Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans

Toxicology and Applied Pharmacology

Volumn 144, Issue 1, 1997, Pages 120-134

  Tardif, Robert ^a   Charest Tardif, Ginette ^a   Brodeur, Jules ^a   Krishnan, Kannan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLBENZENE; ETHYLBENZENE; TOLUENE; XYLENE;

ARTICLE; DRUG METABOLISM; DRUG MIXTURE; HUMAN; METABOLIC INHIBITION; MODEL; NONHUMAN; PHARMACOKINETICS; RAT; SIMULATION; TOXICOKINETICS; VOLUNTEER;

EID: 0031149782     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8096     Document Type: Article

References (26)

1. American Conference of Governmental Industrial Hygienists (ACGIH), 1995-1996, 1995-1996 Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices, American Conference of Governmental Industrial Hygienists, Technical Affairs Office, Cincinnati, Ohio.
2. M. E. Andersen, H. J. Clewell, 1983, Pharmacokinetic interaction of mixtures, Proceedings of the Fourteenth Annual Conference on Environmental Toxicology, 226, 238, AFAMRL-TR-83-099, Dayton, OH.
3. Andersen M. E., Gargas M. L., Clewell H. J. III, Severyn K. M. Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylenein vivo. Toxicol. Appl. Pharmacol. 89:1987;185-205.
4. A. D. Arms, C. C. Travis, 1988, Reference Parameters in Pharmacokinetic Modeling (NTIS PB 88-196019), Washington, DC.
5. Beck B. A., Rudel R., Calabrese E. J. The use of toxicology in the regulatory practice. Principles and Methods of Toxicology. 1994;Raven Press. p. 19-58.
6. Constan A. A., Tessari J. D., Yang R. S. H. Effects of repeated exposure to a mixture of ground water contaminants in Fischer-344 rats: A pilot study of PBPK modeling of chemical mixtures. Toxicologist. 13:1993;448.
7. El-Masri H. A., Tessari J. D., Yang R. S. H. Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: Utilization of PBPK model. Arch. Toxicol. 70:1996;527-539.
8. Gargas M. L., Burgess R. J., Voisard D. J., Cason G. H., Andersen M. E. Partition coefficients of low molecular weight volatile compounds in various liquids and tissues. Toxicol. Appl. Pharmacol. 98:1989;87-99.
9. Kaneko T., Endoh K., Sato A. Biological monitoring of exposure to organic solvent vapors. I. A physiological simulation model ofm. Yamanashi Med. J. 6:1991;127-135.
10. Krishnan K., Brodeur J. Toxicological consequences of combined exposure to environmental pollutants. Arch. Comp. Environ. Studies. 3:1991;1-106.
11. Krishnan K., Andersen M. E., Clewell H. J. III., Yang R. S. H. Physiologically based pharmacokinetic modeling of chemical mixtures. Yang R. S. H. Toxicology of Chemical Mixtures. 1994;399-437 Academic Press.
12. Liira J., Eolvaara R., Raunio H., Riihimaki V., Engstrom K. Metabolic interaction and disposition of methylethyl ketone andm. Xenobiotica. 21:1991;53-65.
13. Nakajima T., Wang R., Elovaara E., Park S. S., Gelboin H. V., Hiltman E., Vainio H. Monoclonal antibody directed characterization of cytochrome P-450 isoenzymes responsible for toluene metabolism in rat liver. Biochem. Pharmacol. 41:1991;395-404.
14. Poggi G., Guisiani M., Palagie V., Paggiaro P. L., Loi W. M., Dazzi F., Siclari C., Baschieri L. High-performance liquid chromatography for the quantitative determination of the urinary metabolites of toluene, xylene and styrene. Int. Arch. Occup. Environ. Health. 50:1982;25-31.
15. Purcell K. J., Cason G. H., Gargas M. L., Andersen M. E., Travis C. C. In vivo. Toxicol. Lett. 52:1990;141-152.
16. Ramsey J. C., Andersen M. E. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:1984;159.
17. Sato A. The effect of environmental factors on the pharmacokinetic behavior of organic solvent vapors. Ann. Occup. Hyg. 35:1991;525-541.
18. Sato A., Endoh K., Kaneko T., Johansson G. Effects of consumption of ethanol on the biological monitoring of exposure to organic solvent vapors: A simulation study with trichloroethylene. Br. J. Ind. Med. 48:1990;548-556.
19. Tardif R., Laparé S., Krishnan K., Brodeur J. Physiologically-based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat. Toxicol. Appl. Pharmacol. 120:1993;266-273.
20. Tardif R., Laparé S., Charest-Tardif G., Brodeur J., Krishnan K. Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans. Risk Anal. 15:1995;335-342.
21. Tardif R., Laparé S., Plaa G. L., Brodeur J. Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices. Int. Arch. Occup. Environ. Health. 63:1991;279-284.
22. Tardif R., Charest-Tardif G., Brodeur J. Comparison of the influence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat. Arch. Toxicol. 70:1996;405-413.
23. Tassanuyakul W., Birkett D. J., Edwards J. W., Veronese M. E., Tassanuyakul W., Tukeg r. H., Miners J. O. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene andomp. J. Pharm. Exp. Ther. 276:1996;101-108.
24. Thakore K. N., Gargas M. L., Andersen M. E., Mehendale H. M. PBPK derived metabolic constants, hepatotoxicity, and lethality of bromodichloromethane in rats pretreated with chlordecone, phenobarbital or Mirex. Toxicol. Appl. Pharmacol. 109:1991;514-528.
25. Toftgard R., Nilsen O. G. Effect of xylene and xylene isomers on cytochrome P-450 andin vitro. Arch. Toxicol. 23:1982;197-212.
26. Truchon G., Tardif R., Brodeur J. Gas chromatographic determination of urinaryo. J. Anal. Toxicol. 20:1996;309-312.