Toxicological evaluation of chemical mixtures

Food and Chemical Toxicology

Volumn 40, Issue 6, 2002, Pages 825-839

  Feron, V J ^a   Groten, J P ^a  

^a TNO   (Netherlands)

Author keywords

Challenges ahead; Chemical mixtures; Current issues; Safety evaluation; Toxicology

Indexed keywords

BROMODICHLOROMETHANE; BUTYLCRESOL; CHLOROFORM; CURCUMIN; FLAVORING AGENT; FOOD ADDITIVE; GALLIC ACID PROPYL ESTER; PHENOL DERIVATIVE; POTASSIUM BROMATE; TIABENDAZOLE; TOXIC SUBSTANCE; WATER;

AIR QUALITY; AIRPORT; AMBIENT AIR; ARTICLE; ATMOSPHERE; CARCINOGENIC ACTIVITY; DISINFECTION; FOOD INTAKE; GENOMICS; HAZARD ASSESSMENT; HUMAN; NONHUMAN; PROTEOMICS; RISK ASSESSMENT; SAFETY; WATER CONTAMINATION; WATER QUALITY;

AIR POLLUTANTS; ANIMALS; DRUG INTERACTIONS; FOOD; HUMANS; MODELS, STATISTICAL; PUBLIC HEALTH; TOXICOLOGY; WATER SUPPLY; XENOBIOTICS;

EID: 0036236038     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00021-2     Document Type: Article

References (111)

1. The animals tried to tell us. Herbert E. Stokinger Lecture
2. Inhalation of sulfuric acid mist
3. Short-term inhalation exposure of healthy and compromised rats and mice to fine and ultrafine carbon particles
4. Criteria for analyzing interactions between biologically active agents
5. Odor - Intensity interaction in binary and tertiary mixtures
6. The toxicity of poisons applied jointly
7. Effects of repeated exposures of geriatic rats to ozone and particle containing atmospheres: An analysis of bronchoalveolar lavage and plasma proteins
8. Comparison of models of odor interaction
9. Response surface methodology for analyzing data from chemical mixture studies
10. A statistical approach to the construction and analysis of isobolograms
11. Sensory irritation to mixtures of formaldehyde, acrolein and acetaldehyde in rats
12. Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde and acrolein
13. Toxicological evaluation and risk assessment of chemical mixtures
14. In vitro toxicity of formaldehyde, acrolein and crotonaldehyde in nasal epithelium cells: Different approaches to study combined exposure
15. Toxicology of chemical mixtures
16. Chemosensory detectability of 1-butanol and 2-heptanone singly and in binary mixtures
17. Estimation of toxic hazard - A decision tree approach
18. Implications of chemical mixtures in public health practice
19. CombiTool - A new computer program for analyzing combination experiments with biologically active agents
20. Resolution of GC-MS data of complex PAC mixtures and regression modeling of mutagenicity by PLS
21. Chronic noise exposure and physiological response: A prospective study of children living under environmental stress
22. Toxicology of chemical mixtures: International perspective
23. International issues on human health effects of exposure to chemical mixtures
24. Toxicology of chemical mixtures: Challenges for today and the future
25. Exposure of humans to complex chemical mixtures: Hazard identification and risk assessment
26. Combination toxicology: From challenge to reality
27. The analysis of toxicity tests on mixtures of poisons
28. Economical designs for detecting and characterizing departure from additivity in mixtures of many chemicals
29. Interpreting plots of a multidimensional dose-response surface in a parallel coordinate system
30. A straightforward method for the study of drug interactions: An isobolographic analysis primer
31. The search for synergy: A critical review from a response surface perspective
32. Mixtures and interactions
33. An analysis of the possibility for health implications of joint actions and interactions between food additives
34. Mixtures
35. Toxicology of simple and complex mixtures
36. Use of factorial designs in combination toxicity studies
37. Subacute toxicity of a combination of nine chemicals in rats: Detecting interactive effects with a two-level factorial design
38. Resistance of very young mice to inhaled allergen sensitization is overcome by coexposure to an air-pollutant aerosol
39. Combined exposure to various chemicals in the environment
40. Ideas for evaluating quantitative formulas for dose-response assessment of chemical mixtures
41. Statistical analysis of array expression data as applied to the problem of tamoxifen resistance
42. Concomitant exposure to carbon black particulates enhances ozone-induced lung inflammation and suppression of alveolar macrophage phagocytosis
43. Toxicity of mixtures of nephrotoxicants with similar and dissimilar mode of action
44. 4-Week oral toxicity study of a combination of eight chemicals in rats: Comparison with the toxicity of the individual chemicals
45. Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: Comparison with the toxicity of the individual compounds
46. Chemical mixtures released from waste sites: Implications for health risk assessment
47. The biomol software package for the mechanistic modeling of the biochemistry of the mixtures
48. Assessing the toxicity of mixtures of chemicals
49. PBPK modeling and extrapolation of interactions from binary to more complex mixtures
50. Threshold of toxicological concern for chemical substances present in the diet: A practical tool for assessing the need for toxicity testing
51. Strange brew: Assessing risk of chemical mixtures
52. Synergistic interaction of ozone and respirable aerosols on rat lungs. I. Importance of aerosol acidity
53. Synergistic interaction between nitrogen dioxide and respirable aerosols of sulfuric acid or sodium chloride on rat lungs
54. Chemometrics: Clustering and classification of analytical data
55. Über Kombinationswirkungen
56. A nonadditive tumor response to a mixture of disinfection by-products
57. Effects of ozone on diesel exhaust particle toxicity in rat lung
58. Approaches and challenges in risk assessment of chemical mixtures
59. Risk assessment of chemical mixtures: Biologic and toxicologic issues
60. Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern
61. Principles for the safety evaluation of flavouring substances
62. Chemical and biological evaluation of building material emissions. II. Approaches for setting indoor air standards or guidelines for chemicals
63. GRAS flavoring substances 18
64. Harmonised hazard classification criteria for mixtures
65. Detection thresholds for an olfactory mixture and its three constituent compounds
66. Nano-opto-chemical sensors for real-time in vivo imaging of physiological processes
67. Statistical aspects of the independent joint action of poisons, particularly insecticides
68. Quantal responses to mixtures of poisons
69. The use of human in vitro metabolic parameters to explore the risk of hazardous compounds: The case of ethylene dibromide
70. Evaluation of experimental combined toxicity by use of dose frequency curves: Comparison with theoretical additivity as well as independence
71. Proteomics and the health effect assessment of chemical mixtures
72. Statistical designs in combination toxicology: A matter of choice
73. Integrated-technology based toxicology studies on drinking water disinfection byproducts
74. Experimental designs, statistics and interpretation
75. Exploitable mechanisms in combined radiotherapy - Chemotherapy: The concept of additivity
76. Zero interaction response surfaces, interaction functions and different response surfaces for combinations of biologically active agents
77. Assessment of interaction of biologically active agents by means of the isobole approach: Fundamental assumptions and recent developments
78. Evaluation of interaction in olfactory and taste mixtures
79. Zero interaction response surfaces for combined-action assessment
80. Parallel dose-response curves in combination experiments
81. Statistical methods for toxicological evaluation
82. Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions
83. Environmental chemical mixtures risk assessment: Current approaches and emerging issues
84. Application of functional genomics to chemical mixture research
85. A proposed approach to study the toxicology of complex mixtures of petroleum products: The integrated use of QSAR, lumping analysis and PBPK/PD modeling
86. Acute pulmonary toxicity of urban particulate matter and ozone
87. Optical sensor micro- and nanoarrays for complex sample analysis
88. Large-scale temporal gene expression mapping of central nervous system development
89. Toxicity of chemical mixtures: Proteomic analysis of persisting liver and kidney protein alterations induced by repeated exposure of rats to JP-8 jet fuel vapor
90. Partial least square projections to latent structures (PLS) in chemistry
91. Toxicology of chemical mixtures: Experimental approaches, underlying concepts, and some results
92. Application of computer modeling to simple or complex mixtures