanidine
    • Hirose, M., Kagawa, M., Ogawa, K., Yamamoto, A. and Ito, N. (1989) Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis, 10, 2223-2226.
    • (1989) Carcinogenesis , vol.10 , pp. 2223-2226
    • Hirose, M.1    Kagawa, M.2    Ogawa, K.3    Yamamoto, A.4    Ito, N.5
  • 17
    • 0025973809 scopus 로고
    • Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N′-nitro-N-nitrosamine
    • Hirose, M., Mutai, M., Takahashi, S., Yamada, M., Fukushima, S. and Ito, N. (1991) Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N′-nitro-N-nitrosamine. Cancer Res., 51, 824-827.
    • (1991) Cancer Res. , vol.51 , pp. 824-827
    • Hirose, M.1    Mutai, M.2    Takahashi, S.3    Yamada, M.4    Fukushima, S.5    Ito, N.6
  • 18
    • 0021227345 scopus 로고
    • Naturally occurring phenolics as antimutagenic and anticarcinogenic agents
    • Stich, H.F. and Rosin, M.P. (1984) Naturally occurring phenolics as antimutagenic and anticarcinogenic agents. Adv. Exp. Med. Biol., 177, 1-29.
    • (1984) Adv. Exp. Med. Biol. , vol.177 , pp. 1-29
    • Stich, H.F.1    Rosin, M.P.2
  • 19
    • 84985286338 scopus 로고
    • Source of antioxidant activity of soybeans and soy products
    • Pratt, D.E. and Birav, P.M. (1979) Source of antioxidant activity of soybeans and soy products. J. Food Sci., 44, 1720-1722.
    • (1979) J. Food Sci. , vol.44 , pp. 1720-1722
    • Pratt, D.E.1    Birav, P.M.2
  • 20
    • 0000146593 scopus 로고
    • On the distribution of caffeic acid and the chlorogenic acid isomers in plants
    • Sondheimer, E. (1958) On the distribution of caffeic acid and the chlorogenic acid isomers in plants. Arch. Biochem. Biophys., 74, 131-138.
    • (1958) Arch. Biochem. Biophys. , vol.74 , pp. 131-138
    • Sondheimer, E.1
  • 21
    • 0002517839 scopus 로고
    • Chemistry and implications of degradation of phenolic antioxidants
    • Hudson, B.J.F. (ed.) Elsevier Applied Sciences, London and New York
    • Kikugawa, K., Kunugi, A. and Kurechi, T. (1991) Chemistry and implications of degradation of phenolic antioxidants. In Hudson, B.J.F. (ed.) Food Antioxidants. Elsevier Applied Sciences, London and New York, pp. 65-98.
    • (1991) Food Antioxidants , pp. 65-98
    • Kikugawa, K.1    Kunugi, A.2    Kurechi, T.3
  • 23
    • 0024808972 scopus 로고
    • Combination effects of forty carcinogens administered at low doses to male rats
    • Takayama, S., Hasegawa, H. and Ohgaki, H. (1989) Combination effects of forty carcinogens administered at low doses to male rats. Japan. J. Cancer Res., 80, 732-736.
    • (1989) Japan. J. Cancer Res. , vol.80 , pp. 732-736
    • Takayama, S.1    Hasegawa, H.2    Ohgaki, H.3
  • 24
    • 0023473297 scopus 로고
    • Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats
    • Takayama, S., Nakatsuru, Y. and Sato, S. (1987) Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats. Japan. J. Cancer Res., 78, 1068-1072.
    • (1987) Japan. J. Cancer Res. , vol.78 , pp. 1068-1072
    • Takayama, S.1    Nakatsuru, Y.2    Sato, S.3
  • 25
    • 0029857907 scopus 로고    scopus 로고
    • Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat
    • Hasegawa, R., Yoshimara, I., Imaida, K., Ito, N. and Shirai, T. (1996) Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Japan. J. Cancer Res., 87, 1125-1133.
    • (1996) Japan. J. Cancer Res. , vol.87 , pp. 1125-1133
    • Hasegawa, R.1    Yoshimara, I.2    Imaida, K.3    Ito, N.4    Shirai, T.5
  • 26
    • 0026344092 scopus 로고
    • Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction
    • Yamane, T., Hagiwara, N., Tateishi, M. et al. (1991) Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction. Japan. J. Cancer Res., 82, 1336-1339.
    • (1991) Japan. J. Cancer Res. , vol.82 , pp. 1336-1339
    • Yamane, T.1    Hagiwara, N.2    Tateishi, M.3
  • 27
    • 0027378288 scopus 로고
    • A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats
    • Narisawa, T. and Fukaura, Y. (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Japan. J. Cancer Res., 84, 1007-1009.
    • (1993) Japan. J. Cancer Res. , vol.84 , pp. 1007-1009
    • Narisawa, T.1    Fukaura, Y.2
  • 28
    • 0027531048 scopus 로고
    • Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats
    • Hagiwara, A., Tanaka, H., Imaida, K., Tamano, S., Fukushima, S. and Ito, N. (1993) Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Japan. J. Cancer Res., 84, 237-245.
    • (1993) Japan. J. Cancer Res. , vol.84 , pp. 237-245
    • Hagiwara, A.1    Tanaka, H.2    Imaida, K.3    Tamano, S.4    Fukushima, S.5    Ito, N.6
  • 29
    • 0029873749 scopus 로고    scopus 로고
    • Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents
    • Ito, N., Hasegawa, R., Imaida, K., Hirose, M. and Shirai, T. (1996) Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp. Toxic. Pathol., 48, 113-119.
    • (1996) Exp. Toxic. Pathol. , vol.48 , pp. 113-119
    • Ito, N.1    Hasegawa, R.2    Imaida, K.3    Hirose, M.4    Shirai, T.5
  • 30
    • 0022897920 scopus 로고
    • Dose-response in butylated hydroxyanixole induction of forestomach carcinogenesis in F344 rats
    • Ito, N., Fukushima, S., Tamano, S., Hirose, M. and Hagiwara, A. (1986) Dose-response in butylated hydroxyanixole induction of forestomach carcinogenesis in F344 rats. J. Natl Cancer Inst., 77, 1261-1265.
    • (1986) J. Natl Cancer Inst. , vol.77 , pp. 1261-1265
    • Ito, N.1    Fukushima, S.2    Tamano, S.3    Hirose, M.4    Hagiwara, A.5
  • 31
    • 0021236673 scopus 로고
    • Effects of butylated hydroxyanisole, butylated hydroxytoluene, and NaCl on gastric carcinogenesis initiated with N-methyl-N′-nitro-N-nitrosoguanidine in F344 rats
    • Shirai, T., Fukushima, S., Ohshima, M., Masuda, A. and Ito, N. (1984) Effects of butylated hydroxyanisole, butylated hydroxytoluene, and NaCl on gastric carcinogenesis initiated with N-methyl-N′-nitro-N-nitrosoguanidine in F344 rats. J. Natl Cancer Inst., 72, 1189-1198.
    • (1984) J. Natl Cancer Inst. , vol.72 , pp. 1189-1198
    • Shirai, T.1    Fukushima, S.2    Ohshima, M.3    Masuda, A.4    Ito, N.5
  • 32
    • 0025028879 scopus 로고
    • Paramethoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis
    • Wada, S., Hirose, M., Takahashi, S., Okazaki, S. and Ito, N. (1990) Paramethoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis. Carcinogenesis, 11, 1891-1894.
    • (1990) Carcinogenesis , vol.11 , pp. 1891-1894
    • Wada, S.1    Hirose, M.2    Takahashi, S.3    Okazaki, S.4    Ito, N.5
  • 33
    • 0023279110 scopus 로고
    • Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N,N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats
    • Fukushima, S., Sakata, T., Tagawa, Y., Shibata, M.-A., Hirose, M. and Ito, N. (1987) Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N,N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res., 47, 2113-2116.
    • (1987) Cancer Res. , vol.47 , pp. 2113-2116
    • Fukushima, S.1    Sakata, T.2    Tagawa, Y.3    Shibata, M.-A.4    Hirose, M.5    Ito, N.6
  • 35
    • 0021875832 scopus 로고
    • Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase
    • Thamavit, W., Tatematsu, M., Ogiso, T., Mera, Y., Tsuda, H. and Ito, N. (1985) Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase. Cancer Lett., 27, 295-303.
    • (1985) Cancer Lett. , vol.27 , pp. 295-303
    • Thamavit, W.1    Tatematsu, M.2    Ogiso, T.3    Mera, Y.4    Tsuda, H.5    Ito, N.6
  • 36
    • 0024401066 scopus 로고
    • Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model
    • Thamavit, W., Fukushima, S., Kurata, Y., Asamoto, M. and Ito, N. (1989) Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. Cancer Lett., 45, 93-101.
    • (1989) Cancer Lett. , vol.45 , pp. 93-101
    • Thamavit, W.1    Fukushima, S.2    Kurata, Y.3    Asamoto, M.4    Ito, N.5
  • 37
    • 0021345702 scopus 로고
    • Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats
    • Maeura, Y. and Williams, G.M. (1984) Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats. Food. Chem. Toxic., 22, 191-198.
    • (1984) Food. Chem. Toxic. , vol.22 , pp. 191-198
    • Maeura, Y.1    Williams, G.M.2


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