Synergy and other ineffective mixture risk definitions

Science of the Total Environment

Volumn 288, Issue 1-2, 2002, Pages 31-42

  Hertzberg, Richard C ^a   MacDonell, Margaret M ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

Additivity; Interaction; Joint toxicity; Mixture; Risk assessment; Synergism

Indexed keywords

HEALTH RISKS; MATHEMATICAL MODELS; PHARMACOKINETICS; TOXIC MATERIALS;

TOXICOLOGIC INTERACTIONS;

RISK ASSESSMENT;

PHARMACEUTICAL INDUSTRY; RISK ASSESSMENT;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; DECISION MAKING; DOSE CALCULATION; EMOTION; ENVIRONMENTAL EXPOSURE; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; PUBLIC HEALTH; RISK ASSESSMENT; TOXICITY;

ANIMALS; DRUG SYNERGISM; FORECASTING; HUMANS; MODELS, THEORETICAL; PHARMACOKINETICS; RISK ASSESSMENT; TERMINOLOGY; TOXICOLOGY;

EID: 0037041199     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0048-9697(01)01113-5     Document Type: Article

References (22)

1. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods
2. Evaluating chemical interaction studies for mixture risk assessment
3. Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: Utilization of a PBPK model
4. Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment
5. Quantitative structure-pharmacokinetic relationship modelling
6. Isobolographic analysis of interactions: An update on applications and utility
7. The search for synergy: A critical review from a response surface perspective
8. Methods for health risk assessment of combustion mixtures
9. Assessing the toxicity of mixtures of chemicals
10. Risk analysis software and databases: Review of Riskware'90 conference and exhibition
11. Implementing a mixtures risk assessment at a cleanup site
12. A weight-of-evidence scheme for assessing interactions in chemical mixtures
13. Chemical mixtures: Current risk assessment methodologies and future directions
14. Comparing occupational and environmental risk assessment methodologies using pharmacokinetic modeling
15. Physiologically-based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans
16. Low dose responses